Gene: CCDC88A

55704
APE|GIRDIN|GIV|GRDN|HkRP1|KIAA1212|PEHO|PEHOL
coiled-coil domain containing 88A
protein-coding
2p16.1
Ensembl:ENSG00000115355 MIM:609736 Vega:OTTHUMG00000151915 UniprotKB:Q3V6T2
NG_031944.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.214e-1 (AD)  3.987e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZFYVE160.91
PTK20.897
SENP60.875
ARAP20.872
MAP4K50.867
GCLC0.866
USP160.865
ARID4B0.858
FAR10.857
U2SURP0.854

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.624
OR4F29-0.614
EPPIN-0.289
OR4F16-0.248
MTRNR2L9-0.224
CMA1-0.217
RNF223-0.21
MTRNR2L6-0.21
MTRNR2L10-0.208
MMP23B-0.196

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of CCDC88A mRNA21983209
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCDC88A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCDC88A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCDC88A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCDC88A mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of CCDC88A mRNA25458485
D000082AcetaminophenAcetaminophen affects the expression of CCDC88A mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CCDC88A gene27153756
D006710HomocysteineHomocysteine results in decreased expression of CCDC88A mRNA17326132
D001280AtrazineAtrazine results in decreased expression of CCDC88A mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CCDC88A mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CCDC88A mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CCDC88A mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CCDC88A mRNA"19150397
C006780bisphenol Abisphenol A results in increased expression of CCDC88A mRNA27685785
D002104CadmiumCadmium results in decreased expression of CCDC88A mRNA21120746
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CCDC88A mRNA24982889
D002994ClofibrateClofibrate results in increased expression of CCDC88A mRNA17585979
D003042CocaineCocaine results in increased expression of CCDC88A mRNA17898221
D019327Copper SulfateCopper Sulfate results in increased expression of CCDC88A mRNA19549813
D002945CisplatinCisplatin results in decreased expression of CCDC88A mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of CCDC88A mRNA21852083
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in decreased expression of CCDC88A mRNA]21852083
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CCDC88A protein23301498
D000431EthanolEthanol results in decreased expression of CCDC88A mRNA29018328
D005557FormaldehydeFormaldehyde results in increased expression of CCDC88A mRNA20655997|2766457
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of CCDC88A mRNA18951874
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CCDC88A mRNA25613284
C544151jinfukangjinfukang results in decreased expression of CCDC88A mRNA27392435
C410337K 7174K 7174 results in increased expression of CCDC88A mRNA24086573
C045463leflunomideleflunomide results in decreased expression of CCDC88A mRNA28988120
D058185Magnetite NanoparticlesMagnetite Nanoparticles results in decreased expression of CCDC88A mRNA24525745
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CCDC88A mRNA21641980
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of CCDC88A mRNA22563483
D009538NicotineNicotine results in increased expression of CCDC88A mRNA17456735
D010100OxygenOxygen deficiency affects the methylation of CCDC88A promoter24205000
D010100OxygenOxygen deficiency results in increased expression of CCDC88A mRNA24205000
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of CCDC88A mRNA22563483
D010269ParaquatParaquat results in increased expression of CCDC88A mRNA22563483
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of CCDC88A mRNA26705709
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CCDC88A mRNA27153767
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCDC88A mRNA"27188386
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CCDC88A mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of CCDC88A mRNA23557933
C428725pyridabenpyridaben results in increased expression of CCDC88A mRNA22563483
D011794QuercetinQuercetin results in decreased expression of CCDC88A mRNA21632981
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in decreased expression of CCDC88A mRNA]21852083
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of CCDC88A mRNA"21148743
D012715Sesame OilSesame Oil results in increased expression of CCDC88A mRNA29191790
C009277sodium arsenatesodium arsenate results in increased expression of CCDC88A mRNA21795629
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CCDC88A mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CCDC88A mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CCDC88A promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CCDC88A mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CCDC88A mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of CCDC88A mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CCDC88A mRNA28065790
D014050TolueneToluene results in increased expression of CCDC88A mRNA28245982
C483909torcetrapibtorcetrapib results in increased expression of CCDC88A mRNA23228038
D014212TretinoinTretinoin results in decreased expression of CCDC88A mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCDC88A mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of CCDC88A mRNA26272509
D014635Valproic AcidValproic Acid results in decreased expression of CCDC88A mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of CCDC88A gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CCDC88A mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of CCDC88A mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CCDC88A gene25560391
C025643vinclozolinvinclozolin affects the expression of CCDC88A mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IDA16139227  
GO:0008017microtubule binding-IBA21873635  
GO:0008017microtubule binding-ISS-  
GO:0035091phosphatidylinositol binding-IDA16139227  
GO:0042803protein homodimerization activity-IPI16139227  
GO:0043422protein kinase B binding-IPI16139227  
GO:0051959dynein light intermediate chain binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001932regulation of protein phosphorylation-ISS-  
GO:0006260DNA replication-IEA-  
GO:0006275regulation of DNA replication-ISS-  
GO:0010975regulation of neuron projection development-ISS-  
GO:0016477cell migration-IMP16139227  
GO:0030032lamellipodium assembly-IMP16139227  
GO:0030705cytoskeleton-dependent intracellular transport-IBA21873635  
GO:0031122cytoplasmic microtubule organization-IBA21873635  
GO:0031929TOR signaling-ISS-  
GO:0032148activation of protein kinase B activity-ISS-  
GO:0032956regulation of actin cytoskeleton organization-IMP16139227  
GO:0042127regulation of cell proliferation-ISS-  
GO:0045724positive regulation of cilium assembly-IMP27623382  
GO:0061024membrane organization-IDA15882442  
GO:1903566positive regulation of protein localization to cilium-IMP27623382  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005783endoplasmic reticulum-IDA15882442  
GO:0005794Golgi apparatus-IDA15882442  
GO:0005813centrosome-IBA21873635  
GO:0005814centriole-IDA27623382  
GO:0005829cytosol-IDA15749703  
GO:0005886plasma membrane-IDA15882442  
GO:0016020membrane-IDA15749703  15882442  
GO:0030027lamellipodium-IDA16139227  
GO:0031410cytoplasmic vesicle-IDA15882442  
GO:0036064ciliary basal body-IDA27623382  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24166409Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci. (2014 Jan)Gelernter JMol Psychiatry