Gene: DDX60

55601
-
DExD/H-box helicase 60
protein-coding
4q32.3
Ensembl:ENSG00000137628 MIM:613974 Vega:OTTHUMG00000161350 UniprotKB:Q8IY21
NG_054636.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.011e-1 (AD)  9.730e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SAMD9L0.902
HERC50.886
DDX60L0.864
PARP140.859
TLR30.853
IFI440.84
DDX580.837
IFIT30.829
RTP40.819
EPSTI10.805

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYADML2-0.406
MAGIX-0.406
TTC9B-0.402
RHO-0.395
ABCC12-0.392
PIP5KL1-0.388
NPAS1-0.384
DLK2-0.384
HYAL3-0.383
ISLR2-0.381

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDX60 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDX60 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of DDX60 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of DDX60 mRNA22230336
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of DDX60 mRNA"23195993
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DDX60 mRNA19619570
D004958EstradiolEstradiol results in increased expression of DDX60 mRNA19619570|2118537
D004958EstradiolEstradiol results in increased expression of DDX60 mRNA19484750
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of DDX60 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of DDX60 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of DDX60 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of DDX60 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of DDX60 mRNA26496021
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of DDX60 mRNA28472532
D003300Copper[Disulfiram binds to Copper] which results in increased expression of DDX60 mRNA24690739
D003471CuprizoneCuprizone results in increased expression of DDX60 mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of DDX60 mRNA27989131
D003703DemecolcineDemecolcine results in increased expression of DDX60 mRNA23649840
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of DDX60 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of DDX60 mRNA27392435
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of DDX60 mRNA28085963
C014476diethyl maleatediethyl maleate results in decreased expression of DDX60 mRNA21161181
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of DDX60 mRNA24690739
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DDX60 mRNA22079256
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of DDX60 mRNA23649840
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of DDX60 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of DDX60 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of DDX60 mRNA23086925|2479639
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DDX60 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DDX60 mRNA19465457
C030589methylmercury cysteinemethylmercury cysteine results in decreased expression of DDX60 mRNA19465457
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of DDX60 mRNA"25554681
D009532NickelNickel results in decreased expression of DDX60 mRNA23195993
D009532NickelNickel results in increased expression of DDX60 mRNA24768652|2558310
C558013NSC 689534NSC 689534 results in increased expression of DDX60 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] affects the expression of DDX60 mRNA25729387
D010416PentachlorophenolPentachlorophenol results in increased expression of DDX60 mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of DDX60 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDX60 mRNA"27188386
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DDX60 mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of DDX60 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of DDX60 mRNA20813756
D010936Plant ExtractsPlant Extracts results in increased expression of DDX60 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DDX60 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DDX60 mRNA22079256|2271453
D011441PropylthiouracilPropylthiouracil results in increased expression of DDX60 mRNA24780913
D012822Silicon DioxideSilicon Dioxide results in increased expression of DDX60 mRNA22300531|2535159
D012834SilverSilver results in decreased expression of DDX60 mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of DDX60 gene28589171
D053260SootSoot results in increased expression of DDX60 mRNA22461453
D013629TamoxifenTamoxifen affects the expression of DDX60 mRNA20937368
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of DDX60 mRNA26496021
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of DDX60 mRNA27914987
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DDX60 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DDX60 mRNA16704738|1961957
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DDX60 mRNA26377647
C009495titanium dioxidetitanium dioxide results in increased expression of DDX60 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of DDX60 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of DDX60 mRNA20133372
C024746tobacco tartobacco tar results in decreased expression of DDX60 mRNA19559774
D019772Topotecan[oxaliplatin co-treated with Topotecan] affects the expression of DDX60 mRNA25729387
D019772TopotecanTopotecan results in increased expression of DDX60 mRNA25729387
C012589trichostatin Atrichostatin A results in decreased expression of DDX60 mRNA24935251
D014635Valproic AcidValproic Acid results in decreased expression of DDX60 mRNA23179753|2493525
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DDX60 gene25560391
D014750VincristineVincristine results in increased expression of DDX60 mRNA23649840
D015034Zinc OxideZinc Oxide analog results in increased expression of DDX60 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003690double-stranded DNA binding-IDA21791617  
GO:0003725double-stranded RNA binding-IDA21791617  
GO:0003727single-stranded RNA binding-IDA21791617  
GO:0004386helicase activity-IEA-  
GO:0005515protein binding-IPI21791617  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0009615response to virus-IDA21791617  
GO:0045087innate immune response-IEA-  
GO:0051607defense response to virus-IEA-  
GO:1900245positive regulation of MDA-5 signaling pathway-IMP21791617  
GO:1900246positive regulation of RIG-I signaling pathway-IMP21791617  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA21791617  
GO:0005829cytosol-IDA-  
GO:0045111intermediate filament cytoskeleton-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27835882Subsite-specific association of DEAD box RNA helicase DDX60 with the development and prognosis of oral squamous cell carcinoma. (2016 Dec 20)Fu TYOncotarget