Gene: GALNT10

55568
GALNACT10|PPGALNACT10|PPGANTASE10
polypeptide N-acetylgalactosaminyltransferase 10
protein-coding
5q33.2
Ensembl:ENSG00000164574 MIM:608043 Vega:OTTHUMG00000130145 UniprotKB:Q86SR1
NC_000005.10
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.360e-1 (AD)  1.327e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs890793chr5:154194378 (GRCh38.p7)C>G / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PARP40.828
SFT2D20.825
LIMD10.818
MPZL10.817
MSN0.817
FAM114A10.81
PRRX10.808
MAPRE10.806
CREB3L20.805
REST0.805

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBLN7-0.521
ADRA1D-0.514
ABCC12-0.511
KCNB2-0.51
CALHM1-0.508
BHLHA9-0.507
MYADML2-0.506
HAS1-0.504
SLC7A4-0.501
F7-0.499

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of GALNT10 mRNA19933214
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GALNT10 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of GALNT10 mRNA"19167446
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GALNT10 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GALNT10 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GALNT10 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GALNT10 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GALNT10 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GALNT10 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GALNT10 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GALNT10 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GALNT10 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of GALNT10 mRNA26690555|2906747
D000082AcetaminophenAcetaminophen affects the expression of GALNT10 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of GALNT10 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GALNT10 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of GALNT10 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GALNT10 mRNA16483693
D001151ArsenicArsenic affects the expression of GALNT10 mRNA18414638
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GALNT10 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GALNT10 mRNA26238291
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of GALNT10 mRNA]24758408
D004958EstradiolEstradiol results in decreased expression of GALNT10 mRNA24758408
C006780bisphenol Abisphenol A results in decreased expression of GALNT10 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GALNT10 gene28505145
C025703bleomycetinbleomycetin results in decreased expression of GALNT10 mRNA21040473
C584509C646 compoundC646 compound results in decreased expression of GALNT10 mRNA26191083
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GALNT10 mRNA"27188386
C018021cobaltous chloridecobaltous chloride results in decreased expression of GALNT10 mRNA19320972
D003300Copper[Disulfiram binds to Copper] which results in increased expression of GALNT10 mRNA24690739
D003300CopperMT1 affects the reaction [Copper results in increased expression of GALNT10 mRNA]16629173
D003300CopperMT2 affects the reaction [Copper results in increased expression of GALNT10 mRNA]16629173
D003300CopperCopper deficiency results in increased expression of GALNT10 mRNA26033743
D019327Copper SulfateCopper Sulfate results in increased expression of GALNT10 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of GALNT10 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of GALNT10 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of GALNT10 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of GALNT10 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of GALNT10 mRNA20106945
D003561CytarabineCytarabine results in decreased expression of GALNT10 mRNA21198554
D002945CisplatinCisplatin results in decreased expression of GALNT10 mRNA27594783
D019422Dietary SucroseDietary Sucrose results in increased expression of GALNT10 mRNA26033743
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GALNT10 mRNA18164116
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of GALNT10 mRNA24690739
C118739entinostatentinostat results in increased expression of GALNT10 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GALNT10 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GALNT10 mRNA17942748
D004397FonofosFonofos results in increased methylation of GALNT10 promoter22847954
D005557FormaldehydeFormaldehyde results in increased expression of GALNT10 mRNA23649840
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of GALNT10 mRNA22634610
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GALNT10 mRNA25613284
D007529IsoflavonesIsoflavones results in increased expression of GALNT10 mRNA17374662
D007854LeadLead results in decreased expression of GALNT10 mRNA19921347
C042720mercuric bromidemercuric bromide results in decreased expression of GALNT10 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GALNT10 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GALNT10 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GALNT10 mRNA23649840
D008774MethylphenidateMethylphenidate results in decreased expression of GALNT10 mRNA22470460
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GALNT10 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GALNT10 mRNA"25620056
C017096n-butoxyethanoln-butoxyethanol results in increased expression of GALNT10 mRNA19812364
D009532NickelNickel results in increased expression of GALNT10 mRNA24768652
D010126OzoneOzone results in increased expression of GALNT10 mRNA28623178
D010278ParathionParathion results in increased methylation of GALNT10 promoter22847954
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of GALNT10 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of GALNT10 mRNA19482888
C006253pirinixic acidpirinixic acid results in decreased expression of GALNT10 mRNA17426115
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GALNT10 mRNA22714537
D011374ProgesteroneGALNT10 gene SNP affects the susceptibility to Progesterone25622337
D011374ProgesteroneProgesterone results in increased expression of GALNT10 mRNA19690047
C005556propionaldehydepropionaldehyde results in increased expression of GALNT10 mRNA26079696
D011794QuercetinQuercetin results in increased expression of GALNT10 mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of GALNT10 mRNA19167446
D013629TamoxifenTamoxifen results in increased expression of GALNT10 mRNA25123088
C012568terbufosterbufos results in increased methylation of GALNT10 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GALNT10 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GALNT10 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GALNT10 mRNA15667827|1993321
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GALNT10 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of GALNT10 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of GALNT10 mRNA28065790
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GALNT10 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of GALNT10 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of GALNT10 mRNA24935251
D014520UrethaneUrethane results in increased expression of GALNT10 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GALNT10 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GALNT10 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GALNT10 mRNA24383497|2627250
D014635Valproic AcidValproic Acid results in increased expression of GALNT10 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of GALNT10 gene29154799
D014638VanadatesVanadates results in increased expression of GALNT10 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GALNT10 gene25560391
D014810Vitamin EVitamin E results in decreased expression of GALNT10 mRNA19244175
C088658zoledronic acidzoledronic acid results in decreased expression of GALNT10 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004653polypeptide N-acetylgalactosaminyltransferase activity-IDA12417297  18562306  19460755  
GO:0004653polypeptide N-acetylgalactosaminyltransferase activity-TAS-  
GO:0030246carbohydrate binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006493protein O-linked glycosylation-IDA12417297  
GO:0016266O-glycan processing-IDA18562306  19460755  
GO:0016266O-glycan processing-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005794Golgi apparatus-IBA21873635  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00512Mucin type O-Glycan biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-913709O-linked glycosylation of mucinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26683835Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study. (2015 Dec 18)Ahmad SBMC Med Genet