Gene: TRIM36

55521
ANPH|HAPRIN|RBCC728|RNF98
tripartite motif containing 36
protein-coding
5q22.3
Ensembl:ENSG00000152503 MIM:609317 Vega:OTTHUMG00000128892 UniprotKB:Q9NQ86
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.256e-2 (AD)  5.059e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OLFM30.954
NELL20.951
PCSK20.95
DPP100.95
DYNC1I10.948
ELAVL20.946
CADPS0.946
KIF3A0.946
MAP2K40.944
SYNJ10.944

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.559
RNF135-0.543
HEY2-0.534
CHST14-0.524
SYDE1-0.519
ASB4-0.512
YES1-0.507
CNN2-0.499
RHOD-0.499
REST-0.496

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRIM36 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRIM36 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRIM36 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRIM36 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of TRIM36 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TRIM36 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TRIM36 gene28458013
D000447AldehydesAldehydes results in increased expression of TRIM36 mRNA25014914
D000638AmiodaroneAmiodarone results in increased expression of TRIM36 mRNA19774075
D001151ArsenicArsenic affects the methylation of TRIM36 gene25304211
C015001arsenitearsenite results in increased methylation of TRIM36 promoter23974009
D001280AtrazineAtrazine results in decreased expression of TRIM36 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TRIM36 mRNA22228805
C006780bisphenol Abisphenol A affects the expression of TRIM36 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of TRIM36 mRNA23798566
C006780bisphenol Abisphenol A affects the expression of TRIM36 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of TRIM36 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TRIM36 gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of TRIM36 mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TRIM36 mRNA20938992
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of TRIM36 mRNA20971185
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TRIM36 mRNA27392435
D002945CisplatinCisplatin results in increased expression of TRIM36 mRNA27594783
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of TRIM36 mRNA27638505
D005485FlutamideFlutamide results in decreased expression of TRIM36 mRNA21126777
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TRIM36 mRNA20938992
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of TRIM36 mRNA22634610
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TRIM36 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of TRIM36 mRNA24796395|2530787
D007649KetamineKetamine results in decreased expression of TRIM36 mRNA20080153
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of TRIM36 mRNA"24972896
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TRIM36 mRNA20938992
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of TRIM36 mRNA20971185
D009966OrphenadrineOrphenadrine affects the expression of TRIM36 mRNA23665939
C046012pentanalpentanal results in increased expression of TRIM36 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRIM36 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of TRIM36 mRNA26272509
D010938Plant OilsPlant Oils results in increased expression of TRIM36 mRNA23370395
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of TRIM36 mRNA22714537
C005556propionaldehydepropionaldehyde results in increased expression of TRIM36 mRNA26079696
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TRIM36 mRNA19059307
D012643SeleniumSelenium results in decreased expression of TRIM36 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in increased expression of TRIM36 mRNA25351596
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in increased expression of TRIM36 mRNA19059307
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TRIM36 mRNA22903824
D013853ThioacetamideThioacetamide results in decreased expression of TRIM36 mRNA23411599
D014212TretinoinTretinoin results in decreased expression of TRIM36 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRIM36 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of TRIM36 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of TRIM36 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TRIM36 mRNA"26179874
D014520UrethaneUrethane results in increased expression of TRIM36 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of TRIM36 mRNA15901671
D014638VanadatesVanadates results in decreased expression of TRIM36 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of TRIM36 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of TRIM36 mRNA21126777

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004842ubiquitin-protein transferase activity-EXP19028597  
GO:0004842ubiquitin-protein transferase activity-ISS-  
GO:0004842ubiquitin-protein transferase activity-TAS-  
GO:0005515protein binding-IPI25416956  
GO:0008270zinc ion binding-IEA-  
GO:0043014alpha-tubulin binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000209protein polyubiquitination-TAS-  
GO:0000281mitotic cytokinesis-IMP28087737  
GO:0007051spindle organization-IMP28087737  
GO:0007340acrosome reaction-IEA-  
GO:0051726regulation of cell cycle-IEA-  
GO:0070507regulation of microtubule cytoskeleton organization-IMP28087737  
GO ID GO Term Qualifier Evidence PubMed
GO:0001669acrosomal vesicle-IEA-  
GO:0005737cytoplasm-IDA28087737  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29618728Association between DNA methylation in cord blood and maternal smoking: The Hokkaido Study on Environment and Children's Health. (2018 Apr 4)Miyake KSci Rep