Gene: FERMT1

55612
C20orf42|DTGCU2|KIND1|UNC112A|URP1
fermitin family member 1
protein-coding
20p12.3
Ensembl:ENSG00000101311 MIM:607900 Vega:OTTHUMG00000031826 UniprotKB:Q9BQL6
NG_016213.1
SNP Mapped
1   ANCO-SNPs
CD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.828e-2 (AD)  6.607e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2295435chr20:6116048 (GRCh38.p7)C>Tcocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDGFRA0.75
PCDH150.733
VCAN0.695
MYT10.662
COL9A10.649
CACNG40.634
GPR170.631
WSCD10.625
STK32A0.62
SEMA5A0.617

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC39A14-0.33
HILPDA-0.305
KRTAP5-5-0.302
GUCY2D-0.281
SLC22A14-0.279
DLX4-0.269
IL1RL1-0.267
LANCL3-0.257
GRB7-0.254
ALOX15B-0.252

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of FERMT1 protein24140754
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FERMT1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FERMT1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FERMT1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FERMT1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FERMT1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FERMT1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FERMT1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FERMT1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FERMT1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FERMT1 mRNA"27188386
C496492abrineabrine results in increased expression of FERMT1 mRNA22595364
D020106AcrylamideAcrylamide results in increased expression of FERMT1 mRNA28959563
C006632arsenic trioxideFERMT1 protein results in decreased susceptibility to arsenic trioxide20707922
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FERMT1 mRNA21714911
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FERMT1 mRNA22316170
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of FERMT1 mRNA20660070
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of FERMT1 mRNA17404688
C006780bisphenol Abisphenol A results in increased expression of FERMT1 mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of FERMT1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of FERMT1 mRNA28628672
C018475butyraldehydebutyraldehyde results in increased expression of FERMT1 mRNA26079696
C100187chloropicrinchloropicrin results in decreased expression of FERMT1 mRNA26352163
C018021cobaltous chloridecobaltous chloride results in decreased expression of FERMT1 mRNA19376846
D019327Copper SulfateCopper Sulfate results in increased expression of FERMT1 mRNA19549813
C014347decitabinedecitabine affects the expression of FERMT1 mRNA23300844
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of FERMT1 mRNA28628672
D002945CisplatinCisplatin affects the expression of FERMT1 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of FERMT1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of FERMT1 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of FERMT1 mRNA28302478
C118739entinostatentinostat results in increased expression of FERMT1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FERMT1 mRNA"27188386
D004397FonofosFonofos results in increased methylation of FERMT1 promoter22847954
C039281furanfuran results in increased expression of FERMT1 mRNA27387713
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of FERMT1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of FERMT1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of FERMT1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FERMT1 mRNA26752646
C008261lead acetatelead acetate results in decreased expression of FERMT1 mRNA22641619
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FERMT1 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of FERMT1 mRNA22129749
D010100OxygenOxygen deficiency results in decreased expression of FERMT1 mRNA26516004
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FERMT1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of FERMT1 mRNA26272509
D010278ParathionParathion results in increased methylation of FERMT1 promoter22847954
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of FERMT1 mRNA26705709
C046012pentanalpentanal results in increased expression of FERMT1 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FERMT1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of FERMT1 mRNA26272509
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of FERMT1 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in increased expression of FERMT1 mRNA23608068
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of FERMT1 mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of FERMT1 mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of FERMT1 mRNA17404688
D011441PropylthiouracilPropylthiouracil results in increased expression of FERMT1 mRNA24780913
C043680ptaquilosideptaquiloside results in decreased expression of FERMT1 mRNA23274088
D011794QuercetinQuercetin results in decreased expression of FERMT1 mRNA21632981
D012643SeleniumSelenium results in decreased expression of FERMT1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of FERMT1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of FERMT1 mRNA25351596
C012568terbufosterbufos results in increased methylation of FERMT1 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FERMT1 mRNA21354282
D014212TretinoinTretinoin results in increased expression of FERMT1 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FERMT1 mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of FERMT1 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of FERMT1 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FERMT1 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of FERMT1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FERMT1 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of FERMT1 mRNA23179753|2438349
D014638VanadatesVanadates results in decreased expression of FERMT1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FERMT1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of FERMT1 mRNA23034163
D014810Vitamin EVitamin E results in decreased expression of FERMT1 mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of FERMT1 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0001954positive regulation of cell-matrix adhesion-IEA-  
GO:0007155cell adhesion-IDA17012746  
GO:0007229integrin-mediated signaling pathway-IEA-  
GO:0010629negative regulation of gene expression-IEA-  
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathway-IEA-  
GO:0033630positive regulation of cell adhesion mediated by integrin-IEA-  
GO:0042308negative regulation of protein import into nucleus-IEA-  
GO:0043616keratinocyte proliferation-IDA17012746  
GO:0051546keratinocyte migration-IDA17012746  
GO:0051886negative regulation of timing of anagen-IEA-  
GO:0071711basement membrane organization-IEA-  
GO:0090090negative regulation of canonical Wnt signaling pathway-IEA-  
GO:0090162establishment of epithelial cell polarity-IDA17012746  
GO:2000647negative regulation of stem cell proliferation-IEA-  
GO:2001203positive regulation of transforming growth factor-beta secretion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA17012746  
GO:0005925focal adhesion-IEA-  
GO:0030054cell junction-IDA17012746  
GO:0031941filamentous actin-IEA-  
GO:0032587ruffle membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal