Gene: CHD7

55636
CRG|HH5|IS3|KAL5
chromodomain helicase DNA binding protein 7
protein-coding
8q12.2
Ensembl:ENSG00000171316 MIM:608892 Vega:OTTHUMG00000165332 UniprotKB:Q9P2D1
NG_007009.1
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.473e-1 (AD)  2.558e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3763591chr8:60851830 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs11993480chr8:60744514 (GRCh38.p7)A>G / A>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
REST0.829
HIP10.812
TJP10.81
TCF120.808
PARP40.805
GALNT100.801
CECR20.799
C2orf680.795
SFT2D20.79
SH3BP40.789

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RTP1-0.511
CDH22-0.506
HAS1-0.506
FBLN7-0.504
BHLHA9-0.503
KCNK3-0.488
KCNB2-0.482
ANKRD34C-0.477
RHOV-0.475
FAM19A2-0.472

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CHD7 mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of CHD7 mRNA21420995
D001280AtrazineAtrazine affects the expression of CHD7 mRNA25929836
C547126AZM551248AZM551248 results in decreased expression of CHD7 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CHD7 mRNA20064835
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CHD7 mRNA"19150397
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CHD7 mRNA"26238291
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of CHD7 promoter22457795
D002922CiguatoxinsCiguatoxins affects the expression of CHD7 mRNA18353800
D019327Copper SulfateCopper Sulfate results in decreased expression of CHD7 mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of CHD7 mRNA19789285
C014347decitabinedecitabine results in increased expression of CHD7 mRNA27915011
D003907DexamethasoneDexamethasone results in increased expression of CHD7 mRNA22733784
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CHD7 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CHD7 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of CHD7 mRNA28302478
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CHD7 mRNA22079256
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CHD7 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of CHD7 mRNA20655997
C039281furanfuran results in increased methylation of CHD7 gene22079235
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of CHD7 mRNA22634610
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CHD7 mRNA27392435
D007854LeadLead affects the expression of CHD7 mRNA28903495
D007854LeadLead results in decreased expression of CHD7 mRNA19921347
C008261lead acetate[lead acetate co-treated with zinc protoporphyrin] results in increased expression of CHD7 mRNA22839698
C045463leflunomideleflunomide results in increased expression of CHD7 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CHD7 mRNA"24972896
D008627Mercuric ChlorideMercuric Chloride affects the expression of CHD7 mRNA20353558
D008627Mercuric ChlorideMercuric Chloride results in increased expression of CHD7 mRNA16507785
C004925methylmercuric chloridemethylmercuric chloride affects the expression of CHD7 mRNA20864626
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CHD7 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CHD7 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CHD7 mRNA"26251327
C517284monomethyl phthalatemonomethyl phthalate affects the expression of CHD7 mRNA26924002
C022838nickel chloridenickel chloride affects the expression of CHD7 mRNA22110744
C028007nickel monoxidenickel monoxide results in increased expression of CHD7 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CHD7 mRNA25729387
C006253pirinixic acidpirinixic acid results in decreased expression of CHD7 mRNA23811191
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CHD7 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CHD7 mRNA22079256
C045950propiconazolepropiconazole results in decreased expression of CHD7 mRNA21278054
C017947sodium arsenitesodium arsenite results in decreased expression of CHD7 mRNA21297353
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of CHD7 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CHD7 mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CHD7 mRNA22298810
C009495titanium dioxidetitanium dioxide results in increased expression of CHD7 mRNA29128614
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CHD7 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of CHD7 mRNA25729387
C057693troglitazonetroglitazone results in decreased expression of CHD7 mRNA28973697
D014415TunicamycinTunicamycin results in decreased expression of CHD7 mRNA22378314
D014635Valproic AcidValproic Acid results in increased methylation of CHD7 gene29154799
D014638VanadatesVanadates results in decreased expression of CHD7 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CHD7 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of CHD7 mRNA18042343
C017803zinc protoporphyrin[lead acetate co-treated with zinc protoporphyrin] results in increased expression of CHD7 mRNA22839698

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0003682chromatin binding-TAS17299439  
GO:0004386helicase activity-IEA-  
GO:0005515protein binding-IPI20130577  20453063  
GO:0005524ATP binding-IEA-  
GO:1990841promoter-specific chromatin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-IMP16155193  
GO:0001701in utero embryonic development-IMP15300250  
GO:0001974blood vessel remodeling-IEA-  
GO:0003007heart morphogenesis-IMP15300250  
GO:0003222ventricular trabecula myocardium morphogenesis-IEA-  
GO:0003226right ventricular compact myocardium morphogenesis-IEA-  
GO:0006338chromatin remodeling-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-NAS17937444  
GO:0006364rRNA processing-IEA-  
GO:0007417central nervous system development-IMP9556299  
GO:0007512adult heart development-IEA-  
GO:0007605sensory perception of sound-IEA-  
GO:0007628adult walking behavior-IEA-  
GO:0008015blood circulation-IEA-  
GO:0010880regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum-IEA-  
GO:0021545cranial nerve development-IMP9556299  
GO:0021553olfactory nerve development-IEA-  
GO:0021772olfactory bulb development-IEA-  
GO:0030217T cell differentiation-IMP17684005  
GO:0030540female genitalia development-IEA-  
GO:0035116embryonic hindlimb morphogenesis-IEA-  
GO:0035909aorta morphogenesis-IEA-  
GO:0036302atrioventricular canal development-IEA-  
GO:0040018positive regulation of multicellular organism growth-IEA-  
GO:0042048olfactory behavior-IEA-  
GO:0042472inner ear morphogenesis-IMP15300250  
GO:0043584nose development-IMP15300250  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0048752semicircular canal morphogenesis-IEA-  
GO:0048806genitalia development-IMP15300250  
GO:0050767regulation of neurogenesis-IEA-  
GO:0050890cognition-IMP16155193  
GO:0060041retina development in camera-type eye-IMP15300250  
GO:0060123regulation of growth hormone secretion-IMP9556299  
GO:0060173limb development-IMP17937444  
GO:0060324face development-IMP15300250  
GO:0060384innervation-IEA-  
GO:0060411cardiac septum morphogenesis-IEA-  
GO:0060429epithelium development-IEA-  
GO:0062009secondary palate development-IMP15300250  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA20453063  
GO:0005634nucleus-TAS17299439  
GO:0005654nucleoplasm-IDA-  
GO:0005730nucleolus-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29302581Novel Genetic Associations Between Lung Cancer and Indoor Radon Exposure. (2017 Dec)Choi JRJ Cancer Prev