Gene info: ID 55691

Gene: FRMD4A

GENE ID: 55691

Synonyms: CCAFCA|FRMD4|bA295P9.4

Description: FERM domain containing 4A

Gene type: protein-coding

Location: 10p13

dbXrefs: Ensembl:ENSG00000151474 MIM:616305 Vega:OTTHUMG00000017708 UniprotKB:Q9P2Q2

RefSeq: NG_047164.1

Retrived from: PubMed|SNP Mapped

SNPs: 2 ANCO-SNPs

Phenotype: ND|AD

# Publications: 7

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.870e-2 (AD) 3.048e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs2895596	chr10:14224086 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs2457861	chr10:13964391 (GRCh38.p7)	G>A	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg11813497	chr10:14372879	FRMD4A		2.960e-23	Maternal smoking in pregnancy	27040690
cg25464840	chr10:14372910	FRMD4A		2.960e-28	Maternal smoking in pregnancy	27040690
cg15507334	chr10:14372913	FRMD4A		3.630e-27	Maternal smoking in pregnancy	27040690
cg20344448	chr10:14372431	FRMD4A		9.500e-18	Maternal smoking in pregnancy	27040690
cg05755354	chr10:14372596	FRMD4A		2.550e-8	Maternal smoking in pregnancy	27040690
cg11813497	chr10:14372879	FRMD4A		1.880e-37	Maternal smoking in pregnancy	27040690
cg25464840	chr10:14372910	FRMD4A		1.260e-34	Maternal smoking in pregnancy	27040690
cg15507334	chr10:14372913	FRMD4A		8.960e-34	Maternal smoking in pregnancy	27040690
cg20344448	chr10:14372431	FRMD4A		1.230e-26	Maternal smoking in pregnancy	27040690
cg05755354	chr10:14372596	FRMD4A		2.890e-12	Maternal smoking in pregnancy	27040690
cg11813497	chr10:14372879	FRMD4A		2.030e-40	Maternal smoking in pregnancy	27040690
cg25464840	chr10:14372910	FRMD4A		1.110e-35	Maternal smoking in pregnancy	27040690
cg15507334	chr10:14372913	FRMD4A		5.540e-33	Maternal smoking in pregnancy	27040690
cg20344448	chr10:14372431	FRMD4A		1.570e-25	Maternal smoking in pregnancy	27040690
cg05755354	chr10:14372596	FRMD4A		3.270e-10	Maternal smoking in pregnancy	27040690
cg11813497	chr10:14372879	FRMD4A		3.900e-11	Maternal smoking in pregnancy	27040690
cg25464840	chr10:14372910	FRMD4A		3.740e-9	Maternal smoking in pregnancy	27040690
cg15507334	chr10:14372913	FRMD4A		8.410e-14	Maternal smoking in pregnancy	27040690
cg25464840	chr10:14372910	FRMD4A		3.500e-11	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SYNE1	0.858
SF3A1	0.854
TNRC18	0.853
BCL9	0.852
TRAK1	0.851
FOXG1	0.845
ATP8B2	0.845
ASTN1	0.844
ZBTB43	0.84
MAST4	0.838

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.556
OR4F29	-0.494
CTNNA3	-0.461
SH2D1A	-0.423
SPINK8	-0.377
SGMS2	-0.376
GNG8	-0.371
KLRC2	-0.367
CD8B	-0.363
CD48	-0.354

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FRMD4A mRNA"	25510870
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FRMD4A mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FRMD4A mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FRMD4A mRNA"	25510870
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of FRMD4A mRNA"	21346803
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FRMD4A mRNA"	25510870
C012796	2-butenal	2-butenal results in decreased expression of FRMD4A mRNA	20471460
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FRMD4A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FRMD4A mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of FRMD4A mRNA	21420995
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of FRMD4A gene	27153756
D047310	Apigenin	Apigenin results in increased expression of FRMD4A mRNA	22359648
C547126	AZM551248	AZM551248 results in decreased expression of FRMD4A mRNA	22323515
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of FRMD4A mRNA	19770486
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FRMD4A mRNA	28628672
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of FRMD4A mRNA	28628672
C006780	bisphenol A	bisphenol A results in decreased expression of FRMD4A mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of FRMD4A gene	28505145
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of FRMD4A mRNA	28628672
C018475	butyraldehyde	butyraldehyde results in decreased expression of FRMD4A mRNA	26079696
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of FRMD4A mRNA	27339419
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FRMD4A gene	20938992
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of FRMD4A mRNA	19320972
D003471	Cuprizone	Cuprizone results in increased expression of FRMD4A mRNA	27523638
D003907	Dexamethasone	Dexamethasone results in decreased expression of FRMD4A mRNA	25136773
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FRMD4A mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of FRMD4A mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of FRMD4A mRNA	28628672
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of FRMD4A mRNA	21266533
D002945	Cisplatin	Cisplatin results in decreased expression of FRMD4A mRNA	19561079
D004317	Doxorubicin	FRMD4A protein affects the susceptibility to Doxorubicin	16217747
C118739	entinostat	entinostat results in decreased expression of FRMD4A mRNA	27188386
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of FRMD4A mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FRMD4A mRNA	17942748
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FRMD4A gene	20938992
D005557	Formaldehyde	Formaldehyde results in decreased expression of FRMD4A mRNA	20655997
C069837	fullerene C60	fullerene C60 results in decreased expression of FRMD4A mRNA	19167457
D017313	Fenretinide	Fenretinide results in increased expression of FRMD4A mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of FRMD4A mRNA	20044591
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FRMD4A mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of FRMD4A mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of FRMD4A mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FRMD4A mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of FRMD4A mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of FRMD4A mRNA	28628672
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of FRMD4A mRNA	24796395\|2625444
D008558	Melphalan	Melphalan results in decreased expression of FRMD4A mRNA	22363485
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FRMD4A gene	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of FRMD4A mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of FRMD4A mRNA	23649840
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of FRMD4A mRNA"	26251327
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of FRMD4A mRNA	24810058
C523799	MRK 003	FRMD4A results in increased susceptibility to MRK 003	19903844
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of FRMD4A mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of FRMD4A mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of FRMD4A mRNA	25583101
C028007	nickel monoxide	nickel monoxide affects the expression of FRMD4A mRNA	19167457
C029938	nickel sulfate	nickel sulfate results in decreased expression of FRMD4A mRNA	22714537
D052638	Particulate Matter	Particulate Matter results in increased expression of FRMD4A mRNA	22178795
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FRMD4A mRNA"	25510870
C046012	pentanal	pentanal results in decreased expression of FRMD4A mRNA	26079696
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of FRMD4A mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of FRMD4A mRNA	19482888
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FRMD4A mRNA"	27188386
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls affects the expression of FRMD4A mRNA	21334430
D011374	Progesterone	Progesterone results in decreased expression of FRMD4A mRNA	18070364
D011441	Propylthiouracil	Propylthiouracil results in increased expression of FRMD4A mRNA	24780913
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of FRMD4A mRNA	25895662
D012834	Silver	Silver results in decreased expression of FRMD4A mRNA	27131904
D012906	Smoke	Smoke results in increased expression of FRMD4A mRNA	21095227
C017947	sodium arsenite	sodium arsenite affects the methylation of FRMD4A gene	28589171
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FRMD4A mRNA	17942748
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased methylation of FRMD4A promoter	24964093
D019772	Topotecan	FRMD4A protein affects the susceptibility to Topotecan	16217747
D014212	Tretinoin	Tretinoin results in increased expression of FRMD4A mRNA	21934132
C012589	trichostatin A	trichostatin A results in decreased expression of FRMD4A mRNA	24935251
C012589	trichostatin A	trichostatin A results in increased expression of FRMD4A mRNA	24935251
D014415	Tunicamycin	Tunicamycin results in decreased expression of FRMD4A mRNA	22378314
D014520	Urethane	Urethane results in increased expression of FRMD4A mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of FRMD4A mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of FRMD4A mRNA	24935251\|2800136
D014635	Valproic Acid	Valproic Acid results in increased expression of FRMD4A mRNA	28001369
D014635	Valproic Acid	Valproic Acid results in increased methylation of FRMD4A gene	29154799
D014638	Vanadates	Vanadates results in increased expression of FRMD4A mRNA	22714537
D024483	Vitamin K 3	Vitamin K 3 affects the expression of FRMD4A mRNA	20044591
C111237	vorinostat	vorinostat results in decreased expression of FRMD4A mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0030674	protein binding, bridging	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0090162	establishment of epithelial cell polarity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IEA	-
GO:0005856	cytoskeleton	-	IEA	-
GO:0005912	adherens junction	-	IEA	-
GO:0005923	bicellular tight junction	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25862628	DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring. (2015 Aug)	Kupers LK	Int J Epidemiol
24906187	Identification of DNA methylation changes in newborns related to maternal smoking during pregnancy. (2014 Oct)	Markunas CA	Environ Health Perspect
24964093	Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation. (2014)	Breton CV	PLoS One
27564456	DNA methylation profiling in human lung tissue identifies genes associated with COPD. (2016 Aug 26)	Morrow JD	Epigenetics
25480659	DNA methylation alterations in response to prenatal exposure of maternal cigarette smoking: A persistent epigenetic impact on health from maternal lifestyle? (2016 Feb)	Nielsen CH	Arch Toxicol
27171005	Maternal Smoking during Pregnancy and DNA-Methylation in Children at Age 5.5 Years: Epigenome-Wide-Analysis in the European Childhood Obesity Project (CHOP)-Study. (2016)	Rzehak P	PLoS One
22006218	Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence. (2012 Jun)	Yoon D	Hum Genet