Gene: CHRNA9

55584
HSA243342|NACHRA9
cholinergic receptor nicotinic alpha 9 subunit
protein-coding
4p14
Ensembl:ENSG00000174343 MIM:605116 Vega:OTTHUMG00000099375 UniprotKB:Q9UGM1
NC_000004.12
PubMed
0   ANCO-SNPs
ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.499e-2 (AD)  2.800e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM72D0.439
OR8B20.438
RSPH4A0.432
BEST40.417
PRSS270.416
LEUTX0.416
NLRP30.416
ZFP690.406
SNTN0.403
ENPP70.401

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRP5-0.31
CRB2-0.308
RAPGEF3-0.288
NWD1-0.281
FGFRL1-0.28
RFTN2-0.278
TBX6-0.278
PLXNB1-0.269
ADAMTSL5-0.268
C1QTNF6-0.267

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00184NicotineSmall Molecule54-11-5ApprovedTarget
DB00674GalantamineSmall Molecule357-70-0ApprovedTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
DB05069ATG003Small Molecule-InvestigationalTarget
DB05137LobelineSmall Molecule90-69-7InvestigationalTarget
DB05740RPI-78MSmall Molecule-InvestigationalTarget
DB08837TetraethylammoniumSmall Molecule66-40-0Experimental|InvestigationalTarget
ID Drug Name Action PubMed
C0261142-xylene2-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]18602458
C0312853-xylene3-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]18602458
C0312864-xylene4-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]18602458
D000082AcetaminophenAcetaminophen results in increased expression of CHRNA9 mRNA26690555
D000109Acetylcholine2-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]18602458
D000109Acetylcholine3-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]18602458
D000109Acetylcholine4-xylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]18602458
D000109AcetylcholineAcetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]18602458
D000109Acetylcholineethylbenzene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]18602458
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CHRNA9 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CHRNA9 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CHRNA9 mRNA16483693
C547126AZM551248AZM551248 results in increased expression of CHRNA9 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of CHRNA9 gene25435355
D004958EstradiolEstradiol affects the expression of CHRNA9 mRNA23557687
C006780bisphenol Abisphenol A affects the expression of CHRNA9 mRNA23557687
C006780bisphenol Abisphenol A results in decreased expression of CHRNA9 mRNA25181051
D002038BungarotoxinsBungarotoxins binds to and results in decreased activity of CHRNA9 protein25282151
D002220CarbamazepineCarbamazepine affects the expression of CHRNA9 mRNA25979313
D002245Carbon DioxideNicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA9 protein]28235547
D002245Carbon Dioxide[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA9 protein28235547
D004390ChlorpyrifosChlorpyrifos affects the expression of CHRNA9 mRNA18812211
C510079conotoxin alpha-RgIA, Conus regius"conotoxin alpha-RgIA, Conus regius analog results in decreased activity of [CHRNA9 protein binds to CHRNA10 protein]"21888386
C510079conotoxin alpha-RgIA, Conus regius"conotoxin alpha-RgIA, Conus regius results in decreased activity of [CHRNA9 protein binds to CHRNA10 protein]"21888386
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of CHRNA9 mRNA26033743
D003300CopperCopper deficiency results in increased expression of CHRNA9 mRNA26033743
D016572CyclosporineCyclosporine results in increased methylation of CHRNA9 promoter27989131
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of CHRNA9 mRNA28962523
D002945CisplatinCisplatin results in increased expression of CHRNA9 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of CHRNA9 mRNA25016146
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of CHRNA9 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of CHRNA9 mRNA26033743
C118739entinostatentinostat results in increased expression of CHRNA9 mRNA27188386
C004912ethylbenzeneethylbenzene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA9 protein binds to CHRNA10 protein]]18602458
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CHRNA9 mRNA25613284
C098607JP8 aviation fuelJP8 aviation fuel affects the expression of CHRNA9 mRNA15182950
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CHRNA9 mRNA24796395|2530787
C054634methyllycaconitinemethyllycaconitine binds to and results in decreased activity of CHRNA9 protein25282151
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate affects the expression of CHRNA9 mRNA21195148
C028577monobutyl phthalatemonobutyl phthalate affects the expression of CHRNA9 mRNA21195148
D009538NicotineNicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA9 protein]28235547
D010100OxygenNicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA9 protein]28235547
D010100Oxygen[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA9 protein28235547
D011192Potassium DichromatePotassium Dichromate results in increased expression of CHRNA9 mRNA23608068
D012906SmokeSmoke analog results in increased expression of CHRNA9 mRNA24607864
D012906SmokeSmoke analog results in increased expression of CHRNA9 protein24607864
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CHRNA9 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CHRNA9 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CHRNA9 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CHRNA9 protein26746805
C012589trichostatin Atrichostatin A results in increased expression of CHRNA9 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of CHRNA9 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CHRNA9 mRNA23179753|2493525
D014635Valproic AcidValproic Acid affects the expression of CHRNA9 mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-IEA-  
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0005262calcium channel activity-IEA-  
GO:0005515protein binding-IPI25282151  
GO:0015276ligand-gated ion channel activity-TAS-  
GO:0022848acetylcholine-gated cation-selective channel activity-IDA25282151  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IBA21873635  
GO:0007204positive regulation of cytosolic calcium ion concentration-IGI18420419  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0042472inner ear morphogenesis-IEA-  
GO:0050877nervous system process-IBA21873635  
GO:0050910detection of mechanical stimulus involved in sensory perception of sound-IEA-  
GO:0060079excitatory postsynaptic potential-IEA-  
GO:0070373negative regulation of ERK1 and ERK2 cascade-IEA-  
GO:0070588calcium ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA25282151  
GO:0005892acetylcholine-gated channel complex-IDA25282151  
GO:0030054cell junction-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-181431Acetylcholine binding and downstream eventsTAS
R-HSA-622327Postsynaptic nicotinic acetylcholine receptorsTAS
R-HSA-629594Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsTAS
R-HSA-629602Activation of Nicotinic Acetylcholine ReceptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17559419Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function. (2008 Mar)Rigbi AGenes Brain Behav
26184988Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder. (2015 Sep 30)Kimbrel NAPsychiatry Res
21498873Associations of nicotine intake measures with CHRN genes in Finnish smokers. (2011 Aug)Keskitalo-Vuokko KNicotine Tob Res
25142973CHRNA9 polymorphisms and smoking exposure synergize to increase the risk of breast cancer in Taiwan. (2014 Nov)Hsieh YCCarcinogenesis
16314871Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes. (2006 Mar)Greenbaum LMol Psychiatry