Gene: H2AFY2

55506
macroH2A2
H2A histone family member Y2
protein-coding
10q22.1
Ensembl:ENSG00000099284 MIM:616141 Vega:OTTHUMG00000018396 UniprotKB:Q9P0M6
NC_000010.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.159e-1 (AD)  3.556e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARMC60.878
TRAPPC120.871
PEF10.866
SPPL30.864
RHBDD20.862
BCL7B0.862
RPUSD20.859
TIMM500.859
RRAGA0.858
BSCL20.857

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.639
OR4F29-0.556
TBX15-0.326
CSAG1-0.304
C9orf153-0.297
RAI14-0.291
ITGA1-0.29
TNFRSF10C-0.288
KCNJ15-0.288
CDA-0.287

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of H2AFY2 mRNA"28903501
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of H2AFY2 mRNA21983209
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of H2AFY2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of H2AFY2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of H2AFY2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of H2AFY2 mRNA17562736
C006632arsenic trioxidearsenic trioxide results in decreased expression of H2AFY2 mRNA22521957
C006780bisphenol Abisphenol A results in decreased expression of H2AFY2 mRNA25181051
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of H2AFY2 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of H2AFY2 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of H2AFY2 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of H2AFY2 mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of H2AFY2 mRNA23914054
C118739entinostatentinostat results in decreased expression of H2AFY2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of H2AFY2 mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of H2AFY2 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of H2AFY2 mRNA23550701
D004397FonofosFonofos results in increased methylation of H2AFY2 promoter22847954
C492448ICG 001ICG 001 results in increased expression of H2AFY2 mRNA26191083
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of H2AFY2 mRNA24796395|2675264
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of H2AFY2 mRNA26011545
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of H2AFY2 mRNA20971185
D010278ParathionParathion results in increased methylation of H2AFY2 promoter22847954
D052638Particulate MatterParticulate Matter results in increased methylation of H2AFY2 gene28495853
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of H2AFY2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of H2AFY2 mRNA22079256|2271453
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of H2AFY2 mRNA22698814
D011374ProgesteroneProgesterone results in decreased expression of H2AFY2 mRNA23012394|2301818
D011441PropylthiouracilPropylthiouracil results in increased expression of H2AFY2 mRNA24780913
D012643SeleniumSelenium results in increased expression of H2AFY2 mRNA19244175
C017947sodium arsenitesodium arsenite affects the expression of H2AFY2 mRNA19590694
C017947sodium arsenitesodium arsenite results in decreased expression of H2AFY2 mRNA22714537
D012969Sodium FluorideSodium Fluoride results in decreased expression of H2AFY2 protein28918527
C012568terbufosterbufos results in increased methylation of H2AFY2 promoter22847954
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of H2AFY2 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of H2AFY2 mRNA26232522
D014520UrethaneUrethane results in decreased expression of H2AFY2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of H2AFY2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of H2AFY2 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in decreased methylation of H2AFY2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of H2AFY2 gene25560391|2849585
C025643vinclozolinvinclozolin results in decreased expression of H2AFY2 mRNA22570695
D014810Vitamin EVitamin E results in increased expression of H2AFY2 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA23595991  
GO:0003677DNA binding-IBA21873635  
GO:0031490chromatin DNA binding-IDA19734898  
GO:0044212transcription regulatory region DNA binding-IDA19734898  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IMP19734898  
GO:0006325chromatin organization-IBA21873635  
GO:0006334nucleosome assembly-IEA-  
GO:0006342chromatin silencing-IBA21873635  
GO:0007420brain development-IMP19734898  
GO:0007549dosage compensation-IDA11331621  
GO:0045618positive regulation of keratinocyte differentiation-IMP23595991  
GO:0045814negative regulation of gene expression, epigenetic-IMP19734898  
GO:0071169establishment of protein localization to chromatin-IMP19734898  
GO:1901837negative regulation of transcription of nucleolar large rRNA by RNA polymerase I-IGI24071584  
GO ID GO Term Qualifier Evidence PubMed
GO:0000784nuclear chromosome, telomeric region-HDA19135898  
GO:0000786nucleosome-IEA-  
GO:0000790nuclear chromatin-IBA21873635  
GO:0000790nuclear chromatin-IDA19734898  
GO:0001740Barr body-IDA11331621  
GO:0005654nucleoplasm-IDA-  
GO:0035098ESC/E(Z) complexcolocalizes_withIDA19734898  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa05322Systemic lupus erythematosus
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29654602A Genome-Wide Association Study identifies new genes potentially associated with eyelid sagging. (2018 Apr 13)Laville VExp Dermatol