Gene: TBC1D22B

55633
C6orf197
TBC1 domain family member 22B
protein-coding
6p21.2
Ensembl:ENSG00000065491 MIM:616880 Vega:OTTHUMG00000014619 UniprotKB:Q9NU19
NC_000006.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.183e-1 (AD)  9.042e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs195411chr6:37333341 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHMP70.95
LARP10.947
UBFD10.946
ATP2A20.944
FOXK20.943
EXTL30.942
ABCF30.941
RAB350.94
LSM14B0.938
PPP5C0.937

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.596
OR4F29-0.534
HEY2-0.409
YES1-0.383
CSAG1-0.38
MYL3-0.38
PPBP-0.379
RAI14-0.376
CTNNA3-0.374
REST-0.374

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of TBC1D22B mRNA22230336
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TBC1D22B mRNA28628672
C006780bisphenol A[bisphenol A co-treated with Genistein] results in decreased methylation of TBC1D22B gene28505145
C006780bisphenol Abisphenol A results in decreased expression of TBC1D22B mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of TBC1D22B protein24552547
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TBC1D22B mRNA28628672
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of TBC1D22B mRNA28472532
D016572CyclosporineCyclosporine results in increased expression of TBC1D22B mRNA25562108
C089595cylindrospermopsincylindrospermopsin results in increased expression of TBC1D22B mRNA24921660
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TBC1D22B mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TBC1D22B mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TBC1D22B mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of TBC1D22B mRNA25016146
D019833Genistein[bisphenol A co-treated with Genistein] results in decreased methylation of TBC1D22B gene28505145
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TBC1D22B mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TBC1D22B mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TBC1D22B mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TBC1D22B mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TBC1D22B mRNA27392435
D008777MethyltestosteroneMethyltestosterone results in decreased expression of TBC1D22B mRNA29191790
C028007nickel monoxidenickel monoxide results in increased expression of TBC1D22B mRNA19167457
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TBC1D22B mRNA19710929
D012715Sesame OilSesame Oil results in increased expression of TBC1D22B mRNA29191790
C025643vinclozolinvinclozolin results in decreased expression of TBC1D22B mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IBA21873635  
GO:0005515protein binding-IPI23572552  25416956  27107012  
GO:0017137Rab GTPase binding-IBA21873635  
GO:007188914-3-3 protein binding-IDA23572552  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IBA21873635  
GO:0090630activation of GTPase activity-IBA21873635  
GO:1902017regulation of cilium assemblyNOTIMP17646400  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal