Gene: PRKCB

5579
PKC-beta|PKCB|PRKCB1|PRKCB2
protein kinase C beta
protein-coding
16p12.2-p12.1
Ensembl:ENSG00000166501 MIM:176970 Vega:OTTHUMG00000131615 UniprotKB:P05771
NG_029003.1
PubMed|SNP Mapped
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.900e-1 (AD)  2.934e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12445719chr16:24202266 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs2238493chr16:24145625 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HLF0.968
KIAA1549L0.966
KIF3C0.964
CREG20.963
ARHGAP440.962
UNC13A0.962
DLGAP10.962
PPP3CB0.961
RBFOX10.961
ITPR10.961

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.561
CSAG1-0.536
RNF135-0.531
WWTR1-0.531
RAB13-0.526
SNHG18-0.524
TFPI2-0.522
FLT3LG-0.519
TGIF1-0.518
HEY2-0.515

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00163Vitamin ESmall Molecule59-02-9Approved|NutraceuticalTarget
DB01738PhosphorylcolamineSmall Molecule1071-23-4ExperimentalTarget
DB06486EnzastaurinSmall Molecule170364-57-5InvestigationalTarget
DB08846Ellagic AcidSmall Molecule476-66-4InvestigationalTarget
DB08862CholecystokininSmall Molecule9011-97-6Approved|InvestigationalTarget
DB14001alpha-Tocopherol succinateSmall Molecule4345-03-3Approved|NutraceuticalTarget
DB14002D-alpha-Tocopherol acetateSmall Molecule58-95-7Approved|NutraceuticalTarget
DB00675TamoxifenSmall Molecule10540-29-1ApprovedTarget
ID Drug Name Action PubMed
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [EGF protein affects the localization of PRKCB protein]"17991733
C02970512-deoxyphorbolphenylacetate-20-acetate12-deoxyphorbolphenylacetate-20-acetate affects the localization of PRKCB protein9852137
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of PRKCB mRNA"19162173
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PRKCB mRNA"21346803
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of PRKCB mRNA"20206263
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of PRKCB protein26194647
C5000673-((5-(6-((3-chlorophenyl)amino)pyrazinyl)-3-pyridinyl)amino)-1-propanol3-((5-(6-((3-chlorophenyl)amino)pyrazinyl)-3-pyridinyl)amino)-1-propanol binds to and results in decreased activity of PRKCB protein15771433
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PRKCB mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRKCB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRKCB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRKCB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCB mRNA"27188386
C4346055,21 - 12,17-dimetheneo-18H-dibenzo(i,o)pyrrolo(3,4-1)(1,8)diazacyclohexandecine-18,10(19H)dione,8((dimethylamino)methyl)-6,7,8,9,10,11-hexahydro,monomethanesulfonate"5,21 - 12,17-dimetheneo-18H-dibenzo(i,o)pyrrolo(3,4-1)(1,8)diazacyclohexandecine-18,10(19H)dione,8((dimethylamino)methyl)-6,7,8,9,10,11-hexahydro,monomethanesulfonate inhibits the reaction [Glucose results in increased expression of PRKCB protein]"16285992
C4346055,21 - 12,17-dimetheneo-18H-dibenzo(i,o)pyrrolo(3,4-1)(1,8)diazacyclohexandecine-18,10(19H)dione,8((dimethylamino)methyl)-6,7,8,9,10,11-hexahydro,monomethanesulfonate"5,21 - 12,17-dimetheneo-18H-dibenzo(i,o)pyrrolo(3,4-1)(1,8)diazacyclohexandecine-18,10(19H)dione,8((dimethylamino)methyl)-6,7,8,9,10,11-hexahydro,monomethanesulfonate inhibits the reaction [Glucose results in increased expression of PRKCB protein alternative form]"16285992
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRKCB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRKCB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRKCB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCB mRNA"27188386
D000079AcetaldehydePRKCB protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde results in increased transport of Inulin]]17991733
D000079AcetaldehydePRKCB protein affects the reaction [EGF protein results in decreased susceptibility to Acetaldehyde]17991733
D000082AcetaminophenAcetaminophen results in increased expression of PRKCB mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of PRKCB mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of PRKCB mRNA15120968
D020106AcrylamideAcrylamide affects the expression of PRKCB mRNA28959563
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of PRKCB mRNA20409345
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of PRKCB protein]16797713
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of PRKCB protein]17222441
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of PRKCB mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PRKCB mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in decreased expression of PRKCB protein16483693
D000661AmphetamineAmphetamine affects the expression of PRKCB mRNA16101753
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PRKCB mRNA24449571
D001151ArsenicArsenic affects the methylation of PRKCB gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of PRKCB mRNA15725085
C006632arsenic trioxidearsenic trioxide results in increased expression of PRKCB mRNA10673743
C006632arsenic trioxidePRKCB mRNA affects the susceptibility to arsenic trioxide23911876
C006632arsenic trioxideTretinoin promotes the reaction [arsenic trioxide results in increased expression of PRKCB mRNA]10673743
C015001arsenitearsenite results in decreased expression of PRKCB mRNA18191166
D001205Ascorbic AcidAscorbic Acid results in increased expression of PRKCB mRNA15305145
D001241AspirinAspirin affects the expression of PRKCB protein17644113
D001241AspirinAspirin inhibits the reaction [Deoxycholic Acid results in increased expression of PRKCB protein]17644113
D001397AzoxymethaneAzoxymethane results in increased phosphorylation of and results in increased activity of PRKCB protein21355597
D001397Azoxymethanepterostilbene inhibits the reaction [Azoxymethane results in increased phosphorylation of and results in increased activity of PRKCB protein]21355597
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of PRKCB mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite results in increased expression of PRKCB mRNA26314263
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PRKCB mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PRKCB mRNA21569818
C090535benzyloxycarbonyl-isoleucyl-glutamyl(O-tert-butyl)-alanyl-leucinalbenzyloxycarbonyl-isoleucyl-glutamyl(O-tert-butyl)-alanyl-leucinal inhibits the reaction [Deoxycholic Acid results in increased expression of PRKCB protein]17644113
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Deoxycholic Acid results in increased expression of PRKCB protein]17644113
D004958EstradiolEstradiol results in decreased expression of PRKCB mRNA20068009
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Glucose results in increased expression of PRKCB protein]16285992
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Glucose results in increased expression of PRKCB protein alternative form]16285992
C006780bisphenol Abisphenol A affects the expression of PRKCB mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of PRKCB mRNA26314263
C046785bryostatin 1[bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein8892972
C046785bryostatin 1[bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein alternative form8892972
C046785bryostatin 1bryostatin 1 results in decreased expression of PRKCB protein8892972
C046785bryostatin 1bryostatin 1 results in decreased expression of PRKCB protein alternative form8892972
D002045Bupivacaine[Bupivacaine co-treated with Tetrodotoxin co-treated with Dexamethasone] results in decreased expression of PRKCB mRNA22341215
D0200011-Butanol1-Butanol affects the localization of PRKCB protein15067001
D0200011-Butanol1-Butanol inhibits the reaction [Thapsigargin results in increased localization of PRKCB protein]15843515
D019328Buthionine SulfoximineButhionine Sulfoximine results in decreased activity of PRKCB protein11118818
C018475butyraldehydebutyraldehyde results in increased expression of PRKCB mRNA26079696
D002087ButyratesButyrates results in increased expression of PRKCB protein15471852
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PRKCB mRNA25993096
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PRKCB protein27389774
D019256Cadmium ChlorideQuercetin inhibits the reaction [Cadmium Chloride results in decreased expression of PRKCB protein]27389774
D002118CalciumCalcium inhibits the reaction [Chlordecone results in increased activity of PRKCB protein]1724372
D002118CalciumCalcium inhibits the reaction [Dicofol results in increased activity of PRKCB protein]1724372
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PRKCB mRNA27339419
D007631ChlordeconeCalcium inhibits the reaction [Chlordecone results in increased activity of PRKCB protein]1724372
D007631ChlordeconeChlordecone results in increased activity of PRKCB protein1724372
D007631ChlordeconePhosphatidylserines promotes the reaction [Chlordecone results in increased activity of PRKCB protein]1724372
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of PRKCB mRNA23650126
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRKCB mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of PRKCB mRNA26272509
D002737ChloropreneChloroprene results in decreased expression of PRKCB mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in increased expression of PRKCB mRNA19368821
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PRKCB20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PRKCB gene20938992
D002794CholineCholine affects the expression of PRKCB mRNA17264169
D002794CholineCholine affects the expression of PRKCB protein17264169
C055162clopidogrelclopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of PRKCB mRNA]19172522
D003024ClozapineClozapine affects the expression of PRKCB protein15967061
D003024ClozapineClozapine results in increased expression of PRKCB mRNA15860345
D060729Coal AshCoal Ash results in decreased expression of PRKCB mRNA19000753
C018021cobaltous chloridecobaltous chloride results in increased oxidation of and results in increased activity of PRKCB protein18375950
D003042CocaineCocaine results in decreased expression of PRKCB mRNA12629581
D003042CocaineCocaine results in increased expression of PRKCB mRNA17898221
D016578Crack CocaineCrack Cocaine results in increased expression of PRKCB mRNA12629581
D003513CycloheximideCycloheximide results in decreased expression of PRKCB mRNA19684285
D003513Cycloheximide[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of PRKCB mRNA19684285
D016572CyclosporineCyclosporine results in increased expression of PRKCB protein22155090
C004742daidzeindaidzein results in increased activity of PRKCB protein16972265
C014347decitabinedecitabine affects the expression of PRKCB mRNA23300844
D003840Deoxycholic AcidAspirin inhibits the reaction [Deoxycholic Acid results in increased expression of PRKCB protein]17644113
D003840Deoxycholic Acidbenzyloxycarbonyl-isoleucyl-glutamyl(O-tert-butyl)-alanyl-leucinal inhibits the reaction [Deoxycholic Acid results in increased expression of PRKCB protein]17644113
D003840Deoxycholic Acidbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Deoxycholic Acid results in increased expression of PRKCB protein]17644113
D003840Deoxycholic AcidDeoxycholic Acid results in increased activity of PRKCB protein7705931
D003840Deoxycholic AcidDeoxycholic Acid results in increased expression of PRKCB protein17644113
D003840Deoxycholic Acidlactacystin inhibits the reaction [Deoxycholic Acid results in increased expression of PRKCB protein]17644113
D003907Dexamethasone[Bupivacaine co-treated with Tetrodotoxin co-treated with Dexamethasone] results in decreased expression of PRKCB mRNA22341215
D002945CisplatinCisplatin affects the expression of PRKCB mRNA23300844
D002945CisplatinCisplatin results in decreased expression of PRKCB mRNA22023808
D004010DicofolCalcium inhibits the reaction [Dicofol results in increased activity of PRKCB protein]1724372
D004010DicofolDicofol results in increased activity of PRKCB protein1724372
D004010DicofolPhosphatidylserines promotes the reaction [Dicofol results in increased activity of PRKCB protein]1724372
D004052DiethylnitrosamineDiethylnitrosamine results in increased phosphorylation of and results in increased activity of PRKCB protein17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of and results in increased activity of PRKCB protein]17942915
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of PRKCB mRNA16636312
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of PRKCB mRNA17005392
D0151279,10-Dimethyl-1,2-benzanthracene"PRKCB protein inhibits the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]"10037446
D0151279,10-Dimethyl-1,2-benzanthracene"PRKCB protein inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]]"10037446
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of PRKCB mRNA25380136
D004137DinitrochlorobenzeneDinitrochlorobenzene affects the localization of PRKCB protein24136171
D004237DiuronDiuron results in increased expression of PRKCB mRNA21551480
C067311docetaxeldocetaxel results in increased phosphorylation of PRKCB protein25634538
C067311docetaxelsotrastaurin inhibits the reaction [docetaxel results in increased phosphorylation of PRKCB protein]25634538
D004317DoxorubicinDoxorubicin results in decreased expression of PRKCB mRNA25896364
D004317DoxorubicinDoxorubicin results in increased phosphorylation of PRKCB protein26318906
C118739entinostatentinostat results in increased expression of PRKCB mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCB mRNA"27188386
D000431Ethanol[Ethanol results in increased localization of and results in increased activity of PRKCB protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides]10651808
D000431EthanolEthanol results in increased expression of and results in increased activity of PRKCB protein22497828
D000431EthanolEthanol results in increased expression of PRKCB protein22497828
D000431EthanolLosartan inhibits the reaction [Ethanol results in increased expression of PRKCB protein]22497828
D000431EthanolPRKCB protein affects the reaction [Ethanol results in increased cleavage of and results in increased activity of CASP3 protein]22497828
D000431EthanolPRKCB protein affects the reaction [Ethanol results in increased expression of NCF1 protein]22497828
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PRKCB mRNA17351261
C559943ethyl-1-(4-(2*3*3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylateethyl-1-(4-(2*3*3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate inhibits the reaction [Zeranol results in increased phosphorylation of PRKCB protein]27224899
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of PRKCB mRNA23649840
C054207etomoxiretomoxir results in increased expression of PRKCB mRNA19234235
D005419FlavonoidsFlavonoids results in decreased expression of PRKCB mRNA18035473
D016666Fluvoxamine[Haloperidol co-treated with Fluvoxamine] affects the expression of PRKCB protein15967061
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PRKCB20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PRKCB gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of PRKCB mRNA23649840
C039281furanfuran results in decreased expression of PRKCB mRNA15120968
C039281furanfuran results in increased methylation of PRKCB gene22079235
D005839GentamicinsGentamicins results in increased expression of PRKCB mRNA22061828
D005947Glucose"5,21 - 12,17-dimetheneo-18H-dibenzo(i,o)pyrrolo(3,4-1)(1,8)diazacyclohexandecine-18,10(19H)dione,8((dimethylamino)methyl)-6,7,8,9,10,11-hexahydro,monomethanesulfonate inhibits the reaction [Glucose results in increased expression of PRKCB protein]"16285992
D005947Glucose"5,21 - 12,17-dimetheneo-18H-dibenzo(i,o)pyrrolo(3,4-1)(1,8)diazacyclohexandecine-18,10(19H)dione,8((dimethylamino)methyl)-6,7,8,9,10,11-hexahydro,monomethanesulfonate inhibits the reaction [Glucose results in increased expression of PRKCB protein alternative form]"16285992
D005947Glucosebisindolylmaleimide I inhibits the reaction [Glucose results in increased expression of PRKCB protein]16285992
D005947Glucosebisindolylmaleimide I inhibits the reaction [Glucose results in increased expression of PRKCB protein alternative form]16285992
D005947GlucoseGlucose results in increased activity of PRKCB protein20578705
D005947GlucoseGlucose results in increased expression of PRKCB protein16285992
D005947GlucoseGlucose results in increased expression of PRKCB protein alternative form16285992
D005947GlucoseGlucose results in increased phosphorylation of PRKCB protein22162761
D005947Glucosemanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Glucose results in increased expression of PRKCB protein]16285992
D005947Glucosemanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Glucose results in increased expression of PRKCB protein alternative form]16285992
D005947GlucoseMannitol inhibits the reaction [Glucose results in increased expression of PRKCB protein]16285992
D005947GlucoseMannitol inhibits the reaction [Glucose results in increased expression of PRKCB protein alternative form]16285992
D005947Glucoseresveratrol inhibits the reaction [Glucose results in increased activity of PRKCB protein]20578705
D005947GlucoseThenoyltrifluoroacetone inhibits the reaction [Glucose results in increased expression of PRKCB protein]16285992
D005947GlucoseThenoyltrifluoroacetone inhibits the reaction [Glucose results in increased expression of PRKCB protein alternative form]16285992
D005947GlucoseGlucose results in increased phosphorylation of and results in increased activity of PRKCB protein19587355
D005947GlucosePRKCB protein affects the reaction [Glucose results in increased activity of RELA protein]19587355
D005947GlucosePRKCB protein affects the reaction [Glucose results in increased expression of NOS2 protein]19587355
D005947GlucosePRKCB protein affects the reaction [Glucose results in increased phosphorylation of and results in increased activity of MAPK1 protein]19587355
D005947GlucosePRKCB protein affects the reaction [Glucose results in increased phosphorylation of and results in increased activity of MAPK3 protein]19587355
D005947Glucoseruboxistaurin inhibits the reaction [Glucose results in increased phosphorylation of and results in increased activity of PRKCB protein]19587355
C081021Go 6976Go 6976 results in decreased activity of PRKCB protein15767308
C508665gold (III) porphyrin 1agold (III) porphyrin 1a results in decreased expression of PRKCB mRNA16206274
D006220Haloperidol[Haloperidol co-treated with Fluvoxamine] affects the expression of PRKCB protein15967061
D006220HaloperidolHaloperidol results in increased expression of PRKCB mRNA15860345
C007946hispidinhispidin results in decreased activity of PRKCB protein16374459
D017313FenretinideFenretinide results in increased expression of PRKCB mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the localization of and results in increased activity of PRKCB protein12821678
D007213IndomethacinIndomethacin results in decreased expression of PRKCB protein alternative form10702201
D007213IndomethacinIndomethacin results in increased expression of PRKCB protein alternative form10702201
D007213IndomethacinPRKCB protein alternative form results in decreased susceptibility to Indomethacin10702201
D007444InulinPRKCB protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde results in increased transport of Inulin]]17991733
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PRKCB mRNA25613284
C051890irinotecanirinotecan metabolite results in increased phosphorylation of PRKCB protein15723263
C051890irinotecanirinotecan results in increased phosphorylation of PRKCB protein15723263
D007545IsoproterenolIsoproterenol results in decreased expression of PRKCB mRNA21335049
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PRKCB mRNA23086925|2725927
C067713lactacystinlactacystin inhibits the reaction [Deoxycholic Acid results in increased expression of PRKCB protein]17644113
D007854LeadLead affects the expression of PRKCB mRNA28903495
D007854LeadLead results in decreased expression of PRKCB protein16547843
C008261lead acetatelead acetate results in decreased expression of PRKCB protein16547843
C045463leflunomideleflunomide results in increased expression of PRKCB mRNA28988120
D008070Lipopolysaccharidesclopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of PRKCB mRNA]19172522
D008095Lithocholic AcidLithocholic Acid results in increased activity of PRKCB protein7705931
D019808LosartanLosartan inhibits the reaction [Ethanol results in increased expression of PRKCB protein]22497828
C018091maduramicinmaduramicin results in decreased expression of PRKCB mRNA29128925
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PRKCB mRNA26378955
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Glucose results in increased expression of PRKCB protein]16285992
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Glucose results in increased expression of PRKCB protein alternative form]16285992
D008353MannitolMannitol inhibits the reaction [Glucose results in increased expression of PRKCB protein]16285992
D008353MannitolMannitol inhibits the reaction [Glucose results in increased expression of PRKCB protein alternative form]16285992
C042720mercuric bromidemercuric bromide results in decreased expression of PRKCB mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRKCB mRNA"27188386
D008687MetforminMetformin results in decreased expression of PRKCB mRNA15531508
D008687MetforminMetformin results in decreased expression of PRKCB protein15531508
D008701MethapyrileneMethapyrilene results in decreased expression of PRKCB mRNA15120968
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PRKCB20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PRKCB gene20938992
D008727MethotrexateMethotrexate results in increased expression of PRKCB mRNA15120968
D008731MethoxychlorMethoxychlor results in decreased expression of PRKCB mRNA23303685
D008731MethoxychlorMethoxychlor results in increased methylation of PRKCB gene23303685
C004925methylmercuric chloridemethylmercuric chloride affects the expression of PRKCB protein27012723
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PRKCB mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PRKCB mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PRKCB mRNA"19285098|2018815
C008493methylselenic acidmethylselenic acid results in increased expression of PRKCB mRNA18548127
C011309mezerein[bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein8892972
C011309mezerein[bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein alternative form8892972
C059539midostaurinmidostaurin results in decreased activity of PRKCB protein15542774
C070571ML 7ML 7 results in decreased expression of PRKCB protein17272349
D009020MorphineHINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]]18652891
D009020MorphineMorphine promotes the reaction [OPRM1 protein binds to PRKCB protein]18652891
D009151Mustard GasMustard Gas results in decreased expression of PRKCB mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PRKCB mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PRKCB mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of PRKCB mRNA25380136
C005273naringeninnaringenin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCB protein]25866363
D009532NickelNickel results in increased expression of PRKCB mRNA24768652|2558310
C017557nickel subsulfidenickel subsulfide affects the expression of PRKCB mRNA24952340
D009538NicotineNicotine affects the localization of PRKCB protein17003101
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of PRKCB protein]"16818790
C025589ochratoxin Aochratoxin A metabolite results in increased expression of PRKCB mRNA26314263
C025589ochratoxin Aochratoxin A results in increased expression of PRKCB mRNA26314263
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PRKCB mRNA25729387
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCB mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PRKCB mRNA26272509
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PRKCB protein19945530
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PRKCB protein19945530
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PRKCB mRNA19162173
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased phosphorylation of and results in decreased expression of PRKCB protein26456889
D010656PhenylephrinePhenylephrine promotes the reaction [RBCK1 protein binds to PRKCB protein]17121852
D010656PhenylephrinePhenylephrine results in increased expression of PRKCB protein17121852
D010656PhenylephrineRBCK1 protein inhibits the reaction [Phenylephrine results in increased expression of PRKCB protein]17121852
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRKCB mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PRKCB mRNA26272509
D010718PhosphatidylserinesPhosphatidylserines promotes the reaction [Chlordecone results in increased activity of PRKCB protein]1724372
D010718PhosphatidylserinesPhosphatidylserines promotes the reaction [Dicofol results in increased activity of PRKCB protein]1724372
D010862PilocarpinePilocarpine results in increased expression of PRKCB protein18774262
D010862PilocarpinePilocarpine results in decreased expression of PRKCB mRNA17971868
D010862PilocarpinePilocarpine results in increased expression of PRKCB protein15058486
D028321Plant PreparationsPlant Preparations results in decreased expression of PRKCB mRNA24973489
C531249Poly(amidoamine)Poly(amidoamine) analog results in increased expression of PRKCB mRNA23806026
D011192Potassium DichromatePotassium Dichromate results in increased expression of PRKCB protein23718831
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of PRKCB mRNA19162173
D011374ProgesteroneProgesterone results in decreased expression of PRKCB mRNA19690047
C107773pterostilbenepterostilbene inhibits the reaction [Azoxymethane results in increased phosphorylation of and results in increased activity of PRKCB protein]21355597
D011794QuercetinQuercetin results in decreased expression of PRKCB protein14750173
D011794QuercetinQuercetin results in decreased expression of PRKCB mRNA26076811
D011794QuercetinQuercetin inhibits the reaction [Cadmium Chloride results in decreased expression of PRKCB protein]27389774
C012526quercitrinquercitrin affects the expression of PRKCB mRNA25193878
C059514resveratrolresveratrol inhibits the reaction [Glucose results in increased activity of PRKCB protein]20578705
C059514resveratrolresveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCB protein]24672638
D019782RiluzoleRiluzole inhibits the reaction [VEGFA protein results in increased phosphorylation of PRKCB protein]16303979
C089730rosiglitazonePRKCB protein affects the susceptibility to rosiglitazone16672634
C099154ruboxistaurinruboxistaurin results in decreased activity of PRKCB protein25634538
C099154ruboxistaurinruboxistaurin inhibits the reaction [Glucose results in increased phosphorylation of and results in increased activity of PRKCB protein]19587355
C099154ruboxistaurinruboxistaurin binds to and results in decreased activity of PRKCB protein20444914
C099154ruboxistaurinruboxistaurin results in decreased activity of PRKCB protein17443133
D012524SarinSarin results in increased expression of PRKCB mRNA19522546
C110822SDZ CPI 975SDZ CPI 975 results in decreased expression of PRKCB mRNA19234235
C094089SDZ FOX 988SDZ FOX 988 results in decreased expression of PRKCB mRNA19234235
D012643SeleniumSelenium results in decreased expression of PRKCB mRNA19244175
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of PRKCB mRNA"21148743
D012822Silicon DioxideSilicon Dioxide analog affects the expression of PRKCB mRNA23806026
C009277sodium arsenatesodium arsenate results in increased expression of PRKCB mRNA21795629
C017947sodium arsenitesodium arsenite results in decreased expression of PRKCB protein24517892
D012969Sodium FluorideSodium Fluoride results in increased expression of PRKCB mRNA27862939
C543528sotrastaurinsotrastaurin inhibits the reaction [docetaxel results in increased phosphorylation of PRKCB protein]25634538
C543528sotrastaurinsotrastaurin results in decreased activity of PRKCB protein25634538
D013311StreptozocinStreptozocin results in increased phosphorylation of PRKCB protein16980342
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PRKCB mRNA26378955
C016766sulforafansulforafan results in increased expression of PRKCB mRNA26833863
D013481Superoxides[Ethanol results in increased localization of and results in increased activity of PRKCB protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides]10651808
D013605T-2 ToxinT-2 Toxin results in decreased expression of PRKCB mRNA26141394
C061133tamibarotenetamibarotene results in increased expression of PRKCB mRNA15498508
D020002tert-Butyl Alcoholtert-Butyl Alcohol inhibits the reaction [Thapsigargin results in increased localization of PRKCB protein]15843515
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of PRKCB mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PRKCB mRNA11007951|1968428
D013749Tetrachlorodibenzodioxin"PRKCB protein inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]]"10037446
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PRKCB mRNA19465110
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin affects the localization of PRKCB protein]16797713
D013749Tetrachlorodibenzodioxinalpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of PRKCB protein]16797713
D013749Tetrachlorodibenzodioxinalpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of PRKCB protein]17222441
D013749TetrachlorodibenzodioxinRACK1 protein affects the reaction [Tetrachlorodibenzodioxin affects the localization of PRKCB protein]16797713
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the localization of PRKCB protein16797713
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PRKCB mRNA20959002
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased localization of PRKCB protein17222441
D013755Tetradecanoylphorbol Acetate[Ethanol results in increased localization of and results in increased activity of PRKCB protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides]10651808
D013755Tetradecanoylphorbol Acetatenaringenin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCB protein]25866363
D013755Tetradecanoylphorbol AcetatePRKCB protein affects the reaction [Tetradecanoylphorbol Acetate affects the localization of Zinc]16495082
D013755Tetradecanoylphorbol AcetatePRKCB protein alternative form affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 mRNA]21705328
D013755Tetradecanoylphorbol Acetateresveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCB protein]24672638
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate affects the localization of PRKCB protein15976015|1944785
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate affects the localization of PRKCB protein alternative form21705328
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of PRKCB protein18313772
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of PRKCB protein modified form15330761
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased phosphorylation of PRKCB protein15380616
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased phosphorylation of PRKCB protein24672638
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased activity of PRKCB protein1724372
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PRKCB mRNA25613284
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased localization of PRKCB protein15843515
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased phosphorylation of PRKCB protein15089098
D013779Tetrodotoxin[Bupivacaine co-treated with Tetrodotoxin co-treated with Dexamethasone] results in decreased expression of PRKCB mRNA22341215
D019284ThapsigarginThapsigargin inhibits the reaction [EGF protein affects the localization of PRKCB protein]17991733
D019284Thapsigargin1-Butanol inhibits the reaction [Thapsigargin results in increased localization of PRKCB protein]15843515
D019284Thapsigargintert-Butyl Alcohol inhibits the reaction [Thapsigargin results in increased localization of PRKCB protein]15843515
D019284ThapsigarginThapsigargin results in increased localization of PRKCB protein15843515
D013804ThenoyltrifluoroacetoneThenoyltrifluoroacetone inhibits the reaction [Glucose results in increased expression of PRKCB protein]16285992
D013804ThenoyltrifluoroacetoneThenoyltrifluoroacetone inhibits the reaction [Glucose results in increased expression of PRKCB protein alternative form]16285992
D013827ThiabendazoleThiabendazole results in increased expression of PRKCB mRNA18539377
D013893ThiramThiram results in decreased activity of PRKCB protein15998240
C080287thymeleatoxinthymeleatoxin affects the localization of PRKCB protein9852137
C009495titanium dioxidetitanium dioxide results in decreased expression of PRKCB mRNA27760801
C009495titanium dioxidetitanium dioxide results in increased expression of PRKCB mRNA23557971
D014050TolueneToluene affects the expression of PRKCB mRNA21827849
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PRKCB mRNA25729387
D014212TretinoinTretinoin promotes the reaction [arsenic trioxide results in increased expression of PRKCB mRNA]10673743
D014212TretinoinTretinoin results in increased expression of PRKCB mRNA15498508|1605412
D014212TretinoinTretinoin results in increased phosphorylation of PRKCB protein19476501
D014212TretinoinTretinoin results in increased phosphorylation of PRKCB protein19476501
C011559tributyltintributyltin results in increased expression of PRKCB mRNA26314263
C012589trichostatin Atrichostatin A results in increased expression of PRKCB mRNA24935251
C057693troglitazonetroglitazone results in increased expression of PRKCB mRNA28973697
D017974Uranium CompoundsUranium Compounds results in decreased expression of PRKCB mRNA19654044
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased activity of PRKCB protein7705931
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCB mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PRKCB mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PRKCB mRNA23179753|2438349
D014639VanadiumVanadium results in decreased expression of PRKCB mRNA19000753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PRKCB gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of PRKCB mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCB mRNA"27188386
C111237vorinostatvorinostat results in increased expression of PRKCB mRNA26272509|2718838
D015029Zeranolethyl-1-(4-(2*3*3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate inhibits the reaction [Zeranol results in increased phosphorylation of PRKCB protein]27224899
D015029ZeranolZeranol results in increased phosphorylation of PRKCB protein27224899
D015032ZincPRKCB protein affects the reaction [Tetradecanoylphorbol Acetate affects the localization of Zinc]16495082
D015032ZincZinc promotes the reaction [FCER1A protein affects the localization of PRKCB protein]16818790
D015032ZincZinc promotes the reaction [OPRM1 protein binds to PRKCB protein]18652891

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IDA20228790  
GO:0004674protein serine/threonine kinase activity-EXP12391145  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0004697protein kinase C activity-TAS-  
GO:0004698calcium-dependent protein kinase C activity-TAS-  
GO:0005080protein kinase C binding-IPI20228790  
GO:0005515protein binding-IPI20228790  21044950  25852190  
GO:0005524ATP binding-IEA-  
GO:0008270zinc ion binding-IEA-  
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity-IMP20228790  
GO:0035403histone kinase activity (H3-T6 specific)-IDA20228790  
GO:0042393histone binding-IDA20228790  
GO:0050681androgen receptor binding-IDA20228790  
GO ID GO Term Qualifier Evidence PubMed
GO:0002250adaptive immune response-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IMP20228790  
GO:0006468protein phosphorylation-TAS3755548  
GO:0006915apoptotic process-IEA-  
GO:0007077mitotic nuclear envelope disassembly-TAS-  
GO:0007165signal transduction-NAS3755548  
GO:0010829negative regulation of glucose transmembrane transport-ISS-  
GO:0018105peptidyl-serine phosphorylation-IBA21873635  
GO:0030168platelet activation-TAS-  
GO:0030949positive regulation of vascular endothelial growth factor receptor signaling pathway-ISS-  
GO:0035408histone H3-T6 phosphorylation-IDA20228790  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0042113B cell activation-ISS-  
GO:0042953lipoprotein transport-TAS18981301  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-ISS-  
GO:0045637regulation of myeloid cell differentiation-TAS-  
GO:0045766positive regulation of angiogenesis-ISS-  
GO:0046627negative regulation of insulin receptor signaling pathway-ISS-  
GO:0050853B cell receptor signaling pathway-ISS-  
GO:0050861positive regulation of B cell receptor signaling pathway-ISS-  
GO:0051092positive regulation of NF-kappaB transcription factor activity-ISS-  
GO:1903508positive regulation of nucleic acid-templated transcription-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA20228790  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA15632189  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA15632189  
GO:0005886plasma membrane-TAS-  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04020Calcium signaling pathway
hsa04062Chemokine signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa04270Vascular smooth muscle contraction
hsa04310Wnt signaling pathway
hsa04370VEGF signaling pathway
hsa04510Focal adhesion
hsa04530Tight junction
hsa04540Gap junction
hsa04650Natural killer cell mediated cytotoxicity
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04670Leukocyte transendothelial migration
hsa04720Long-term potentiation
hsa04730Long-term depression
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa04960Aldosterone-regulated sodium reabsorption
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04973Carbohydrate digestion and absorption
hsa05110Vibrio cholerae infection
hsa05140Leishmaniasis
hsa05143African trypanosomiasis
hsa05146Amoebiasis
hsa05200Pathways in cancer
hsa05214Glioma
hsa05223Non-small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-114516Disinhibition of SNARE formationTAS
R-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)TAS
R-HSA-1169091Activation of NF-kappaB in B cellsTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1640170Cell CycleTAS
R-HSA-168256Immune SystemTAS
R-HSA-194138Signaling by VEGFTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2980766Nuclear Envelope BreakdownTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-388396GPCR downstream signallingIEA
R-HSA-399719Trafficking of AMPA receptorsTAS
R-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticityTAS
R-HSA-4086400PCP/CE pathwayTAS
R-HSA-416993Trafficking of GluR2-containing AMPA receptorsTAS
R-HSA-418597G alpha (z) signalling eventsIEA
R-HSA-4419969Depolymerisation of the Nuclear LaminaTAS
R-HSA-4420097VEGFA-VEGFR2 PathwayTAS
R-HSA-5099900WNT5A-dependent internalization of FZD4TAS
R-HSA-5218921VEGFR2 mediated cell proliferationTAS
R-HSA-68875Mitotic ProphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939246RUNX1 regulates transcription of genes involved in differentiation of myeloid cellsTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25939814CREB-BDNF pathway influences alcohol cue-elicited activation in drinkers. (2015 Aug)Chen JHum Brain Mapp