Gene: MFN1

55669
hfzo1|hfzo2
mitofusin 1
protein-coding
3q26.33
Ensembl:ENSG00000171109 MIM:608506 Vega:OTTHUMG00000157385 UniprotKB:Q8IWA4
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.260e-1 (AD)  7.065e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TCERG10.933
BIVM0.931
ICA1L0.927
EXOC10.92
C2CD50.919
YTHDC20.915
CCPG10.914
DDI20.913
DOPEY10.912
PPIP5K20.905

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.524
OR4F29-0.47
EVC2-0.394
WDR38-0.391
CCDC102A-0.385
FOXJ1-0.378
RHOD-0.352
MTRNR2L6-0.342
MTRNR2L10-0.342
PDZK1IP1-0.341

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C47781915-deoxyprostaglandin J215-deoxyprostaglandin J2 results in decreased expression of MFN1 protein20678484
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MFN1 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of MFN1 mRNA"18648102
C0423754-diphenylacetoxy-1,1-dimethylpiperidinium"4-diphenylacetoxy-1,1-dimethylpiperidinium results in decreased expression of MFN1 protein"27491814
C0821644-methoxycinnamate methyl ester4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of MFN1 mRNA]19442820
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in decreased expression of MFN1 protein"27491814
D000082AcetaminophenAcetaminophen results in decreased expression of MFN1 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MFN1 mRNA27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MFN1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MFN1 mRNA24449571
D001386AzidesMFN1 protein inhibits the reaction [Azides results in increased activity of BAX protein]21160028
D001386AzidesMFN1 protein results in decreased susceptibility to Azides21160028
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MFN1 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MFN1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MFN1 mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of MFN1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of MFN1 mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of MFN1 mRNA20977926
C040048caffeic acidcaffeic acid promotes the reaction [Thapsigargin results in decreased expression of MFN1 mRNA]19442820
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of MFN1 mRNA23650126
D019327Copper SulfateCopper Sulfate results in increased expression of MFN1 mRNA19549813
D003474CurcuminCurcumin results in increased expression of MFN1 protein28698153
D016572CyclosporineCyclosporine results in increased expression of MFN1 mRNA20106945
D002945CisplatinMFN1 protein results in decreased susceptibility to Cisplatin21160028
D002945CisplatinMFN1 protein inhibits the reaction [Cisplatin results in increased activity of BAX protein]21160028
D002945CisplatinMFN1 protein results in decreased susceptibility to Cisplatin21160028
C000944dicrotophosdicrotophos results in decreased expression of MFN1 mRNA28302478
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of MFN1 mRNA18313992
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of MFN1 mRNA27638505
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of MFN1 mRNA"22485181
D004317Doxorubicin[resveratrol co-treated with Doxorubicin] results in increased expression of MFN1 protein23695218
D004317DoxorubicinDoxorubicin results in decreased expression of MFN1 protein26678157
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of MFN1 mRNA]"19442820
C062669epicatechin gallateARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of MFN1 protein]]29061316
C062669epicatechin gallate[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of MFN1 protein]29061316
C045651epigallocatechin gallateARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of MFN1 protein]]29061316
C045651epigallocatechin gallate[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of MFN1 protein]29061316
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MFN1 mRNA22079256
D000431EthanolEthanol results in increased degradation of MFN1 protein25460735
D000431EthanolNR1H4 gene mutant form inhibits the reaction [Ethanol results in increased degradation of MFN1 protein]25460735
D005459FluoridesFluorides results in decreased expression of MFN1 mRNA23007560
D005459FluoridesFluorides results in decreased expression of MFN1 protein23007560
D005707Gallic AcidARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of MFN1 protein]]29061316
D005707Gallic Acid[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of MFN1 protein]29061316
C057580gallocatecholARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of MFN1 protein]]29061316
C057580gallocatechol[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of MFN1 protein]29061316
