Gene info: ID 55651

Gene: NHP2

GENE ID: 55651

Synonyms: DKCB2|NHP2P|NOLA2

Description: NHP2 ribonucleoprotein

Gene type: protein-coding

Location: 5q35.3

dbXrefs: Ensembl:ENSG00000145912 MIM:606470 Vega:OTTHUMG00000130886 UniprotKB:Q9NX24

RefSeq: NG_011765.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.632e-4 (AD) 4.133e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MEA1	0.96
PDAP1	0.953
IMP4	0.949
MRPS7	0.949
CUEDC2	0.948
PSMB6	0.948
CUTA	0.947
HINT1	0.944
NDUFC2	0.944
UQCRH	0.943

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.774
OR4F29	-0.747
MTRNR2L6	-0.348
P2RY14	-0.338
MTRNR2L9	-0.328
IL18RAP	-0.319
CXCR2	-0.314
MTRNR2L10	-0.314
KCNJ15	-0.308
EBF1	-0.305

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of NHP2 gene	27153756
D001151	Arsenic	Arsenic affects the methylation of NHP2 gene	25304211
C006780	bisphenol A	[bisphenol A co-treated with Genistein] results in decreased methylation of NHP2 gene	28505145
C006780	bisphenol A	[bisphenol A co-treated with Genistein] results in increased methylation of NHP2 gene	28505145
C006780	bisphenol A	bisphenol A results in decreased expression of NHP2 mRNA	25181051
D002065	Buspirone	Buspirone results in decreased expression of NHP2 mRNA	24136188
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of NHP2 mRNA	27339419
D002509	Cephaloridine	Cephaloridine results in increased expression of NHP2 mRNA	18500788
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of NHP2 mRNA	18804290
C100187	chloropicrin	chloropicrin results in increased expression of NHP2 mRNA	26352163
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of NHP2 mRNA	28472532
C018021	cobaltous chloride	cobaltous chloride results in increased expression of NHP2 mRNA	24612858
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of NHP2 mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in decreased expression of NHP2 mRNA	25562108
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of NHP2 mRNA	21266533
D004178	Diquat	Diquat affects the expression of NHP2 mRNA	22814884
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of NHP2 protein	23301498
D018120	Finasteride	Finasteride results in increased expression of NHP2 mRNA	24136188
D005485	Flutamide	Flutamide results in increased expression of NHP2 mRNA	24136188
C039281	furan	furan results in increased expression of NHP2 mRNA	25539665\|2619464
D019833	Genistein	[bisphenol A co-treated with Genistein] results in decreased methylation of NHP2 gene	28505145
D019833	Genistein	[bisphenol A co-treated with Genistein] results in increased methylation of NHP2 gene	28505145
D019833	Genistein	Genistein results in decreased methylation of NHP2 gene	28505145
D005897	Glafenine	Glafenine results in increased expression of NHP2 mRNA	24136188
C544151	jinfukang	jinfukang results in increased expression of NHP2 mRNA	27392435
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of NHP2 mRNA	18804290
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of NHP2 mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of NHP2 mRNA	23649840
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of NHP2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of NHP2 mRNA"	25554681\|2562005
C051752	nefazodone	nefazodone results in increased expression of NHP2 mRNA	24136188
C022838	nickel chloride	nickel chloride results in increased expression of NHP2 mRNA	24612858
C012655	nimesulide	nimesulide results in increased expression of NHP2 mRNA	24136188
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of NHP2 mRNA	18804290
D010634	Phenobarbital	Phenobarbital affects the expression of NHP2 mRNA	23091169
C006253	pirinixic acid	pirinixic acid results in increased expression of NHP2 mRNA	23811191
D010936	Plant Extracts	Plant Extracts results in increased expression of NHP2 mRNA	23557933
C016104	sodium bichromate	sodium bichromate results in increased expression of NHP2 mRNA	24612858
C016104	sodium bichromate	sodium bichromate results in decreased expression of NHP2 mRNA	22561333
C016104	sodium bichromate	sodium bichromate results in increased expression of NHP2 mRNA	25993096
D013750	Tetrachloroethylene	Tetrachloroethylene results in decreased expression of NHP2 mRNA	28973375
D013853	Thioacetamide	Thioacetamide results in increased expression of NHP2 mRNA	23411599
C406224	valdecoxib	valdecoxib results in increased expression of NHP2 mRNA	24136188
C025643	vinclozolin	vinclozolin results in increased expression of NHP2 mRNA	22615374

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003723	RNA binding	-	HDA	22658674
GO:0003723	RNA binding	-	IBA	21873635
GO:0003723	RNA binding	-	IPI	18082603 20351177 22527283
GO:0005515	protein binding	-	IPI	23685356 25416956 25910212
GO:0034513	box H/ACA snoRNA binding	-	IBA	21873635
GO:0034513	box H/ACA snoRNA binding	-	IPI	18082603
GO:0070034	telomerase RNA binding	-	IPI	18082603 20351177 22527283

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000469	cleavage involved in rRNA processing	-	IBA	21873635
GO:0000470	maturation of LSU-rRNA	-	IBA	21873635
GO:0006412	translation	-	IBA	21873635
GO:0007004	telomere maintenance via telomerase	-	TAS	22527283
GO:0031118	rRNA pseudouridine synthesis	-	IBA	21873635
GO:0031118	rRNA pseudouridine synthesis	-	ISS	-
GO:0031120	snRNA pseudouridine synthesis	-	IBA	21873635
GO:1904874	positive regulation of telomerase RNA localization to Cajal body	-	HMP	25467444

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000784	nuclear chromosome, telomeric region	-	HDA	19135898
GO:0005654	nucleoplasm	-	TAS	-
GO:0005697	telomerase holoenzyme complex	-	IDA	18082603
GO:0005697	telomerase holoenzyme complex	-	TAS	20351177 22527283
GO:0005732	small nucleolar ribonucleoprotein complex	-	ISS	-
GO:0022625	cytosolic large ribosomal subunit	-	IBA	21873635
GO:0031429	box H/ACA snoRNP complex	-	IBA	21873635
GO:0031429	box H/ACA snoRNP complex	-	IDA	18082603
GO:0031429	box H/ACA snoRNP complex	-	TAS	22527283
GO:0072589	box H/ACA scaRNP complex	-	TAS	22527283
GO:0090661	box H/ACA telomerase RNP complex	-	IDA	18082603
GO:0090661	box H/ACA telomerase RNP complex	-	TAS	22527283

KEGG ID	KEGG Term
hsa03008	Ribosome biogenesis in eukaryotes

Reactome ID	Reactome Term	Evidence
R-HSA-157579	Telomere Maintenance	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-171319	Telomere Extension By Telomerase	TAS
R-HSA-180786	Extension of Telomeres	TAS
R-HSA-6790901	rRNA modification in the nucleus and cytosol	TAS
R-HSA-72312	rRNA processing	TAS
R-HSA-73886	Chromosome Maintenance	TAS
R-HSA-8868773	rRNA processing in the nucleus and cytosol	TAS
R-HSA-8953854	Metabolism of RNA	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20301779	Dyskeratosis Congenita (1993)	Savage SA	-