Gene: STAB2

55576
FEEL2|FELE-2|FELL2|FEX2|HARE|SCARH1
stabilin 2
protein-coding
12q23.3
Ensembl:ENSG00000136011 MIM:608561 Vega:OTTHUMG00000170056 UniprotKB:Q8WWQ8
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.674e-1 (AD)  1.221e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHST150.449
ZSCAN220.445
AVIL0.443
ZNF280A0.441
KDELC10.437
HAS30.432
TRIO0.429
CSMD20.429
FOXD4L30.428
C15orf620.428

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HMGN5-0.268
ALDH1L1-AS2-0.245
ACSM5-0.243
MBNL3-0.241
ASB4-0.237
CDNF-0.237
FAM227B-0.234
HEPACAM2-0.224
CCDC153-0.221
ROPN1B-0.22

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB08818Hyaluronic acidSmall Molecule9004-61-9ApprovedTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of STAB2 mRNA"26377693
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of STAB2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of STAB2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of STAB2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of STAB2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of STAB2 mRNA"25510870
C496492abrineabrine results in increased expression of STAB2 mRNA22595364
D000082AcetaminophenAcetaminophen affects the expression of STAB2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of STAB2 mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of STAB2 mRNA21298039
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of STAB2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of STAB2 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of STAB2 mRNA19770486
C006780bisphenol Abisphenol A results in increased expression of STAB2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of STAB2 gene28505145
D003471CuprizoneCuprizone results in decreased expression of STAB2 mRNA27523638
D004041Dietary FatsDietary Fats results in decreased expression of STAB2 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of STAB2 mRNA25016146
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of STAB2 mRNA"27840820
D000431EthanolEthanol results in increased expression of STAB2 mRNA29018328
D005897GlafenineGlafenine results in increased expression of STAB2 mRNA24136188
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of STAB2 mRNA17183730
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of STAB2 mRNA26011545
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of STAB2 mRNA22401849
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of STAB2 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of STAB2 mRNA26516004
D000073878Palm OilPalm Oil results in decreased expression of STAB2 mRNA18042831
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of STAB2 mRNA"25510870
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of STAB2 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of STAB2 mRNA19482888
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of STAB2 mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of STAB2 mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of STAB2 mRNA19690047
C009277sodium arsenatesodium arsenate results in decreased expression of STAB2 mRNA21795629
D013739TestosteroneTestosterone results in increased expression of STAB2 mRNA20403060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STAB2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of STAB2 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of STAB2 mRNA19770486
C009495titanium dioxidetitanium dioxide results in increased expression of STAB2 mRNA19695317
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of STAB2 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of STAB2 mRNA25729387
D019772TopotecanTopotecan results in increased expression of STAB2 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of STAB2 mRNA19042947
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of STAB2 mRNA17183730
D014640VancomycinVancomycin results in increased expression of STAB2 mRNA18930951

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005041low-density lipoprotein particle receptor activity-IBA21873635  
GO:0005041low-density lipoprotein particle receptor activity-IDA12077138  
GO:0005044scavenger receptor activity-IDA12077138  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI18519035  
GO:0005540hyaluronic acid binding-ISS-  
GO:0015035protein disulfide oxidoreductase activity-NAS12077138  
GO:0030169low-density lipoprotein particle binding-IBA21873635  
GO:0030169low-density lipoprotein particle binding-IDA12077138  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-NAS12077138  
GO:0006897endocytosis-ISS-  
GO:0006898receptor-mediated endocytosis-TAS12077138  
GO:0007155cell adhesion-NAS12077138  
GO:0030214hyaluronan catabolic process-TAS-  
GO:0042742defense response to bacterium-IDA12077138  
GO:0050830defense response to Gram-positive bacterium-IDA11829752  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA12077138  
GO:0009897external side of plasma membrane-ISS-  
GO:0030666endocytic vesicle membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-2142845Hyaluronan metabolismTAS
R-HSA-2160916Hyaluronan uptake and degradationTAS
R-HSA-2173782Binding and Uptake of Ligands by Scavenger ReceptorsTAS
R-HSA-3000497Scavenging by Class H ReceptorsTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25828346Distribution, genetic and cardiovascular determinants of FVIII:c - Data from the population-based Gutenberg Health Study. (2015)Hermanns MIInt J Cardiol