Gene: ENOSF1

55556
FUCD|RTS|TYMSAS
enolase superfamily member 1
protein-coding
18p11.32
Ensembl:ENSG00000132199 MIM:607427 Vega:OTTHUMG00000131470 UniprotKB:Q7L5Y1
NC_000018.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.532e-1 (AD)  6.478e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEK30.873
SLC25A130.802
SEMA6A0.799
PLEKHH10.796
PDE8A0.792
SGK20.78
TSPAN150.78
COL4A50.776
KCNH80.772
EFS0.767

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EPPIN-0.382
KCNK12-0.356
KCNG1-0.354
CHRNA2-0.338
BEND4-0.327
GPR153-0.316
HCN4-0.316
SCRT2-0.314
PSPN-0.305
CUX2-0.304

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ENOSF1 mRNA"19167446
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENOSF1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENOSF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENOSF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENOSF1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ENOSF1 mRNA25704631|2906747
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ENOSF1 protein20106945
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ENOSF1 mRNA24449571
C004656chloroacetaldehydechloroacetaldehyde results in decreased expression of ENOSF1 mRNA25596134
C059262cidofovircidofovir results in decreased expression of ENOSF1 mRNA25596134
C018021cobaltous chloridecobaltous chloride results in decreased expression of ENOSF1 mRNA19320972|1937684
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ENOSF1 mRNA"19167446
D016572CyclosporineCyclosporine results in decreased expression of ENOSF1 mRNA25562108|2559613
D002945CisplatinCisplatin results in decreased expression of ENOSF1 mRNA25596134
D002117CalcitriolCalcitriol results in increased expression of ENOSF1 mRNA12875902
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ENOSF1 mRNA23649840
D005472FluorouracilENOSF1 protein affects the susceptibility to Fluorouracil15548681
D005472FluorouracilENOSF1 protein results in decreased susceptibility to Fluorouracil18357371
D007069IfosfamideIfosfamide results in decreased expression of ENOSF1 mRNA25596134
C054474manumycinmanumycin affects the localization of ENOSF1 protein18357371
C054474manumycinmanumycin results in decreased expression of ENOSF1 protein18357371
D008727MethotrexateENOSF1 protein affects the susceptibility to Methotrexate16217747
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ENOSF1 mRNA28001369
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ENOSF1 mRNA26924002
C523799MRK 003MRK 003 results in decreased expression of ENOSF1 mRNA21169257
D010100OxygenOxygen deficiency results in increased expression of ENOSF1 mRNA25596134
D010126Ozone"[Water Pollutants, Chemical co-treated with Ozone] results in decreased expression of ENOSF1 mRNA"23246600
D010936Plant ExtractsPlant Extracts results in increased expression of ENOSF1 mRNA23557933
D011794QuercetinQuercetin results in decreased expression of ENOSF1 mRNA21632981
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ENOSF1 mRNA25351596
D014212TretinoinTretinoin results in decreased expression of ENOSF1 mRNA23724009
D014212TretinoinTretinoin results in increased expression of ENOSF1 mRNA12875902
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENOSF1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of ENOSF1 mRNA24935251|2627250
D014520UrethaneUrethane results in decreased expression of ENOSF1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENOSF1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ENOSF1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ENOSF1 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased expression of ENOSF1 mRNA23179753|2627250
D024483Vitamin K 3Vitamin K 3 affects the expression of ENOSF1 mRNA20044591
D014874Water Pollutants, Chemical"[Water Pollutants, Chemical co-treated with Ozone] results in decreased expression of ENOSF1 mRNA"23246600

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IDA24697329  
GO:0016853isomerase activity-IEA-  
GO:0050023L-fuconate dehydratase activity-IDA24697329  
GO ID GO Term Qualifier Evidence PubMed
GO:0009063cellular amino acid catabolic process-IEA-  
GO:0044275cellular carbohydrate catabolic process-IDA24697329  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005739mitochondrion-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18635682Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. (2008 Nov)Giusti BJ Med Genet