C089796hexabromocyclododecanehexabromocyclododecane affects the expression of MFN1 mRNA24680724
D006820Hyaluronic AcidHyaluronic Acid analog results in decreased expression of MFN1 protein23178681
D006861Hydrogen PeroxideARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of MFN1 protein]]29061316
D006861Hydrogen Peroxide[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of MFN1 protein]29061316
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of MFN1 protein29061316
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of MFN1 protein23178681
D007545IsoproterenolIsoproterenol results in decreased expression of MFN1 protein27491814
C544151jinfukangjinfukang results in decreased expression of MFN1 mRNA27392435
C410337K 7174K 7174 results in increased expression of MFN1 mRNA24086573
C045463leflunomideleflunomide results in decreased expression of MFN1 mRNA28988120
C517284monomethyl phthalatemonomethyl phthalate affects the expression of MFN1 mRNA26924002
C502362N-butyrylglucosamineN-butyrylglucosamine results in increased expression of MFN1 mRNA16142878
D019319Okadaic AcidOkadaic Acid results in increased expression of MFN1 protein26732598
C016030pantogabpantogab results in decreased expression of MFN1 mRNA17379144
D052638Particulate MatterParticulate Matter affects the expression of MFN1 mRNA25560372
D052638Particulate MatterParticulate Matter affects the expression of MFN1 protein25560372
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of MFN1 mRNA27153767
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MFN1 protein26879310
D010936Plant ExtractsPlant Extracts results in increased expression of MFN1 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MFN1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MFN1 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in decreased expression of MFN1 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of MFN1 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of MFN1 mRNA21632981
C059514resveratrolresveratrol results in increased expression of MFN1 mRNA21224254
C059514resveratrol[resveratrol co-treated with Doxorubicin] results in increased expression of MFN1 protein23695218
C059514resveratrolresveratrol results in increased expression of MFN1 mRNA21224254
D012402RotenoneRotenone results in increased expression of MFN1 mRNA23186747
D012524SarinSarin results in decreased expression of MFN1 mRNA19522546
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MFN1 mRNA21570461
D019284Thapsigargin4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of MFN1 mRNA]19442820
D019284Thapsigargincaffeic acid promotes the reaction [Thapsigargin results in decreased expression of MFN1 mRNA]19442820
D019284Thapsigargin"Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of MFN1 mRNA]"19442820
C012589trichostatin Atrichostatin A results in increased expression of MFN1 mRNA15901671
C012589trichostatin Atrichostatin A affects the expression of MFN1 mRNA28542535
D014635Valproic AcidValproic Acid results in increased expression of MFN1 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of MFN1 mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of MFN1 mRNA17963808
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of MFN1 mRNA18313992

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IBA21873635  
GO:0003924GTPase activity-IDA27920125  
GO:0003924GTPase activity-IMP28114303  
GO:0005515protein binding-IPI20019757  
GO:0005525GTP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008053mitochondrial fusion-IBA21873635  
GO:0008053mitochondrial fusion-IDA20436456  
GO:0008053mitochondrial fusion-IMP23921378  27920125  28114303  
GO:0016236macroautophagy-TAS-  
GO:0046039GTP metabolic process-IDA27920125  
GO:0051646mitochondrion localization-IBA21873635  
GO:0051646mitochondrion localization-IMP12759376  
GO:1990613mitochondrial membrane fusion-IMP12759376  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA20871098  27920125  
GO:0005741mitochondrial outer membrane-TAS-  
GO:0016021integral component of membrane-IDA27920125  
GO:0031306intrinsic component of mitochondrial outer membrane-IBA21873635  
GO:0031307integral component of mitochondrial outer membrane-IDA12759376  
GO:0098799outer mitochondrial membrane protein complex-IDA12759376  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-5205647MitophagyTAS
R-HSA-5205685Pink/Parkin Mediated MitophagyTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24088173Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells. (2013 Oct 2)Hoffmann RFRespir Res