Gene: PRKAA1

5562
AMPK|AMPKa1
protein kinase AMP-activated catalytic subunit alpha 1
protein-coding
5p13.1
Ensembl:ENSG00000132356 MIM:602739 Vega:OTTHUMG00000162269 UniprotKB:Q13131
NC_000005.10
PubMed
0   ANCO-SNPs
ND
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.004e-1 (AD)  9.266e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DNAJC100.901
SENP60.88
SEC23IP0.878
SUZ120.866
IBTK0.864
TRIM330.863
RCOR30.86
VPS4B0.859
GMCL10.853
MFSD80.85

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.51
OR4F29-0.483
C7orf61-0.325
FOXJ1-0.287
FAM151A-0.278
MIA-0.276
CELSR1-0.272
CXorf67-0.263
S100A1-0.263
GAGE10-0.263

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00131Adenosine monophosphateSmall Molecule61-19-8Approved|Investigational|NutraceuticalTarget
DB00171ATPSmall Molecule56-65-5Investigational|NutraceuticalTarget
DB00914PhenforminSmall Molecule114-86-3Approved|Investigational|WithdrawnTarget
DB00945Acetylsalicylic acidSmall Molecule50-78-2ApprovedTarget
ID Drug Name Action PubMed
C0782191,2,3,4,7,8-hexachlorodibenzodioxin"1,2,3,4,7,8-hexachlorodibenzodioxin results in increased phosphorylation of PRKAA1 protein"15703265
C0326681-nitropyrene1-nitropyrene results in increased expression of PRKAA1 mRNA19041380
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PRKAA1 mRNA"27291303
C0717382-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate[2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate co-treated with resveratrol] affects the phosphorylation of PRKAA1 protein24885036
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]21186350
C4411283-N-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate"3-N-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate affects the reaction [Dietary Fats affects the phosphorylation of PRKAA1 protein]"28899902
C0415944-nonylphenolPRKAA1 protein promotes the reaction [4-nonylphenol results in decreased phosphorylation of EIF4EBP1 protein]28041982
C0415944-nonylphenolPRKAA1 protein promotes the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]28041982
C0415944-nonylphenolPRKAA1 protein promotes the reaction [4-nonylphenol results in decreased phosphorylation of RPS6KB1 protein]28041982
C0415944-nonylphenolPRKAA1 protein promotes the reaction [4-nonylphenol results in increased expression of BECN1 protein]28041982
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [PRKAA1 protein results in decreased phosphorylation of RPS6 protein]"19625624
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [PRKAA1 protein results in increased phosphorylation of ACACA protein]"19625624
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Quercetin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]"19293639
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]]"24465016
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [AICA ribonucleotide results in increased phosphorylation of PRKAA1 protein]"24465016
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [PRKAA1 protein results in decreased activity of TNFSF11 protein]"20696287
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Quercetin inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]]"24465016
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Quercetin results in increased phosphorylation of PRKAA1 mRNA]"24465016
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol results in increased phosphorylation of PRKAA1 protein]"25761413
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in decreased activity of PRKAA1 protein"20696287
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in decreased phosphorylation of PRKAA1 protein"24465016
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [mangiferin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]"22292039
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in decreased activity of [PRKAA1 protein binds to PRKAB2 protein binds to PRKAG1 protein]"22898769
C4385056,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one"6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]"16873680
C4385056,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one"6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of and results in increased activity of PRKAA1 protein"16873680
C4385056,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one"6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of PRKAA1 protein"18482975
C4385056,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one"Niacinamide inhibits the reaction [6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of PRKAA1 protein]"18482975
C4385056,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one"SIRT1 protein promotes the reaction [6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of PRKAA1 protein]"18482975
C4732178-(4-chloro-phenylthio)-2'-O-methyladenosine-3'-5'-cyclic monophosphate8-(4-chloro-phenylthio)-2'-O-methyladenosine-3'-5'-cyclic monophosphate results in increased phosphorylation of PRKAA1 protein19167487
C099958acanthoic acidPRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of CASP1 mRNA]]28964808
C099958acanthoic acidPRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of IL18 mRNA]]28964808
C099958acanthoic acidPRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]]28964808
C099958acanthoic acidPRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of IRAK4 protein]]28964808
C099958acanthoic acidPRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of TNF mRNA]]28964808
D000082AcetaminophenAcetaminophen results in decreased expression of PRKAA1 mRNA21420995
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of PRKAA1 protein]21195169
D000111AcetylcysteineAcetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of PRKAA1 protein]24386346
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Quercetin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]19293639
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Quercetin results in increased phosphorylation of PRKAA1 protein]20083342|2453566
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of PRKAA1 protein]21195169
C016601afimoxifenePRKAA1 results in decreased susceptibility to afimoxifene21233418
C031143AICA ribonucleotideAICA ribonucleotide results in increased phosphorylation of PRKAA1 protein16837613
C031143AICA ribonucleotidePRKAA1 gene mutant form inhibits the reaction [FSHB protein affects the reaction [AICA ribonucleotide results in increased phosphorylation of MAPK1 protein]]16837613
C031143AICA ribonucleotidePRKAA1 protein affects the reaction [AICA ribonucleotide affects the reaction [FSHB protein results in increased secretion of Progesterone]]16837613
C031143AICA ribonucleotidePRKAA1 protein affects the reaction [FSHB protein affects the reaction [AICA ribonucleotide results in increased expression of STAR protein]]16837613
C031143AICA ribonucleotideAICA ribonucleotide promotes the reaction [Quercetin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]19293639
C031143AICA ribonucleotideAICA ribonucleotide results in increased expression of PRKAA1 protein modified form25743752
C031143AICA ribonucleotideAICA ribonucleotide results in increased phosphorylation of and results in increased activity of PRKAA1 protein16873680|1929363
C031143AICA ribonucleotideAICA ribonucleotide results in increased phosphorylation of PRKAA1 protein22815988|2326626
C031143AICA ribonucleotidePRKAA1 protein affects the reaction [AICA ribonucleotide results in increased expression of CYP4F2 mRNA]21205922
C031143AICA ribonucleotideQuercetin promotes the reaction [AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PRKAA1 protein]19293639
C031143AICA ribonucleotide"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]]"24465016
C031143AICA ribonucleotide"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [AICA ribonucleotide results in increased phosphorylation of PRKAA1 protein]"24465016
C031143AICA ribonucleotideAICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]24465016
C031143AICA ribonucleotideAICA ribonucleotide results in increased phosphorylation of PRKAA1 protein24465016
C031143AICA ribonucleotideAICA ribonucleotide inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of PRKAA1 protein]21195169
C031143AICA ribonucleotide"AICA ribonucleotide inhibits the reaction [Sodium Chloride, Dietary results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]"20349193
C031143AICA ribonucleotide"AICA ribonucleotide inhibits the reaction [Sodium Chloride, Dietary results in increased expression of PRKAA1 mRNA]"20349193
C031143AICA ribonucleotideAICA ribonucleotide results in increased activity of PRKAA1 protein12519745
C031143AICA ribonucleotideAICA ribonucleotide results in increased phosphorylation of PRKAA1 protein16020477
C031143AICA ribonucleotide[AICA ribonucleotide results in increased phosphorylation of PRKAA1 protein] which results in decreased secretion of Progesterone16020477
C031143AICA ribonucleotideAICA ribonucleotide results in decreased activity of [PRKAA1 protein binds to PRKAB2 protein binds to PRKAG1 protein]22898769
D013196DihydrotestosteroneDihydrotestosterone results in decreased phosphorylation of PRKAA1 protein16990341
D013196DihydrotestosteroneEstradiol inhibits the reaction [Dihydrotestosterone results in decreased phosphorylation of PRKAA1 protein]16990341
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of PRKAA1 mRNA21298039
D000622Aminolevulinic AcidAminolevulinic Acid analog results in increased activity of PRKAA1 protein20426806
D000638AmiodaroneAmiodarone results in increased phosphorylation of PRKAA1 protein23912912
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PRKAA1 mRNA16483693
C032456antimycinantimycin results in increased phosphorylation of PRKAA1 protein19901985
D047310ApigeninApigenin inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]16873680
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of PRKAA1 mRNA"17331233
D001241AspirinAspirin results in increased expression of PRKAA1 protein modified form25743752
D001241AspirinCES1 protein promotes the reaction [Aspirin results in increased expression of PRKAA1 protein modified form]25743752
C058278atpenin A5atpenin A5 results in increased phosphorylation of PRKAA1 protein19901985
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PRKAA1 mRNA"19150397
D004958EstradiolEstradiol results in decreased expression of PRKAA1 mRNA23373633
D004958EstradiolEstradiol inhibits the reaction [Dihydrotestosterone results in decreased phosphorylation of PRKAA1 protein]16990341
D004958EstradiolEstradiol results in increased phosphorylation of and results in increased activity of PRKAA1 protein15967841
D001688Biological ProductsBiological Products results in increased phosphorylation of PRKAA1 protein23266269
C006780bisphenol Abisphenol A affects the expression of PRKAA1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of PRKAA1 mRNA24959901
C006780bisphenol Abisphenol A affects the expression of PRKAA1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of PRKAA1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased phosphorylation of PRKAA1 protein22174045
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of PRKAA1 mRNA17553608
C542815BLX 1002BLX 1002 results in increased phosphorylation of and results in increased activity of PRKAA1 protein19052259
D002104CadmiumPRKAA1 mutant form inhibits the reaction [Cadmium results in decreased phosphorylation of MTOR protein]21767558
D019256Cadmium ChlorideAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of PRKAA1 protein]21195169
D019256Cadmium ChlorideCadmium Chloride results in decreased phosphorylation of PRKAA1 protein21195169
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PRKAA1 protein21195169
D019256Cadmium ChlorideAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of PRKAA1 protein]21195169
D019256Cadmium ChlorideAICA ribonucleotide inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of PRKAA1 protein]21195169
