Gene: VPS35

55737
MEM3|PARK17
VPS35, retromer complex component
protein-coding
16q11.2
Ensembl:ENSG00000069329 MIM:601501 Vega:OTTHUMG00000132542 UniprotKB:Q96QK1
NG_029970.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.854e-2 (AD)  2.222e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CAND10.979
NAPG0.977
CUL20.976
WDR470.976
CLTC0.975
COL4A3BP0.975
RANBP60.969
UBQLN10.969
ATP6V1A0.966
UBE2K0.966

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.56
OR4F29-0.521
CSAG1-0.429
HEY2-0.401
RAI14-0.386
FZD10-0.381
KLRB1-0.379
MTRNR2L10-0.379
MTRNR2L6-0.377
MYL3-0.371

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of VPS35 mRNA19933214
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of VPS35 mRNA"20206263
C0293704-toluidine4-toluidine results in increased expression of VPS35 mRNA27638505
D000082AcetaminophenAcetaminophen results in increased expression of VPS35 mRNA22230336
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of VPS35 mRNA"23195993
D001280AtrazineAtrazine results in decreased expression of VPS35 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of VPS35 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of VPS35 mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of VPS35 mRNA"20018196
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of VPS35 mRNA"26238291
C006780bisphenol Abisphenol A affects the expression of VPS35 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of VPS35 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of VPS35 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of VPS35 mRNA25979313
D003976DiazinonDiazinon results in increased methylation of VPS35 gene22964155
C000944dicrotophosdicrotophos results in decreased expression of VPS35 mRNA28302478
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of VPS35 mRNA27638505
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of VPS35 mRNA23649840
D018120FinasterideFinasteride results in increased expression of VPS35 mRNA24136188
D005472FluorouracilFluorouracil affects the expression of VPS35 mRNA16584549
D005485FlutamideFlutamide results in increased expression of VPS35 mRNA24136188
C056933fumonisin B1fumonisin B1 results in increased expression of VPS35 mRNA16221962
D006540HerbicidesHerbicides results in decreased expression of VPS35 mRNA28711546
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of VPS35 mRNA19376150
C492448ICG 001ICG 001 results in increased expression of VPS35 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of VPS35 mRNA25613284
D007854LeadLead results in decreased expression of VPS35 mRNA19921347
D0156551-Methyl-4-phenylpyridiniumVPS35 protein results in decreased susceptibility to 1-Methyl-4-phenylpyridinium23411763
D008777MethyltestosteroneMethyltestosterone results in decreased expression of VPS35 mRNA29191790
C523184mocetinostatmocetinostat results in decreased expression of VPS35 mRNA27255383
C051752nefazodonenefazodone results in increased expression of VPS35 mRNA24136188
D009532NickelNickel affects the expression of VPS35 mRNA14575637
D009532NickelNickel results in decreased expression of VPS35 mRNA23195993
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of VPS35 mRNA]14575637
D009532NickelMT1 affects the reaction [Nickel affects the expression of VPS35 mRNA]16166738
D009532NickelMT2 affects the reaction [Nickel affects the expression of VPS35 mRNA]16166738
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of VPS35 mRNA28973697
C006253pirinixic acidpirinixic acid results in increased expression of VPS35 mRNA16221962|2381119
D010936Plant ExtractsPlant Extracts results in increased expression of VPS35 mRNA23557933
C009277sodium arsenatesodium arsenate results in increased expression of VPS35 mRNA23922661
D013467SulindacSulindac results in decreased expression of VPS35 mRNA24136188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of VPS35 mRNA21570461|2468072
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of VPS35 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of VPS35 mRNA23557971
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of VPS35 mRNA]14575637
D014635Valproic AcidValproic Acid affects the expression of VPS35 mRNA25979313
C111237vorinostatvorinostat results in decreased expression of VPS35 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11102511  15078903  16732284  17616579  17891154  18160348  
19553991  19619496  20923837  21725319  22719997  23331060  
23452853  24344282  24747528  25278552  25416956  26496610  
26618722  27385586  27460146  
GO:0008565protein transporter activity-IBA21873635  
GO:0031748D1 dopamine receptor binding-IPI27460146  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IBA21873635  
GO:0007040lysosome organization-IEA-  
GO:0010628positive regulation of gene expression-IDA26618722  
GO:0010629negative regulation of gene expression-IEA-  
GO:0010821regulation of mitochondrion organization-IGI26618722  
GO:0016055Wnt signaling pathway-NAS24115276  
GO:0016055Wnt signaling pathway-TAS-  
GO:0016241regulation of macroautophagy-TAS26172538  
GO:0031647regulation of protein stability-IMP18193037  
GO:0031648protein destabilization-IEA-  
GO:0032268regulation of cellular protein metabolic process-IDA26618722  
GO:0032268regulation of cellular protein metabolic process-IGI25533483  
GO:0032463negative regulation of protein homooligomerization-IEA-  
GO:0033365protein localization to organelle-IEA-  
GO:0042147retrograde transport, endosome to Golgi-IBA21873635  
GO:0042147retrograde transport, endosome to Golgi-IMP15078903  26618722  27385586  
GO:0042147retrograde transport, endosome to Golgi-NAS11102511  18193037  26220253  
GO:0043653mitochondrial fragmentation involved in apoptotic process-IMP26618722  
GO:0045056transcytosis-IDA15247922  
GO:0050728negative regulation of inflammatory response-IGI25533483  
GO:0050882voluntary musculoskeletal movement-IEA-  
GO:0060161positive regulation of dopamine receptor signaling pathway-IDA27460146  
GO:0060548negative regulation of cell death-IGI25533483  
GO:0061357positive regulation of Wnt protein secretion-IEA-  
GO:0090141positive regulation of mitochondrial fission-IMP26618722  
GO:0090263positive regulation of canonical Wnt signaling pathway-IEA-  
GO:0090326positive regulation of locomotion involved in locomotory behavior-IEA-  
GO:0099074mitochondrion to lysosome transport-IMP26618722  
GO:0099639neurotransmitter receptor transport, endosome to plasma membrane-IDA27460146  
GO:1901215negative regulation of neuron death-IGI25533483  
GO:1902823negative regulation of late endosome to lysosome transport-IMP23563491  
GO:1902950regulation of dendritic spine maintenance-IMP26618722  
GO:1903181positive regulation of dopamine biosynthetic process-IEA-  
GO:1903364positive regulation of cellular protein catabolic process-IGI25533483  
GO:1903828negative regulation of cellular protein localization-IEA-  
GO:1905166negative regulation of lysosomal protein catabolic process-IEA-  
GO:1905606regulation of presynapse assembly-ISS25533483  
GO:1990126retrograde transport, endosome to plasma membrane-IMP20164305  21602791  
GO:2000331regulation of terminal button organization-IMP26618722  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrioncolocalizes_withIDA26618722  
GO:0005764lysosome-IDA-  
GO:0005765lysosomal membrane-HDA17897319  
GO:0005768endosome-IDA15078903  
GO:0005769early endosome-IDA18160348  20164305  27385586  
GO:0005770late endosome-IBA21873635  
GO:0005829cytosol-IDA11102511  
GO:0005829cytosol-TAS-  
GO:0010008endosome membrane-IDA27385586  
GO:0014069postsynaptic density-IEA-  
GO:0030904retromer complex-IBA21873635  
GO:0030904retromer complex-IDA11102511  
GO:0030904retromer complex-NAS18193037  
GO:0030904retromer complex-TAS17239604  24115276  
GO:0030906retromer, cargo-selective complex-IDA27385586  
GO:0030906retromer, cargo-selective complex-NAS26220253  
GO:0043005neuron projection-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:0070062extracellular exosome-HDA19056867  
GO:0097422tubular endosome-IDA15078903  
GO:0099073mitochondrion-derived vesicle-IDA26618722  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-3238698WNT ligand biogenesis and traffickingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28289797[Epidemiology and causes of Parkinson's disease]. (2017 Apr)Lill CMNervenarzt