Gene: OSGEP

55644
GAMOS3|GCPL1|KAE1|OSGEP1|PRSMG1|TCS3
O-sialoglycoprotein endopeptidase
protein-coding
14q11.2
Ensembl:ENSG00000092094 MIM:610107 Vega:OTTHUMG00000029543 UniprotKB:Q9NPF4
NC_000014.9
PubMed
0   ANCO-SNPs
ND
1   
8.234e-1 (AD)  6.880e-1 (ND)   (Frontal_Cortex)
7.171e-1 (AD)  4.357e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EXOSC100.865
ZNF2510.857
CDRT40.852
TTC21A0.843
SPPL2B0.842
ZNF2760.835
ZNF760.834
AMY2B0.833
COQ40.832
CAD0.831

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.511
OR4F29-0.477
PPBP-0.317
MTRNR2L9-0.312
MTRNR2L6-0.298
CYP39A1-0.279
CCDC102A-0.258
ELF5-0.254
MTRNR2L10-0.252
DLEU1-0.245

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of OSGEP mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of OSGEP mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of OSGEP mRNA16483693
D001151ArsenicArsenic affects the methylation of OSGEP gene25304211
D001280AtrazineAtrazine results in decreased expression of OSGEP mRNA22378314
C006780bisphenol Abisphenol A results in decreased expression of OSGEP mRNA25047013|2927551
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of OSGEP mRNA28628672
C006780bisphenol Abisphenol A affects the expression of OSGEP mRNA21786754
C006780bisphenol Abisphenol A affects the expression of OSGEP mRNA25181051
D002994ClofibrateClofibrate results in decreased expression of OSGEP mRNA23811191
D019327Copper SulfateCopper Sulfate results in decreased expression of OSGEP mRNA19549813
D003471CuprizoneCuprizone results in increased expression of OSGEP mRNA26577399
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of OSGEP mRNA28628672
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of OSGEP mRNA26924002
C024629dimethyl phthalatedimethyl phthalate affects the expression of OSGEP mRNA26924002
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of OSGEP mRNA22079256
D005897GlafenineGlafenine results in increased expression of OSGEP mRNA24136188
D017313FenretinideFenretinide results in decreased expression of OSGEP mRNA28973697
C016517indole-3-carbinolindole-3-carbinol affects the expression of OSGEP mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of OSGEP mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of OSGEP mRNA28628672
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of OSGEP mRNA23458150
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of OSGEP mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of OSGEP mRNA"25620056
D010936Plant ExtractsPlant Extracts results in increased expression of OSGEP mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of OSGEP mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of OSGEP mRNA22079256
D012643SeleniumSelenium results in increased expression of OSGEP mRNA19244175
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of OSGEP mRNA21570461
D014241TrichloroethyleneTrichloroethylene affects the expression of OSGEP mRNA21135412
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of OSGEP mRNA"26179874
D014635Valproic AcidValproic Acid results in increased expression of OSGEP mRNA23179753

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17353931  27173435  27903914  
GO:0046872metal ion binding-IEA-  
GO:0061711N(6)-L-threonylcarbamoyladenine synthase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002949tRNA threonylcarbamoyladenosine modification-IDA28805828  
GO ID GO Term Qualifier Evidence PubMed
GO:0000408EKC/KEOPS complex-IBA21873635  
GO:0000408EKC/KEOPS complex-IDA27903914  28805828  
GO:0005634nucleus-IDA27903914  28805828  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA28805828  
GO:0005886plasma membrane-IDA-  
GO:0016607nuclear speck-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-6782315tRNA modification in the nucleus and cytosolIEA
R-HSA-72306tRNA processingIEA
R-HSA-8953854Metabolism of RNAIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26033827Genetic variation affects congenital heart defect susceptibility in offspring exposed to maternal tobacco use. (2015 Oct)Tang XBirth Defects Res A Clin Mol Teratol