Gene: AP5M1

55745
C14orf108|MUDENG|Mu5|MuD
adaptor related protein complex 5 subunit mu 1
protein-coding
14q22.3
Ensembl:ENSG00000053770 MIM:614368 Vega:OTTHUMG00000140318 UniprotKB:Q9H0R1
NC_000014.9
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.479e-1 (AD)  4.362e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10498486chr14:57292674 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs17093036chr14:57267302 (GRCh38.p7)C>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NUDT210.933
KPNA30.931
CRBN0.929
BTF3L40.929
CNOT70.926
VAMP40.924
KPNA40.923
EIF1AX0.922
TAX1BP10.921
ATAD10.921

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.622
OR4F29-0.571
CSAG1-0.292
MTRNR2L6-0.258
MTRNR2L10-0.257
MTRNR2L9-0.25
ADAMTSL5-0.249
ANPEP-0.243
MTRNR2L8-0.232
KLRK1-0.23

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of AP5M1 mRNA"28903501
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AP5M1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AP5M1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of AP5M1 mRNA21420995
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of AP5M1 mRNA24449571
D001280AtrazineAtrazine results in increased expression of AP5M1 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of AP5M1 mRNA22378314
C487081belinostatbelinostat results in increased expression of AP5M1 mRNA26272509
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AP5M1 mRNA"20018196
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of AP5M1 mRNA21453500
D004958EstradiolEstradiol results in decreased expression of AP5M1 mRNA21453500
C006780bisphenol Abisphenol A results in decreased expression of AP5M1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of AP5M1 mRNA27571134
D003042CocaineCocaine affects the expression of AP5M1 mRNA20187946
D016572CyclosporineCyclosporine results in decreased expression of AP5M1 mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of AP5M1 mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of AP5M1 mRNA28302478
C001277geldanamycingeldanamycin results in increased expression of AP5M1 mRNA26705709
C492448ICG 001ICG 001 results in decreased expression of AP5M1 mRNA26191083
C544151jinfukangjinfukang results in decreased expression of AP5M1 mRNA27392435
D007649KetamineKetamine results in decreased expression of AP5M1 mRNA20080153
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AP5M1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of AP5M1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of AP5M1 mRNA"26251327
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of AP5M1 mRNA19710929
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of AP5M1 mRNA21453500
D011794QuercetinQuercetin results in decreased expression of AP5M1 mRNA21632981
D012834SilverSilver results in decreased expression of AP5M1 mRNA27131904
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AP5M1 mRNA24680724
D019772TopotecanAP5M1 protein affects the susceptibility to Topotecan16217747
C012589trichostatin Atrichostatin A results in decreased expression of AP5M1 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of AP5M1 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AP5M1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of AP5M1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of AP5M1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of AP5M1 mRNA23179753|2519280

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0015031protein transport-IEA-  
GO:0016197endosomal transport-IMP22022230  
GO ID GO Term Qualifier Evidence PubMed
GO:0005764lysosome-IDA22022230  
GO:0005765lysosomal membrane-IEA-  
GO:0005770late endosome-IDA22022230  
GO:0005829cytosol-IDA22022230  
GO:0016020membrane-IDA22022230  
GO:0030119AP-type membrane coat adaptor complex-IDA22022230  
GO:0031902late endosome membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal