Gene: PRKAB1

5564
AMPK|HAMPKb
protein kinase AMP-activated non-catalytic subunit beta 1
protein-coding
12q24.23
Ensembl:ENSG00000111725 MIM:602740 Vega:OTTHUMG00000168954 UniprotKB:Q9Y478
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.030e-1 (AD)  3.905e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
XPNPEP10.919
TMED40.916
TXNDC110.9
EIF2B10.896
SMARCD10.891
NAT100.891
TFG0.888
HARS20.888
TRPC4AP0.886
TMEM2480.886

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.689
OR4F29-0.649
MTRNR2L9-0.292
MTRNR2L6-0.274
KLRC2-0.262
MTRNR2L10-0.235
KLRB1-0.227
IFNG-0.207
KRT73-0.206
CETP-0.203

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00131Adenosine monophosphateSmall Molecule61-19-8Approved|Investigational|NutraceuticalTarget
DB00331MetforminSmall Molecule657-24-9ApprovedTarget
DB00945Acetylsalicylic acidSmall Molecule50-78-2ApprovedTarget
ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PRKAB1 mRNA"21346803
C4734844-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine results in increased expression of PRKAB1 mRNA14610520
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PRKAB1 mRNA"18648102
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of PRKAB1 mRNA20829426
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of PRKAB1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PRKAB1 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PRKAB1 mRNA21641981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PRKAB1 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PRKAB1 mRNA16483693
D001280AtrazineAtrazine results in increased expression of PRKAB1 mRNA25929836
C547126AZM551248AZM551248 results in decreased expression of PRKAB1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PRKAB1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PRKAB1 mRNA21569818
C006780bisphenol Abisphenol A results in increased expression of PRKAB1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PRKAB1 mRNA25596134
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PRKAB1 mRNA18804290
C004656chloroacetaldehydechloroacetaldehyde affects the expression of PRKAB1 mRNA25596134
D004002Clodronic AcidClodronic Acid results in increased expression of PRKAB1 mRNA25596134
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of PRKAB1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PRKAB1 mRNA]17585979
D002994ClofibrateClofibrate results in decreased expression of PRKAB1 mRNA21318169
D003078ColchicineColchicine results in decreased expression of PRKAB1 mRNA24211769
D019327Copper SulfateCopper Sulfate results in decreased expression of PRKAB1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PRKAB1 mRNA25596134
D016572CyclosporineCyclosporine results in increased expression of PRKAB1 mRNA20106945
D003703DemecolcineDemecolcine results in increased expression of PRKAB1 mRNA23649840
D003840Deoxycholic AcidPRKAB1 protein results in decreased susceptibility to Deoxycholic Acid12507930
D003907Dexamethasone[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein co-treated with Quercetin] results in increased phosphorylation of PRKAB1 protein18586010
D002945CisplatinCisplatin results in increased expression of PRKAB1 mRNA21532991|2559613
D004026DieldrinDieldrin results in increased expression of PRKAB1 mRNA28385952
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of PRKAB1 mRNA21318169
C014476diethyl maleatediethyl maleate results in decreased expression of PRKAB1 mRNA25270620
D004147DioxinsDioxins affects the expression of PRKAB1 mRNA20463971
D004317DoxorubicinDoxorubicin results in increased expression of PRKAB1 mRNA19277126
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of PRKAB1 mRNA23649840
D005047EtoposideEtoposide results in increased expression of PRKAB1 mRNA24211769
D011345FenofibrateFenofibrate results in increased phosphorylation of PRKAB1 protein25545733
D011345FenofibrateFenofibrate results in decreased expression of PRKAB1 mRNA21318169
D011345FenofibratePPARA protein affects the reaction [Fenofibrate results in decreased expression of PRKAB1 mRNA]21318169
D005485FlutamideFlutamide results in decreased expression of PRKAB1 mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of PRKAB1 mRNA23649840
C039281furanfuran results in increased methylation of PRKAB1 gene22079235
D006918HydroxyureaHydroxyurea results in increased expression of PRKAB1 mRNA24211769
D007069IfosfamideIfosfamide affects the expression of PRKAB1 mRNA25596134
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein co-treated with Quercetin] results in increased phosphorylation of PRKAB1 protein18586010
C045463leflunomideleflunomide results in decreased expression of PRKAB1 mRNA24136188
D008627Mercuric ChlorideMercuric Chloride affects the expression of PRKAB1 mRNA20353558
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to PRKAB1 promoter]20348232
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PRKAB1 mRNA23649840
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PRKAB1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PRKAB1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PRKAB1 mRNA]"20230807
C008548morinmorin results in decreased expression of PRKAB1 mRNA28689916
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PRKAB1 mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of PRKAB1 mRNA24136188
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PRKAB1 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PRKAB1 mRNA]"20230807
C012655nimesulidenimesulide results in decreased expression of PRKAB1 mRNA24136188
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of PRKAB1 mRNA19074003
D010098OxycodoneOxycodone results in decreased expression of PRKAB1 mRNA23439660
D010100OxygenOxygen deficiency results in decreased expression of PRKAB1 mRNA25596134
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PRKAB1 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PRKAB1 mRNA18804290
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PRKAB1 mRNA19162173|2131816
C006253pirinixic acidpirinixic acid results in decreased expression of PRKAB1 mRNA21318169
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in decreased expression of PRKAB1 mRNA]21318169
C006253pirinixic acidpirinixic acid results in decreased expression of PRKAB1 mRNA19162173|2131816
D011794QuercetinQuercetin results in increased expression of PRKAB1 mRNA21632981
D011794Quercetin[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein co-treated with Quercetin] results in increased phosphorylation of PRKAB1 protein18586010
C488333Ro 65-7199Ro 65-7199 affects the expression of PRKAB1 mRNA14610520
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary results in decreased expression of PRKAB1 mRNA"20349193
D053260SootSoot results in increased expression of PRKAB1 mRNA26551751
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of PRKAB1 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PRKAB1 mRNA11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRKAB1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PRKAB1 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PRKAB1 mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PRKAB1 mRNA21215274
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PRKAB1 mRNA20133372
D014635Valproic AcidValproic Acid results in decreased expression of PRKAB1 mRNA21318169
C025643vinclozolinvinclozolin results in increased expression of PRKAB1 mRNA23869203
D000225AdenineAdenine results in decreased expression of PRKAB1 mRNA24211769

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IDA17028174  
GO:0004679AMP-activated protein kinase activityCONTRIBUTES_TOIBA21873635  
GO:0004679AMP-activated protein kinase activity-IEA-  
GO:0005515protein binding-IPI16306228  17028174  17353931  18403135  18480843  18624398  
20562859  21988832  22363791  23455922  25852190  
GO:0019901protein kinase binding-IBA21873635  
GO:0019901protein kinase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IDA17028174  
GO:0006633fatty acid biosynthetic process-IEA-  
GO:0007050cell cycle arrest-TAS-  
GO:0007165signal transduction-TAS9575201  
GO:0010628positive regulation of gene expression-IDA17028174  
GO:0016236macroautophagy-TAS-  
GO:0035878nail development-IEA-  
GO:0050790regulation of catalytic activity-IEA-  
GO:0051291protein heterooligomerization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0031588nucleotide-activated protein kinase complex-IBA21873635  
GO:0031588nucleotide-activated protein kinase complex-IEA-  
KEGG ID KEGG Term
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa05410Hypertrophic cardiomyopathy (HCM)
Reactome ID Reactome Term Evidence
R-HSA-1445148Translocation of GLUT4 to the plasma membraneIEA
R-HSA-1592230Mitochondrial biogenesisIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1632852MacroautophagyTAS
R-HSA-165159mTOR signallingTAS
R-HSA-1852241Organelle biogenesis and maintenanceIEA
R-HSA-199991Membrane TraffickingIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2151209Activation of PPARGC1A (PGC-1alpha) by phosphorylationIEA
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-380972Energy dependent regulation of mTOR by LKB1-AMPKTAS
R-HSA-5628897TP53 Regulates Metabolic GenesTAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5653656Vesicle-mediated transportIEA
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19948975Integrative predictive model of coronary artery calcification in atherosclerosis. (2009 Dec 15)McGeachie MCirculation