Gene: PREP

5550
PE|PEP
prolyl endopeptidase
protein-coding
6q21
Ensembl:ENSG00000085377 MIM:600400 Vega:OTTHUMG00000015297 UniprotKB:P48147
NG_011472.1
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.271e-1 (AD)  5.784e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP1A10.954
PAK10.952
ATP6V1B20.95
LRFN50.945
ARHGEF30.945
ATP6V1C10.942
FBXO340.942
PDP10.941
MAPK80.94
BTBD100.94

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.517
RAI14-0.506
YES1-0.495
MYOM1-0.475
OR4F5-0.475
MYL3-0.474
MBNL3-0.469
REST-0.466
ASB4-0.458
SH2D1A-0.45

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB016841-Hydroxy-1-Thio-GlycerolSmall MoleculeExperimentalTarget
DB03382S-oxy-L-cysteineSmall MoleculeExperimentalTarget
DB03535Z-Pro-ProlinalSmall MoleculeExperimentalTarget
DB03864MonothioglycerolSmall MoleculeExperimentalTarget
DB07148(6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)pyrrolo[1,2-a]pyrazin-4(6H)-oneSmall MoleculeExperimentalTarget
DB087381-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-oneSmall MoleculeExperimentalTarget
DB087392-{3-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-3-oxopropyl}-isoindole-1,3(2H)-dioneSmall MoleculeExperimentalTarget
DB00107OxytocinBiotechDrug50-56-6ApprovedEnzyme
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PREP mRNA"19114083
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of PREP mRNA28522335
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PREP mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PREP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PREP mRNA"27188386
D000082AcetaminophenPREP gene polymorphism affects the susceptibility to Acetaminophen26104854
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PREP gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PREP mRNA16483693
D001241AspirinAspirin results in decreased expression of PREP mRNA15928584
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PREP mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PREP mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PREP mRNA"19150397
C006780bisphenol Abisphenol A results in increased expression of PREP mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PREP gene28505145
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PREP mRNA20360939
D016572CyclosporineCyclosporine results in decreased expression of PREP mRNA20106945
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PREP mRNA20360939
D004317DoxorubicinDoxorubicin results in increased expression of PREP mRNA22008532
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PREP protein23301498
C062669epicatechin gallateepicatechin gallate results in decreased activity of PREP protein10923840
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PREP mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PREP mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PREP mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of PREP mRNA23649840
D015025ZearalenoneZearalenone results in decreased expression of PREP protein25058043
D005419FlavonoidsFlavonoids results in increased expression of PREP mRNA18035473
D005485FlutamideFlutamide results in decreased expression of PREP mRNA24793618
D005485FlutamideFlutamide results in increased expression of PREP mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of PREP mRNA23649840
C039281furanfuran results in increased methylation of PREP gene22079235
D007052IbuprofenIbuprofen results in increased expression of PREP mRNA28201806
D007213IndomethacinIndomethacin results in increased expression of PREP mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PREP mRNA25613284
C094211JTP 4819JTP 4819 results in decreased activity of PREP protein21487212
C094211JTP 4819JTP 4819 results in decreased activity of PREP protein7562510
D007854LeadLead results in decreased expression of PREP mRNA19921347
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PREP mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PREP mRNA23649840
C038541N-benzyloxycarbonylprolylprolinalN-benzyloxycarbonylprolylprolinal results in decreased activity of PREP protein21487212
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of PREP mRNA19812364
D009532NickelNickel results in increased expression of PREP mRNA25583101
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of PREP mRNA17616710
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PREP mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PREP mRNA26272509
D010889PiracetamPiracetam inhibits the reaction [Scopolamine Hydrobromide results in increased expression of PREP protein]18318186
C014153pirimiphos methylpirimiphos methyl results in decreased activity of PREP protein9204212
D012601Scopolamine HydrobromidePiracetam inhibits the reaction [Scopolamine Hydrobromide results in increased expression of PREP protein]18318186
D012601Scopolamine HydrobromidePREP protein results in increased susceptibility to Scopolamine Hydrobromide17244263
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in increased expression of PREP protein18318186
C025462sulindac sulfidesulindac sulfide results in increased expression of PREP mRNA12734198
D013629TamoxifenTamoxifen affects the expression of PREP mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PREP mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of PREP mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PREP mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of PREP mRNA25975270
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PREP mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of PREP mRNA22378314
C112001tokaku-joki-totokaku-joki-to results in decreased activity of PREP protein10923840
C505532trans-3,5,4'-trihydroxystilbene-4'-O-beta-D-glucopyranoside"trans-3,5,4'-trihydroxystilbene-4'-O-beta-D-glucopyranoside results in decreased activity of PREP protein"10923840
D014212TretinoinTretinoin affects the activity of and affects the localization of PREP protein21487212
D014212TretinoinTretinoin results in increased expression of PREP mRNA21487212
D014212TretinoinTretinoin results in increased expression of PREP protein21487212
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of PREP mRNA19042947
D014415TunicamycinTunicamycin results in decreased expression of PREP mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of PREP mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PREP mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of PREP mRNA23179753|2800136
D024483Vitamin K 3Vitamin K 3 affects the expression of PREP mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004175endopeptidase activity-IBA21873635  
GO:0004252serine-type endopeptidase activity-IEA-  
GO:0005515protein binding-IPI23348613  
GO:0008236serine-type peptidase activity-TAS7959018  
GO:0070008serine-type exopeptidase activity-IEA-  
GO:0070012oligopeptidase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-TAS9695945  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18768457PREP advertisement features affect smokers' beliefs regarding potential harm. (2008 Sep)Strasser AATob Control
16484135Evaluation of urinary 1-hydroxypyrene, S-phenylmercapturic acid, trans,trans-muconic acid, 3-methyladenine, 3-ethyladenine, 8-hydroxy-2'-deoxyguanosine and thioethers as biomarkers of exposure to cigarette smoke. (2006 Jan-Feb)Feng SBiomarkers
21051089Higher levels of cervicovaginal inflammatory and regulatory cytokines and chemokines in healthy young women with immature cervical epithelium. (2011 Jan)Hwang LYJ Reprod Immunol
27851714Preexposure Prophylaxis for HIV Prevention in a Large Integrated Health Care System: Adherence, Renal Safety, and Discontinuation. (2016 Dec 15)Marcus JLJ Acquir Immune Defic Syndr
21434303[Endocervical adenocarcinoma--a current diagnostic problem]. (2010)Marinova PAkush Ginekol (Sofiia)