Gene: ENAH

55740
ENA|MENA|NDPP1
ENAH, actin regulator
protein-coding
1q42.12
Ensembl:ENSG00000154380 MIM:609061 Vega:OTTHUMG00000037742 UniprotKB:Q8N8S7
NG_051578.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.342e-1 (AD)  2.215e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3795443chr1:225487301 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YBX10.855
EFCAB140.849
KTN10.839
SYNM0.836
PRPF38A0.833
PTPN210.833
ZNF240.824
SSFA20.824
IL6ST0.819
LSM14A0.816

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.603
OR4F5-0.584
ABCC12-0.349
TPBGL-0.327
ADRA1D-0.327
ASB18-0.32
HTR6-0.319
WNT10A-0.318
CALHM1-0.318
CRYBA2-0.315

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ENAH mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ENAH mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ENAH mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ENAH mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ENAH mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ENAH mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ENAH mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ENAH mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ENAH mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ENAH mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ENAH mRNA19770486
D006710HomocysteineHomocysteine results in decreased expression of ENAH mRNA17326132
C006632arsenic trioxidearsenic trioxide results in increased expression of ENAH mRNA22521957
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ENAH mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ENAH mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ENAH mRNA"19150397
D004958EstradiolEstradiol affects the expression of ENAH mRNA22574217
D004958EstradiolEstradiol promotes the reaction [ENAH protein binds to ESR1 protein]27156127
D004958EstradiolEstradiol results in increased expression of ENAH mRNA19484750
C551172bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in decreased expression of ENAH mRNA"20162321
C006780bisphenol Abisphenol A affects the expression of ENAH mRNA21786754
C515564bromovaninbromovanin results in decreased expression of ENAH protein21419150
C018475butyraldehydebutyraldehyde results in decreased expression of ENAH mRNA26079696
C117342calfactant"[Nanotubes, Carbon co-treated with calfactant] results in increased expression of ENAH protein"23026733
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ENAH mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ENAH mRNA20938992
D003042CocaineCocaine results in increased expression of ENAH mRNA17898221
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of ENAH mRNA15467011
D019327Copper SulfateCopper Sulfate results in increased expression of ENAH mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of ENAH mRNA27989131
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ENAH mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ENAH mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ENAH mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ENAH mRNA27392435
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ENAH mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ENAH mRNA29097150
D005472FluorouracilENAH protein affects the susceptibility to Fluorouracil16217747
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ENAH mRNA20938992
C039281furanfuran results in increased expression of ENAH mRNA27387713
D017313FenretinideFenretinide results in increased expression of ENAH mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ENAH mRNA27392435
C544151jinfukangjinfukang results in decreased expression of ENAH mRNA27392435
D048628KetolidesKetolides analog results in decreased expression of ENAH mRNA24967691
C045463leflunomideleflunomide results in increased expression of ENAH mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ENAH mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ENAH mRNA26011545
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of ENAH mRNA24128854
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of ENAH mRNA20024957
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with calfactant] results in increased expression of ENAH protein"23026733
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of ENAH mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of ENAH mRNA25729387
C046012pentanalpentanal results in decreased expression of ENAH mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of ENAH mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ENAH mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ENAH mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of ENAH mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ENAH mRNA22714537
D011794QuercetinQuercetin results in decreased expression of ENAH mRNA21632981
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of ENAH mRNA21427059
D012715Sesame OilSesame Oil results in increased expression of ENAH mRNA29191790
D012834SilverSilver results in decreased expression of ENAH mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of ENAH mRNA21795629
D012999SomanSoman results in increased expression of ENAH mRNA19281266
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ENAH mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ENAH mRNA19770486
C009495titanium dioxidetitanium dioxide results in decreased expression of ENAH mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ENAH mRNA28111298
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of ENAH mRNA25729387
D019772TopotecanTopotecan results in increased expression of ENAH mRNA25729387
D014212TretinoinTretinoin results in decreased expression of ENAH mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ENAH mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of ENAH mRNA22723015|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ENAH mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ENAH mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ENAH mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of ENAH mRNA17963808
D014635Valproic AcidValproic Acid results in decreased expression of ENAH mRNA19136453|2142705
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ENAH gene25560391
D002762CholecalciferolCholecalciferol results in increased expression of ENAH mRNA17170073

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0005515protein binding-IPI16979624  21044950  21278383  
GO:0017124SH3 domain binding-IEA-  
GO:0050699WW domain binding-IPI17686488  
GO ID GO Term Qualifier Evidence PubMed
GO:0007411axon guidance-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IEA-  
GO:0005886plasma membrane-IDA-  
GO:0005925focal adhesion-HDA21423176  
GO:0005925focal adhesion-IDA-  
GO:0030027lamellipodium-IEA-  
GO:0030054cell junction-IDA-  
GO:0030175filopodium-IEA-  
GO:0045202synapse-IEA-  
KEGG ID KEGG Term
hsa04810Regulation of actin cytoskeleton
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-168256Immune SystemIEA
R-HSA-202403TCR signalingIEA
R-HSA-202433Generation of second messenger moleculesIEA
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-376176Signaling by ROBO receptorsTAS
R-HSA-422475Axon guidanceIEA
R-HSA-422475Axon guidanceTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal