Gene: AMBRA1

55626
DCAF3|WDR94
autophagy and beclin 1 regulator 1
protein-coding
11p11.2
Ensembl:ENSG00000110497 MIM:611359 Vega:OTTHUMG00000166500 UniprotKB:Q9C0C7
NC_000011.10
PubMed
0   ANCO-SNPs
OD|CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.508e-1 (AD)  6.121e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBE2O0.944
FOXK20.93
GBF10.925
SIK20.923
SMG70.922
ANKRD520.919
EXTL30.918
MEF2D0.918
URGCP0.918
KPNA60.918

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.505
OR4F29-0.453
COPZ2-0.42
MYL3-0.414
ASB4-0.406
YES1-0.389
HEY2-0.388
MTRNR2L6-0.388
MTRNR2L9-0.385
KLRB1-0.377

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of AMBRA1 mRNA"19114083
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AMBRA1 mRNA16483693
D001151ArsenicArsenic affects the methylation of AMBRA1 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AMBRA1 mRNA26238291
C006780bisphenol Abisphenol A results in increased expression of AMBRA1 mRNA25181051
D002258Carbonyl Cyanide m-Chlorophenyl HydrazoneCarbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [AMBRA1 protein binds to PRKN protein]24879156
D003042CocaineCocaine results in decreased expression of AMBRA1 mRNA17898221
D019327Copper SulfateCopper Sulfate results in decreased expression of AMBRA1 mRNA19549813
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of AMBRA1 mRNA23914054
D002945CisplatinAMBRA1 protein results in decreased susceptibility to Cisplatin26763392
D002945CisplatinCisplatin results in increased expression of AMBRA126763392
C000944dicrotophosdicrotophos results in increased expression of AMBRA1 mRNA28302478
D005557FormaldehydeFormaldehyde results in decreased expression of AMBRA1 mRNA20655997
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of AMBRA1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of AMBRA1 mRNA24796395
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of AMBRA1 mRNA"26251327
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of AMBRA1 mRNA25729387
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of AMBRA1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of AMBRA1 mRNA19482888
C045950propiconazolepropiconazole results in decreased expression of AMBRA1 mRNA21278054
D012402RotenoneRotenone results in decreased expression of AMBRA1 mRNA23186747
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AMBRA1 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of AMBRA1 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of AMBRA1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of AMBRA1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of AMBRA1 mRNA25729387
D014635Valproic AcidValproic Acid results in decreased expression of AMBRA1 mRNA21427059
D014810Vitamin EVitamin E results in increased expression of AMBRA1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI20562859  21358617  22190034  23524951  23954414  23974797  
25127057  25215947  25438055  
GO:0031625ubiquitin protein ligase binding-IPI21753002  
GO:0051020GTPase binding-IPI25891078  
GO ID GO Term Qualifier Evidence PubMed
GO:0000045autophagosome assembly-IMP25215947  
GO:0000422autophagy of mitochondrion-IGI25215947  
GO:0000423mitophagy-IDA21753002  
GO:0000423mitophagy-IMP25215947  
GO:0006914autophagy-IBA21873635  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0009267cellular response to starvation-IEA-  
GO:0010508positive regulation of autophagy-IEA-  
GO:0010667negative regulation of cardiac muscle cell apoptotic process-IEA-  
GO:0016236macroautophagy-TAS-  
GO:0021915neural tube development-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity-IDA21753002  
GO:0098780response to mitochondrial depolarisation-IDA21753002  
GO:0098780response to mitochondrial depolarisation-IGI25215947  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA17589504  
GO:0005739mitochondrion-IDA25215947  
GO:0005739mitochondrioncolocalizes_withIDA21753002  
GO:0005741mitochondrial outer membrane-NAS25215947  
GO:0005776autophagosome-IEA-  
GO:0005829cytosol-IDA21753002  
GO:0005829cytosol-TAS-  
GO:0005930axoneme-ISS-  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
GO:0045335phagocytic vesicle-IEA-  
GO:0048471perinuclear region of cytoplasm-TAS21753002  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1632852MacroautophagyTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27269905African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction. (2016 Jun)Levran OPharmacogenomics