Gene: PRG2

5553
BMPG|MBP|MBP1|proMBP
proteoglycan 2, pro eosinophil major basic protein
protein-coding
11q12.1
Ensembl:ENSG00000186652 MIM:605601 Vega:OTTHUMG00000167027 UniprotKB:P13727
NC_000011.10
PubMed
0   ANCO-SNPs
CD|ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.089e-3 (AD)  5.348e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CTSG0.761
OR5B30.722
DEFA40.721
BPI0.719
CEACAM80.692
DEFA30.689
MS4A30.671
CEACAM30.667
FCRL30.631
SERPINB100.626

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1orf53-0.363
ZNF835-0.354
MAGIX-0.353
C16orf46-0.332
ASPDH-0.328
MYADML2-0.325
ZBTB45-0.321
C19orf73-0.321
THY1-0.32
LRRC38-0.319

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00020SargramostimBiotechDrug123774-72-1Approved|InvestigationalTarget
ID Drug Name Action PubMed
C496492abrineabrine results in increased expression of PRG2 mRNA22595364
D000082AcetaminophenAcetaminophen affects the expression of PRG2 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of PRG2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PRG2 mRNA]17585979
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PRG2 mRNA16483693
D001104ArbutinArbutin results in decreased expression of PRG2 mRNA17103032
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of PRG2 mRNA"19446018
D001554BenzeneBenzene affects the expression of PRG2 mRNA21147609
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PRG2 mRNA21839799
C006780bisphenol Abisphenol A results in decreased expression of PRG2 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of PRG2 mRNA25270620
C018475butyraldehydebutyraldehyde results in decreased expression of PRG2 mRNA26079696
D020148Butyric AcidButyric Acid results in increased expression of PRG2 protein14769150
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of PRG2 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PRG2 mRNA]17585979
D019327Copper SulfateCopper Sulfate results in increased expression of PRG2 mRNA19549813
C014347decitabinedecitabine results in increased expression of PRG2 mRNA19194470
D002945CisplatinCisplatin results in decreased expression of PRG2 mRNA27594783
D019422Dietary SucroseDietary Sucrose results in increased expression of PRG2 mRNA26033743
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PRG2 mRNA21527772
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PRG2 mRNA20360939
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRG2 mRNA17942748
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PRG2 mRNA25613284
C011890kojic acidkojic acid results in decreased expression of PRG2 mRNA16595896
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of PRG2 mRNA29162477
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PRG2 mRNA"25511174
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PRG2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PRG2 mRNA"25554681|2710602
C025589ochratoxin Aochratoxin A results in increased expression of PRG2 mRNA22124623
D011192Potassium DichromatePotassium Dichromate results in increased expression of PRG2 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of PRG2 mRNA24780913
C017947sodium arsenitesodium arsenite results in increased expression of PRG2 protein20050688
C016766sulforafansulforafan results in decreased expression of PRG2 mRNA26833863
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRG2 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PRG2 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of PRG2 mRNA23409001|2355797
D014635Valproic AcidValproic Acid results in increased methylation of PRG2 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008201heparin binding-IEA-  
GO:0030246carbohydrate binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002215defense response to nematode-IEA-  
GO:0032693negative regulation of interleukin-10 production-IEA-  
GO:0032753positive regulation of interleukin-4 production-IEA-  
GO:0042742defense response to bacterium-IEA-  
GO:0043312neutrophil degranulation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0030133transport vesicle-IEA-  
GO:0070062extracellular exosome-HDA23533145  
GO:1904813ficolin-1-rich granule lumen-TAS-  
KEGG ID KEGG Term
hsa05310Asthma
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal