Gene: NOP10

55505
DKCB1|NOLA3|NOP10P
NOP10 ribonucleoprotein
protein-coding
15q14
Ensembl:ENSG00000182117 MIM:606471 Vega:OTTHUMG00000129440 UniprotKB:Q9NPE3
NG_011562.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.975e-1 (AD)  2.124e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EIF3I0.933
LSM100.932
TRMT1120.931
TMED90.929
JTB0.927
SNRPC0.924
UBL50.921
PSMA70.92
SNRPD20.92
SF3B50.919

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.808
OR4F29-0.772
P2RY14-0.213
OR6C74-0.189
OR13C3-0.176
SLC26A5-0.172
TRPV5-0.171
TCL1A-0.161
PRDM14-0.157
GRXCR2-0.156

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of NOP10 mRNA"15215175
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NOP10 mRNA27153756
D004958EstradiolEstradiol affects the expression of NOP10 mRNA23557687
C006780bisphenol Abisphenol A results in increased expression of NOP10 mRNA25181051
C100187chloropicrinchloropicrin results in increased expression of NOP10 mRNA26352163
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of NOP10 mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of NOP10 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of NOP10 mRNA24386269
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of NOP10 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NOP10 mRNA21266533
D002945CisplatinCisplatin results in increased expression of NOP10 mRNA27392435
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of NOP10 protein23301498
D005839GentamicinsGentamicins results in increased expression of NOP10 mRNA22061828
C005290oxybenzoneoxybenzone results in decreased expression of NOP10 mRNA22721600
C045362prochlorazprochloraz results in increased expression of NOP10 mRNA21470553
C009277sodium arsenatesodium arsenate results in decreased expression of NOP10 mRNA23922661
D014050TolueneToluene results in decreased expression of NOP10 mRNA22967744
D014635Valproic AcidValproic Acid affects the expression of NOP10 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NOP10 mRNA23179753

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-IPI18082603  
GO:0005515protein binding-IPI16601202  23685356  25416956  25910212  
GO:0034513box H/ACA snoRNA binding-IBA21873635  
GO:0034513box H/ACA snoRNA binding-IPI18082603  
GO:0070034telomerase RNA binding-IBA21873635  
GO:0070034telomerase RNA binding-IPI18082603  
GO:0070034telomerase RNA binding-TAS22527283  
GO ID GO Term Qualifier Evidence PubMed
GO:0000454snoRNA guided rRNA pseudouridine synthesis-IEA-  
GO:0001522pseudouridine synthesis-NAS9843512  
GO:0007004telomere maintenance via telomerase-TAS22527283  
GO:0031118rRNA pseudouridine synthesis-IBA21873635  
GO:0031120snRNA pseudouridine synthesis-IBA21873635  
GO:1904874positive regulation of telomerase RNA localization to Cajal body-HMP25467444  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0005697telomerase holoenzyme complex-IDA18082603  
GO:0005697telomerase holoenzyme complex-TAS20351177  22527283  
GO:0005732small nucleolar ribonucleoprotein complex-TAS9843512  
GO:0016604nuclear body-IDA-  
GO:0031429box H/ACA snoRNP complex-IBA21873635  
GO:0031429box H/ACA snoRNP complex-IDA18082603  
GO:0031429box H/ACA snoRNP complex-TAS22527283  
GO:0072589box H/ACA scaRNP complex-TAS22527283  
GO:0090661box H/ACA telomerase RNP complex-IBA21873635  
GO:0090661box H/ACA telomerase RNP complex-IDA18082603  
GO:0090661box H/ACA telomerase RNP complex-TAS22527283  
KEGG ID KEGG Term
hsa03008Ribosome biogenesis in eukaryotes
Reactome ID Reactome Term Evidence
R-HSA-6790901rRNA modification in the nucleus and cytosolTAS
R-HSA-72312rRNA processingTAS
R-HSA-8868773rRNA processing in the nucleus and cytosolTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20301779Dyskeratosis Congenita (1993)Savage SA-