Gene info: ID 5551

Gene: PRF1

GENE ID: 5551

Synonyms: HPLH2|P1|PFP

Description: perforin 1

Gene type: protein-coding

Location: 10q22.1

dbXrefs: Ensembl:ENSG00000180644 MIM:170280 Vega:OTTHUMG00000018412 UniprotKB:P14222

RefSeq: NG_009615.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.369e-1 (AD) 5.013e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg20408402	chr10:72362452	PRF1		7.600e-20	Smoking	27651444
cg23059461	chr10:72362694	PRF1		8.400e-12	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GZMB	0.906
IL2RB	0.89
NKG7	0.878
SLAMF7	0.868
PYHIN1	0.849
TBX21	0.842
CTSW	0.838
KLRD1	0.828
KLRB1	0.825
GZMA	0.818

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MYADML2	-0.454
SVOP	-0.438
PRKCZ	-0.437
HTR5A	-0.436
CLCN4	-0.435
HCN1	-0.433
SCN2B	-0.432
HRH3	-0.427
BCL11A	-0.427
TENM3	-0.424

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of PRF1 protein]	20082299
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [resveratrol results in increased expression of PRF1 protein]	20082299
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of PRF1 mRNA"	21346803
C585004	2-monochloropropanediol	2-monochloropropanediol results in decreased expression of PRF1 mRNA	28522335
D000241	Adenosine	[Adenosine co-treated with Coformycin] results in decreased expression of PRF1 mRNA	11992407
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in decreased expression of PRF1 mRNA"	23195993
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PRF1 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of PRF1 mRNA	24449571
D001151	Arsenic	Arsenic affects the expression of PRF1 mRNA	18414638
D001205	Ascorbic Acid	Ascorbic Acid deficiency results in decreased expression of PRF1 mRNA	22306178
D001374	Azacitidine	Azacitidine inhibits the reaction [IL2 protein results in increased secretion of PRF1 protein]	19394699
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of PRF1 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PRF1 mRNA	22228805
C006780	bisphenol A	bisphenol A affects the methylation of PRF1 promoter	27415467
C006780	bisphenol A	bisphenol A results in decreased expression of PRF1 mRNA	25181051
D000069286	Bortezomib	Bortezomib results in decreased expression of PRF1 mRNA	20977926
C025191	bromodichloromethane	[PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form]	24211274
C025191	bromodichloromethane	[PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA]	24211274
C025191	bromodichloromethane	[PRF1 protein co-treated with RAG2 protein] affects the susceptibility to [bromodichloromethane co-treated with Dietary Fats]	24211274
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of PRF1 mRNA	18804290
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of PRF1 mRNA	18804290
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of PRF1 mRNA	18804290
D002737	Chloroprene	Chloroprene results in decreased expression of PRF1 mRNA	23125180
D003070	Coformycin	[Adenosine co-treated with Coformycin] results in decreased expression of PRF1 mRNA	11992407
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of PRF1 mRNA	28962523
D004006	Dichlorvos	Dichlorvos results in decreased expression of PRF1 mRNA	16002202
D004006	Dichlorvos	Dichlorvos results in decreased expression of PRF1 protein	16002202
D004041	Dietary Fats	Dietary Fats results in increased expression of PRF1 mRNA	25016146
D004041	Dietary Fats	[PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form]	24211274
D004041	Dietary Fats	[PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA]	24211274
D004041	Dietary Fats	[PRF1 protein co-treated with RAG2 protein] affects the susceptibility to [bromodichloromethane co-treated with Dietary Fats]	24211274
D019813	1,2-Dimethylhydrazine	"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of PRF1 mRNA"	27840820
C034959	enterotoxin C, staphylococcal	"enterotoxin C, staphylococcal analog results in increased secretion of PRF1 mRNA"	27742270
C034959	enterotoxin C, staphylococcal	"enterotoxin C, staphylococcal analog results in increased secretion of PRF1 protein"	27742270
C034959	enterotoxin C, staphylococcal	"enterotoxin C, staphylococcal results in increased secretion of PRF1 mRNA"	27742270
C034959	enterotoxin C, staphylococcal	"enterotoxin C, staphylococcal results in increased secretion of PRF1 protein"	27742270
D000431	Ethanol	Ethanol inhibits the reaction [IL2 protein results in increased expression of PRF1 mRNA]	12700414
C000499	ferric oxide	ferric oxide analog results in decreased expression of PRF1 mRNA	24525745
D005557	Formaldehyde	Formaldehyde results in decreased expression of PRF1 mRNA	24060340
D005557	Formaldehyde	Formaldehyde results in decreased expression of PRF1 protein	24060340
D005620	Freund's Adjuvant	[Urethane co-treated with Freund's Adjuvant] results in decreased expression of PRF1 mRNA	12400877
C070081	fulvestrant	fulvestrant results in decreased expression of PRF1 mRNA	20145137
C070081	fulvestrant	fulvestrant results in decreased expression of PRF1 protein	20145137
C070081	fulvestrant	[fulvestrant results in increased expression of TGFB1 protein] which results in increased expression of PRF1 mRNA	20145137
D005839	Gentamicins	Gentamicins results in increased expression of PRF1 mRNA	22061828
D006221	Halothane	PRF1 protein affects the reaction [Halothane results in increased expression of IFNG protein]	21245496
D006221	Halothane	PRF1 protein affects the susceptibility to Halothane	21245496
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of PRF1 mRNA	25613284
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of PRF1 mRNA	26752646
D058185	Magnetite Nanoparticles	Magnetite Nanoparticles results in decreased expression of PRF1 mRNA	24525745
D015122	Mercaptopurine	Mercaptopurine results in increased expression of PRF1 mRNA	23358152
D008748	Methylcholanthrene	Methylcholanthrene results in decreased expression of PRF1 mRNA	18804290
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PRF1 mRNA"	26251327
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of PRF1 mRNA"	25554681
D019829	Nevirapine	Nevirapine metabolite results in decreased expression of PRF1 mRNA	23947594
D009532	Nickel	Nickel results in decreased expression of PRF1 mRNA	23195993
D009532	Nickel	Nickel results in increased expression of PRF1 mRNA	25583101
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of PRF1 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of PRF1 mRNA	25729387
D052638	Particulate Matter	Particulate Matter inhibits the reaction [Poly I-C results in increased expression of PRF1 protein]	23618096
D010431	Pentoxifylline	Pentoxifylline results in decreased secretion of PRF1 protein	17880773
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of PRF1 mRNA	18804290
D011070	Poly I-C	Particulate Matter inhibits the reaction [Poly I-C results in increased expression of PRF1 protein]	23618096
D011070	Poly I-C	Poly I-C results in increased expression of PRF1 mRNA	23618096
D011070	Poly I-C	Poly I-C results in increased expression of PRF1 protein	23618096
D011070	Poly I-C	Vehicle Emissions inhibits the reaction [Poly I-C results in increased expression of PRF1 protein]	23618096
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [resveratrol results in increased expression of PRF1 protein]	20082299
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid inhibits the reaction [IL2 protein results in increased expression of PRF1 mRNA]	12700414
C059514	resveratrol	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [resveratrol results in increased expression of PRF1 protein]	20082299
C059514	resveratrol	MAPK1 protein affects the reaction [resveratrol results in increased expression of PRF1 protein]	20082299
C059514	resveratrol	MAPK8 protein affects the reaction [resveratrol results in increased expression of PRF1 protein]	20082299
C059514	resveratrol	pyrazolanthrone inhibits the reaction [resveratrol results in increased expression of PRF1 protein]	20082299
C059514	resveratrol	resveratrol results in increased expression of PRF1 mRNA	20082299
C059514	resveratrol	resveratrol results in increased expression of PRF1 protein	20082299
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in decreased expression of PRF1 protein"	19822075
D020123	Sirolimus	Sirolimus results in decreased expression of PRF1 protein	16477233
D012906	Smoke	Smoke affects the expression of PRF1 mRNA	23693141
D013629	Tamoxifen	Tamoxifen results in decreased expression of PRF1 mRNA	20145137
D013629	Tamoxifen	Tamoxifen results in decreased expression of PRF1 protein	20145137
D013629	Tamoxifen	[Tamoxifen results in increased expression of TGFB1 protein] which results in increased expression of PRF1 mRNA	20145137
C004648	testosterone enanthate	testosterone enanthate affects the expression of PRF1 mRNA	17440010
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PRF1 mRNA	21570461
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of PRF1 mRNA	25613284
D013792	Thalidomide	Thalidomide results in increased expression of PRF1	17089043
D013853	Thioacetamide	Thioacetamide results in decreased expression of PRF1 mRNA	23411599
C009495	titanium dioxide	titanium dioxide analog results in increased expression of PRF1 mRNA	25111187
C009495	titanium dioxide	titanium dioxide results in increased expression of PRF1 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of PRF1	23851003
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of PRF1 mRNA	20133372
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of PRF1 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of PRF1 mRNA	25729387
D014107	Tosyllysine Chloromethyl Ketone	Tosyllysine Chloromethyl Ketone inhibits the reaction [IL2 protein results in increased expression of PRF1 mRNA]	12700414
D014107	Tosyllysine Chloromethyl Ketone	Tosyllysine Chloromethyl Ketone results in decreased expression of PRF1 mRNA	11266287
D014118	Toxins, Biological	"Toxins, Biological affects the expression of PRF1 mRNA"	19682533
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of PRF1 mRNA	29024780
D014520	Urethane	[Urethane co-treated with Freund's Adjuvant] results in decreased expression of PRF1 mRNA	12400877
D014520	Urethane	Urethane results in decreased expression of PRF1 mRNA	12400877
D014635	Valproic Acid	Valproic Acid results in increased expression of PRF1 mRNA	28001369
D014635	Valproic Acid	Valproic Acid results in increased methylation of PRF1 gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions inhibits the reaction [Poly I-C results in increased expression of PRF1 protein]	23618096
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of PRF1 gene	25560391
D015039	Ziram	Ziram results in decreased expression of PRF1 protein	21859362\|2203814

