Gene: SLF2

55719
C10orf6|FAM178A
SMC5-SMC6 complex localization factor 2
protein-coding
10q24.31
Ensembl:ENSG00000119906 MIM:610348 Vega:OTTHUMG00000018919 UniprotKB:Q8IX21
NC_000010.11
SNP Mapped
4   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.040e-1 (AD)  3.668e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7911957chr10:100933213 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs12241232chr10:100932847 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs4917916chr10:100913535 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs3802724chr10:100912961 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLF2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLF2 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of SLF2 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLF2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLF2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of SLF2 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SLF2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SLF2 mRNA19770486
D047310ApigeninApigenin results in decreased expression of SLF2 mRNA22359648
D001280AtrazineAtrazine results in increased expression of SLF2 mRNA25929836
C006780bisphenol Abisphenol A affects the expression of SLF2 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of SLF2 mRNA26079696
C018021cobaltous chloridecobaltous chloride results in increased expression of SLF2 mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of SLF2 mRNA19549813
D003375CoumestrolCoumestrol results in increased expression of SLF2 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of SLF2 mRNA25562108
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of SLF2 mRNA23649840
D017313FenretinideFenretinide results in increased expression of SLF2 mRNA28973697
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of SLF2 mRNA"24972896
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SLF2 mRNA23179753|2800136
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SLF2 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SLF2 mRNA23649840
D010936Plant ExtractsPlant Extracts results in increased expression of SLF2 mRNA23557933
C513428pyrachlostrobinpyrachlostrobin results in increased expression of SLF2 mRNA27029645
C009277sodium arsenatesodium arsenate results in increased expression of SLF2 mRNA21795629
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLF2 mRNA21570461
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLF2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SLF2 mRNA24935251|2627250
C057693troglitazonetroglitazone results in decreased expression of SLF2 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLF2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SLF2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SLF2 mRNA23179753|2627250
D014810Vitamin EVitamin E results in increased expression of SLF2 mRNA19244175
C088658zoledronic acidzoledronic acid results in decreased expression of SLF2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25931565  
GO:0031625ubiquitin protein ligase binding-IPI25931565  
GO:0044877protein-containing complex binding-IPI25931565  
GO ID GO Term Qualifier Evidence PubMed
GO:0006281DNA repair-IEA-  
GO:0006974cellular response to DNA damage stimulus-IDA25931565  
GO:0031334positive regulation of protein complex assembly-IMP25931565  
GO:0034184positive regulation of maintenance of mitotic sister chromatid cohesion-IMP25931565  
GO:1990166protein localization to site of double-strand break-IDA25931565  
GO:2000781positive regulation of double-strand break repair-IDA25931565  
GO ID GO Term Qualifier Evidence PubMed
GO:0000785chromatin-IDA24561620  
GO:0005615extracellular space-HDA22664934  
GO:0005634nucleus-IDA24561620  
GO:0035861site of double-strand break-IDA25931565  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal