Gene: WDR12

55759
YTM1
WD repeat domain 12
protein-coding
2q33.2
Ensembl:ENSG00000138442 MIM:616620 Vega:OTTHUMG00000132855 UniprotKB:Q9GZL7
NC_000002.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.984e-1 (AD)  5.963e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
G3BP20.963
SLC35B40.96
LMBR10.955
MTMR90.953
DMXL20.953
CHM0.953
SYNJ10.952
SDAD10.951
MYCBP20.95
SEC23A0.948

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.535
HEY2-0.485
MYL3-0.464
STON2-0.461
RAB13-0.46
COPZ2-0.456
ROM1-0.456
RNF135-0.456
FXYD3-0.433
MAGEA12-0.433

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of WDR12 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of WDR12 mRNA"21346803
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of WDR12 mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of WDR12 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of WDR12 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of WDR12 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of WDR12 gene27153756
C006632arsenic trioxidearsenic trioxide results in increased expression of WDR12 mRNA15725085
C044887beta-methylcholinebeta-methylcholine affects the expression of WDR12 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of WDR12 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of WDR12 mRNA25047013
C006780bisphenol Abisphenol A results in increased expression of WDR12 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of WDR12 mRNA28196854
C006780bisphenol Abisphenol A results in increased expression of WDR12 mRNA25181051
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of WDR12 mRNA28472532
D002995Clofibric AcidClofibric Acid affects the expression of WDR12 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of WDR12 mRNA19320972
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of WDR12 mRNA23640034
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of WDR12 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of WDR12 mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of WDR12 mRNA28302478
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of WDR12 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of WDR12 mRNA17555576
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of WDR12 mRNA23649840
D005485FlutamideFlutamide results in increased expression of WDR12 mRNA24136188
D005839GentamicinsGentamicins results in increased expression of WDR12 mRNA22061828
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of WDR12 mRNA20044591
C492448ICG 001ICG 001 results in increased expression of WDR12 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of WDR12 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of WDR12 mRNA26254443
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of WDR12 mRNA25982114
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of WDR12 mRNA21641980
D008628MercuryMercury results in decreased expression of WDR12 mRNA22688007
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of WDR12 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of WDR12 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of WDR12 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of WDR12 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of WDR12 mRNA"25554681
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of WDR12 mRNA17616710
D010634PhenobarbitalPhenobarbital affects the expression of WDR12 mRNA19159669
C006253pirinixic acidpirinixic acid results in increased expression of WDR12 mRNA18301758|1844570
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of WDR12 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of WDR12 mRNA22079256
D011794QuercetinQuercetin results in decreased expression of WDR12 mRNA21632981
C089730rosiglitazonerosiglitazone results in increased expression of WDR12 mRNA25572481
D012834SilverSilver results in decreased expression of WDR12 mRNA27131904
C016104sodium bichromatesodium bichromate results in increased expression of WDR12 mRNA25993096
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of WDR12 mRNA21641980
D013629TamoxifenTamoxifen affects the expression of WDR12 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of WDR12 mRNA20159946
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of WDR12 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of WDR12 mRNA23411599
D014212TretinoinTretinoin results in decreased expression of WDR12 mRNA23724009
D014241TrichloroethyleneTrichloroethylene results in increased methylation of WDR12 gene27618143
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of WDR12 mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of WDR12 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of WDR12 mRNA19101580
D014635Valproic AcidValproic Acid results in decreased methylation of WDR12 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of WDR12 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16043514  16738141  17353269  
GO ID GO Term Qualifier Evidence PubMed
GO:0000460maturation of 5.8S rRNA-IBA21873635  
GO:0000463maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)-IMP16043514  17353269  
GO:0000466maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)-IMP16043514  
GO:0000470maturation of LSU-rRNA-IBA21873635  
GO:0006364rRNA processing-TAS-  
GO:0007219Notch signaling pathway-IEA-  
GO:0008283cell proliferation-IMP16043514  
GO:0042273ribosomal large subunit biogenesis-IC16043514  17353269  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA16043514  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA16043514  
GO:0030687preribosome, large subunit precursor-IBA21873635  
GO:0030687preribosome, large subunit precursor-IDA17353269  
GO:0070545PeBoW complex-IBA21873635  
GO:0070545PeBoW complex-IDA16043514  16738141  17353269  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosolTAS
R-HSA-72312rRNA processingTAS
R-HSA-8868773rRNA processing in the nucleus and cytosolTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22216278Large scale association analysis identifies three susceptibility loci for coronary artery disease. (2011)Saade SPLoS One