Gene info: ID 55714

Gene: TENM3

GENE ID: 55714

Synonyms: MCOPCB9|ODZ3|TNM3|Ten-m3|ten-3

Description: teneurin transmembrane protein 3

Gene type: protein-coding

Location: 4q34.3-q35.1

dbXrefs: Ensembl:ENSG00000218336 MIM:610083 Vega:OTTHUMG00000160682 UniprotKB:Q9P273

RefSeq: NG_042859.1

Retrived from: SNP Mapped

SNPs: 0 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.997e-1 (AD) 4.896e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NBEA	0.947
PGM2L1	0.941
CLCN4	0.94
PTPRR	0.939
DGKI	0.939
WDR7	0.938
SLITRK5	0.938
GDA	0.936
PCLO	0.936
FRMPD4	0.935

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RNF135	-0.62
CSAG1	-0.601
RAB13	-0.592
GNG11	-0.575
COPZ2	-0.564
YES1	-0.554
HEY2	-0.553
CMTM3	-0.551
EMP3	-0.55
MYL3	-0.548

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TENM3 mRNA	19933214
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TENM3 mRNA"	23146750
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TENM3 mRNA"	23146750
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane affects the expression of TENM3 mRNA"	18648102
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in decreased expression of TENM3 mRNA"	25912373
D000082	Acetaminophen	Acetaminophen results in increased expression of TENM3 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of TENM3 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of TENM3 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of TENM3 mRNA	19770486
D000638	Amiodarone	Amiodarone results in increased expression of TENM3 mRNA	24535564
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of TENM3 mRNA	24449571
D001280	Atrazine	Atrazine results in decreased expression of TENM3 mRNA	25929836
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TENM3 mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TENM3 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TENM3 mRNA	21839799
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TENM3 mRNA"	20382639
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TENM3 mRNA	19619570
D004958	Estradiol	Estradiol results in decreased expression of TENM3 mRNA	19619570\|2118537
C044887	beta-methylcholine	beta-methylcholine affects the expression of TENM3 mRNA	21179406
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in decreased expression of TENM3 mRNA	25912373
C006780	bisphenol A	bisphenol A results in decreased expression of TENM3 mRNA	23146750
C006780	bisphenol A	bisphenol A results in decreased expression of TENM3 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of TENM3 gene	28505145
C018475	butyraldehyde	butyraldehyde results in decreased expression of TENM3 mRNA	26079696
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of TENM3 mRNA	27339419
D004390	Chlorpyrifos	[Copper co-treated with Chlorpyrifos] results in decreased expression of TENM3 mRNA	21356183
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of TENM3 mRNA	20938992
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TENM3 gene	20938992
D002994	Clofibrate	Clofibrate results in increased expression of TENM3 mRNA	23811191
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of TENM3 mRNA	24386269
D003042	Cocaine	TENM3 gene SNP affects the susceptibility to Cocaine	18438686
D003300	Copper	[Copper co-treated with Chlorpyrifos] results in decreased expression of TENM3 mRNA	21356183
D003300	Copper	Copper results in decreased expression of TENM3 mRNA	21356183
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TENM3 mRNA]	27941970
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of TENM3 mRNA	28962523
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of TENM3 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of TENM3 mRNA	27392435
D004041	Dietary Fats	Dietary Fats results in increased expression of TENM3 mRNA	18042831
D002117	Calcitriol	Calcitriol results in decreased expression of TENM3 mRNA	26485663
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of TENM3 mRNA	20227414
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of TENM3 mRNA	17606305
D005411	Flame Retardants	Flame Retardants results in increased expression of TENM3 mRNA	18482827
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of TENM3 mRNA	20938992
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TENM3 gene	20938992
C039281	furan	furan results in increased expression of TENM3 mRNA	27387713
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of TENM3 mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of TENM3 mRNA	27392435
C008261	lead acetate	lead acetate results in decreased expression of TENM3 mRNA	25270620
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of TENM3 mRNA	20938992
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TENM3 gene	20938992
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of TENM3 mRNA	26011545
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of TENM3 protein	24625837
D009151	Mustard Gas	Mustard Gas results in increased expression of TENM3 mRNA	15674844
C029938	nickel sulfate	nickel sulfate results in decreased expression of TENM3 mRNA	22714537
D000073878	Palm Oil	Palm Oil results in increased expression of TENM3 mRNA	18042831
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of TENM3 mRNA	18482827
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of TENM3 mRNA	23146750
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of TENM3 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in decreased expression of TENM3 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in increased expression of TENM3 mRNA	19482888
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TENM3 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of TENM3 mRNA	18301758\|2081375
D011441	Propylthiouracil	Propylthiouracil results in increased expression of TENM3 mRNA	24780913
D012834	Silver	Silver results in decreased expression of TENM3 mRNA	27131904
C009277	sodium arsenate	sodium arsenate results in increased expression of TENM3 mRNA	21795629
C017947	sodium arsenite	sodium arsenite results in decreased expression of TENM3 mRNA	22714537
C017947	sodium arsenite	sodium arsenite results in decreased expression of TENM3 mRNA	25270620
C020806	tetrabromobisphenol A	tetrabromobisphenol A affects the expression of TENM3 mRNA	18976794
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TENM3 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TENM3 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TENM3 mRNA	22298810
D014212	Tretinoin	Tretinoin results in increased expression of TENM3 mRNA	20530235
D014212	Tretinoin	Tretinoin results in decreased expression of TENM3 mRNA	21934132
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of TENM3 mRNA	29024780
D014635	Valproic Acid	Valproic Acid affects the expression of TENM3 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased methylation of TENM3 gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of TENM3 mRNA	17292431
D014635	Valproic Acid	Valproic Acid results in increased expression of TENM3 mRNA	24535564
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of TENM3 gene	25560391
D024483	Vitamin K 3	Vitamin K 3 affects the expression of TENM3 mRNA	20044591
C111237	vorinostat	vorinostat results in decreased expression of TENM3 mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0042803	protein homodimerization activity	-	IBA	21873635
GO:0042803	protein homodimerization activity	-	ISS	-
GO:0046982	protein heterodimerization activity	-	IBA	21873635
GO:0046982	protein heterodimerization activity	-	ISS	-
GO:0050839	cell adhesion molecule binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	-	ISS	-
GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	-	IBA	21873635
GO:0007165	signal transduction	-	IEA	-
GO:0010976	positive regulation of neuron projection development	-	ISS	-
GO:0048593	camera-type eye morphogenesis	-	IMP	22766609
GO:0048666	neuron development	-	IBA	21873635
GO:0097264	self proteolysis	-	IEA	-
GO:1903385	regulation of homophilic cell adhesion	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005887	integral component of plasma membrane	-	ISS	-
GO:0016020	membrane	-	ISS	-
GO:0030424	axon	-	IEA	-
GO:0043005	neuron projection	-	IBA	21873635

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal