Gene: PRKCA

5578
AAG6|PKC-alpha|PKCA|PRKACA
protein kinase C alpha
protein-coding
17q24.2
Ensembl:ENSG00000154229 MIM:176960 Vega:OTTHUMG00000179533 UniprotKB:P17252
NG_012206.1
PubMed|SNP Mapped
ND|AD
3   
NA (AD)  4.888e-1 (ND)   (Frontal_Cortex)
8.198e-1 (AD)  4.213e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11079657chr17:66435948 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs973753chr17:66432564 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg15212295chr17:64710687PRKCAGene body6.089e-4Alcohol use disorders26763658
cg25909396chr17:64300729PRKCA4.400e-10Tobacco smoking28225026

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAP3K50.873
FAM168A0.858
FMN20.855
ABLIM10.855
ADCY20.854
ARHGEF120.85
ABI10.847
LRP10.844
AHCYL20.843
DCLK20.841

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.705
OR4F29-0.645
OR6C74-0.359
CLEC6A-0.306
CTNNA3-0.29
GADL1-0.281
GNG8-0.28
CETP-0.278
TNFRSF13B-0.277
C17orf112-0.276

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00144Phosphatidyl serineSmall Molecule1446756-47-3Approved|Investigational|NutraceuticalTarget
DB00163Vitamin ESmall Molecule59-02-9Approved|NutraceuticalTarget
DB05013Ingenol MebutateSmall Molecule75567-37-2ApprovedTarget
DB06451AprinocarsenSmall Molecule151879-73-1InvestigationalTarget
DB06595MidostaurinSmall Molecule120685-11-2Approved|InvestigationalTarget
DB06641PerifosineSmall Molecule157716-52-4InvestigationalTarget
DB08846Ellagic AcidSmall Molecule476-66-4InvestigationalTarget
DB14001alpha-Tocopherol succinateSmall Molecule4345-03-3Approved|NutraceuticalTarget
DB14002D-alpha-Tocopherol acetateSmall Molecule58-95-7Approved|NutraceuticalTarget
DB00675TamoxifenSmall Molecule10540-29-1ApprovedTarget
ID Drug Name Action PubMed
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [4-cresol results in increased phosphorylation of PRKCA protein]"22813906
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [4-cresol results in increased activity of PRKCA protein]"23466501
C02970512-deoxyphorbolphenylacetate-20-acetate12-deoxyphorbolphenylacetate-20-acetate affects the localization of PRKCA protein9852137
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of PRKCA mRNA"19162173
C0389831,3-dimethylthiourea"1,3-dimethylthiourea inhibits the reaction [manganese chloride affects the localization of PRKCA protein]"17084486
C0389831,3-dimethylthiourea"1,3-dimethylthiourea inhibits the reaction [zinc chloride affects the localization of and results in increased activity of PRKCA protein]"20800666
C0389831,3-dimethylthiourea"1,3-dimethylthiourea inhibits the reaction [zinc chloride affects the localization of PRKCA protein]"21575692
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"15-hydroxy-5,8,11,13-eicosatetraenoic acid affects the localization of PRKCA protein"15613483
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"15-hydroxy-5,8,11,13-eicosatetraenoic acid promotes the reaction [EGF protein affects the localization of PRKCA protein]"15613483
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"15-hydroxy-5,8,11,13-eicosatetraenoic acid promotes the reaction [HGF protein affects the localization of PRKCA protein]"15613483
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased activity of PRKCA protein"15451026
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"calphostin C inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased activity of PRKCA protein]"15451026
C0602291-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [IL1B protein affects the localization of PRKCA protein]"19281832
C0602291-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione promotes the reaction [Corticosterone results in increased activity of PRKCA protein]"16581232
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of PRKCA protein"26988655|2818902
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [EGF protein affects the localization of PRKCA protein]15613483
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [HGF protein affects the localization of PRKCA protein]15613483
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Corticosterone results in increased activity of PRKCA protein]16581232
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased activity of PRKCA protein"16263226
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of PRKCA protein"16263226
C0340472-cresol2-cresol results in increased expression of PRKCA mRNA21705299
C0340472-cresolSodium Selenite inhibits the reaction [2-cresol results in increased expression of PRKCA mRNA]21705299
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl results in increased activity of PRKCA protein"16263226
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl results in increased expression of PRKCA protein"16263226
C5054173-hydrogenkwadaphnin3-hydrogenkwadaphnin results in increased expression of PRKCA protein21396949
C0888604-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [EGF protein affects the localization of PRKCA protein]"15613483
C0888604-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead acetate results in increased activity of PRKCA protein]"19133285
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein]"20172950
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of PRKCA mRNA"21346803
C0325384-cresol"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [4-cresol results in increased phosphorylation of PRKCA protein]"22813906
C0325384-cresol4-cresol results in increased phosphorylation of and results in increased activity of PRKCA protein23466501
C0325384-cresol4-cresol results in increased phosphorylation of PRKCA protein22813906
C0325384-cresolPRKCA mutant form inhibits the reaction [4-cresol affects the localization of and results in decreased phosphorylation of CTNND1 protein]23466501
C0325384-cresolPRKCA mutant form inhibits the reaction [4-cresol results in decreased phosphorylation of GJA1 protein]22813906
C0325384-cresolPRKCA protein results in increased susceptibility to 4-cresol22813906
C0325384-cresol"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [4-cresol results in increased activity of PRKCA protein]"23466501
C575152(5-formylfuran-2-yl)methyl 4-hydroxy-2-methylenebutanoate(5-formylfuran-2-yl)methyl 4-hydroxy-2-methylenebutanoate inhibits the reaction [glutathionyl 4-hydroxy-2-nonenal conjugate results in increased phosphorylation of PRKCA protein]24021941
C575152(5-formylfuran-2-yl)methyl 4-hydroxy-2-methylenebutanoate"(5-formylfuran-2-yl)methyl 4-hydroxy-2-methylenebutanoate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of PRKCA protein]"24021941
C5805985-OH-BDE-475-OH-BDE-47 results in increased phosphorylation of PRKCA protein26988655
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCA mRNA"27188386
C0582066-chloro-3,5-diaminopyrazine-3-carboxamide"6-chloro-3,5-diaminopyrazine-3-carboxamide results in decreased expression of PRKCA protein"12225976
C5805996-OH-BDE-476-OH-BDE-47 results in increased phosphorylation of PRKCA protein26988655
C0548527-hydroxystaurosporine7-hydroxystaurosporine results in decreased activity of PRKCA protein10998351
D000082AcetaminophenAcetaminophen results in decreased expression of PRKCA mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of PRKCA mRNA25704631|2906747
D000255Adenosine Triphosphate[[Adenosine Triphosphate co-treated with PRKCA protein] results in increased phosphorylation of RALBP1 protein] which results in increased transport of Doxorubicin16087181
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PRKCA mRNA21641981
C096920AGN 193109AGN 193109 inhibits the reaction [Tretinoin results in increased expression of PRKCA mRNA]16505366
D000450AldosteroneAldosterone results in decreased expression of PRKCA protein12225976
D017962alpha-Linolenic Acidalpha-Linolenic Acid affects the localization of PRKCA protein23285216
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PRKCA mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in decreased expression of PRKCA protein16483693
D000661AmphetamineAmphetamine results in increased expression of PRKCA mRNA16101753
D000661AmphetaminePRKCA protein promotes the reaction [Amphetamine results in decreased expression of NPY mRNA]16101753
D000661AmphetaminePRKCA protein results in increased susceptibility to Amphetamine16101753
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PRKCA mRNA24449571
C028617aroclor 1248aroclor 1248 results in increased activity of PRKCA protein16263226
C028617aroclor 1248aroclor 1248 results in increased expression of PRKCA protein16263226
C028617aroclor 1248aroclor 1248 results in increased transport of PRKCA protein16263226
D001151ArsenicArsenic affects the methylation of PRKCA gene25304211
C006632arsenic trioxidePRKCA mRNA affects the susceptibility to arsenic trioxide23911876
C006632arsenic trioxidearsenic trioxide results in decreased expression of PRKCA mRNA24831965
C006632arsenic trioxidearsenic trioxide promotes the reaction [Berberine results in decreased activity of PRKCA protein]18294404
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased activity of PRKCA protein"12626342
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of PRKCA protein"12626342
D001280AtrazineAtrazine results in decreased expression of PRKCA mRNA25929836
D001280AtrazineAtrazine results in increased expression of PRKCA mRNA18585445
D001397AzoxymethaneAzoxymethane results in increased expression of PRKCA mRNA11983831
C006680baicaleinbaicalein results in decreased phosphorylation of PRKCA protein21803068
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PRKCA mRNA16269432|2006483
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PRKCA mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PRKCA mRNA"19150397|2623829
D001599Berberinearsenic trioxide promotes the reaction [Berberine results in decreased activity of PRKCA protein]18294404
D001599BerberineBerberine results in decreased activity of and affects the localization of PRKCA protein18294404
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PRKCA mRNA19619570
D004958EstradiolEstradiol results in decreased activity of PRKCA protein8946564
D004958EstradiolEstradiol results in increased expression of PRKCA mRNA19619570
D004958EstradiolEstradiol results in increased phosphorylation of PRKCA protein23000059
D004958EstradiolRICTOR mutant form inhibits the reaction [Estradiol results in increased phosphorylation of PRKCA protein]23000059
D004958EstradiolSirolimus inhibits the reaction [Estradiol results in increased phosphorylation of PRKCA protein]23000059
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of PRKCA mRNA26496021
C044887beta-methylcholinebeta-methylcholine affects the expression of PRKCA mRNA21179406
C477843bicyclolbicyclol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PRKCA mRNA]17106253
C477843bicyclolbicyclol inhibits the reaction [Diethylnitrosamine results in increased expression of PRKCA mRNA]17106253
D001647Bile Acids and SaltsBile Acids and Salts promotes the reaction [PRKCA protein results in increased phosphorylation of ABCB11 protein]11343252
C088060bisindolylmaleimidebisindolylmaleimide inhibits the reaction [Capsaicin results in increased expression of PRKCA protein]21474332
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein]20172950
D017298BisoprololBisoprolol results in decreased expression of PRKCA protein20668454
C006780bisphenol Abisphenol A results in increased phosphorylation of PRKCA protein22564983
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of PRKCA mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of PRKCA mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of PRKCA mRNA29097150
C006780bisphenol A[Phytochemicals co-treated with bisphenol A] affects the expression of PRKCA20136622
D000068438Brimonidine TartrateBrimonidine Tartrate affects the localization of PRKCA protein12388232
D000068438Brimonidine TartrateNitric Oxide deficiency promotes the reaction [Brimonidine Tartrate affects the localization of PRKCA protein]12388232
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PRKCA mRNA22079614
C046785bryostatin 1[bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCA protein8892972
C046785bryostatin 1bryostatin 1 results in decreased expression of PRKCA protein8892972
D0200011-Butanol[1-Butanol inhibits the reaction [PRKCA protein binds to PLD1 protein]] which results in decreased activity of PLD1 protein15652502
D0200011-Butanol1-Butanol inhibits the reaction [Thapsigargin results in increased localization of PRKCA protein]15843515
D019328Buthionine SulfoximineButhionine Sulfoximine results in decreased activity of PRKCA protein11118818
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in decreased expression of PRKCA protein7716780
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of PRKCA mRNA15336504
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the localization of PRKCA protein16716901
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased activity of PRKCA protein16716901
D002101Cacodylic AcidCacodylic Acid results in increased expression of PRKCA mRNA17481689
D002104CadmiumCadmium results in decreased expression of PRKCA protein25981801
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PRKCA protein25981801
D002118CalciumPRKCA protein results in increased susceptibility to Calcium12388232
D002118Calcium[Tretinoin co-treated with Calcium] results in increased activity of PRKCA protein16114872
C058819calphostin Ccalphostin C inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of PRKCA protein]19121332
C058819calphostin Ccalphostin C inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein]16091123
C058819calphostin C"calphostin C inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased activity of PRKCA protein]"15451026
C058819calphostin Ccalphostin C inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]16343552
C058819calphostin Ccalphostin C inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCA protein]]18652891
C058819calphostin Ccalphostin C inhibits the reaction [Heptachlor affects the localization of PRKCA protein]14678745
C058819calphostin Ccalphostin C inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]14678745
D002211Capsaicinbisindolylmaleimide inhibits the reaction [Capsaicin results in increased expression of PRKCA protein]21474332
D002211CapsaicinCapsaicin results in increased expression of PRKCA protein21474332
D002211CapsaicinCapsaicin results in increased expression of PRKCA mRNA18752301
D002211CapsaicinCapsaicin results in increased expression of PRKCA protein18752301
D002211Capsaicinchelerythrine inhibits the reaction [Capsaicin results in increased expression of PRKCA protein]18752301
D002211Capsaiciniodoresiniferatoxin inhibits the reaction [Capsaicin results in increased expression of PRKCA protein]18752301
D002220CarbamazepineCarbamazepine affects the expression of PRKCA mRNA24752500
C043211carvedilolcarvedilol results in decreased expression of PRKCA protein20668454
D002518CeramidesCeramides affects the localization of PRKCA protein10444459
D002518CeramidesVIP protein inhibits the reaction [Ceramides affects the localization of PRKCA protein]10444459
C016299chelerythrinechelerythrine inhibits the reaction [Capsaicin results in increased expression of PRKCA protein]18752301
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) affects the localization of PRKCA protein15475174
D004390ChlorpyrifosChlorpyrifos results in decreased expression of PRKCA mRNA18668222
D002793Cholic Acids[Methyltestosterone co-treated with Cholic Acids] affects the expression of PRKCA mRNA27344345
C018021cobaltous chloridecobaltous chloride results in decreased expression of PRKCA mRNA19320972|1937684
C018021cobaltous chloridecobaltous chloride results in increased oxidation of and results in increased activity of PRKCA protein18375950
D003042CocaineCocaine results in decreased expression of PRKCA mRNA18355967
D003042CocaineFOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of PRKCA mRNA]18355967
D003042CocaineCocaine results in increased expression of PRKCA protein12808488
D003300Copper[Thiosemicarbazones binds to Copper] which results in decreased expression of PRKCA protein20931265
D003300CopperCopper deficiency results in decreased expression of PRKCA protein11983831
D003345Corticosterone"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione promotes the reaction [Corticosterone results in increased activity of PRKCA protein]"16581232
D003345Corticosterone2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Corticosterone results in increased activity of PRKCA protein]16581232
D003471CuprizoneCuprizone results in decreased expression of PRKCA mRNA26577399
D003474CurcuminCurcumin analog results in decreased expression of PRKCA mRNA26409325
D003474Curcumin[PRKCA protein results in increased phosphorylation of CFTR protein] promotes the reaction [Curcumin results in increased activity of CFTR protein]17178710
C004742daidzeindaidzein results in increased activity of PRKCA protein16972265
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of PRKCA mRNA24317228
D013759DronabinolDronabinol results in increased expression of PRKCA mRNA18163980
D003840Deoxycholic Acid[gluconic acid co-treated with Deoxycholic Acid] results in increased expression of PRKCA mRNA16556975
D003907DexamethasoneDexamethasone affects the expression of PRKCA mRNA12732289
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PRKCA mRNA17361019|2126653
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of PRKCA mRNA28962523
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of PRKCA mRNA]27392435
D002945CisplatinCisplatin results in decreased expression of PRKCA mRNA19561079|2545074
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of PRKCA mRNA]27392435
D002945Cisplatin[PRKCA protein results in increased phosphorylation of GSTP1 protein] which results in increased metabolism of Cisplatin20654585
D002945Cisplatin[[PRKCA protein results in increased phosphorylation of GSTP1 protein] which results in increased metabolism of Cisplatin] which results in decreased susceptibility to Cisplatin20654585
D004008DiclofenacDiclofenac affects the expression of PRKCA mRNA24752500
C000944dicrotophosdicrotophos results in increased expression of PRKCA mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of PRKCA mRNA18042831
D004052DiethylnitrosamineDiethylnitrosamine results in increased phosphorylation of and results in increased activity of PRKCA protein17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of and results in increased activity of PRKCA protein]17942915
D004052Diethylnitrosaminebicyclol inhibits the reaction [Diethylnitrosamine results in increased expression of PRKCA mRNA]17106253
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PRKCA mRNA17106253
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PRKCA protein28804948
D004052DiethylnitrosaminePlant Extracts inhibits the reaction [Diethylnitrosamine results in increased expression of PRKCA protein]28804948
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of PRKCA17943652
D004075DiglyceridesDiglycerides affects the reaction [Phenylephrine results in increased localization of PRKCA protein]18487437
C039060dihydroartemisinindihydroartemisinin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]20152819
C039060dihydroartemisinindihydroartemisinin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCA protein]20152819
C472511dimethylarsinous aciddimethylarsinous acid results in decreased expression of PRKCA mRNA16507463
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in decreased expression of PRKCA mRNA"26388957
D004202DisinfectantsPRKCA gene SNP affects the susceptibility to Disinfectants27504716
D016291Dizocilpine MaleateDizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]18652891
D004317Doxorubicin[[Adenosine Triphosphate co-treated with PRKCA protein] results in increased phosphorylation of RALBP1 protein] which results in increased transport of Doxorubicin16087181
D004317DoxorubicinPRKCA protein affects the reaction [RALBP1 protein affects the transport of and affects the susceptibility to Doxorubicin]16579994
D004317DoxorubicinDoxorubicin inhibits the reaction [Quercetin results in decreased expression of PRKCA protein]15538571
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of PRKCA mRNA"26539117
D004391DustDust results in increased activity of PRKCA protein23281135
D004391DustVitamin D inhibits the reaction [Dust results in increased activity of PRKCA protein]23281135
D004533Egtazic AcidEgtazic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein]20172950
D004642EmodinEmodin affects the localization of PRKCA protein15133857
D004656EnalaprilEnalapril results in decreased expression of PRKCA protein modified form21565836
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of PRKCA mRNA25198161
C118739entinostatentinostat results in increased expression of PRKCA mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCA mRNA"27188386
C025483estradiol-17 beta-glucuronideestradiol-17 beta-glucuronide affects the localization of PRKCA protein18972403
C025483estradiol-17 beta-glucuronideGo 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of PRKCA protein]18972403
D000431Ethanol[Ethanol results in increased localization of and results in increased activity of PRKCA protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides]10651808
D000431EthanolEthanol inhibits the reaction [Streptozocin results in increased expression of PRKCA protein]12198386
D000431EthanolEthanol results in decreased expression of PRKCA mRNA20655511
D000431Ethanol"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of PRKCA mRNA]"20655511
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PRKCA mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PRKCA mRNA29097150
C049639evodiamineEGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of PRKCA protein]19854188
C049639evodiamineevodiamine results in increased phosphorylation of PRKCA protein19854188
C049639evodiaminetyrphostin AG 1478 inhibits the reaction [evodiamine results in increased phosphorylation of PRKCA protein]19854188
C049347fasudilfasudil results in decreased activity of PRKCA protein17222050
D005411Flame RetardantsFlame Retardants affects the localization of PRKCA protein15475174
D000068298FluticasoneFluticasone results in decreased expression of PRKCA protein15634547
D005707Gallic AcidGallic Acid results in decreased activity of PRKCA protein22387266
D019833GenisteinGenistein results in increased expression of PRKCA mRNA16705744
D019833GenisteinGenistein inhibits the reaction [lead acetate results in increased phosphorylation of PRKCA protein]26797587
C030691gluconic acid[gluconic acid co-treated with Deoxycholic Acid] results in increased expression of PRKCA mRNA16556975
D005947GlucoseGlucose results in increased phosphorylation of PRKCA protein22162761
D005947GlucoseGlucose promotes the reaction [zinc chloride affects the localization of and results in increased activity of PRKCA protein]20800666
C524061glutathionyl 4-hydroxy-2-nonenal conjugate(5-formylfuran-2-yl)methyl 4-hydroxy-2-methylenebutanoate inhibits the reaction [glutathionyl 4-hydroxy-2-nonenal conjugate results in increased phosphorylation of PRKCA protein]24021941
C524061glutathionyl 4-hydroxy-2-nonenal conjugateglutathionyl 4-hydroxy-2-nonenal conjugate results in increased phosphorylation of PRKCA protein24021941
C081021Go 6976Go 6976 inhibits the reaction [isophthalate analog affects the localization of PRKCA protein]23643828
C081021Go 6976Go 6976 results in decreased expression of and results in decreased activity of PRKCA protein16374459
C081021Go 6976Go 6976 results in decreased expression of PRKCA mRNA16374459
C081021Go 6976Go 6976 results in decreased phosphorylation of PRKCA protein19393235
C081021Go 6976Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of PRKCA protein]18972403
C081021Go 6976Go 6976 results in decreased activity of PRKCA protein15767308
D0193071-(5-Isoquinolinesulfonyl)-2-Methylpiperazine1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Heptachlor affects the localization of PRKCA protein]14678745
D0193071-(5-Isoquinolinesulfonyl)-2-Methylpiperazine1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]14678745
D006533Heptachlor1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Heptachlor affects the localization of PRKCA protein]14678745
D006533Heptachlorcalphostin C inhibits the reaction [Heptachlor affects the localization of PRKCA protein]14678745
D006533HeptachlorHeptachlor affects the localization of and results in increased activity of PRKCA protein14678745
D006533HeptachlorStaurosporine inhibits the reaction [Heptachlor affects the localization of PRKCA protein]14678745
D017313FenretinideFenretinide results in decreased expression of PRKCA mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PRKCA mRNA21179406
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PRKCA protein21179406
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of PRKCA protein19699794
D006861Hydrogen PeroxideHydrogen Peroxide results in increased activity of PRKCA protein12626342
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of PRKCA protein12626342
D006861Hydrogen Peroxide[PI103 co-treated with Hydrogen Peroxide] results in decreased expression of PRKCA protein27494022
D006861Hydrogen Peroxide[Quercetin co-treated with Hydrogen Peroxide] results in decreased expression of PRKCA protein27494022
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Vanadates] results in increased phosphorylation of [PLD1 protein binds to PRKCA protein]15150437
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Vanadates] results in increased phosphorylation of PRKCA protein15150437
C078006imidaprilatimidaprilat inhibits the reaction [AGT protein results in increased activity of and results in increased localization of PRKCA protein]16257180
C468130iodoresiniferatoxiniodoresiniferatoxin inhibits the reaction [Capsaicin results in increased expression of PRKCA protein]18752301
C051890irinotecanirinotecan metabolite results in increased phosphorylation of PRKCA protein15723263
C051890irinotecanirinotecan results in increased phosphorylation of PRKCA protein15723263
C059768isophthalateGo 6976 inhibits the reaction [isophthalate analog affects the localization of PRKCA protein]23643828
C059768isophthalateisophthalate analog affects the localization of PRKCA protein23643828
D007545IsoproterenolIsoproterenol results in increased expression of PRKCA mRNA12775975
D007545IsoproterenolIsoproterenol results in increased expression of PRKCA protein12775975
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of PRKCA mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of PRKCA mRNA]27392435
C037642kemptidePRKCA protein results in increased metabolism of kemptide17222050
C063302KN 62KN 62 results in decreased activity of PRKCA protein17222050
D007854LeadLead results in decreased expression of PRKCA protein16547843|2598180
D007854LeadLead results in increased activity of and affects the localization of PRKCA protein19133285
C008261lead acetate"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead acetate results in increased activity of PRKCA protein]"19133285
C008261lead acetateEGFR mutant form inhibits the reaction [lead acetate results in increased activity of PRKCA protein]19133285
C008261lead acetatelead acetate results in decreased expression of PRKCA protein11861786
C008261lead acetate[lead acetate results in decreased expression of PRKCA protein] inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]11861786
C008261lead acetate[lead acetate results in decreased expression of PRKCA protein] inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]11861786
C008261lead acetatelead acetate results in increased activity of and affects the localization of PRKCA protein19133285
C008261lead acetatePRKCA mutant form inhibits the reaction [lead acetate results in increased activity of HRAS protein]19133285
C008261lead acetateSU 6656 inhibits the reaction [lead acetate results in increased activity of PRKCA protein]19133285
C008261lead acetatelead acetate results in increased expression of PRKCA mRNA22609695
C008261lead acetateGenistein inhibits the reaction [lead acetate results in increased phosphorylation of PRKCA protein]26797587
C008261lead acetatelead acetate results in decreased expression of PRKCA protein16547843|2598180
C008261lead acetatelead acetate results in increased phosphorylation of PRKCA protein26797587
C045463leflunomideleflunomide results in increased expression of PRKCA mRNA28988120
C038753leptomycin B[leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of PRKCA mRNA20803015
C002385linsidomine[linsidomine co-treated with Staurosporine] results in decreased expression of PRKCA protein11994256
C002385linsidomineStaurosporine inhibits the reaction [linsidomine results in increased phosphorylation of PRKCA protein]11994256
C482199lipopolysaccharide, E coli O55-B5"(5-formylfuran-2-yl)methyl 4-hydroxy-2-methylenebutanoate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of PRKCA protein]"24021941
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of PRKCA protein"24021941
D008070LipopolysaccharidesLipopolysaccharides affects the localization of and results in increased activity of PRKCA protein16330529
D008070LipopolysaccharidesPRKCA promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]22102721
D008094LithiumPRKCA gene mutant form inhibits the reaction [Lithium results in decreased expression of AQP2 protein]25006961
D008094LithiumPRKCA gene mutant form inhibits the reaction [Lithium results in decreased expression of SLC14A2 protein]25006961
D008094LithiumPRKCA gene mutant form results in decreased susceptibility to Lithium25006961
D008094LithiumPRKCA gene results in increased susceptibility to Lithium25006961
D008345ManganeseManganese results in decreased expression of PRKCA protein25981801
D008345ManganeseManganese results in increased phosphorylation of PRKCA protein21812036
C025340manganese chloride"1,3-dimethylthiourea inhibits the reaction [manganese chloride affects the localization of PRKCA protein]"17084486
C025340manganese chloridemanganese chloride affects the localization of PRKCA protein17084486
C025340manganese chloridemanganese chloride results in decreased expression of PRKCA protein25981801
C025340manganese chloridemanganese chloride results in increased activity of PRKCA protein17084486
C025340manganese chlorideReactive Oxygen Species affects the reaction [manganese chloride results in increased activity of PRKCA protein]17084486
D008628MercuryMercury results in increased expression of PRKCA mRNA12730625
D008687MetforminMetformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCA protein]20590612
D008727MethotrexatePRKCA mRNA results in decreased susceptibility to Methotrexate18694510
D008731MethoxychlorMethoxychlor results in decreased expression of PRKCA mRNA23303685
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium affects the expression of PRKCA mRNA12710931
C008493methylselenic acidmethylselenic acid results in increased expression of PRKCA mRNA12517777
D008777Methyltestosterone[Methyltestosterone co-treated with Cholic Acids] affects the expression of PRKCA mRNA27344345
D015741MetriboloneMetribolone promotes the reaction [EZR protein binds to PRKCA protein]16873375
D015741MetribolonePRKCA protein affects the reaction [Metribolone results in increased phosphorylation of EZR protein]16873375
C011309mezerein[bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCA protein8892972
D008803MianserinMianserin results in decreased expression of PRKCA mRNA24154490
C059539midostaurinmidostaurin results in decreased activity of PRKCA protein15542774
D015735MifepristoneMifepristone binds to and results in decreased activity of PRKCA protein16581232
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of PRKCA mRNA22401849
C020300monomethylarsonic acidmonomethylarsonic acid results in increased expression of PRKCA mRNA17481689
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of PRKCA mRNA16507463
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of PRKCA mRNA20886546
D009020MorphineDizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]18652891
D009020MorphineHINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]18652891
D009020MorphineMorphine promotes the reaction [OPRM1 protein binds to PRKCA protein]18652891
D009173Mycophenolic AcidMycophenolic Acid results in increased expression of PRKCA protein21396949
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased activity of PRKCA protein16361081
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased activity of PRKCA protein17222050
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PRKCA mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PRKCA mRNA"25554681|2562005
C005273naringeninnaringenin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]25866363
D009532NickelNickel results in increased expression of PRKCA mRNA24768652|2558310
C022838nickel chloridenickel chloride results in increased expression of PRKCA mRNA17312168
D009538NicotineNicotine results in increased activity of PRKCA protein12421819
D009538NicotineNicotine results in increased expression of PRKCA mRNA20426880
D009569Nitric OxideNitric Oxide deficiency promotes the reaction [Brimonidine Tartrate affects the localization of PRKCA protein]12388232
D026423S-Nitroso-N-AcetylpenicillamineS-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCA protein]18652891
C520612N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of PRKCA mRNA]"20655511
C464660obeticholic acidobeticholic acid results in increased expression of PRKCA mRNA27939613
C025589ochratoxin Aochratoxin A results in decreased expression of PRKCA mRNA12700408
D019301Oleic AcidOleic Acid affects the localization of PRKCA protein23285216
D000073878Palm OilPalm Oil results in decreased expression of PRKCA mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCA mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PRKCA mRNA26272509
C084656paricalcitolparicalcitol inhibits the reaction [EDN1 protein results in increased expression of PRKCA protein modified form]21565836
C084656paricalcitolparicalcitol inhibits the reaction [Phenylephrine results in increased expression of PRKCA protein modified form]21565836
C084656paricalcitolparicalcitol results in decreased expression of PRKCA protein modified form21565836
D052638Particulate MatterParticulate Matter results in increased expression of PRKCA mRNA24769257
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of PRKCA mRNA18593933
C086401pentabromodiphenyl etherpentabromodiphenyl ether affects the localization of PRKCA protein15475174
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of PRKCA mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PRKCA protein19945530
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of PRKCA mRNA19429403
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased phosphorylation of and results in decreased expression of PRKCA protein26456889
D010634PhenobarbitalPhenobarbital affects the expression of PRKCA mRNA19136022
D010656PhenylephrineDGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCA protein]18487437
D010656PhenylephrineDiglycerides affects the reaction [Phenylephrine results in increased localization of PRKCA protein]18487437
D010656PhenylephrinePhenylephrine results in increased localization of PRKCA protein18487437
D010656PhenylephrineGLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCA protein]16809552
D010656Phenylephrineparicalcitol inhibits the reaction [Phenylephrine results in increased expression of PRKCA protein modified form]21565836
D010656PhenylephrinePhenylephrine results in increased activity of PRKCA protein12435817
D010656PhenylephrinePhenylephrine results in increased expression of PRKCA protein modified form21565836
D010656PhenylephrinePhenylephrine results in increased phosphorylation of and results in increased activity of PRKCA protein16809552
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCA mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PRKCA mRNA26272509
D015240Phorbol 12,13-Dibutyrate"Phorbol 12,13-Dibutyrate results in decreased expression of PRKCA protein"17171646
D015240Phorbol 12,13-Dibutyrate"Phorbol 12,13-Dibutyrate results in increased expression of PRKCA protein"12626342
D010703Phorbol EstersPhorbol Esters promotes the reaction [PRKCA protein results in increased phosphorylation of ABCB11 protein]11343252
D010703Phorbol EstersPhorbol Esters affects the localization of and results in increased activity of PRKCA protein14679204
D010718Phosphatidylserines[Tretinoin co-treated with Phosphatidylserines] results in decreased activity of PRKCA protein16114872
D064209Phytochemicals[Phytochemicals co-treated with bisphenol A] affects the expression of PRKCA20136622
C522973PI103[PI103 co-treated with Hydrogen Peroxide] results in decreased expression of PRKCA protein27494022
C008922piperinepiperine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and affects the localization of PRKCA protein]21354279
C006253pirinixic acidpirinixic acid affects the expression of PRKCA mRNA19136022
C006253pirinixic acidpirinixic acid results in increased expression of PRKCA mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of PRKCA mRNA12832660
D010936Plant ExtractsPlant Extracts inhibits the reaction [Diethylnitrosamine results in increased expression of PRKCA protein]28804948
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of PRKCA mRNA21334430
D011280PregnanolonePregnanolone results in decreased expression of PRKCA protein16581232
C479580procyanidin B2procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of PRKCA protein]25199697
D011374ProgesteronePRKCA protein promotes the reaction [[Tetradecanoylphorbol Acetate results in increased expression of and results in increased phosphorylation of STAR protein] which results in increased abundance of Progesterone]21047949
D011374ProgesteroneProgesterone inhibits the reaction [C3 protein results in increased phosphorylation of PRKCA protein]18615583
D011374ProgesteroneProgesterone results in decreased phosphorylation of PRKCA protein18615583
D011433PropranololPropranolol results in decreased expression of PRKCA protein20668454
D011441PropylthiouracilPropylthiouracil results in decreased expression of PRKCA mRNA24780913
D019269Phosphatidylinositol 4,5-Diphosphate"[Tretinoin co-treated with Phosphatidylinositol 4,5-Diphosphate] results in decreased activity of PRKCA protein"16114872
D011794QuercetinQuercetin results in decreased expression of PRKCA protein26311153
D011794QuercetinDoxorubicin inhibits the reaction [Quercetin results in decreased expression of PRKCA protein]15538571
D011794Quercetin[Quercetin co-treated with Hydrogen Peroxide] results in decreased expression of PRKCA protein27494022
D011794QuercetinQuercetin results in decreased expression of PRKCA24275163
D011794QuercetinQuercetin results in decreased expression of PRKCA mRNA26076811
D011794QuercetinQuercetin results in decreased expression of PRKCA protein15538571|2607681
D017382Reactive Oxygen SpeciesReactive Oxygen Species affects the reaction [manganese chloride results in increased activity of PRKCA protein]17084486
C059514resveratrolresveratrol analog affects the localization of PRKCA protein23285216
C059514resveratrolresveratrol analog inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]23285216
C059514resveratrolresveratrol analog results in decreased expression of PRKCA protein23285216
C059514resveratrolresveratrol analog results in increased activity of PRKCA protein23285216
C059514resveratrolresveratrol analog results in increased expression of PRKCA protein23285216
C059514resveratrolPRKCA protein affects the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein]]15542774
C059514resveratrolPRKCA protein affects the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK3 protein]]15542774
C059514resveratrolPRKCA protein affects the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]]15542774
C059514resveratrolresveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of and results in increased phosphorylation of and results in increased activity of PRKCA protein]14739659
C059514resveratrolresveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCA protein]24672638
C059514resveratrolresveratrol results in decreased activity of PRKCA protein11709203
C059514resveratrolresveratrol results in decreased expression of PRKCA protein25505154
C059514resveratrolresveratrol inhibits the reaction [PRKCA protein results in increased expression of PTGS2 mRNA]9705326
C013672riddelliineriddelliine results in increased expression of PRKCA mRNA18047727
D019438RitonavirRitonavir binds to and affects the localization of PRKCA protein22020176
D019438RitonavirRitonavir results in increased activity of PRKCA protein22020176
D019438RitonavirRitonavir results in increased expression of PRKCA protein22020176
C089730rosiglitazonerosiglitazone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]20032081
C089730rosiglitazonerosiglitazone inhibits the reaction [VEGFA protein affects the localization of PRKCA protein]20032081
C085746rottlerinrottlerin results in decreased activity of PRKCA protein17222050
C099154ruboxistaurinPRKCA affects the susceptibility to ruboxistaurin19556521
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PRKCA mRNA23221170
D020123SirolimusSirolimus inhibits the reaction [Estradiol results in increased phosphorylation of PRKCA protein]23000059
D012906SmokeSmoke analog results in increased activity of and affects the localization of PRKCA protein19394402
D012906SmokeSmoke results in increased expression of PRKCA mRNA21095227
C017947sodium arsenitesodium arsenite results in decreased expression of PRKCA mRNA16507463
C017947sodium arsenitesodium arsenite results in increased expression of PRKCA mRNA12016162
D012965Sodium ChlorideSodium Chloride results in increased expression of PRKCA mRNA23634900
D018038Sodium SeleniteSodium Selenite inhibits the reaction [2-cresol results in increased expression of PRKCA mRNA]21705299
C471405sorafenibsorafenib results in decreased expression of PRKCA mRNA26409325
D019311StaurosporineStaurosporine affects the localization of and affects the activity of PRKCA protein16225760
D019311Staurosporine[linsidomine co-treated with Staurosporine] results in decreased expression of PRKCA protein11994256
D019311StaurosporineStaurosporine inhibits the reaction [Heptachlor affects the localization of PRKCA protein]14678745
D019311StaurosporineStaurosporine inhibits the reaction [linsidomine results in increased phosphorylation of PRKCA protein]11994256
D019311StaurosporineStaurosporine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]14678745
D013311StreptozocinEthanol inhibits the reaction [Streptozocin results in increased expression of PRKCA protein]12198386
D013311Streptozocinprocyanidin B2 inhibits the reaction [Streptozocin results in increased expression of PRKCA protein]25199697
D013311StreptozocinStreptozocin results in increased expression of PRKCA protein12198386|2519969
C416927SU 6656SU 6656 inhibits the reaction [lead acetate results in increased activity of PRKCA protein]19133285
C016766sulforafansulforafan results in increased expression of PRKCA mRNA26833863
D013481Superoxides[Ethanol results in increased localization of and results in increased activity of PRKCA protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides]10651808
D013629TamoxifenTamoxifen affects the expression of PRKCA mRNA17555576
D013629TamoxifenTamoxifen results in decreased phosphorylation of PRKCA protein19393235
D013654TaurineTaurine results in decreased expression of PRKCA protein18822960
D020002tert-Butyl Alcoholtert-Butyl Alcohol inhibits the reaction [Thapsigargin results in increased localization of PRKCA protein]15843515
D013739TestosteroneTestosterone inhibits the reaction [C3 protein results in increased phosphorylation of PRKCA protein]18615583
D013739TestosteroneTestosterone results in decreased phosphorylation of PRKCA protein18615583
C004648testosterone enanthatetestosterone enanthate results in decreased expression of PRKCA mRNA25603467
C010792testosterone undecanoatetestosterone undecanoate results in increased expression of PRKCA mRNA19074003
D013749Tetrachlorodibenzodioxincalphostin C inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of PRKCA protein]19121332
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PRKCA mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the activity of PRKCA protein8946564
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the localization of PRKCA protein19121332
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PRKCA mRNA19619570|1968428
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PRKCA mRNA12377990|1968428
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of PRKCA protein19121332
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRKCA mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PRKCA17943652
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which affects the localization of PRKCA protein15761253
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased localization of PRKCA protein17222441
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of PRKCA mRNA28973375
C117155tetracycline CMT-3tetracycline CMT-3 results in decreased activity of PRKCA protein16134060
D013755Tetradecanoylphorbol Acetateresveratrol analog inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]23285216
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate affects the localization of PRKCA protein23285216
D013755Tetradecanoylphorbol Acetatecalphostin C inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein]16091123
D013755Tetradecanoylphorbol Acetatedihydroartemisinin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]20152819
D013755Tetradecanoylphorbol Acetatedihydroartemisinin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCA protein]20152819
D013755Tetradecanoylphorbol Acetate[Ethanol results in increased localization of and results in increased activity of PRKCA protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides]10651808
D013755Tetradecanoylphorbol AcetateMetformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCA protein]20590612
D013755Tetradecanoylphorbol Acetatenaringenin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]25866363
D013755Tetradecanoylphorbol Acetatepiperine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and affects the localization of PRKCA protein]21354279
D013755Tetradecanoylphorbol AcetatePRKCA protein affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 mRNA]21705328
D013755Tetradecanoylphorbol Acetateresveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of and results in increased phosphorylation of and results in increased activity of PRKCA protein]14739659
D013755Tetradecanoylphorbol Acetateresveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCA protein]24672638
D013755Tetradecanoylphorbol Acetaterosiglitazone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]20032081
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate affects the localization of and results in increased activity of PRKCA protein15978937|1609112
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate affects the localization of PRKCA protein15976015|1944785
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of PRKCA protein15330761|1717164
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased phosphorylation of PRKCA protein15380616
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased activity of and affects the localization of PRKCA protein19394402
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased activity of PRKCA protein21705328
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein] which results in increased expression of SOD221705328
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of PRKCA protein modified form16532021
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased localization of and results in increased phosphorylation of and results in increased activity of PRKCA protein14739659
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased phosphorylation of and affects the localization of PRKCA protein21354279
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased phosphorylation of PRKCA protein20152819|2059061
D013755Tetradecanoylphorbol Acetate"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein]"20172950
D013755Tetradecanoylphorbol Acetatebicyclol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PRKCA mRNA]17106253
D013755Tetradecanoylphorbol Acetatebisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein]20172950
D013755Tetradecanoylphorbol Acetatecalphostin C inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]16343552
D013755Tetradecanoylphorbol AcetateEgtazic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein]20172950
D013755Tetradecanoylphorbol AcetatePRKCA protein promotes the reaction [[Tetradecanoylphorbol Acetate results in increased expression of and results in increased phosphorylation of STAR protein] which results in increased abundance of Progesterone]21047949
D013755Tetradecanoylphorbol AcetatePRKCA protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAR mRNA]21047949
D013755Tetradecanoylphorbol AcetatePRKCA protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAR protein]21047949
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate affects the localization of PRKCA protein16343552
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate binds to and affects the localization of PRKCA protein22020176
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased activity of and results in increased localization of PRKCA protein16099101
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased activity of PRKCA protein20172950
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of and results in increased phosphorylation of PRKCA protein21047949
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of PRKCA mRNA17106253
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased localization of PRKCA protein10656618
D013755Tetradecanoylphorbol AcetateTGFB1 affects the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein]20172950
D013755Tetradecanoylphorbol AcetateTGFB1 promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCA protein]20172950
D013755Tetradecanoylphorbol Acetate1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]14678745
D013755Tetradecanoylphorbol Acetatecalphostin C inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]14678745
D013755Tetradecanoylphorbol AcetateStaurosporine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]14678745
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate affects the localization of and results in increased activity of PRKCA protein12590138
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate affects the localization of PRKCA protein12720544|1467874
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of PRKCA protein12590138
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased localization of PRKCA protein15843515
C014215tetrahydropalmatinetetrahydropalmatine results in decreased expression of PRKCA protein20109541
D019284ThapsigarginThapsigargin results in decreased expression of PRKCA mRNA22378314
D019284ThapsigarginThapsigargin results in increased expression of PRKCA protein24648495
D019284Thapsigargin1-Butanol inhibits the reaction [Thapsigargin results in increased localization of PRKCA protein]15843515
D019284Thapsigargintert-Butyl Alcohol inhibits the reaction [Thapsigargin results in increased localization of PRKCA protein]15843515
D019284ThapsigarginThapsigargin results in increased localization of PRKCA protein15843515
D013806TheophyllineTheophylline results in decreased expression of PRKCA mRNA16083514
D013853ThioacetamideThioacetamide results in increased expression of PRKCA mRNA23411599
D013882Thiosemicarbazones[Thiosemicarbazones binds to Copper] which results in decreased expression of PRKCA protein20931265
D013893ThiramThiram results in decreased activity of PRKCA protein15998240
C080287thymeleatoxinthymeleatoxin affects the localization of PRKCA protein9852137
C080287thymeleatoxinthymeleatoxin affects the localization of PRKCA protein14679204
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PRKCA protein20215583
D014212TretinoinPRKCA protein affects the reaction [Tretinoin results in increased activity of STS protein]16178010
D014212TretinoinTretinoin results in increased phosphorylation of PRKCA protein19476501
D014212TretinoinAGN 193109 inhibits the reaction [Tretinoin results in increased expression of PRKCA mRNA]16505366
D014212TretinoinTretinoin results in increased expression of PRKCA mRNA11851873|1650536
D014212TretinoinTretinoin results in increased expression of PRKCA protein11851873
D014212TretinoinTretinoin results in increased phosphorylation of PRKCA protein19476501
D014212Tretinoin[Tretinoin co-treated with Calcium] results in increased activity of PRKCA protein16114872
D014212Tretinoin"[Tretinoin co-treated with Phosphatidylinositol 4,5-Diphosphate] results in decreased activity of PRKCA protein"16114872
D014212Tretinoin[Tretinoin co-treated with Phosphatidylserines] results in decreased activity of PRKCA protein16114872
C011559tributyltintributyltin results in decreased expression of PRKCA mRNA27678064
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCA mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of PRKCA mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of PRKCA mRNA19042947
C052920trimethylarsine oxidetrimethylarsine oxide results in increased expression of PRKCA mRNA17481689
D014415TunicamycinTunicamycin results in increased expression of PRKCA mRNA17127020
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [evodiamine results in increased phosphorylation of PRKCA protein]19854188
D014520UrethaneUrethane results in increased expression of PRKCA mRNA28818685
D014520UrethaneIFNG protein inhibits the reaction [Urethane results in decreased expression of PRKCA mRNA]11091364
D014520UrethaneUrethane results in decreased expression of PRKCA mRNA11091364
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCA mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PRKCA mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PRKCA mRNA25192806
D014635Valproic AcidValproic Acid results in increased expression of PRKCA mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in increased methylation of PRKCA gene29154799
D014635Valproic AcidValproic Acid affects the expression of PRKCA mRNA17963808
D014635Valproic AcidValproic Acid results in decreased expression of PRKCA protein15249158
D014638VanadatesVanadates results in increased expression of PRKCA mRNA22714537
D014638Vanadates[Hydrogen Peroxide co-treated with Vanadates] results in increased phosphorylation of [PLD1 protein binds to PRKCA protein]15150437
D014638Vanadates[Hydrogen Peroxide co-treated with Vanadates] results in increased phosphorylation of PRKCA protein15150437
D014638VanadatesVanadates promotes the reaction [zinc chloride affects the localization of PRKCA protein]21575692
D014639VanadiumPRKCA protein affects the reaction [Vanadium results in increased phosphorylation of and results in increased activity of AKT1 protein]14971662
D014639VanadiumPRKCA protein affects the reaction [Vanadium results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]14971662
D014807Vitamin DVitamin D inhibits the reaction [Dust results in increased activity of PRKCA protein]23281135
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCA mRNA"27188386
C111237vorinostatvorinostat results in increased expression of PRKCA mRNA26272509
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of PRKCA mRNA"25198161
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of PRKCA mRNA18593933
D015032Zinccalphostin C inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCA protein]]18652891
D015032ZincZinc promotes the reaction [OPRM1 protein binds to PRKCA protein]18652891
C016837zinc chloride"1,3-dimethylthiourea inhibits the reaction [zinc chloride affects the localization of and results in increased activity of PRKCA protein]"20800666
C016837zinc chloride"1,3-dimethylthiourea inhibits the reaction [zinc chloride affects the localization of PRKCA protein]"21575692
C016837zinc chlorideGlucose promotes the reaction [zinc chloride affects the localization of and results in increased activity of PRKCA protein]20800666
C016837zinc chlorideVanadates promotes the reaction [zinc chloride affects the localization of PRKCA protein]21575692
C016837zinc chloridezinc chloride affects the localization of and results in increased activity of PRKCA protein20800666
C016837zinc chloridezinc chloride affects the localization of PRKCA protein21575692

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IDA10770950  
GO:0004674protein serine/threonine kinase activity-EXP7520444  7539802  12391145  17392515  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0004697protein kinase C activity-ISS-  
GO:0004697protein kinase C activity-TAS-  
GO:0004698calcium-dependent protein kinase C activity-TAS-  
GO:0005178integrin binding-ISS-  
GO:0005515protein binding-IPI12571249  12893243  17244820  18566587  21703451  21952047  
24658140  
GO:0005524ATP binding-IEA-  
GO:0008270zinc ion binding-IEA-  
GO:0019899enzyme binding-IDA18556656  
GO:0035403histone kinase activity (H3-T6 specific)-IDA20228790  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0001938positive regulation of endothelial cell proliferation-IMP11909826  
GO:0002159desmosome assembly-IMP18474624  
GO:0006468protein phosphorylation-IDA10770950  
GO:0007077mitotic nuclear envelope disassembly-TAS-  
GO:0007155cell adhesion-IEA-  
GO:0007411axon guidance-TAS-  
GO:0010595positive regulation of endothelial cell migration-IMP11909826  
GO:0010613positive regulation of cardiac muscle hypertrophy-ISS-  
GO:0018105peptidyl-serine phosphorylation-IBA21873635  
GO:0018105peptidyl-serine phosphorylation-TAS26078884  
GO:0018107peptidyl-threonine phosphorylation-ISS16717194  
GO:0030168platelet activation-TAS-  
GO:0030335positive regulation of cell migration-IMP23990668  
GO:0031666positive regulation of lipopolysaccharide-mediated signaling pathway-IMP9830023  
GO:0034351negative regulation of glial cell apoptotic process-IMP9927633  
GO:0035408histone H3-T6 phosphorylation-IDA20228790  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0038128ERBB2 signaling pathway-TAS-  
GO:0043488regulation of mRNA stability-TAS-  
GO:0043536positive regulation of blood vessel endothelial cell migration-IDA20011604  
GO:0045651positive regulation of macrophage differentiation-ISS-  
GO:0045766positive regulation of angiogenesis-IMP11909826  
GO:0045780positive regulation of bone resorption-ISS-  
GO:0045785positive regulation of cell adhesion-IMP11909826  
GO:0045931positive regulation of mitotic cell cycle-IMP10848585  
GO:0050796regulation of insulin secretion-TAS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-ISS-  
GO:0070555response to interleukin-1-IMP19281832  
GO:0090330regulation of platelet aggregation-IDA12724315  
GO:0097190apoptotic signaling pathway-TAS10825394  
GO:0106071positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway-ISS-  
GO:2000707positive regulation of dense core granule biogenesis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA15632189  23990668  
GO:0005739mitochondrion-HDA20833797  
GO:0005783endoplasmic reticulum-IDA18556656  
GO:0005829cytosol-IDA17983652  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA15632189  23990668  
GO:0005886plasma membrane-TAS-  
GO:0031966mitochondrial membrane-IEA-  
GO:0035866alphav-beta3 integrin-PKCalpha complex-ISS-  
GO:0048471perinuclear region of cytoplasm-ISS-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04020Calcium signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa04270Vascular smooth muscle contraction
hsa04310Wnt signaling pathway
hsa04370VEGF signaling pathway
hsa04510Focal adhesion
hsa04530Tight junction
hsa04540Gap junction
hsa04650Natural killer cell mediated cytotoxicity
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04670Leukocyte transendothelial migration
hsa04720Long-term potentiation
hsa04730Long-term depression
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa04960Aldosterone-regulated sodium reabsorption
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa05110Vibrio cholerae infection
hsa05130Pathogenic Escherichia coli infection
hsa05143African trypanosomiasis
hsa05146Amoebiasis
hsa05200Pathways in cancer
hsa05214Glioma
hsa05223Non-small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-111885Opioid SignallingTAS
R-HSA-111933Calmodulin induced eventsTAS
R-HSA-111996Ca-dependent eventsTAS
R-HSA-111997CaM pathwayTAS
R-HSA-112040G-protein mediated eventsTAS
R-HSA-112043PLC beta mediated eventsTAS
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-114516Disinhibition of SNARE formationTAS
R-HSA-1227986Signaling by ERBB2TAS
R-HSA-1250196SHC1 events in ERBB2 signalingTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1430728MetabolismTAS
R-HSA-1433557Signaling by SCF-KITTAS
R-HSA-1433559Regulation of KIT signalingTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1489509DAG and IP3 signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-163685Integration of energy metabolismTAS
R-HSA-1640170Cell CycleTAS
R-HSA-194138Signaling by VEGFTAS
R-HSA-195721Signaling by WNTIEA
R-HSA-195721Signaling by WNTTAS
R-HSA-2179392EGFR Transactivation by GastrinTAS
R-HSA-2187338Visual phototransductionIEA
R-HSA-2514856The phototransduction cascadeIEA
R-HSA-2514859Inactivation, recovery and regulation of the phototransduction cascadeIEA
R-HSA-2980766Nuclear Envelope BreakdownTAS
R-HSA-3000170Syndecan interactionsTAS
R-HSA-3000171Non-integrin membrane-ECM interactionsTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-376176Signaling by ROBO receptorsTAS
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-3858494Beta-catenin independent WNT signalingIEA
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-388396GPCR downstream signallingIEA
R-HSA-399719Trafficking of AMPA receptorsTAS
R-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticityTAS
R-HSA-399997Acetylcholine regulates insulin secretionTAS
R-HSA-4086398Ca2+ pathwayIEA
R-HSA-4086400PCP/CE pathwayTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-416993Trafficking of GluR2-containing AMPA receptorsTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-418594G alpha (i) signalling eventsIEA
R-HSA-418597G alpha (z) signalling eventsIEA
R-HSA-422356Regulation of insulin secretionTAS
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-4419969Depolymerisation of the Nuclear LaminaTAS
R-HSA-4420097VEGFA-VEGFR2 PathwayTAS
R-HSA-450520HuR (ELAVL1) binds and stabilizes mRNATAS
R-HSA-450531Regulation of mRNA stability by proteins that bind AU-rich elementsTAS
R-HSA-5099900WNT5A-dependent internalization of FZD4TAS
R-HSA-5218921VEGFR2 mediated cell proliferationTAS
R-HSA-68875Mitotic ProphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS
R-HSA-881907Gastrin-CREB signalling pathway via PKC and MAPKTAS
R-HSA-8853659RET signalingTAS
R-HSA-8953854Metabolism of RNATAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9010642ROBO receptors bind AKAP5TAS
R-HSA-9010642ROBO receptors bind AKAP5IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28592245In silico identification of potential key regulatory factors in smoking-induced lung cancer. (2017 Jun 7)El-Aarag SABMC Med Genomics
23908141Interaction of polymorphisms in mitotic regulator genes with cigarette smoking and pancreatic cancer risk. (2013 Nov)Jang JHMol Carcinog
25939814CREB-BDNF pathway influences alcohol cue-elicited activation in drinkers. (2015 Aug)Chen JHum Brain Mapp