Gene: PRKAA2

5563
AMPK|AMPK2|AMPKa2|PRKAA
protein kinase AMP-activated catalytic subunit alpha 2
protein-coding
1p32.2
Ensembl:ENSG00000162409 MIM:600497 Vega:OTTHUMG00000008282 UniprotKB:P54646
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.884e-1 (AD)  5.381e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
XK0.946
SLC4A100.945
SCN2A0.942
CHL10.941
CHIC10.941
LZTFL10.941
SCAI0.94
ADAM220.94
PPM1L0.939
ZYG11B0.938

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.538
RAB13-0.516
ROM1-0.489
HEY2-0.481
EMP3-0.479
MYL3-0.475
FLT3LG-0.472
RHOD-0.469
RNF135-0.461
CNN2-0.459

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00945Acetylsalicylic acidSmall Molecule50-78-2ApprovedTarget
ID Drug Name Action PubMed
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Metformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein]21186350
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PRKAA2 mRNA"23196670
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of PRKAA2 mRNA"27567155
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRKAA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKAA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [PRKAA2 protein results in decreased phosphorylation of RPS6 protein]"19625624
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [PRKAA2 protein results in increased phosphorylation of ACACA protein]"19625624
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRKAA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKAA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in decreased activity of [PRKAA2 protein binds to PRKAB2 protein binds to PRKAG1 protein]"22898769
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"PRKAA2 protein affects the reaction [(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol affects the localization of FOXO1 protein]]"25065674
C4385056,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one"6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of and results in increased activity of PRKAA2 protein"16873680
C4385056,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one"6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of PRKAA2 protein"18482975
C4385056,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one"Niacinamide inhibits the reaction [6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of PRKAA2 protein]"18482975
C4385056,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one"SIRT1 protein promotes the reaction [6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of PRKAA2 protein]"18482975
C4385056,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one"STK11 protein promotes the reaction [[6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased activity of SIRT1 protein] which results in increased phosphorylation of PRKAA2 protein]"18482975
D000082AcetaminophenAcetaminophen affects the expression of PRKAA2 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Nicotine results in increased phosphorylation of PRKAA2 protein]17635921
D020106AcrylamideAcrylamide results in decreased expression of PRKAA2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PRKAA2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PRKAA2 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PRKAA2 mRNA19770486
C031143AICA ribonucleotideAICA ribonucleotide results in increased phosphorylation of PRKAA2 protein16837613
C031143AICA ribonucleotidePRKAA2 protein promotes the reaction [AICA ribonucleotide affects the reaction [IGF1 protein results in increased expression of STAR protein]]17478073
C031143AICA ribonucleotidePRKAA2 protein promotes the reaction [AICA ribonucleotide affects the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]]17478073
C031143AICA ribonucleotidePRKAA2 protein promotes the reaction [AICA ribonucleotide affects the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]]17478073
C031143AICA ribonucleotidePRKAA2 protein promotes the reaction [AICA ribonucleotide affects the reaction [IGF1 protein results in increased secretion of Progesterone]]17478073
C031143AICA ribonucleotideAICA ribonucleotide results in increased phosphorylation of and results in increased activity of PRKAA2 protein16873680
C031143AICA ribonucleotideAICA ribonucleotide results in increased phosphorylation of PRKAA2 protein18482975
C031143AICA ribonucleotidePRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CYP4F2 mRNA]21205922
C031143AICA ribonucleotideAICA ribonucleotide results in increased activity of PRKAA2 protein17635921
C031143AICA ribonucleotide[AICA ribonucleotide results in increased activity of PRKAA2 protein] which results in decreased activity of FASN protein17635921
C031143AICA ribonucleotidePRKAA2 protein affects the reaction [AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form affects the susceptibility to Glucose deficiency]]15806154
C031143AICA ribonucleotidePRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CTNNB1 mRNA]21454484
C031143AICA ribonucleotidePRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CTNNB1 protein]21454484
C031143AICA ribonucleotidePRKAA2 protein promotes the reaction [AICA ribonucleotide promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]]22815988
C031143AICA ribonucleotideAICA ribonucleotide results in decreased activity of [PRKAA2 protein binds to PRKAB2 protein binds to PRKAG1 protein]22898769
D013196DihydrotestosteroneDihydrotestosterone results in decreased phosphorylation of PRKAA2 protein16990341
D013196DihydrotestosteroneEstradiol inhibits the reaction [Dihydrotestosterone results in decreased phosphorylation of PRKAA2 protein]16990341
D000638AmiodaroneAmiodarone results in increased phosphorylation of PRKAA2 protein23912912
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PRKAA2 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PRKAA2 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PRKAA2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PRKAA2 mRNA"20018196
D004958EstradiolEstradiol inhibits the reaction [Dihydrotestosterone results in decreased phosphorylation of PRKAA2 protein]16990341
D004958EstradiolEstradiol results in decreased expression of PRKAA2 mRNA19484750
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of PRKAA2 mRNA26496021
D004958EstradiolEstradiol results in decreased expression of PRKAA2 mRNA20068009
C542674bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II)"PRKAA2 protein promotes the reaction [bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II) affects the localization of TP53 protein]"21548882
C542674bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II)"PRKAA2 protein promotes the reaction [bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II) results in increased expression of TP53 protein]"21548882
C006780bisphenol Abisphenol A results in increased methylation of PRKAA2 promoter27312807
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of PRKAA2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of PRKAA2 mRNA27539358
C006780bisphenol Abisphenol A results in increased expression of PRKAA2 mRNA25181051|2909715
C006780bisphenol Abisphenol A results in increased methylation of PRKAA2 gene28505145
C542815BLX 1002BLX 1002 results in increased phosphorylation of and results in increased activity of PRKAA2 protein19052259
C018475butyraldehydebutyraldehyde results in decreased expression of PRKAA2 mRNA26079696
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of PRKAA2 mRNA]16221973
D002110CaffeineCaffeine results in increased expression of PRKAA2 mRNA22583948
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PRKAA2 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PRKAA2 mRNA12734012
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PRKAA2 mRNA16239168
D002330CarmustinePRKAA2 mRNA affects the susceptibility to Carmustine16365179
D003300CopperCopper results in decreased expression of PRKAA2 mRNA22465980
D019327Copper SulfateCopper Sulfate results in increased expression of PRKAA2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PRKAA2 mRNA27989131
C093628cyproconazolecyproconazole results in increased expression of PRKAA2 mRNA22045034
D013759DronabinolDronabinol results in increased activity of PRKAA2 protein15899896
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PRKAA2 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PRKAA2 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PRKAA2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of PRKAA2 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of PRKAA2 mRNA21034554
D004041Dietary Fatsrosiglitazone inhibits the reaction [Dietary Fats results in decreased expression of PRKAA2 mRNA]21034554
D004317DoxorubicinDoxorubicin results in decreased expression of PRKAA2 mRNA26721193
C118739entinostatentinostat results in increased expression of PRKAA2 mRNA27188386
D000431Ethanol[Ethanol co-treated with PRKAA2 protein] affects the expression of PRKAA1 protein23448468
D000431EthanolPRKAA2 protein affects the reaction [Ethanol results in decreased expression of COX4 protein]23448468
D000431EthanolPRKAA2 protein affects the reaction [Ethanol results in decreased phosphorylation of MTOR protein]23448468
D000431EthanolPRKAA2 protein affects the reaction [Ethanol results in increased expression of PLN protein]23448468
D000431EthanolPRKAA2 protein affects the reaction [Ethanol results in increased expression of ULK1 protein]23448468
D000431EthanolPRKAA2 protein affects the reaction [Ethanol results in increased phosphorylation of RPTOR protein]23448468
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRKAA2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PRKAA2 mRNA29097150
D005485FlutamideFlutamide results in decreased expression of PRKAA2 mRNA24136188
D005897GlafenineGlafenine results in decreased expression of PRKAA2 mRNA24136188
D005947GlucoseGlucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein18482975
D005947GlucosePRKAA2 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in increased abundance of Triglycerides]]18482975
D005947GlucosePRKAA2 protein promotes the reaction [SIRT1 protein inhibits the reaction [Glucose results in decreased phosphorylation of ACACA protein]]18482975
D005947GlucosePRKAA2 protein promotes the reaction [SIRT1 protein inhibits the reaction [Glucose results in increased abundance of Triglycerides]]18482975
D005947GlucosePRKAA2 protein promotes the reaction [SIRT1 protein inhibits the reaction [Glucose results in increased expression of FASN protein]]18482975
D005947Glucoseresveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]18482975
D005947Glucose[resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]] which results in decreased abundance of Triglycerides18482975
D005947Glucose[resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]18482975
D005947GlucoseSIRT1 protein promotes the reaction [[resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]] which results in decreased abundance of Triglycerides]18482975
D005947GlucoseGlucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein19052259
D005947GlucosePRKAA2 protein affects the reaction [AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form affects the susceptibility to Glucose deficiency]]15806154
D005947GlucosePRKAA2 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]]23090186
D005947GlucoseGlucose results in decreased expression of PRKAA2 mRNA24349266
D005947GlucoseGlucose results in decreased expression of PRKAA2 protein24349266
D005947GlucosePRKAA2 protein mutant form affects the susceptibility to Glucose deficiency15806154
C409722hexaconazolehexaconazole results in increased expression of PRKAA2 mRNA22045034
D006632Histamine[PRKAA1 protein co-treated with PRKAA2 protein] affects the reaction [Histamine results in increased phosphorylation of NOS2 protein]21145922
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PRKAA2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of PRKAA2 mRNA27392435
C482199lipopolysaccharide, E coli O55-B5"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of PRKAA2 mRNA"20371263
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PRKAA2 mRNA26378955
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of PRKAA2 mRNA22019852
D008687MetforminMetformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein16873680
D008687MetforminMetformin results in increased activity of PRKAA2 protein17635921
D008687Metformin[Metformin results in increased activity of PRKAA2 protein] which results in decreased activity of FASN protein17635921
D008687MetforminMetformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein19052259
D008687MetforminPRKAA2 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]24428821
D008687MetforminPRKAA2 protein affects the susceptibility to Metformin20847317
D008687Metformin2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Metformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein]21186350
D008687MetforminMetformin results in increased activity of PRKAA2 protein18484962
D008687MetforminMetformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein21186350
D008687MetforminMetformin results in increased phosphorylation of PRKAA2 protein19594306
D008727MethotrexatePRKAA2 mutant form inhibits the reaction [Methotrexate results in increased expression of HMOX1 mRNA]25575725
D008727MethotrexatePRKAA2 mutant form inhibits the reaction [Methotrexate results in increased expression of SOD2 mRNA]25575725
D008727MethotrexatePRKAA2 mutant form inhibits the reaction [Methotrexate results in increased expression of SOD2 protein]25575725
D008727MethotrexatePRKAA2 mutant form inhibits the reaction [Methotrexate results in increased phosphorylation of CREB1 protein]25575725
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of PRKAA2 protein24625837
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PRKAA2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PRKAA2 mRNA"25554681
D009525NiacinNiacin results in increased activity of PRKAA2 protein14749208
D009532NickelNickel results in decreased expression of PRKAA2 mRNA24768652|2558310
D009538NicotineAcetylcysteine inhibits the reaction [Nicotine results in increased phosphorylation of PRKAA2 protein]17635921
D009538NicotineNicotine promotes the reaction [Peroxynitrous Acid results in increased activity of PRKAA2 protein]17635921
D009538Nicotine[Nicotine promotes the reaction [Peroxynitrous Acid results in increased activity of PRKAA2 protein]] which results in increased phosphorylation of FASN protein17635921
D009538Nicotine[[Nicotine promotes the reaction [Peroxynitrous Acid results in increased activity of PRKAA2 protein]] which results in increased phosphorylation of FASN protein] which results in decreased activity of FASN protein17635921
D009538Nicotine[Nicotine results in decreased activity of FASN protein] which results in increased phosphorylation of PRKAA2 protein17635921
D009538Nicotine[Nicotine results in increased activity of PRKAA2 protein] which results in decreased activity of FASN protein17635921
D009538NicotineNicotine results in increased phosphorylation of and results in increased activity of PRKAA2 protein17635921
D009538NicotinePRKAA2 protein mutant form inhibits the reaction [Nicotine results in decreased activity of FASN protein]17635921
D009538NicotineReactive Oxygen Species affects the reaction [Nicotine results in increased phosphorylation of PRKAA2 protein]17635921
D009538NicotineNicotine results in increased expression of PRKAA2 mRNA22265867
D009573NitritesPRKAA2 mutant form inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA]22892143
D010100OxygenOxygen deficiency results in increased expression of PRKAA2 mRNA24236059
D010100OxygenOxygen results in increased expression of PRKAA2 mRNA22911455
D010100OxygenPRKAA2 mutant form inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA]22892143
C016030pantogabpantogab results in decreased expression of PRKAA2 mRNA17379144
D010269ParaquatParaquat results in increased expression of PRKAA2 protein27324791
D010269ParaquatParaquat results in increased phosphorylation of PRKAA2 protein25092649
D010269ParaquatPRKAA2 gene affects the susceptibility to Paraquat25092649
D030421Peroxynitrous AcidNicotine promotes the reaction [Peroxynitrous Acid results in increased activity of PRKAA2 protein]17635921
D030421Peroxynitrous Acid[Nicotine promotes the reaction [Peroxynitrous Acid results in increased activity of PRKAA2 protein]] which results in increased phosphorylation of FASN protein17635921
D030421Peroxynitrous Acid[[Nicotine promotes the reaction [Peroxynitrous Acid results in increased activity of PRKAA2 protein]] which results in increased phosphorylation of FASN protein] which results in decreased activity of FASN protein17635921
D030421Peroxynitrous Acid[Peroxynitrous Acid results in increased activity of PRKAA2 protein] which results in decreased activity of FASN protein17635921
D030421Peroxynitrous AcidPeroxynitrous Acid results in increased phosphorylation of and results in increased activity of PRKAA2 protein17635921
D030421Peroxynitrous AcidPRKAA2 protein mutant form inhibits the reaction [Peroxynitrous Acid results in decreased activity of FASN protein]17635921
D010634PhenobarbitalPhenobarbital results in decreased expression of PRKAA2 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRKAA2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PRKAA2 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of PRKAA2 mRNA18301758
C006253pirinixic acidpirinixic acid results in increased expression of PRKAA2 mRNA19236843
D028321Plant PreparationsPlant Preparations results in increased expression of PRKAA2 mRNA24973489
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of PRKAA2 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of PRKAA2 mRNA28903501
D011374ProgesteronePRKAA2 protein promotes the reaction [AICA ribonucleotide affects the reaction [IGF1 protein results in increased secretion of Progesterone]]17478073
D011374ProgesteroneProgesterone results in increased expression of PRKAA2 mRNA20726854
D017382Reactive Oxygen SpeciesPRKAA2 protein affects the abundance of Reactive Oxygen Species21145922
D017382Reactive Oxygen SpeciesReactive Oxygen Species affects the reaction [Nicotine results in increased phosphorylation of PRKAA2 protein]17635921
C059514resveratrolPRKAA2 mutant form inhibits the reaction [resveratrol results in increased expression of NR0B2 mRNA]26044878
C059514resveratrolPRKAA2 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in increased abundance of Triglycerides]]18482975
C059514resveratrolresveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]18482975
C059514resveratrol[resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]] which results in decreased abundance of Triglycerides18482975
C059514resveratrol[resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]18482975
C059514resveratrol[resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in increased activity of PRKAA2 protein18482975
C059514resveratrolresveratrol results in increased phosphorylation of and results in increased activity of PRKAA2 protein16873680
C059514resveratrolresveratrol results in increased phosphorylation of PRKAA2 protein18482975|2008096
C059514resveratrol[resveratrol results in increased phosphorylation of PRKAA2 protein] which results in decreased abundance of Triglycerides18482975
C059514resveratrolSIRT1 protein promotes the reaction [[resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]] which results in decreased abundance of Triglycerides]18482975
C059514resveratrolSIRT1 protein promotes the reaction [resveratrol results in increased phosphorylation of PRKAA2 protein]18482975
C059514resveratrolSTK11 protein promotes the reaction [[resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of PRKAA2 protein]18482975
C059514resveratrolPRKAA2 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]]23090186
C059514resveratrolPRKAA2 protein affects the reaction [resveratrol results in decreased phosphorylation of AKT1 protein]25603053
C059514resveratrolPRKAA2 protein affects the reaction [resveratrol results in increased cleavage of CASP3 protein]25603053
C059514resveratrolPRKAA2 protein affects the susceptibility to resveratrol23090186
C059514resveratrolPRKAA2 protein promotes the reaction [resveratrol results in increased expression of UCP1 mRNA]19934007
C059514resveratrolPRKAA2 protein promotes the reaction [resveratrol results in increased expression of UCP2 mRNA]19934007
C059514resveratrolPRKAA2 protein promotes the reaction [resveratrol results in increased expression of UCP3 mRNA]19934007
C059514resveratrolresveratrol results in decreased activity of PRKAA2 protein19934007
C059514resveratrolresveratrol results in decreased expression of PRKAA2 mRNA22610192
C059514resveratrolresveratrol results in increased phosphorylation of and results in increased activity of PRKAA2 protein17464184
C059514resveratrolresveratrol results in increased phosphorylation of PRKAA2 protein17438283
C059514resveratrolSTK11 protein promotes the reaction [resveratrol results in increased phosphorylation of PRKAA2 protein]17438283
C059514resveratrol"PRKAA2 protein affects the reaction [(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol affects the localization of FOXO1 protein]]"25065674
C059514resveratrolPRKAA2 protein affects the reaction [resveratrol promotes the reaction [FOXO1 protein results in increased expression of CAT mRNA]]25065674
C059514resveratrolPRKAA2 protein affects the reaction [resveratrol promotes the reaction [FOXO1 protein results in increased expression of SOD2 mRNA]]25065674
C059514resveratrolPRKAA2 protein affects the reaction [resveratrol results in decreased ubiquitination of FOXO1 protein]25065674
C059514resveratrolPRKAA2 protein affects the reaction [resveratrol results in increased expression of CAT mRNA]25065674
C059514resveratrolPRKAA2 protein affects the reaction [resveratrol results in increased expression of SOD2 mRNA]25065674
C059514resveratrolPRKAA2 protein affects the susceptibility to resveratrol25065674
C059514resveratrolresveratrol results in decreased activity of [PRKAA2 protein binds to PRKAB2 protein binds to PRKAG1 protein]22898769
C089730rosiglitazonerosiglitazone inhibits the reaction [Dietary Fats results in decreased expression of PRKAA2 mRNA]21034554
C009277sodium arsenatesodium arsenate results in increased expression of PRKAA2 mRNA21795629
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PRKAA2 mRNA26378955
D013467Sulindac"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of PRKAA2 mRNA"20371263
C047246temozolomidePRKAA2 mRNA affects the susceptibility to temozolomide16365179
C001803tempoltempol inhibits the reaction [PRKAA2 protein affects the expression of HSPA5 protein]21145922
C004648testosterone enanthatetestosterone enanthate affects the expression of PRKAA2 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRKAA2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRKAA2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PRKAA2 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PRKAA2 mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRKAA2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PRKAA2 mRNA21215274
C012589trichostatin Atrichostatin A results in increased expression of PRKAA2 mRNA24935251
D014280TriglyceridesPRKAA2 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in increased abundance of Triglycerides]]18482975
D014280TriglyceridesPRKAA2 protein promotes the reaction [SIRT1 protein inhibits the reaction [Glucose results in increased abundance of Triglycerides]]18482975
D014280Triglycerides[resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]] which results in decreased abundance of Triglycerides18482975
D014280Triglycerides[resveratrol results in increased phosphorylation of PRKAA2 protein] which results in decreased abundance of Triglycerides18482975
D014280TriglyceridesSIRT1 protein promotes the reaction [[resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]] which results in decreased abundance of Triglycerides]18482975
C001899triptolidetriptolide results in increased expression of PRKAA2 mRNA23639586
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKAA2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PRKAA2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PRKAA2 mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in increased expression of PRKAA2 mRNA22045034
D014640VancomycinVancomycin results in increased expression of PRKAA2 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PRKAA2 gene25560391
C025643vinclozolinvinclozolin affects the expression of PRKAA2 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of PRKAA2 mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of PRKAA2 mRNA23555832
C029297vinylidene chloridevinylidene chloride results in decreased expression of PRKAA2 mRNA26682919
D009536Niacinamide"Niacinamide inhibits the reaction [6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of PRKAA2 protein]"18482975

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-ISS-  
GO:0004672protein kinase activity-TAS7959015  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-ISS-  
GO:0004679AMP-activated protein kinase activity-IDA18439900  
GO:0004679AMP-activated protein kinase activity-ISS-  
GO:0004712protein serine/threonine/tyrosine kinase activity-IDA22797923  
GO:0005515protein binding-IPI18439900  20562859  20801214  21516116  25416956  
GO:0005524ATP binding-IEA-  
GO:0035174histone serine kinase activity-ISS-  
GO:0046872metal ion binding-IEA-  
GO:0047322[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity-IEA-  
GO:0050405[acetyl-CoA carboxylase] kinase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0006468protein phosphorylation-IBA21873635  
GO:0006468protein phosphorylation-TAS7959015  
GO:0006633fatty acid biosynthetic process-IEA-  
GO:0006695cholesterol biosynthetic process-IEA-  
GO:0007050cell cycle arrest-TAS-  
GO:0007165signal transduction-TAS7959015  
GO:0008610lipid biosynthetic process-ISS-  
GO:0010508positive regulation of autophagy-ISS-  
GO:0010629negative regulation of gene expression-ISS-  
GO:0014850response to muscle activity-IEA-  
GO:0016055Wnt signaling pathway-IEA-  
GO:0016236macroautophagy-TAS-  
GO:0016239positive regulation of macroautophagy-TAS25126726  
GO:0016241regulation of macroautophagy-ISS-  
GO:0031669cellular response to nutrient levels-ISS-  
GO:0032007negative regulation of TOR signaling-IBA21873635  
GO:0032007negative regulation of TOR signaling-ISS-  
GO:0034599cellular response to oxidative stress-ISS-  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0035690cellular response to drug-IEA-  
GO:0042149cellular response to glucose starvation-IBA21873635  
GO:0042149cellular response to glucose starvation-ISS-  
GO:0042304regulation of fatty acid biosynthetic process-TAS-  
GO:0042593glucose homeostasis-ISS-  
GO:0042752regulation of circadian rhythm-ISS-  
GO:0043066negative regulation of apoptotic process-ISS-  
GO:0045821positive regulation of glycolytic process-ISS-  
GO:0048511rhythmic process-IEA-  
GO:0055089fatty acid homeostasis-ISS-  
GO:0070507regulation of microtubule cytoskeleton organization-ISS-  
GO:0071277cellular response to calcium ion-ISS-  
GO:0071333cellular response to glucose stimulus-ISS-  
GO:0071380cellular response to prostaglandin E stimulus-IEA-  
GO:0097009energy homeostasis-ISS-  
GO:1903829positive regulation of cellular protein localization-ISS-  
GO:1904428negative regulation of tubulin deacetylation-ISS-  
GO:2000758positive regulation of peptidyl-lysine acetylation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-TAS21768291  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005794Golgi apparatus-IDA-  
GO:0005829cytosol-TAS-  
GO:0010494cytoplasmic stress granule-ISS-  
GO:0016607nuclear speck-IDA-  
GO:0030424axon-ISS-  
GO:0030425dendrite-ISS-  
GO:0031588nucleotide-activated protein kinase complex-IBA21873635  
GO:0043025neuronal cell body-ISS-  
KEGG ID KEGG Term
hsa04140Regulation of autophagy
hsa04150mTOR signaling pathway
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa05410Hypertrophic cardiomyopathy (HCM)
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-1445148Translocation of GLUT4 to the plasma membraneIEA
R-HSA-1592230Mitochondrial biogenesisIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1632852MacroautophagyTAS
R-HSA-163680AMPK inhibits chREBP transcriptional activation activityTAS
R-HSA-163680AMPK inhibits chREBP transcriptional activation activityIEA
R-HSA-163685Integration of energy metabolismTAS
R-HSA-163685Integration of energy metabolismIEA
R-HSA-165159mTOR signallingTAS
R-HSA-1852241Organelle biogenesis and maintenanceIEA
R-HSA-199991Membrane TraffickingIEA
R-HSA-200425Import of palmitoyl-CoA into the mitochondrial matrixTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2151209Activation of PPARGC1A (PGC-1alpha) by phosphorylationIEA
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-380972Energy dependent regulation of mTOR by LKB1-AMPKTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-5628897TP53 Regulates Metabolic GenesTAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5653656Vesicle-mediated transportIEA
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22561688Activation of AMP-activated protein kinase alpha2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo. (2012 Jun)Wang SNat Med