Gene: MREG

55686
DSU|WDT2
melanoregulin
protein-coding
2q35
Ensembl:ENSG00000118242 MIM:609207 Vega:OTTHUMG00000154828 UniprotKB:Q8N565
NC_000002.12
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.900e-1 (AD)  7.761e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC9B20.845
RNF1110.842
GNPNAT10.84
C16orf700.839
TOPBP10.837
MCTP10.837
HEATR5B0.836
RAPGEF20.834
CPEB10.833
SERAC10.832

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A1-0.427
EYA2-0.426
ASB4-0.423
PLA2G5-0.421
PINLYP-0.419
COPZ2-0.418
RBP1-0.41
RARRES2-0.407
PON3-0.403
GPR143-0.399

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of MREG mRNA"28903501
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MREG mRNA"23146750
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of MREG mRNA"21920950
C0293704-toluidine4-toluidine results in decreased expression of MREG mRNA27638505
D000082AcetaminophenAcetaminophen results in decreased expression of MREG mRNA29067470
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of MREG mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MREG protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MREG mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MREG mRNA19770486
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of MREG mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MREG mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MREG mRNA19770486|2171566
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MREG mRNA"19150397
D004958EstradiolEGF protein promotes the reaction [Estradiol results in increased expression of MREG mRNA]24758408
D004958EstradiolEstradiol affects the expression of MREG mRNA22574217
D004958EstradiolEstradiol results in increased expression of MREG mRNA21795739|2475840
C006780bisphenol Abisphenol A results in decreased expression of MREG mRNA21932408
C006780bisphenol Abisphenol A affects the expression of MREG mRNA25181051
C006780bisphenol Abisphenol A inhibits the reaction [Triiodothyronine results in decreased expression of MREG mRNA]19228888
D002220CarbamazepineCarbamazepine affects the expression of MREG mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MREG mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of MREG mRNA27339419
D002737ChloropreneChloroprene results in decreased expression of MREG mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MREG gene20938992
D019327Copper SulfateCopper Sulfate results in increased expression of MREG mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of MREG mRNA25562108
D003703DemecolcineDemecolcine results in increased expression of MREG mRNA23649840
C016366dibenzothiophenedibenzothiophene results in decreased expression of MREG mRNA23656968
D002117CalcitriolCalcitriol results in increased expression of MREG mRNA26485663
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of MREG mRNA20064776
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of MREG mRNA]21233418
D004967EstrogensEstrogens results in increased expression of MREG mRNA21233418
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MREG gene20938992
C039281furanfuran results in decreased expression of MREG mRNA25539665|2619464
C546771gardiquimodgardiquimod results in increased expression of MREG mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of MREG mRNA]28003376
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MREG mRNA25613284
C045463leflunomideleflunomide results in decreased expression of MREG mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MREG gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MREG mRNA23649840
C568376MT19c compoundMT19c compound results in increased expression of MREG mRNA21781307
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MREG mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MREG mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MREG mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MREG mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MREG mRNA"24911292
D010634PhenobarbitalPhenobarbital affects the expression of MREG mRNA23091169
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of MREG mRNA28903501
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of MREG mRNA]28003376
D053260SootSoot results in increased expression of MREG mRNA26551751
D014284Triiodothyroninebisphenol A inhibits the reaction [Triiodothyronine results in decreased expression of MREG mRNA]19228888
D014284TriiodothyronineTriiodothyronine results in decreased expression of MREG mRNA19228888
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of MREG mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MREG mRNA21570461|2892240
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of MREG mRNA25975270
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of MREG mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MREG mRNA25613284
D013853ThioacetamideThioacetamide results in decreased expression of MREG mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of MREG mRNA23409001
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of MREG mRNA20133372
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MREG mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of MREG mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MREG mRNA19101580|2718838
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MREG gene25560391
C111237vorinostatvorinostat results in increased expression of MREG mRNA27188386
C088658zoledronic acidzoledronic acid results in increased expression of MREG mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0030318melanocyte differentiation-IBA21873635  
GO:0030318melanocyte differentiation-IEA-  
GO:0032402melanosome transport-IBA21873635  
GO:0032402melanosome transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016324apical plasma membrane-IEA-  
GO:0032991protein-containing complex-IEA-  
GO:0042470melanosome-IBA21873635  
GO:0042470melanosome-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25278008Genome-wide association discoveries of alcohol dependence. (2014 Nov-Dec)Zuo LAm J Addict