Gene: CHFR

55743
RNF116|RNF196
checkpoint with forkhead and ring finger domains
protein-coding
12q24.33
Ensembl:ENSG00000072609 MIM:605209 Vega:OTTHUMG00000167930 UniprotKB:Q96EP1
NG_033999.1
PubMed
0   ANCO-SNPs
ND
5   
6.191e-1 (AD)  1.823e-1 (ND)   (Frontal_Cortex)
9.102e-1 (AD)  8.126e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF310.868
FNBP40.859
AKAP17A0.856
DCAF150.851
FBXL120.847
SETDB10.837
WDR910.831
ZNF2760.826
NFX10.825
SGSH0.825

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.558
OR4F29-0.538
MTRNR2L9-0.312
MTRNR2L6-0.302
MTRNR2L10-0.267
OR4F16-0.241
MOGAT2-0.232
CYP39A1-0.226
EPPIN-0.212
RAX2-0.204

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenCHFR gene polymorphism affects the susceptibility to Acetaminophen26104854
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CHFR mRNA24449571
D001151ArsenicArsenic affects the methylation of CHFR gene25304211
C044887beta-methylcholinebeta-methylcholine affects the expression of CHFR mRNA21179406
C006780bisphenol Abisphenol A affects the expression of CHFR mRNA21786754
C006780bisphenol Abisphenol A affects the expression of CHFR mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of CHFR mRNA26982218
C006780bisphenol Abisphenol A results in increased methylation of CHFR gene28505145
D000069286BortezomibBortezomib results in decreased expression of CHFR mRNA20977926
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CHFR mRNA17484886
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of CHFR mRNA16934159
D002922CiguatoxinsCiguatoxins affects the expression of CHFR mRNA18353800
C018021cobaltous chloridecobaltous chloride results in increased expression of CHFR mRNA19376846
D003042CocaineCocaine affects the expression of CHFR mRNA20187946
D019327Copper SulfateCopper Sulfate results in increased expression of CHFR mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of CHFR mRNA25562108
C014347decitabinedecitabine results in increased expression of CHFR mRNA16367923
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CHFR mRNA]27941970
D002945CisplatinCHFR protein affects the susceptibility to [Cisplatin co-treated with Erlotinib Hydrochloride]20705357
C067311docetaxelCHFR protein modified form affects the susceptibility to docetaxel17786301
C067311docetaxelCHFR protein results in decreased susceptibility to docetaxel17786301
D000069347Erlotinib HydrochlorideCHFR protein affects the susceptibility to [Cisplatin co-treated with Erlotinib Hydrochloride]20705357
C061365flusilazoleflusilazole results in decreased expression of CHFR mRNA22382673
C061365flusilazoleflusilazole results in increased expression of CHFR mRNA22382673
D005485FlutamideFlutamide results in decreased expression of CHFR mRNA24136188
D005839GentamicinsGentamicins results in decreased expression of CHFR mRNA22061828
D005839GentamicinsGentamicins results in increased expression of CHFR mRNA22061828
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CHFR mRNA"18930950
D008727MethotrexateMethotrexate results in decreased expression of CHFR mRNA24449571
D008748Methylcholanthrene"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of CHFR mRNA"25926378
D037742Nanotubes, Carbon"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of CHFR mRNA"25926378
D017239PaclitaxelCHFR protein modified form affects the susceptibility to Paclitaxel17786301
D017239PaclitaxelCHFR protein results in decreased susceptibility to Paclitaxel17786301
D010416PentachlorophenolPentachlorophenol results in increased expression of CHFR mRNA24642059
C006253pirinixic acidpirinixic acid results in decreased expression of CHFR mRNA18445702
D010936Plant ExtractsPlant Extracts results in increased expression of CHFR mRNA23557933
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of CHFR mRNA21334430
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of CHFR mRNA21427059
C009277sodium arsenatesodium arsenate results in decreased expression of CHFR mRNA23922661
C017947sodium arsenitesodium arsenite results in decreased expression of CHFR mRNA16014739
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CHFR mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CHFR promoter]19654925
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of CHFR mRNA28973375
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CHFR mRNA"26179874
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CHFR mRNA"18930950
D014635Valproic AcidValproic Acid results in increased expression of CHFR mRNA19136453|2142705
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CHFR gene25560391
C025643vinclozolinvinclozolin results in decreased expression of CHFR mRNA23555832

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000166nucleotide binding-IDA18172500  
GO:0004842ubiquitin-protein transferase activity-IBA21873635  
GO:0004842ubiquitin-protein transferase activity-IDA18172500  19182791  
GO:0005515protein binding-IPI15467728  18172500  19182791  
GO:0046872metal ion binding-IEA-  
GO:0061630ubiquitin protein ligase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000209protein polyubiquitination-IDA19182791  
GO:0006511ubiquitin-dependent protein catabolic process-IBA21873635  
GO:0007093mitotic cell cycle checkpoint-IBA21873635  
GO:0007093mitotic cell cycle checkpoint-IMP18172500  19182791  
GO:0007093mitotic cell cycle checkpoint-TAS10935642  
GO:0016567protein ubiquitination-IBA21873635  
GO:0019941modification-dependent protein catabolic process-IDA19182791  
GO:0031398positive regulation of protein ubiquitination-IEA-  
GO:0031648protein destabilization-IEA-  
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process-IEA-  
GO:0051301cell division-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA18172500  
GO:0016605PML body-IDA15467728  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29312643Clinicopathological significance of CHFR methylation in non-small cell lung cancer: a systematic review and meta-analysis. (2017 Dec 12)Wang COncotarget
20855974Alternative efficacy-predicting markers for paclitaxel instead of CHFR in non-small-cell lung cancer. (2010 Nov 1)Takeshita MCancer Biol Ther
18623126CHFR expression is preferentially impaired in smoking-related squamous cell carcinoma of the lung, and the diminished expression significantly harms outcomes. (2008 Oct 1)Takeshita MInt J Cancer
27110300The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma. (2016)Ma KClin Epigenetics
20473935CHFR hypermethylation and EGFR mutation are mutually exclusive and exhibit contrastive clinical backgrounds and outcomes in non-small cell lung cancer. (2011 Mar 1)Koga TInt J Cancer