Gene: TTC17

55761
-
tetratricopeptide repeat domain 17
protein-coding
11p12-p11.2
Ensembl:ENSG00000052841 Vega:OTTHUMG00000166398 UniprotKB:Q96AE7
NC_000011.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.845e-1 (AD)  5.151e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3816766chr11:43427735 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TNRC6A0.925
DDX170.92
SETDB10.92
PNISR0.919
RBM50.918
FNBP40.918
RBM250.913
NKTR0.913
ASXL10.912
EXOSC100.911

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.62
OR4F29-0.591
KLRC2-0.275
PAGE4-0.186
IAPP-0.18
CNBD2-0.179
PLA2G5-0.174
LHX5-0.171
MTRNR2L6-0.17
OR4F16-0.17

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TTC17 mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TTC17 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TTC17 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TTC17 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of TTC17 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of TTC17 mRNA22230336
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TTC17 mRNA20106945|2163298
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TTC17 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TTC17 mRNA28628672
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of TTC17 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of TTC17 mRNA19549813
D016572CyclosporineCyclosporine affects the expression of TTC17 mRNA25562108
D016572CyclosporineCyclosporine results in decreased methylation of TTC17 promoter27989131
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TTC17 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TTC17 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TTC17 mRNA28628672
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TTC17 mRNA17555576
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TTC17 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of TTC17 mRNA23649840
C039281furanfuran results in decreased expression of TTC17 mRNA25539665
D005839GentamicinsGentamicins results in increased expression of TTC17 mRNA22061828
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of TTC17 mRNA26846883
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TTC17 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TTC17 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TTC17 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TTC17 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TTC17 mRNA28628672
C045463leflunomideleflunomide results in increased expression of TTC17 mRNA24136188
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TTC17 mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in increased expression of TTC17 mRNA29191790
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of TTC17 mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of TTC17 mRNA20971185
D011794QuercetinQuercetin results in increased expression of TTC17 mRNA21632981
D012643SeleniumSelenium results in decreased expression of TTC17 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in decreased expression of TTC17 mRNA25351596
C017947sodium arsenitesodium arsenite results in decreased expression of TTC17 mRNA28595984
D012999SomanSoman results in increased expression of TTC17 mRNA19281266
D013629TamoxifenTamoxifen affects the expression of TTC17 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TTC17 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TTC17 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TTC17 mRNA18796159
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TTC17 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of TTC17 protein24648495
C012589trichostatin Atrichostatin A results in increased expression of TTC17 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TTC17 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TTC17 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of TTC17 mRNA23179753|2438349
C025643vinclozolinvinclozolin results in decreased expression of TTC17 mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of TTC17 mRNA23034163
D014810Vitamin EVitamin E results in decreased expression of TTC17 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI24475127  
GO ID GO Term Qualifier Evidence PubMed
GO:0030041actin filament polymerization-IBA21873635  
GO:0030041actin filament polymerization-IMP24475127  
GO:0044782cilium organization-IBA21873635  
GO:0044782cilium organization-IMP24475127  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA24475127  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA24475127  
GO:0015629actin cytoskeleton-IBA21873635  
GO:0015629actin cytoskeleton-IDA24475127  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal