Gene: SOX6

55553
HSSOX6|SOXD
SRY-box 6
protein-coding
11p15.2
Ensembl:ENSG00000110693 MIM:607257 Vega:OTTHUMG00000165876 UniprotKB:P35712
NG_012881.1
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.187e-2 (AD)  1.325e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1503452chr11:16430585 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs11603071chr11:16386702 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1370465chr11:16372522 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NT5E0.817
PCDHGC30.812
PTPRZ10.791
SOX210.779
GOLIM40.776
CRB10.763
SOX50.762
AMOT0.762
ANTXR10.756
EDNRB0.754

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.389
F12-0.342
CACNA1F-0.326
OR4F29-0.326
RASEF-0.325
GAL-0.318
REM2-0.317
NRG1-0.31
CLPSL1-0.307
GNB1L-0.304

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of SOX6 mRNA"23829299
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SOX6 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX6 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SOX6 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of SOX6 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of SOX6 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SOX6 mRNA19770486
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX6 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SOX6 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SOX6 mRNA19770486
C006780bisphenol Abisphenol A results in increased expression of SOX6 mRNA29275510
C006780bisphenol Abisphenol A affects the methylation of SOX6 promoter27334623
C006780bisphenol Abisphenol A results in decreased methylation of SOX6 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of SOX6 mRNA28938450
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of SOX6 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of SOX6 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of SOX6 mRNA29097150
C006780bisphenol Abisphenol A results in increased methylation of SOX6 gene28505145
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX6 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of SOX6 mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SOX6 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of SOX6 mRNA20105288
D016572CyclosporineCyclosporine results in decreased expression of SOX6 mRNA25562108|2798913
D016572CyclosporineCyclosporine results in decreased expression of SOX6 mRNA19770486
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SOX6 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SOX6 mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SOX6 mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SOX6 mRNA26924002
D004026DieldrinDieldrin results in increased expression of SOX6 mRNA28385952
C118739entinostatentinostat results in decreased expression of SOX6 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX6 mRNA"27188386
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOX6 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SOX6 mRNA29097150
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SOX6 mRNA20938992
C069837fullerene C60fullerene C60 results in decreased expression of SOX6 mRNA19167457
D005839GentamicinsGentamicins results in decreased expression of SOX6 mRNA22061828
D007545IsoproterenolIsoproterenol results in decreased expression of SOX6 mRNA21177286
D007545IsoproterenolIsoproterenol results in decreased expression of SOX6 protein21177286
D007545IsoproterenolJUNB protein promotes the reaction [Isoproterenol results in decreased expression of SOX6 mRNA]21177286
D007545IsoproterenolJUNB protein promotes the reaction [Isoproterenol results in decreased expression of SOX6 protein]21177286
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SOX6 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of SOX6 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SOX6 mRNA26752646
D007854LeadLead affects the expression of SOX6 mRNA28903495
C042720mercuric bromidemercuric bromide results in decreased expression of SOX6 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX6 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SOX6 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SOX6 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SOX6 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX6 mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SOX6 mRNA26011545
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SOX6 mRNA26924002
C017096n-butoxyethanoln-butoxyethanol results in increased expression of SOX6 mRNA19812364
D009532NickelNickel results in decreased expression of SOX6 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in decreased expression of SOX6 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SOX6 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of SOX6 mRNA25729387
C030110oxaliplatin[Topotecan co-treated with oxaliplatin] results in decreased expression of SOX6 mRNA25729387
D010416PentachlorophenolPentachlorophenol results in decreased expression of SOX6 mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of SOX6 mRNA23091169
D010656PhenylephrinePhenylephrine results in decreased expression of SOX6 mRNA18158353
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX6 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SOX6 mRNA26272509
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SOX6 mRNA23608068
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of SOX6 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SOX6 mRNA24058054
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOX6 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SOX6 mRNA19770486
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of SOX6 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SOX6 mRNA25729387
D019772Topotecan[Topotecan co-treated with oxaliplatin] results in decreased expression of SOX6 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of SOX6 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of SOX6 mRNA21934132
C011559tributyltintributyltin results in decreased expression of SOX6 mRNA24513447
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of SOX6 mRNA29024780
C057693troglitazonetroglitazone results in decreased expression of SOX6 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of SOX6 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SOX6 mRNA24383497|2519280
D014635Valproic AcidValproic Acid results in decreased expression of SOX6 mRNA23042728
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SOX6 gene25560391
C025643vinclozolinvinclozolin results in increased expression of SOX6 mRNA23034163
D002762CholecalciferolCholecalciferol results in increased expression of SOX6 mRNA17170073
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOX6 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of SOX6 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0003677DNA binding-NAS1614875  
GO:0003700DNA-binding transcription factor activity-NAS1614875  
GO:0005515protein binding-IPI21262861  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0000902cell morphogenesis-IEA-  
GO:0001701in utero embryonic development-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-NAS1614875  
GO:0007399nervous system development-IBA21873635  
GO:0007417central nervous system development-IBA21873635  
GO:0007517muscle organ development-NAS11255018  
GO:0009791post-embryonic development-IEA-  
GO:0016458gene silencing-IEA-  
GO:0021778oligodendrocyte cell fate specification-IEA-  
GO:0032332positive regulation of chondrocyte differentiation-IBA21873635  
GO:0032332positive regulation of chondrocyte differentiation-IDA21401405  
GO:0045165cell fate commitment-IBA21873635  
GO:0045892negative regulation of transcription, DNA-templated-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0048708astrocyte differentiation-IEA-  
GO:0048821erythrocyte development-IEA-  
GO:0051216cartilage development-IEA-  
GO:0055007cardiac muscle cell differentiation-IEA-  
GO:0061036positive regulation of cartilage development-IDA21401405  
GO:0071560cellular response to transforming growth factor beta stimulus-IDA21401405  
GO:2000726negative regulation of cardiac muscle cell differentiation-IMP20081117  
GO:2000741positive regulation of mesenchymal stem cell differentiation-IDA21401405  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005634nucleus-NAS1614875  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-3769402Deactivation of the beta-catenin transactivating complexTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal