Gene: CCAR1

55749
-
cell division cycle and apoptosis regulator 1
protein-coding
10q21.3
Ensembl:ENSG00000060339 MIM:612569 Vega:OTTHUMG00000018361 UniprotKB:Q8IX12
NC_000010.11
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.474e-1 (AD)  6.702e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DDX50.909
N4BP2L20.899
THOC20.884
SF3B10.878
ERCC50.874
SRSF110.871
PRPF4B0.87
RBM390.869
UBXN40.869
TTC170.868

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.673
OR4F29-0.654
HES5-0.251
REN-0.19
BTBD17-0.184
CARD17-0.155
RERGL-0.148
KRTAP19-1-0.14
SLC22A6-0.136
OR4F16-0.135

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5691071-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one"1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one binds to CCAR1 protein"21903591
C5691071-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one"1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one inhibits the reaction [CCAR1 protein binds to ANAPC2 protein]"21903591
C5691071-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one"1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in increased expression of CCAR1 protein"21903591|2382612
C5691071-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one"CCAR1 protein affects the reaction [1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in increased activity of CASP3 protein]"21903591
C5691071-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one"CCAR1 protein affects the reaction [1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in increased activity of CASP8 protein]"21903591
C5691071-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one"CCAR1 protein affects the reaction [1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in increased activity of CASP9 protein]"21903591
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of CCAR1 mRNA21983209
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCAR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCAR1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of CCAR1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CCAR1 mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of CCAR1 mRNA21298039
D001104ArbutinArbutin results in increased expression of CCAR1 mRNA17103032
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CCAR1 mRNA22228805
C006780bisphenol Abisphenol A affects the expression of CCAR1 mRNA25181051
D000069286BortezomibBortezomib results in increased expression of CCAR1 protein21594647|2190359
C013418bromfenacoumbromfenacoum results in decreased expression of CCAR1 protein28903499
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CCAR1 mRNA21297351
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CCAR1 mRNA23650126
D002737ChloropreneChloroprene results in increased expression of CCAR1 mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in increased expression of CCAR1 mRNA20350560
D003300Copper[Disulfiram binds to Copper] which results in increased expression of CCAR1 protein24690739
D003300Copper[Disulfiram binds to Copper] which results in increased expression of CCAR1 protein24690739
D003474CurcuminCurcumin results in increased expression of CCAR1 protein21594647
D003474CurcuminCurcumin results in increased expression of CCAR1 protein21594647
D013759DronabinolDronabinol results in increased expression of CCAR1 mRNA16597638
D003907DexamethasoneDexamethasone results in increased expression of CCAR1 mRNA17998272
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CCAR1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CCAR1 mRNA21266533
D002945CisplatinCisplatin results in increased expression of CCAR1 mRNA21151649
C000944dicrotophosdicrotophos results in decreased expression of CCAR1 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of CCAR1 mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of CCAR1 mRNA]19030233
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CCAR1 mRNA19041683
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of CCAR1 protein24690739
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of CCAR1 protein24690739
D004317DoxorubicinDoxorubicin promotes the reaction [CCAR1 protein binds to ANAPC2 protein]21903591
D004317DoxorubicinDoxorubicin results in increased expression of CCAR1 protein23826121
D004640EmetineEmetine inhibits the reaction [sodium arsenite affects the localization of CCAR1 protein]19073175
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CCAR1 protein23301498
C492448ICG 001ICG 001 results in decreased expression of CCAR1 mRNA26191083
C410337K 7174K 7174 results in increased expression of CCAR1 mRNA24086573
C011890kojic acidkojic acid results in increased expression of CCAR1 mRNA16595896
D008713MethimazoleMethimazole results in increased expression of CCAR1 mRNA22504374
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CCAR1 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CCAR1 mRNA"25620056
D015739NocodazoleNocodazole inhibits the reaction [sodium arsenite affects the localization of CCAR1 protein]19073175
D015739NocodazoleNocodazole promotes the reaction [CCAR1 protein binds to ANAPC2 protein]21903591
D015739NocodazoleNocodazole results in increased expression of CCAR1 protein21903591
D017239PaclitaxelPaclitaxel results in increased expression of CCAR1 mRNA18058816
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CCAR1 mRNA26794494
D010634PhenobarbitalPhenobarbital results in decreased expression of CCAR1 mRNA23091169
D011374ProgesteroneProgesterone results in increased expression of CCAR1 mRNA23018184
D011441PropylthiouracilPropylthiouracil results in increased expression of CCAR1 mRNA22504374
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of CCAR1 mRNA]19030233
C017947sodium arseniteEmetine inhibits the reaction [sodium arsenite affects the localization of CCAR1 protein]19073175
C017947sodium arseniteNocodazole inhibits the reaction [sodium arsenite affects the localization of CCAR1 protein]19073175
C017947sodium arsenitesodium arsenite affects the localization of CCAR1 protein19073175
C025462sulindac sulfidesulindac sulfide results in increased expression of CCAR1 mRNA12734198
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CCAR1 mRNA21570461
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CCAR1 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of CCAR1 mRNA28973697
D014415TunicamycinTunicamycin results in increased expression of CCAR1 mRNA17127020
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCAR1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of CCAR1 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CCAR1 gene25560391
C025643vinclozolinvinclozolin affects the expression of CCAR1 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of CCAR1 mRNA18042343
D014750VincristineVincristine results in decreased expression of CCAR1 mRNA23649840
C111237vorinostatvorinostat results in decreased expression of CCAR1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding-IDA24245781  
GO:0003713transcription coactivator activity-IDA24245781  
GO:0003713transcription coactivator activity-IMP23887938  
GO:0003714transcription corepressor activity-IMP23887938  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0005515protein binding-IPI14743216  18157088  20594350  23887938  24245781  25416956  
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity-IGI18722177  
GO ID GO Term Qualifier Evidence PubMed
GO:0000398mRNA splicing, via spliceosome-TAS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0006915apoptotic process-IEA-  
GO:0007049cell cycle-IEA-  
GO:0008284positive regulation of cell proliferation-IMP23887938  
GO:0030335positive regulation of cell migration-IMP23887938  
GO:1903507negative regulation of nucleic acid-templated transcription-IEA-  
GO:1903508positive regulation of nucleic acid-templated transcription-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-72163mRNA Splicing - Major PathwayTAS
R-HSA-72172mRNA SplicingTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24690739Disulfiram suppresses growth of the malignant pleural mesothelioma cells in part by inducing apoptosis. (2014)Cheriyan VTPLoS One