D019256Cadmium ChlorideCadmium Chloride results in decreased phosphorylation of PRKAA1 protein21195169
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PRKAA1 protein21195169
D019256Cadmium ChlorideSirolimus inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of PRKAA1 protein]21195169
D002211Capsaicin[Genistein co-treated with Capsaicin] results in increased activity of PRKAA1 protein19723084
D002211CapsaicinCapsaicin results in increased expression of PRKAA1 protein22150557
D002211Capsaicin[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PRKAA1 protein]22150557
D002211CapsaicinNaproxen inhibits the reaction [Capsaicin results in increased expression of PRKAA1 protein]22150557
D002211CapsaicinSumatriptan inhibits the reaction [Capsaicin results in increased expression of PRKAA1 protein]22150557
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PRKAA1 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PRKAA1 mRNA12734012
D002259Carbonyl Cyanide p-TrifluoromethoxyphenylhydrazoneCarbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased phosphorylation of PRKAA1 protein19901985
D000068579CelecoxibCelecoxib promotes the reaction [Quercetin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]19293639
D002746ChlorpromazineChlorpromazine results in decreased phosphorylation of PRKAA1 protein17512020
D004390ChlorpyrifosChlorpyrifos results in increased expression of PRKAA1 mRNA17452286
C018021cobaltous chlorideAcetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of PRKAA1 protein]24386346
C018021cobaltous chloridecobaltous chloride results in increased phosphorylation of and results in increased activity of PRKAA1 protein16678800
C018021cobaltous chloridecobaltous chloride results in increased phosphorylation of PRKAA1 protein24386346
C018021cobaltous chlorideginsenoside Rg1 inhibits the reaction [cobaltous chloride results in increased phosphorylation of PRKAA1 protein]24386346
C018021cobaltous chloridePRKAA1 protein affects the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]16678800
C018021cobaltous chloridePRKAA1 protein affects the reaction [cobaltous chloride results in increased secretion of VEGFA protein]16678800
C018021cobaltous chloridecobaltous chloride results in increased expression of PRKAA1 mRNA24386269
D005576ColforsinColforsin results in increased phosphorylation of and results in increased activity of PRKAA1 protein18390901
D005576ColforsinPNPLA2 protein affects the reaction [Colforsin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]18390901
D019327Copper SulfateCopper Sulfate results in increased expression of PRKAA1 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of PRKAA1 mRNA26577399
D003471CuprizoneCuprizone results in increased expression of PRKAA1 mRNA27523638
D003474CurcuminCurcumin results in increased phosphorylation of PRKAA1 protein18790744
C089595cylindrospermopsincylindrospermopsin results in increased expression of PRKAA1 mRNA24921660
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of PRKAA1 mRNA23640034
C107676deguelindeguelin results in increased phosphorylation of PRKAA1 protein19901985
D013759DronabinolDronabinol results in increased activity of PRKAA1 protein15899896
D003976DiazinonDiazinon results in increased expression of PRKAA1 mRNA17452286
D002945CisplatinCisplatin results in increased expression of PRKAA1 mRNA19561079|2759478
D004041Dietary Fats"3-N-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate affects the reaction [Dietary Fats affects the phosphorylation of PRKAA1 protein]"28899902
D004041Dietary FatsDietary Fats affects the phosphorylation of PRKAA1 protein28899902
D004041Dietary FatsDietary Fats results in decreased phosphorylation of PRKAA1 protein21971952|2446501
D004041Dietary Fatsginsenoside Re inhibits the reaction [Dietary Fats results in decreased phosphorylation of PRKAA1 protein]21971952
D004041Dietary FatsQuercetin inhibits the reaction [Dietary Fats results in decreased phosphorylation of PRKAA1 protein]24465016
D002117CalcitriolPRKAA1 mutant form inhibits the reaction [Calcitriol affects the localization of CAMP protein]19748465
D004656EnalaprilEnalapril results in increased expression of PRKAA1 protein25037058
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PRKAA1 protein23301498
D000431EthanolPRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of CASP1 mRNA]]28964808
D000431EthanolPRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of IL18 mRNA]]28964808
D000431EthanolPRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]]28964808
D000431EthanolPRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of IRAK4 protein]]28964808
D000431EthanolPRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of TNF mRNA]]28964808
D000431EthanolPRKAA1 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Ethanol results in decreased expression of ATG5 mRNA]]24582693
D000431Ethanol[Ethanol co-treated with PRKAA2 protein] affects the expression of PRKAA1 protein23448468
D004997Ethinyl EstradiolEthinyl Estradiol affects the localization of PRKAA1 protein27090119
D004997Ethinyl EstradiolEthinyl Estradiol results in increased phosphorylation of and affects the localization of PRKAA1 protein27090119
D004997Ethinyl EstradiolPRKAA1 protein affects the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]27090119
D004997Ethinyl EstradiolPRKAA1 protein affects the reaction [Ethinyl Estradiol results in decreased expression of NR1H4 mRNA]27090119
D004997Ethinyl EstradiolPRKAA1 protein affects the reaction [Ethinyl Estradiol results in decreased expression of NR1H4 protein]27090119
D004997Ethinyl EstradiolPRKAA1 protein inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA]27090119
D004997Ethinyl EstradiolPRKAA1 protein inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]27090119
D004997Ethinyl EstradiolPRKAA1 protein inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 mRNA]27090119
D011345FenofibratePRKAA1 gene mutant form results in decreased susceptibility to Fenofibrate25545733
D011345FenofibratePRKAA1 protein affects the reaction [Fenofibrate results in decreased susceptibility to ALB protein modified form]20580385
D011345FenofibratePRKAA1 protein affects the reaction [Fenofibrate results in increased abundance of Nitric Oxide]20580385
D011345FenofibratePRKAA1 protein affects the reaction [Fenofibrate results in increased activity of NOS3 protein]20580385
D005419FlavonoidsFlavonoids results in decreased expression of PRKAA1 mRNA18035473
D005557FormaldehydeFormaldehyde results in decreased expression of PRKAA1 mRNA20655997|2364984
C039281furanfuran results in increased expression of PRKAA1 mRNA25539665
D019833Genistein[Genistein co-treated with Capsaicin] results in increased activity of PRKAA1 protein19723084
D005839GentamicinsGentamicins results in decreased expression of PRKAA1 mRNA22061828
C049864ginsenoside Reginsenoside Re results in increased phosphorylation of PRKAA1 protein21971952
C049864ginsenoside Reginsenoside Re inhibits the reaction [Dietary Fats results in decreased phosphorylation of PRKAA1 protein]21971952
C035054ginsenoside Rg1ginsenoside Rg1 inhibits the reaction [cobaltous chloride results in increased phosphorylation of PRKAA1 protein]24386346
D005947Glucose"6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]"16873680
D005947GlucoseApigenin inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]16873680
D005947GlucoseGlucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein16873680|1848297
D005947GlucoseMetformin inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]16873680
D005947GlucosePRKAA1 protein affects the reaction [Metformin inhibits the reaction [Glucose deficiency results in increased chemical synthesis of Reactive Oxygen Species]]16380484
D005947GlucosePRKAA1 protein affects the reaction [Ribonucleosides inhibits the reaction [Glucose deficiency results in increased chemical synthesis of Reactive Oxygen Species]]16380484
D005947GlucosePRKAA1 protein affects the reaction [rosiglitazone inhibits the reaction [Glucose affects the localization of NCF1 protein]]17916771
D005947GlucosePRKAA1 protein affects the reaction [rosiglitazone inhibits the reaction [Glucose affects the localization of RAC1 protein]]17916771
D005947GlucosePRKAA1 protein affects the reaction [rosiglitazone inhibits the reaction [Glucose results in increased abundance of Reactive Oxygen Species]]17916771
D005947Glucoseresveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]16873680
D005947Glucose[resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]18482975
D005947GlucoseGlucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein19052259
D005947GlucosePRKAA1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]]23090186
D006632Histamine[PRKAA1 protein co-treated with PRKAA2 protein] affects the reaction [Histamine results in increased phosphorylation of NOS2 protein]21145922
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of PRKAA1 mRNA18951874
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of and results in increased phosphorylation of and results in increased activity of PRKAA1 protein15297373
C051890irinotecanirinotecan analog results in decreased expression of PRKAA1 mRNA18927307
D007501IronIron deficiency results in decreased expression of PRKAA1 mRNA19821111
D0150561-Methyl-3-isobutylxanthine1-Methyl-3-isobutylxanthine results in increased phosphorylation of and results in increased activity of PRKAA1 protein18390901
D0150561-Methyl-3-isobutylxanthineorlistat inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased phosphorylation of and results in increased activity of PRKAA1 protein]18390901
D007545IsoproterenolIsoproterenol results in increased phosphorylation of and results in increased activity of PRKAA1 protein18390901
D007545Isoproterenolorlistat inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of PRKAA1 protein]18390901
D007545Isoproterenoltriacsin C inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of PRKAA1 protein]18390901
D007545IsoproterenolINS protein inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]19167487
D007545IsoproterenolIsoproterenol results in increased phosphorylation of PRKAA1 protein19167487
D007545IsoproterenolN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]19167487
D007545IsoproterenolOPC 3911 inhibits the reaction [INS protein inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]]19167487
D007545Isoproterenolorlistat inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]19167487
D007545Isoproterenol[PDE3B protein co-treated with AKT1 protein] inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]19167487
C544151jinfukangjinfukang results in decreased expression of PRKAA1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of PRKAA1 mRNA26254443
D008070Lipopolysaccharides"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]]"24465016
D008070Lipopolysaccharides"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Quercetin inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]]"24465016
D008070LipopolysaccharidesAICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]24465016
D008070LipopolysaccharidesLipopolysaccharides results in decreased phosphorylation of PRKAA1 protein24465016
D008070LipopolysaccharidesQuercetin inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]24465016
C013592mangiferin"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [mangiferin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]"22292039
C013592mangiferinmangiferin results in increased phosphorylation of and results in increased activity of PRKAA1 protein22292039
D008627Mercuric ChlorideMercuric Chloride results in increased expression of PRKAA1 mRNA16507785
D008687MetforminMetformin inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]16873680
D008687MetforminMetformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein16873680
D008687MetforminMetformin results in increased phosphorylation of PRKAA1 protein25601987
D008687MetforminOrotic Acid inhibits the reaction [Metformin results in increased phosphorylation of PRKAA1 protein]25601987
D008687MetforminPRKAA1 protein affects the reaction [Metformin inhibits the reaction [Glucose deficiency results in increased chemical synthesis of Reactive Oxygen Species]]16380484
D008687MetforminPRKAA1 protein affects the reaction [Metformin results in decreased expression of ABCB1 protein]21054339
D008687MetforminPRKAA1 protein affects the reaction [Metformin results in decreased expression of RELA protein]21054339
D008687MetforminPRKAA1 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]16380484
D008687MetforminPRKAA1 protein affects the reaction [Metformin results in increased expression of SOD2 mRNA]16380484
D008687MetforminPRKAA1 protein affects the susceptibility to Metformin16380484
D008687MetforminMetformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein19052259
D008687MetforminMetformin results in increased phosphorylation of PRKAA1 protein22815988|2649736
D008687MetforminPRKAA1 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]24428821
D008687Metformin2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]21186350
D008687MetforminMetformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein21186350
D008687MetforminMetformin results in increased phosphorylation of PRKAA1 protein16760380|1959430
D008687MetforminPRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of HSD3B protein]]16760380
D008687MetforminPRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of STAR protein]]16760380
D008687MetforminPRKAA1 gene mutant form inhibits the reaction [Metformin promotes the reaction [FSHB protein results in increased phosphorylation of PRKAA1 protein]]16760380|1676038
D008687MetforminPRKAA1 gene mutant form inhibits the reaction [Metformin results in decreased expression of HSD3B protein]16760380
D008687MetforminPRKAA1 gene mutant form inhibits the reaction [Metformin results in decreased secretion of Progesterone]16760380
D008687MetforminPRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of MAPK1 protein]16760380
D008687MetforminPRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of MAPK3 protein]16760380
D008687MetforminPRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of PRKAA1 protein]16760380|1676038
D008727MethotrexatePRKAA1 mutant form inhibits the reaction [Methotrexate results in increased expression of HMOX1 mRNA]25575725
D008727MethotrexatePRKAA1 mutant form inhibits the reaction [Methotrexate results in increased expression of SOD2 mRNA]25575725
D008727MethotrexatePRKAA1 mutant form inhibits the reaction [Methotrexate results in increased expression of SOD2 protein]25575725
D008727MethotrexatePRKAA1 mutant form inhibits the reaction [Methotrexate results in increased phosphorylation of CREB1 protein]25575725
C013598methoxyacetic acidmethoxyacetic acid affects the expression of PRKAA1 mRNA20864626
D008767Methylmercury CompoundsPRKAA1 protein results in decreased susceptibility to Methylmercury Compounds20686348
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]19167487
D009288Naproxen[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PRKAA1 protein]22150557
D009288NaproxenNaproxen inhibits the reaction [Capsaicin results in increased expression of PRKAA1 protein]22150557
D009532NickelNickel results in increased expression of PRKAA1 mRNA25583101
D009569Nitric OxidePRKAA1 protein affects the reaction [Fenofibrate results in increased abundance of Nitric Oxide]20580385
D009840OligomycinsOligomycins results in increased phosphorylation of PRKAA1 protein19901985
C060853OPC 3911OPC 3911 inhibits the reaction [INS protein inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]]19167487
C055122orlistatorlistat inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased phosphorylation of and results in increased activity of PRKAA1 protein]18390901
C055122orlistatorlistat inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of PRKAA1 protein]18390901
C055122orlistatorlistat inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]19167487
D009963Orotic AcidOrotic Acid inhibits the reaction [Metformin results in increased phosphorylation of PRKAA1 protein]25601987
D010269ParaquatParaquat results in increased phosphorylation of PRKAA1 protein25092649
D010269ParaquatPRKAA1 protein affects the reaction [Paraquat results in increased phosphorylation of ACACA protein]27324791
C084656paricalcitolparicalcitol results in increased expression of PRKAA1 protein25037058
C046012pentanalpentanal results in increased expression of PRKAA1 mRNA26079696
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PRKAA1 mRNA19162173
D010629PhenforminPhenformin results in increased phosphorylation of PRKAA1 protein19901985
D010634PhenobarbitalPhenobarbital results in increased phosphorylation of PRKAA1 protein22815988
D010634PhenobarbitalPhenobarbital results in increased phosphorylation of PRKAA1 protein22815988
C018637phoronephorone affects the expression of PRKAA1 mRNA18198479
C121565pifithrin[pifithrin co-treated with Quercetin] results in increased phosphorylation of PRKAA1 protein24535669
C060836pioglitazonePRKAA1 protein affects the reaction [pioglitazone inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of RPS6 protein]]26643070
C060836pioglitazonePRKAA1 protein affects the reaction [pioglitazone results in increased expression of CDKN1B protein]26643070
C060836pioglitazonePRKAA1 protein affects the reaction [pioglitazone results in increased phosphorylation of RPTOR protein]26643070
C006253pirinixic acidpirinixic acid results in increased expression of PRKAA1 mRNA19236843
D010938Plant OilsPlant Oils results in increased expression of PRKAA1 mRNA23370395
D011374ProgesteronePRKAA1 protein affects the reaction [AICA ribonucleotide affects the reaction [FSHB protein results in increased secretion of Progesterone]]16837613
D011374ProgesteroneProgesterone results in increased expression of PRKAA1 mRNA19690047
D011374Progesterone[AICA ribonucleotide results in increased phosphorylation of PRKAA1 protein] which results in decreased secretion of Progesterone16020477
D011374ProgesteronePRKAA1 gene mutant form inhibits the reaction [Metformin results in decreased secretion of Progesterone]16760380
C107773pterostilbenePRKAA1 protein affects the reaction [pterostilbene results in increased phosphorylation of HDAC5 protein]26443543
C107773pterostilbenePRKAA1 protein affects the reaction [pterostilbene results in increased phosphorylation of MAPK7 protein]26443543
C107773pterostilbenepterostilbene results in increased phosphorylation of PRKAA1 protein26443543
D011794Quercetin"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Quercetin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]"19293639
D011794QuercetinAcetylcysteine inhibits the reaction [Quercetin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]19293639
D011794QuercetinAcetylcysteine inhibits the reaction [Quercetin results in increased phosphorylation of PRKAA1 protein]20083342|2453566
D011794QuercetinAICA ribonucleotide promotes the reaction [Quercetin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]19293639
D011794QuercetinCelecoxib promotes the reaction [Quercetin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]19293639
D011794Quercetin[pifithrin co-treated with Quercetin] results in increased phosphorylation of PRKAA1 protein24535669
D011794QuercetinQuercetin promotes the reaction [AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PRKAA1 protein]19293639
D011794QuercetinQuercetin results in increased phosphorylation of and results in increased activity of PRKAA1 protein19293639
D011794QuercetinQuercetin results in increased phosphorylation of PRKAA1 protein20083342|2453566
D011794Quercetin[SB 203580 co-treated with Quercetin] results in increased phosphorylation of PRKAA1 protein24535669
D011794Quercetin"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Quercetin inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]]"24465016
D011794Quercetin"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Quercetin results in increased phosphorylation of PRKAA1 mRNA]"24465016
D011794QuercetinQuercetin inhibits the reaction [Dietary Fats results in decreased phosphorylation of PRKAA1 protein]24465016
D011794QuercetinQuercetin inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]24465016
D011794QuercetinQuercetin results in increased phosphorylation of PRKAA1 protein24343960|2446501
D017382Reactive Oxygen SpeciesPRKAA1 protein affects the abundance of Reactive Oxygen Species19442239|2114592
D017382Reactive Oxygen SpeciesPRKAA1 protein affects the reaction [Metformin inhibits the reaction [Glucose deficiency results in increased chemical synthesis of Reactive Oxygen Species]]16380484
D017382Reactive Oxygen SpeciesPRKAA1 protein affects the reaction [Ribonucleosides inhibits the reaction [Glucose deficiency results in increased chemical synthesis of Reactive Oxygen Species]]16380484
D017382Reactive Oxygen SpeciesPRKAA1 protein affects the reaction [rosiglitazone inhibits the reaction [Glucose results in increased abundance of Reactive Oxygen Species]]17916771
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in increased activity of PRKAA1 protein19442239
C059514resveratrolPRKAA1 mutant form inhibits the reaction [resveratrol results in increased expression of NR0B2 mRNA]26044878
C059514resveratrolPRKAA1 protein promotes the reaction [resveratrol results in decreased phosphorylation of and results in decreased activity of MTOR protein]19928762
C059514resveratrolresveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]16873680
C059514resveratrol[resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]18482975
C059514resveratrol[resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in increased activity of PRKAA1 protein18482975
C059514resveratrolresveratrol results in increased phosphorylation of and results in increased activity of PRKAA1 protein16873680
C059514resveratrolresveratrol results in increased phosphorylation of PRKAA1 protein20080969|2644354
C059514resveratrol[resveratrol results in increased phosphorylation of PRKAA1 protein] which results in decreased expression of APP protein modified form20080969
C059514resveratrol[2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate co-treated with resveratrol] affects the phosphorylation of PRKAA1 protein24885036
C059514resveratrol"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol results in increased phosphorylation of PRKAA1 protein]"25761413
C059514resveratrolPRKAA1 gene mutant form inhibits the reaction [resveratrol results in increased expression of CIDEA mRNA]25761413
C059514resveratrolPRKAA1 gene mutant form inhibits the reaction [resveratrol results in increased expression of CYCS protein]25761413
C059514resveratrolPRKAA1 gene mutant form inhibits the reaction [resveratrol results in increased expression of ELOVL3 mRNA]25761413
C059514resveratrolPRKAA1 gene mutant form inhibits the reaction [resveratrol results in increased expression of PDHA1 protein]25761413
C059514resveratrolPRKAA1 gene mutant form inhibits the reaction [resveratrol results in increased expression of PPARGC1A mRNA]25761413
C059514resveratrolPRKAA1 gene mutant form inhibits the reaction [resveratrol results in increased expression of PRDM16 mRNA]25761413
C059514resveratrolPRKAA1 gene mutant form inhibits the reaction [resveratrol results in increased expression of PRDM16 protein]25761413
C059514resveratrolPRKAA1 gene mutant form inhibits the reaction [resveratrol results in increased expression of SIRT1 protein]25761413
C059514resveratrolPRKAA1 gene mutant form inhibits the reaction [resveratrol results in increased expression of UCP1 mRNA]25761413
C059514resveratrolPRKAA1 gene mutant form inhibits the reaction [resveratrol results in increased expression of UCP1 protein]25761413
C059514resveratrolPRKAA1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]]23090186
C059514resveratrolPRKAA1 protein affects the susceptibility to resveratrol23090186
C059514resveratrolPRKAA1 protein promotes the reaction [resveratrol results in increased expression of UCP1 mRNA]19934007
C059514resveratrolPRKAA1 protein promotes the reaction [resveratrol results in increased expression of UCP2 mRNA]19934007
C059514resveratrolPRKAA1 protein promotes the reaction [resveratrol results in increased expression of UCP3 mRNA]19934007
C059514resveratrolPRKAA1 protein results in increased susceptibility to resveratrol19934007
C059514resveratrolresveratrol results in decreased activity of PRKAA1 protein19934007
C059514resveratrolresveratrol results in increased activity of PRKAA1 protein24756886
C059514resveratrolresveratrol results in increased phosphorylation of and results in increased activity of PRKAA1 protein17464184|2576141
C059514resveratrolresveratrol results in increased phosphorylation of PRKAA1 protein17438283
C059514resveratrolSTK11 protein promotes the reaction [resveratrol results in increased phosphorylation of PRKAA1 protein]17438283
C059514resveratrolresveratrol results in decreased activity of [PRKAA1 protein binds to PRKAB2 protein binds to PRKAG1 protein]22898769
D012263RibonucleosidesPRKAA1 protein affects the reaction [Ribonucleosides inhibits the reaction [Glucose deficiency results in increased chemical synthesis of Reactive Oxygen Species]]16380484
D012263RibonucleosidesPRKAA1 protein affects the reaction [Ribonucleosides results in increased expression of PPARGC1A mRNA]16380484
D012263RibonucleosidesPRKAA1 protein affects the reaction [Ribonucleosides results in increased expression of SOD2 mRNA]16380484
D012263RibonucleosidesPRKAA1 protein affects the susceptibility to Ribonucleosides16380484
C089730rosiglitazonePRKAA1 protein affects the reaction [rosiglitazone inhibits the reaction [Glucose affects the localization of NCF1 protein]]17916771
C089730rosiglitazonePRKAA1 protein affects the reaction [rosiglitazone inhibits the reaction [Glucose affects the localization of RAC1 protein]]17916771
C089730rosiglitazonePRKAA1 protein affects the reaction [rosiglitazone inhibits the reaction [Glucose results in increased abundance of Reactive Oxygen Species]]17916771
D012402RotenoneRotenone results in increased expression of PRKAA1 mRNA17651460
C093642SB 203580[SB 203580 co-treated with Quercetin] results in increased phosphorylation of PRKAA1 protein24535669
D019821SimvastatinSimvastatin results in increased expression of PRKAA1 mRNA25055962
D020123SirolimusSirolimus inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of PRKAA1 protein]21195169
C017947sodium arsenitePRKAA1 protein affects the reaction [sodium arsenite results in increased expression of HIF1A protein]16678800
C017947sodium arsenitePRKAA1 protein affects the reaction [sodium arsenite results in increased expression of VEGFA mRNA]16678800
C017947sodium arsenitePRKAA1 protein affects the reaction [sodium arsenite results in increased secretion of VEGFA protein]16678800
C017947sodium arsenitesodium arsenite results in increased phosphorylation of and results in increased activity of PRKAA1 protein16678800
C016104sodium bichromatesodium bichromate results in increased expression of PRKAA1 mRNA25993096
D017673Sodium Chloride, Dietary"AICA ribonucleotide inhibits the reaction [Sodium Chloride, Dietary results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]"20349193
D017673Sodium Chloride, Dietary"AICA ribonucleotide inhibits the reaction [Sodium Chloride, Dietary results in increased expression of PRKAA1 mRNA]"20349193
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein"20349193
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary results in increased expression of PRKAA1 mRNA"20349193
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PRKAA1 mRNA]25554529
D018170Sumatriptan[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PRKAA1 protein]22150557
D018170SumatriptanSumatriptan inhibits the reaction [Capsaicin results in increased expression of PRKAA1 protein]22150557
D013739TestosteroneTestosterone results in increased phosphorylation of PRKAA1 protein21632903
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PRKAA1 mRNA21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased phosphorylation of PRKAA1 protein15703265
D013806TheophyllineTheophylline results in decreased expression of PRKAA1 mRNA18951874
D013853ThioacetamideThioacetamide results in increased expression of PRKAA1 mRNA23411599
C003466thymoquinonePRKAA1 protein promotes the reaction [thymoquinone results in increased expression of PPARG protein]27688165
C034613triacsin Ctriacsin C inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of PRKAA1 protein]18390901
C001899triptolidetriptolide results in increased expression of PRKAA1 mRNA23639586
D014415TunicamycinTunicamycin results in decreased expression of PRKAA1 mRNA17127020
D014638VanadatesPRKAA1 protein affects the reaction [Vanadates results in increased expression of HIF1A protein]16678800
D014638VanadatesPRKAA1 protein affects the reaction [Vanadates results in increased expression of VEGFA mRNA]16678800
D014638VanadatesPRKAA1 protein affects the reaction [Vanadates results in increased secretion of VEGFA protein]16678800
D014638VanadatesVanadates results in increased phosphorylation of and results in increased activity of PRKAA1 protein15297373|1667880
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PRKAA1 gene25560391
D009536Niacinamide"Niacinamide inhibits the reaction [6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of PRKAA1 protein]"18482975

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-ISS-  
GO:0004672protein kinase activity-IDA17028174  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004679AMP-activated protein kinase activity-IDA18439900  
GO:0004679AMP-activated protein kinase activity-ISS-  
GO:0004679AMP-activated protein kinase activity-TAS21768291  
GO:0004691cAMP-dependent protein kinase activity-NAS8557660  
GO:0005515protein binding-IPI16306228  17028174  18403135  18439900  18480843  18663353  
19914239  20562859  21988832  22363791  22939624  23455922  
25416956  25751139  25751140  25852190  
GO:0005524ATP binding-IEA-  
GO:0008022protein C-terminus binding-IEA-  
GO:0035174histone serine kinase activity-ISS-  
GO:0046872metal ion binding-IEA-  
GO:0047322[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity-IEA-  
GO:0050321tau-protein kinase activity-IEA-  
GO:0050405[acetyl-CoA carboxylase] kinase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-NAS11546797  
GO:0001666response to hypoxia-NAS8557660  
GO:0006006glucose metabolic process-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006468protein phosphorylation-IBA21873635  
GO:0006468protein phosphorylation-IDA17028174  
GO:0006633fatty acid biosynthetic process-IEA-  
GO:0006695cholesterol biosynthetic process-IEA-  
GO:0007050cell cycle arrest-TAS-  
GO:0007165signal transduction-TAS8557660  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0008610lipid biosynthetic process-ISS-  
GO:0009411response to UV-IEA-  
GO:0009631cold acclimation-IEA-  
GO:0010332response to gamma radiation-ISS-  
GO:0010508positive regulation of autophagy-IDA22012985  
GO:0010508positive regulation of autophagy-IMP26103054  
GO:0010508positive regulation of autophagy-ISS-  
GO:0010628positive regulation of gene expression-IDA17028174  
GO:0010629negative regulation of gene expression-ISS-  
GO:0014823response to activity-IEA-  
GO:0016055Wnt signaling pathway-IEA-  
GO:0016236macroautophagy-TAS-  
GO:0019395fatty acid oxidation-IEA-  
GO:0031000response to caffeine-IEA-  
GO:0031669cellular response to nutrient levels-ISS-  
GO:0032007negative regulation of TOR signaling-IBA21873635  
GO:0032007negative regulation of TOR signaling-ISS-  
GO:0033135regulation of peptidyl-serine phosphorylation-IEA-  
GO:0034599cellular response to oxidative stress-ISS-  
GO:0035404histone-serine phosphorylation-IEA-  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0042149cellular response to glucose starvation-IBA21873635  
GO:0042149cellular response to glucose starvation-ISS-  
GO:0042593glucose homeostasis-ISS-  
GO:0042752regulation of circadian rhythm-ISS-  
GO:0043066negative regulation of apoptotic process-ISS-  
GO:0045542positive regulation of cholesterol biosynthetic process-NAS8557660  
GO:0045821positive regulation of glycolytic process-ISS-  
GO:0046318negative regulation of glucosylceramide biosynthetic process-NAS11165240  
GO:0048511rhythmic process-IEA-  
GO:0048643positive regulation of skeletal muscle tissue development-IEA-  
GO:0050995negative regulation of lipid catabolic process-ISS-  
GO:0051291protein heterooligomerization-IEA-  
GO:0055089fatty acid homeostasis-ISS-  
GO:0060627regulation of vesicle-mediated transport-IEA-  
GO:0061744motor behavior-IGI21768291  
GO:0061762CAMKK-AMPK signaling cascade-IC22012985  
GO:0061762CAMKK-AMPK signaling cascade-IMP26103054  
GO:0061762CAMKK-AMPK signaling cascade-TAS21768291  
GO:0070050neuron cellular homeostasis-IGI21768291  
GO:0070301cellular response to hydrogen peroxide-IEA-  
GO:0070507regulation of microtubule cytoskeleton organization-ISS-  
GO:0071277cellular response to calcium ion-ISS-  
GO:0071333cellular response to glucose stimulus-ISS-  
GO:0071361cellular response to ethanol-IEA-  
GO:0071380cellular response to prostaglandin E stimulus-IEA-  
GO:0071417cellular response to organonitrogen compound-IEA-  
GO:0071456cellular response to hypoxia-IEA-  
GO:0097009energy homeostasis-ISS-  
GO:0097009energy homeostasis-TAS21768291  
GO:1901563response to camptothecin-IEA-  
GO:1903109positive regulation of mitochondrial transcription-IEA-  
GO:1903829positive regulation of cellular protein localization-ISS-  
GO:1903955positive regulation of protein targeting to mitochondrion-IEA-  
GO:1904428negative regulation of tubulin deacetylation-ISS-  
GO:2000758positive regulation of peptidyl-lysine acetylation-ISS-  
GO:2001274negative regulation of glucose import in response to insulin stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IMP26103054  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA21768291  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0016324apical plasma membrane-IEA-  
GO:0016607nuclear speck-IDA-  
GO:0030424axon-ISS-  
GO:0030425dendrite-ISS-  
GO:0031588nucleotide-activated protein kinase complex-IBA21873635  
GO:0031588nucleotide-activated protein kinase complex-ISS-  
GO:0031588nucleotide-activated protein kinase complex-TAS21768291  
GO:0043025neuronal cell body-ISS-  
KEGG ID KEGG Term
hsa04140Regulation of autophagy
hsa04150mTOR signaling pathway
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa05410Hypertrophic cardiomyopathy (HCM)
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1632852MacroautophagyTAS
R-HSA-165159mTOR signallingTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-380972Energy dependent regulation of mTOR by LKB1-AMPKTAS
R-HSA-5628897TP53 Regulates Metabolic GenesTAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24395629Synergistic effect of smoking with genetic variants in the AMPKalpha1 gene on the risk of coronary artery disease in type 2 diabetes. (2014 Sep)Ma XDiabetes Metab Res Rev
22561688Activation of AMP-activated protein kinase alpha2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo. (2012 Jun)Wang SNat Med
20422711Benzo(a)pyrene causes PRKAA1/2-dependent ID2 loss in trophoblast stem cells. (2010 Jun)Xie YMol Reprod Dev
26485766Genetic variant of PRKAA1 and gastric cancer risk in an eastern Chinese population. (2015 Dec 15)Qiu LXOncotarget
28592245In silico identification of potential key regulatory factors in smoking-induced lung cancer. (2017 Jun 7)El-Aarag SABMC Med Genomics
23861218Genetic variations in the PRKAA1 and ZBTB20 genes and gastric cancer susceptibility in a Korean population. (2013 Nov)Song HRMol Carcinog