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005509	calcium ion binding	-	ISS	-
GO:0005515	protein binding	-	IPI	11911826 25416956
GO:0022829	wide pore channel activity	-	IDA	20889983
GO:0042802	identical protein binding	-	IPI	21037563 21685908

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001771	immunological synapse formation	-	IDA	21438968
GO:0002357	defense response to tumor cell	-	ISS	-
GO:0002418	immune response to tumor cell	-	ISS	-
GO:0006915	apoptotic process	-	TAS	10779745
GO:0006968	cellular defense response	-	TAS	10779745
GO:0019835	cytolysis	-	ISS	-
GO:0051260	protein homooligomerization	-	IDA	20889983
GO:0051607	defense response to virus	-	ISS	-
GO:0051712	positive regulation of killing of cells of other organism	-	IDA	9756476
GO:0055085	transmembrane transport	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	IEA	-
GO:0005829	cytosol	-	IDA	-
GO:0005886	plasma membrane	-	IEA	-
GO:0016020	membrane	-	HDA	19946888
GO:0016021	integral component of membrane	-	IDA	20889983
GO:0031904	endosome lumen	-	IEA	-
GO:0044194	cytolytic granule	-	IDA	9756476
GO:0044194	cytolytic granule	-	ISS	-

KEGG ID	KEGG Term
hsa04650	Natural killer cell mediated cytotoxicity
hsa04940	Type I diabetes mellitus
hsa05320	Autoimmune thyroid disease
hsa05330	Allograft rejection
hsa05332	Graft-versus-host disease
hsa05416	Viral myocarditis

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25569648	Cord blood PRF1 methylation patterns and risk of lower respiratory tract infections in infants: findings from the Ulm Birth Cohort. (2015 Jan)	Elgizouli M	Medicine (Baltimore)