Gene: MAML3

55534
CAGH3|ERDA3|GDN|MAM-2|MAM2|TNRC3
mastermind like transcriptional coactivator 3
protein-coding
4q31.1
Ensembl:ENSG00000196782 MIM:608991 Vega:OTTHUMG00000161441 UniprotKB:Q96JK9
NC_000004.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.526e-1 (AD)  1.658e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg10136560chr4:140737518MAML35.170e-8Maternal smoking in pregnancy27040690
cg10136560chr4:140737518MAML31.470e-10Maternal smoking in pregnancy27040690
cg10136560chr4:140737518MAML34.210e-11Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MEF2A0.729
B3GNT20.717
NFATC2IP0.712
KLF80.705
RPS6KA30.705
ESYT20.7
ZBTB8A0.699
MIS18BP10.697
VHL0.697
SETBP10.696

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A1-0.356
OR4F5-0.308
C7orf61-0.297
OR4F29-0.283
HMX1-0.267
TMEM253-0.26
S100A14-0.258
EYA2-0.251
WDR38-0.249
FOXJ1-0.246

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of MAML3 mRNA29067470
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of MAML3 mRNA21298039
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of MAML3 mRNA"17331233
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of MAML3 mRNA"20382639
C006780bisphenol Abisphenol A results in increased methylation of MAML3 gene28505145
C018021cobaltous chloridecobaltous chloride results in decreased expression of MAML3 mRNA24386269
D002945CisplatinCisplatin results in decreased expression of MAML3 mRNA27392435
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of MAML3 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of MAML3 mRNA23649840
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MAML3 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MAML3 mRNA23649840
D015735MifepristoneMifepristone results in increased expression of MAML3 mRNA17584828
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MAML3 mRNA"25554681
D009532NickelNickel results in decreased expression of MAML3 mRNA24768652|2558310
C017947sodium arsenitesodium arsenite affects the methylation of MAML3 gene28589171
D018038Sodium SeleniteSodium Selenite results in decreased expression of MAML3 mRNA18175754
D013629TamoxifenTamoxifen results in increased expression of MAML3 mRNA25123088
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of MAML3 mRNA25172293
D014241TrichloroethyleneTrichloroethylene results in increased methylation of MAML3 gene27618143
C012589trichostatin Atrichostatin A results in increased expression of MAML3 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of MAML3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MAML3 mRNA24935251
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MAML3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003713transcription coactivator activity-IBA21873635  
GO:0003713transcription coactivator activity-IDA12370315  
GO ID GO Term Qualifier Evidence PubMed
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0007219Notch signaling pathway-IDA12370315  
GO:0007219Notch signaling pathway-TAS-  
GO:0007221positive regulation of transcription of Notch receptor target-IBA21873635  
GO:0007221positive regulation of transcription of Notch receptor target-TAS-  
GO:0045747positive regulation of Notch signaling pathway-TAS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA12370315  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA12370315  
GO:0005654nucleoplasm-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0016607nuclear speck-IDA-  
KEGG ID KEGG Term
hsa04330Notch signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-157118Signaling by NOTCHIEA
R-HSA-157118Signaling by NOTCHTAS
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-1912408Pre-NOTCH Transcription and TranslationIEA
R-HSA-1912408Pre-NOTCH Transcription and TranslationTAS
R-HSA-1912422Pre-NOTCH Expression and ProcessingIEA
R-HSA-1912422Pre-NOTCH Expression and ProcessingTAS
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-1980143Signaling by NOTCH1TAS
R-HSA-1980145Signaling by NOTCH2TAS
R-HSA-1980145Signaling by NOTCH2IEA
R-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionIEA
R-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionTAS
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2197563NOTCH2 intracellular domain regulates transcriptionTAS
R-HSA-2197563NOTCH2 intracellular domain regulates transcriptionIEA
R-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in CancerTAS
R-HSA-2644603Signaling by NOTCH1 in CancerTAS
R-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain MutantsTAS
R-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in CancerTAS
R-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsTAS
R-HSA-350054Notch-HLH transcription pathwayTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878159Transcriptional regulation by RUNX3IEA
R-HSA-8878159Transcriptional regulation by RUNX3TAS
R-HSA-8941856RUNX3 regulates NOTCH signalingIEA
R-HSA-8941856RUNX3 regulates NOTCH signalingTAS
R-HSA-9012852Signaling by NOTCH3TAS
R-HSA-9012852Signaling by NOTCH3IEA
R-HSA-9013508NOTCH3 Intracellular Domain Regulates TranscriptionTAS
R-HSA-9013508NOTCH3 Intracellular Domain Regulates TranscriptionIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25234806Dissecting the genetics of chronic mucus hypersecretion in smokers with and without COPD. (2015 Jan)Dijkstra AEEur Respir J
27709636PTTG1IP and MAML3, novel genomewide association study genes for severity of hyperresponsiveness in adult asthma. (2017 May)Nieuwenhuis MAAllergy