Gene: HIF1AN

55662
FIH1
hypoxia inducible factor 1 subunit alpha inhibitor
protein-coding
10q24.31
Ensembl:ENSG00000166135 MIM:606615 Vega:OTTHUMG00000018911 UniprotKB:Q9NWT6
NC_000010.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.241e-1 (AD)  7.446e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LARP10.948
MTOR0.945
KIAA01000.941
BTRC0.94
DROSHA0.939
WIPF20.938
RALGAPB0.936
UBE3C0.935
TCF200.935
SLC35E10.933

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.561
OR4F29-0.516
HEY2-0.417
MYL3-0.409
CSAG1-0.401
TFPI2-0.392
SH2D1A-0.388
FAM89A-0.387
SNHG18-0.384
RAB13-0.38

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01694D-tartaric acidSmall Molecule147-71-7ExperimentalTarget
DB08263N-(carboxycarbonyl)-D-phenylalanineSmall Molecule856680-67-6ExperimentalTarget
DB09459Tartaric acidSmall MoleculeApprovedEnzyme
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of HIF1AN mRNA"22698814
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of HIF1AN mRNA"23829299
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of HIF1AN mRNA"23829299
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of HIF1AN mRNA"27567155
D000082AcetaminophenAcetaminophen results in increased expression of HIF1AN mRNA22230336
D000666Amphotericin BAmphotericin B promotes the reaction [HIF1AN protein binds to and results in increased hydroxylation of and results in decreased activity of HIF1A protein]16189267
D001280AtrazineAtrazine results in decreased expression of HIF1AN mRNA22378314
D001507BeclomethasoneBeclomethasone results in increased expression of HIF1AN mRNA23656298
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of HIF1AN mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of HIF1AN mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of HIF1AN mRNA29097150
D000069286BortezomibBortezomib promotes the reaction [HIF1AN protein binds to HIF1A protein]18174379
D004390ChlorpyrifosChlorpyrifos results in increased expression of HIF1AN mRNA21356183
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HIF1AN gene20938992
D007464ClioquinolClioquinol inhibits the reaction [HIF1AN protein results in increased hydroxylation of HIF1A protein]16973622
D007464ClioquinolClioquinol results in decreased activity of HIF1AN protein16973622
C018021cobaltous chloridecobaltous chloride results in decreased expression of HIF1AN mRNA15695372|1670579
C018021cobaltous chloridecobaltous chloride results in decreased expression of HIF1AN protein26174737
C018021cobaltous chloridetetraethylenepentamine inhibits the reaction [cobaltous chloride results in decreased expression of HIF1AN protein]26174737
D019327Copper SulfateCopper Sulfate affects the reaction [tetraethylenepentamine affects the localization of HIF1AN protein]25687434
D016572CyclosporineCyclosporine results in decreased expression of HIF1AN mRNA25562108
C024629dimethyl phthalatedimethyl phthalate affects the expression of HIF1AN mRNA26924002
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of HIF1AN mRNA28939011
D004147DioxinsDioxins affects the expression of HIF1AN mRNA20463971
C012301domoic aciddomoic acid results in decreased expression of HIF1AN mRNA18936300
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HIF1AN mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HIF1AN mRNA29097150
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HIF1AN gene20938992
D007213IndomethacinIndomethacin results in increased expression of HIF1AN mRNA28201806
D007545IsoproterenolIsoproterenol results in decreased expression of HIF1AN mRNA24286936
C045463leflunomideleflunomide results in decreased expression of HIF1AN mRNA28988120
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of HIF1AN mRNA25613284
D008345ManganeseManganese results in decreased expression of HIF1AN mRNA17175027
C025340manganese chloridemanganese chloride results in decreased expression of HIF1AN mRNA17175027
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HIF1AN gene20938992
C022838nickel chloridenickel chloride results in decreased expression of HIF1AN mRNA16705796
D010416PentachlorophenolPentachlorophenol results in increased expression of HIF1AN mRNA24642059
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HIF1AN mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of HIF1AN mRNA22079256
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of HIF1AN mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HIF1AN mRNA28213091
C034269tetraethylenepentamineCopper Sulfate affects the reaction [tetraethylenepentamine affects the localization of HIF1AN protein]25687434
C034269tetraethylenepentaminetetraethylenepentamine affects the localization of HIF1AN protein25687434
C034269tetraethylenepentaminetetraethylenepentamine inhibits the reaction [cobaltous chloride results in decreased expression of HIF1AN protein]26174737
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of HIF1AN mRNA27404394
D014212TretinoinTretinoin results in decreased expression of HIF1AN mRNA20530235
C057693troglitazonetroglitazone results in decreased expression of HIF1AN mRNA28973697
D014415TunicamycinTunicamycin results in decreased expression of HIF1AN mRNA17127020
D014635Valproic AcidValproic Acid affects the expression of HIF1AN mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of HIF1AN mRNA25716160
D014635Valproic AcidValproic Acid affects the expression of HIF1AN mRNA17292431
D014810Vitamin EVitamin E results in increased expression of HIF1AN mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005112Notch binding-IPI17573339  18299578  
GO:0005506iron ion binding-IDA12446723  
GO:0005515protein binding-IPI11641274  12446723  16189514  17003112  17573339  19060904  
19071119  19726677  21251231  25609649  26751287  26752685  
26948053  26972000  27107014  29426014  
GO:0008270zinc ion binding-IDA12446723  
GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors-EXP12042299  12080085  14701857  15239670  
GO:0019826oxygen sensor activity-NAS12080085  
GO:0031406carboxylic acid binding-IDA17135241  
GO:0036139peptidyl-histidine dioxygenase activity-IDA21251231  
GO:0036140peptidyl-asparagine 3-dioxygenase activity-IDA12215170  14734545  
GO:0036140peptidyl-asparagine 3-dioxygenase activity-IMP19245366  
GO:0042803protein homodimerization activity-IDA12446723  
GO:0048037cofactor binding-IDA12446723  
GO:0051059NF-kappaB binding-IPI17003112  
GO:0071532ankyrin repeat binding-IPI17003112  17636018  21177872  21251231  
GO:0102113hypoxia-inducible factor-asparagine oxygenase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0036138peptidyl-histidine hydroxylation-IDA21251231  
GO:0042264peptidyl-aspartic acid hydroxylation-IDA21177872  
GO:0042265peptidyl-asparagine hydroxylation-IDA12080085  12215170  14734545  21177872  
GO:0042265peptidyl-asparagine hydroxylation-IMP19245366  
GO:0045663positive regulation of myoblast differentiation-IDA18299578  
GO:0045746negative regulation of Notch signaling pathway-IDA18299578  
GO:0055114oxidation-reduction process-IDA12080085  12215170  
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia-TAS-  
GO:0061428negative regulation of transcription from RNA polymerase II promoter in response to hypoxia-IDA11641274  
GO:2001214positive regulation of vasculogenesis-NAS17636018  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleuscolocalizes_withIDA18299578  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA14734545  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0048471perinuclear region of cytoplasm-IDA19726677  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1234162Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor AlphaTAS
R-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygenTAS
R-HSA-2262749Cellular response to hypoxiaTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21751195Interactions between environmental factors and polymorphisms in angiogenesis pathway genes in esophageal adenocarcinoma risk: a case-only study. (2012 Feb 1)Zhai RCancer