Gene: ITLN1

55600
HL-1|HL1|INTL|ITLN|LFR|hIntL|omentin
intelectin 1
protein-coding
1q23.3
Ensembl:ENSG00000179914 MIM:609873 Vega:OTTHUMG00000028604 UniprotKB:Q8WWA0
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.046e-1 (AD)  4.658e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL40.697
BMP100.681
SBK20.678
MYH60.634
MMP190.577
SPANXN20.565
ACCSL0.532
DEFA10.521
MYL70.518
MAGEA20.499

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ISLR2-0.258
HS3ST2-0.234
ZNF835-0.232
GRIK3-0.224
ZNF286B-0.223
PALM2-0.222
KRT31-0.22
GALNT14-0.22
GEMIN7-0.219
MUC20-0.218

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ITLN1 mRNA"25614096
D000082AcetaminophenAcetaminophen results in increased expression of ITLN1 mRNA26690555
D020106AcrylamideAcrylamide results in decreased expression of ITLN1 mRNA28959563
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of ITLN1 mRNA"15777968
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of ITLN1 mRNA26496021
C006780bisphenol Abisphenol A results in increased methylation of ITLN1 promoter27312807
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of ITLN1 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of ITLN1 mRNA26496021
C019304ciprofibrateciprofibrate results in increased expression of ITLN1 mRNA12771043
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ITLN1 mRNA26924002
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ITLN1 mRNA12771043
C024629dimethyl phthalatedimethyl phthalate affects the expression of ITLN1 mRNA26924002
C039281furanfuran results in increased expression of ITLN1 mRNA27387713
D006418HemeHeme results in decreased expression of ITLN1 mRNA15539406
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ITLN1 mRNA20044591
D007501IronITLN1 protein binds to and results in increased uptake of Iron16936804
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of ITLN1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ITLN1 mRNA"25554681
C060836pioglitazonepioglitazone results in increased expression of ITLN1 protein23555749
C006253pirinixic acidpirinixic acid results in decreased expression of ITLN1 mRNA17426115
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ITLN1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ITLN1 mRNA23806026
D053260SootSoot results in increased expression of ITLN1 mRNA26551751
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of ITLN1 mRNA26496021
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ITLN1 mRNA20133372
D019287Zinc SulfateZinc Sulfate results in decreased expression of ITLN1 mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IDA26148048  
GO:0042802identical protein binding-IPI26148048  
GO:0070492oligosaccharide binding-IDA26148048  
GO ID GO Term Qualifier Evidence PubMed
GO:0001934positive regulation of protein phosphorylation-IDA16531507  
GO:0009624response to nematode-ISS-  
GO:0019730antimicrobial humoral response-TAS-  
GO:0046326positive regulation of glucose import-IDA16531507  
GO:0070207protein homotrimerization-IDA26148048  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0031225anchored component of membrane-IEA-  
GO:0031526brush border membrane-ISS-  
GO:0043235receptor complex-IDA23382219  
GO:0045121membrane raft-ISS-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6803157Antimicrobial peptidesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28442700Role of the rs2274907 allelic variant of the ITLN1 gene in patients with diabetic foot. (2017 May 31)Mrozikiewicz-Rakowska BPol Arch Intern Med