Gene: ASAP3

55616
ACAP4|CENTB6|DDEFL1|UPLC1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
protein-coding
1p36.12
Ensembl:ENSG00000088280 MIM:616594 Vega:OTTHUMG00000003234 UniprotKB:Q8TDY4
NC_000001.11
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.439e-3 (AD)  9.802e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7522616chr1:23468421 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNN30.905
NEK60.887
TMBIM10.867
ITPKB0.865
DTNA0.858
ABHD40.854
LRP100.85
SLC39A10.849
TP530.848
LIMK20.846

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.464
ADRA1D-0.463
MYOZ3-0.451
SLC7A4-0.439
FBLN7-0.437
PPEF1-0.431
NMU-0.42
AGMAT-0.416
CALHM1-0.415
MARCH4-0.414

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASAP3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASAP3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASAP3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASAP3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ASAP3 mRNA22230336
D020106AcrylamideAcrylamide affects the expression of ASAP3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ASAP3 mRNA27153756
D001104ArbutinArbutin results in decreased expression of ASAP3 mRNA17103032
C006780bisphenol Abisphenol A results in increased expression of ASAP3 mRNA29275510
C006780bisphenol Abisphenol A results in increased methylation of ASAP3 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of ASAP3 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of ASAP3 mRNA26191083
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of ASAP3 mRNA24763279
D019327Copper SulfateCopper Sulfate results in decreased expression of ASAP3 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of ASAP3 mRNA25562108
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ASAP3 mRNA27392435
C118739entinostatentinostat results in increased expression of ASAP3 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASAP3 mRNA"27188386
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of ASAP3 mRNA24763279
C492448ICG 001ICG 001 results in increased expression of ASAP3 mRNA26191083
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ASAP3 mRNA27392435
C544151jinfukangjinfukang results in increased expression of ASAP3 mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ASAP3 mRNA26011545
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of ASAP3 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ASAP3 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ASAP3 mRNA"25554681
D015474IsotretinoinIsotretinoin results in increased expression of ASAP3 mRNA20436886
D012643SeleniumSelenium results in increased expression of ASAP3 mRNA19244175
D012834SilverSilver results in increased expression of ASAP3 mRNA27131904
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ASAP3 mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ASAP3 mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ASAP3 mRNA"26743178
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ASAP3 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASAP3 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of ASAP3 mRNA26272509
D014635Valproic AcidValproic Acid results in increased methylation of ASAP3 gene29154799
D014810Vitamin EVitamin E results in increased expression of ASAP3 mRNA19244175
D015032ZincZinc deficiency results in increased expression of ASAP3 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IDA18400762  
GO:0005515protein binding-IPI19380743  25416956  26871637  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016477cell migration-IMP18400762  
GO:0043547positive regulation of GTPase activity-IDA18400762  
GO:0051492regulation of stress fiber assembly-IBA21873635  
GO:0051492regulation of stress fiber assembly-IMP18400762  
GO ID GO Term Qualifier Evidence PubMed
GO:0001726ruffle-IBA21873635  
GO:0001726ruffle-IDA18400762  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0005925focal adhesion-IBA21873635  
GO:0005925focal adhesion-IDA18400762  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
hsa04144Endocytosis
hsa04666Fc gamma R-mediated phagocytosis
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal