Gene: SLC30A10

55532
HMDPC|HMNDYT1|ZNT10|ZNT8|ZRC1|ZnT-10
solute carrier family 30 member 10
protein-coding
1q41
Ensembl:ENSG00000196660 MIM:611146 Vega:OTTHUMG00000037434 UniprotKB:Q6XR72
NG_032153.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.259e-1 (AD)  1.852e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12129498chr1:219934575 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RHOJ0.737
CGNL10.724
CD3020.723
PDGFRB0.715
EPS80.707
AHNAK0.699
CMYA50.698
FAM111A0.697
SBF20.691
CD1090.684

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHST8-0.392
GALNT14-0.38
CORT-0.378
RHO-0.367
LIPH-0.366
TMEFF2-0.365
GNB1L-0.364
MAGIX-0.364
GALNTL5-0.36
HAS1-0.359

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of SLC30A10 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of SLC30A10 mRNA"28903501
C0380902,2-dithiobis(4,6-dichlorophenol)"SLC30A10 gene SNP affects the susceptibility to 2,2-dithiobis(4,6-dichlorophenol)"25622337
C4879483-iodothyronamineSLC30A10 mRNA affects the uptake of 3-iodothyronamine19074582
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC30A10 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC30A10 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC30A10 mRNA"27188386
C0293704-toluidine4-toluidine results in decreased expression of SLC30A10 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC30A10 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC30A10 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC30A10 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SLC30A10 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SLC30A10 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC30A10 mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SLC30A10 gene27153756
D001379AzathioprineAzathioprine results in decreased expression of SLC30A10 mRNA22623647
C547126AZM551248AZM551248 results in decreased expression of SLC30A10 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC30A10 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC30A10 mRNA19770486
D004958EstradiolEstradiol results in decreased expression of SLC30A10 mRNA20106945|2163298
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of SLC30A10 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of SLC30A10 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of SLC30A10 mRNA25181051
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of SLC30A10 mRNA28472532
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of SLC30A10 mRNA16197558
C039671ciglitazone[ciglitazone binds to PPARG protein] which results in increased expression of SLC30A10 mRNA16197558
D019327Copper SulfateCopper Sulfate results in decreased expression of SLC30A10 mRNA19549813
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SLC30A10 mRNA]18200517
D016572CyclosporineCyclosporine results in decreased expression of SLC30A10 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of SLC30A10 mRNA19770486
D004041Dietary FatsDietary Fats results in decreased expression of SLC30A10 mRNA25016146
D002117CalcitriolCalcitriol promotes the reaction [[VDR protein binds to RXRA protein] which binds to SLC30A10 promoter]27107558
D002117Calcitriol[Calcitriol results in increased activity of VDR protein] which results in increased expression of SLC30A10 mRNA27107558
D002117CalcitriolCalcitriol results in increased expression of SLC30A10 mRNA27107558
D002117CalcitriolCalcitriol results in increased expression of SLC30A10 protein27107558
D004492Edetic AcidEdetic Acid inhibits the reaction [SLC30A10 gene mutant form results in increased abundance of Manganese]22926781
D004492Edetic AcidEdetic Acid results in increased expression of SLC30A10 mRNA22341971
D004492Edetic AcidEdetic Acid results in increased expression of SLC30A10 protein22341971
C039281furanfuran results in increased expression of SLC30A10 mRNA24183702
C511402Grape Seed ProanthocyanidinsGrape Seed Proanthocyanidins results in decreased expression of SLC30A10 mRNA20471814
C425931GW 501516[GW 501516 binds to PPARD protein] which results in increased expression of SLC30A10 mRNA16197558
D017313FenretinideFenretinide results in decreased expression of SLC30A10 mRNA28973697
D008345ManganeseEdetic Acid inhibits the reaction [SLC30A10 gene mutant form results in increased abundance of Manganese]22926781
D008345Manganese[IL6 protein results in decreased expression of SLC30A10 mRNA] which results in decreased export of Manganese24576911
D008345Manganese[IL6 protein results in decreased expression of SLC30A10 protein] which results in decreased export of Manganese24576911
D008345ManganeseSLC30A10 gene mutant form results in increased abundance of Manganese22926781
D008345ManganeseSLC30A10 gene SNP affects the transport of Manganese26025379
D008345ManganeseSLC30A10 gene SNP results in decreased abundance of Manganese26628504
D008345ManganeseSLC30A10 gene SNP results in increased abundance of Manganese26628504
D008345ManganeseSLC30A10 protein results in increased secretion of Manganese28860195
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SLC30A10 mRNA19465457
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of SLC30A10 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SLC30A10 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SLC30A10 mRNA"25620056
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of SLC30A10 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of SLC30A10 mRNA19270015|1948288
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC30A10 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SLC30A10 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SLC30A10 mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of SLC30A10 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of SLC30A10 mRNA20813756|2381119
D010936Plant ExtractsPlant Extracts results in decreased expression of SLC30A10 mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SLC30A10 mRNA27413110
D011441PropylthiouracilPropylthiouracil results in increased expression of SLC30A10 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of SLC30A10 mRNA21632981
D015125OxyquinolineOxyquinoline results in decreased expression of SLC30A10 mRNA21632981
D017382Reactive Oxygen Species[SLC30A10 protein affects the expression of CAT protein] which affects the abundance of Reactive Oxygen Species22427991
D017382Reactive Oxygen SpeciesSLC30A10 protein results in decreased abundance of Reactive Oxygen Species22427991
D015474IsotretinoinIsotretinoin results in decreased expression of SLC30A10 mRNA20436886
D012293RifampinRifampin results in decreased expression of SLC30A10 mRNA27199754
D012312RitodrineRitodrine results in decreased expression of SLC30A10 mRNA23370008
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC30A10 mRNA21632981|2199813
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC30A10 mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SLC30A10 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC30A10 mRNA19770486|2629044
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC30A10 mRNA22298810
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of SLC30A10 mRNA28973375
D013853ThioacetamideThioacetamide results in decreased expression of SLC30A10 mRNA23411599
D013974ThyroxineSLC30A10 gene mutant form results in decreased chemical synthesis of Thyroxine28860195
D014212TretinoinTretinoin results in decreased expression of SLC30A10 mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC30A10 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SLC30A10 mRNA24935251|2627250
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SLC30A10 mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of SLC30A10 mRNA18200517
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SLC30A10 mRNA"26743178
D014635Valproic AcidValproic Acid affects the expression of SLC30A10 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SLC30A10 gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC30A10 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of SLC30A10 mRNA26272509
D015032ZincSLC30A10 protein results in decreased susceptibility to Zinc22427991
D015032ZincSLC30A10 protein affects the abundance of Zinc22427991
D015032Zinc[SLC30A10 protein affects the abundance of Zinc] which affects the expression of CDKN1A protein22427991
D015032Zinc[SLC30A10 protein affects the abundance of Zinc] which affects the expression of TP53 protein22427991
D015032ZincZinc results in decreased expression of SLC30A10 mRNA22427991
D015032ZincSLC30A10 protein results in increased export of Zinc17126599

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005384manganese ion transmembrane transporter activity-TAS-  
GO:0005515protein binding-IPI26728129  
GO ID GO Term Qualifier Evidence PubMed
GO:0006828manganese ion transport-IMP22341972  26728129  
GO:0007173epidermal growth factor receptor signaling pathway-IDA26728129  
GO:0043524negative regulation of neuron apoptotic process-IMP25319704  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA26728129  
GO:0071421manganese ion transmembrane transport-IDA25319704  
GO:0071577zinc ion transmembrane transport-IEA-  
GO:0071579regulation of zinc ion transport-IDA22427991  26728129  
GO:1903427negative regulation of reactive oxygen species biosynthetic process-IDA22427991  
GO:1904385cellular response to angiotensin-IDA22427991  
GO:1905802regulation of cellular response to manganese ion-IDA25319704  
GO:2000773negative regulation of cellular senescence-IDA22427991  
GO ID GO Term Qualifier Evidence PubMed
GO:0005769early endosome-IDA26728129  
GO:0005794Golgi apparatus-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0055037recycling endosome-IDA26728129  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-425410Metal ion SLC transportersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal