Gene: AXL

558
ARK|JTK11|Tyro7|UFO
AXL receptor tyrosine kinase
protein-coding
19q13.2
Ensembl:ENSG00000167601 MIM:109135 Vega:OTTHUMG00000182727 UniprotKB:P30530
NC_000019.10
PubMed
0   ANCO-SNPs
ND
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.231e-1 (AD)  8.823e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLEKHO20.92
S1PR10.903
ARHGEF260.9
HEPH0.9
FKBP100.897
EZR0.895
CDC42EP40.893
SDC20.893
PLTP0.883
NOTCH20.88

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CACNA1F-0.501
NRG1-0.5
TYRP1-0.486
ZNF860-0.484
TMEFF2-0.478
CALHM1-0.47
ENPP6-0.469
CNTN6-0.468
ADTRP-0.467
ROPN1L-0.466

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0319031-UFT protocolAXL protein results in decreased susceptibility to 1-UFT protocol16734730
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of AXL mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of AXL mRNA"23196670
C0144643,4-dichloroaniline"3,4-dichloroaniline results in decreased expression of AXL mRNA"24172598
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of AXL mRNA16788091
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of AXL mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of AXL mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AXL mRNA"27188386
C5495694-cyano-N-(2-(1-cyclohexen-1-yl)-4-(1-((dimethylamino)acetyl)-4-piperidinyl)phenyl)-1H-imidazole-2-carboxamide4-cyano-N-(2-(1-cyclohexen-1-yl)-4-(1-((dimethylamino)acetyl)-4-piperidinyl)phenyl)-1H-imidazole-2-carboxamide results in decreased activity of AXL protein22039836
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AXL mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of AXL mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of AXL mRNA17562736
C106812adefovir dipivoxiladefovir dipivoxil results in increased expression of AXL mRNA25596134
D000244Adenosine DiphosphateAXL protein results in decreased susceptibility to Adenosine Diphosphate15733062
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of AXL mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of AXL protein21527772
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of AXL gene27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of AXL mRNA21757418
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AXL mRNA16483693
D000880AnthraquinonesAnthraquinones analog results in decreased activity of AXL protein27473261
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AXL mRNA21632981|2187194
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to AXL promoter]19654925
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of AXL mRNA"19150397
C006780bisphenol Abisphenol A results in increased expression of AXL mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of AXL mRNA18958704
D002065BuspironeBuspirone results in decreased expression of AXL mRNA24136188
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of AXL mRNA15878706
C584509C646 compoundC646 compound results in increased expression of AXL mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of AXL mRNA25596134
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of AXL mRNA25993096
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of AXL mRNA20360939
D000069287CapecitabineAXL protein results in decreased susceptibility to Capecitabine16734730
D002220CarbamazepineCarbamazepine affects the expression of AXL mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of AXL mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of AXL mRNA12734012
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of AXL protein16799993
C004656chloroacetaldehydechloroacetaldehyde affects the expression of AXL mRNA25596134
C059262cidofovircidofovir results in increased expression of AXL mRNA25596134
D004002Clodronic AcidClodronic Acid results in increased expression of AXL mRNA25596134
D002994ClofibrateClofibrate affects the expression of AXL mRNA16081524
D002994ClofibrateClofibrate results in increased expression of AXL mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of AXL mRNA17553155|1932097
C018021cobaltous chloridecobaltous chloride results in increased expression of AXL mRNA17553155
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of AXL mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of AXL mRNA19549813
C030973cupric oxidecupric oxide results in decreased expression of AXL mRNA22077320
D003520CyclophosphamideCyclophosphamide results in increased expression of AXL mRNA21527772
D016572CyclosporineCyclosporine results in decreased expression of AXL mRNA25596134|2798913
D016572CyclosporineCyclosporine results in increased expression of AXL mRNA25562108
D003561CytarabineCytarabine results in decreased expression of AXL mRNA21198554
D003609DactinomycinDactinomycin results in increased expression of AXL mRNA21527772
C014347decitabinedecitabine affects the expression of AXL mRNA23300844
C014347decitabine[decitabine results in decreased methylation of AXL gene] which results in increased expression of AXL18522535
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of AXL mRNA21266533
D002945CisplatinCisplatin affects the expression of AXL mRNA23300844
D002945CisplatinCisplatin results in increased expression of AXL mRNA16061661|2559613
D002945CisplatinCisplatin results in increased expression of AXL mRNA21151649
D002945CisplatinCisplatin results in decreased expression of AXL mRNA22023808
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of AXL mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of AXL mRNA22609946
D004041Dietary FatsDietary Fats results in decreased expression of AXL mRNA21852083
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of AXL mRNA20360939
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of AXL mRNA"21527772
C024629dimethyl phthalatedimethyl phthalate affects the expression of AXL mRNA26924002
D004237DiuronDiuron metabolite results in decreased expression of AXL mRNA24172598
D004237DiuronDiuron results in decreased expression of AXL mRNA25152437
C025034doxifluridineAXL protein results in decreased susceptibility to doxifluridine16734730
D004317DoxorubicinAXL protein affects the susceptibility to Doxorubicin16217747
D004317DoxorubicinDoxorubicin results in increased expression of AXL mRNA22008532
D000069347Erlotinib HydrochlorideAXL results in decreased susceptibility to Erlotinib Hydrochloride22751098
D000069347Erlotinib Hydrochloride[GSK 1363089 results in decreased activity of AXL protein] which results in increased susceptibility to Erlotinib Hydrochloride22751098
D000069347Erlotinib Hydrochloride[MP470 results in decreased activity of AXL protein] which results in increased susceptibility to Erlotinib Hydrochloride22751098
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of AXL mRNA23649840
D005047EtoposideEtoposide results in increased expression of AXL mRNA21527772
C540355fenamidonefenamidone results in increased expression of AXL mRNA27029645
D005485FlutamideFlutamide results in decreased expression of AXL mRNA24136188
C039281furanfuran results in increased expression of AXL mRNA27387713
C056507gemcitabineAXL protein promotes the reaction [Warfarin results in increased susceptibility to gemcitabine]26206560
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of AXL mRNA22634610
C544831GSK 1363089GSK 1363089 results in decreased activity of AXL protein22751098
C544831GSK 1363089[GSK 1363089 results in decreased activity of AXL protein] which results in increased susceptibility to Erlotinib Hydrochloride22751098
D006861Hydrogen PeroxideAXL protein promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]15123721
D006861Hydrogen PeroxideGAS6 protein promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AXL protein]15123721
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of AXL protein15123721
D006861Hydrogen PeroxideWarfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of AXL protein]15123721
C492448ICG 001ICG 001 results in increased expression of AXL mRNA26191083
D007069IfosfamideIfosfamide results in increased expression of AXL mRNA25596134
C045463leflunomideleflunomide results in increased expression of AXL mRNA28988120
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of AXL mRNA21527772|2364984
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of AXL mRNA12634122
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of AXL mRNA24810058
C517284monomethyl phthalatemonomethyl phthalate affects the expression of AXL mRNA26924002
C521047MP470MP470 results in decreased activity of AXL protein22751098
C521047MP470[MP470 results in decreased activity of AXL protein] which results in increased susceptibility to Erlotinib Hydrochloride22751098
C523799MRK 003AXL results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of AXL mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of AXL mRNA"25554681
C000621033napabucasinnapabucasin results in decreased expression of AXL mRNA25605917
C000621033napabucasinnapabucasin results in decreased expression of AXL protein25605917
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of AXL mRNA25380136
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of AXL mRNA19812364
C028007nickel monoxidenickel monoxide results in increased expression of AXL mRNA19167457
C012655nimesulidenimesulide results in decreased expression of AXL mRNA24136188
D009569Nitric OxideNitric Oxide deficiency results in decreased expression of AXL mRNA15878706
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of AXL mRNA20971185
D010081OxazoloneOxazolone results in increased expression of AXL mRNA11379042
D010100OxygenOxygen deficiency results in increased expression of AXL mRNA25596134
D017239PaclitaxelAXL protein results in increased susceptibility to Paclitaxel16734730
C006253pirinixic acidpirinixic acid results in decreased expression of AXL mRNA20813756
D008926PlicamycinPlicamycin results in decreased expression of AXL18522535
C513428pyrachlostrobinpyrachlostrobin results in increased expression of AXL mRNA27029645
D011794QuercetinQuercetin results in increased expression of AXL mRNA21632981
C548378R428 compoundR428 compound results in decreased expression of AXL protein modified form26206560
D012643SeleniumSelenium results in decreased expression of AXL mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of AXL mRNA25895662
D012834SilverSilver results in increased expression of AXL mRNA27131904
D019821SimvastatinSimvastatin results in decreased expression of AXL mRNA17428261
D053260SootSoot results in decreased expression of AXL mRNA26551751
D013311StreptozocinStreptozocin results in increased expression of AXL protein12644472
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AXL mRNA12377990
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AXL mRNA21570461|2892240
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of AXL mRNA28065790
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in decreased expression of AXL mRNA"11379042
D014118Toxins, Biological"Toxins, Biological affects the expression of AXL mRNA"19682533
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of AXL mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of AXL mRNA29024780
C057693troglitazonetroglitazone results in increased expression of AXL mRNA28973697
D014520UrethaneUrethane results in decreased expression of AXL mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AXL mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of AXL mRNA24383497|2627250
D014635Valproic AcidValproic Acid affects the expression of AXL mRNA17292431
D014640VancomycinVancomycin results in decreased expression of AXL mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of AXL gene25560391
D014747VinblastineAXL protein affects the susceptibility to Vinblastine16217747
C025643vinclozolinvinclozolin results in increased expression of AXL mRNA23034163
C029297vinylidene chloridevinylidene chloride results in increased expression of AXL mRNA26682919
D014810Vitamin EVitamin E results in decreased expression of AXL mRNA19244175
D014812Vitamin KVitamin K inhibits the reaction [Warfarin results in decreased expression of AXL protein modified form]26206560
D014812Vitamin KVitamin K results in increased expression of AXL protein modified form26206560
D010837Vitamin K 1Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of AXL protein]27212383
D010837Vitamin K 1[Warfarin co-treated with Vitamin K 1] results in decreased expression of AXL protein27212383
D024482Vitamin K 2Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of AXL protein]27212383
D014859WarfarinAXL protein promotes the reaction [Warfarin results in increased susceptibility to gemcitabine]26206560
D014859WarfarinAXL protein results in increased susceptibility to Warfarin26206560
D014859WarfarinVitamin K inhibits the reaction [Warfarin results in decreased expression of AXL protein modified form]26206560
D014859WarfarinWarfarin inhibits the reaction [GAS6 protein results in increased activity of AXL protein]26206560
D014859WarfarinWarfarin results in decreased expression of AXL protein26206560
D014859WarfarinWarfarin results in decreased expression of AXL protein modified form26206560
D014859WarfarinWarfarin results in decreased phosphorylation of AXL protein26206560
D014859WarfarinVitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of AXL protein]27212383
D014859Warfarin[Warfarin co-treated with Vitamin K 1] results in decreased expression of AXL protein27212383
D014859WarfarinWarfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of AXL protein]15123721
C088658zoledronic acidzoledronic acid results in decreased expression of AXL mRNA24714768|2559613

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IEA-  
GO:0001786phosphatidylserine binding-IDA21501828  
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-EXP22327215  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IEA-  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005515protein binding-IPI7854420  9178760  16362042  18760998  20088931  25873175  
GO:0005524ATP binding-IEA-  
GO:0017147Wnt-protein binding-IBA21873635  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO:0032036myosin heavy chain binding-IEA-  
GO:0043548phosphatidylinositol 3-kinase binding-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001764neuron migration-IEA-  
GO:0001779natural killer cell differentiation-IEA-  
GO:0001961positive regulation of cytokine-mediated signaling pathway-IDA18840707  
GO:0001974blood vessel remodeling-IEA-  
GO:0006909phagocytosis-IBA21873635  
GO:0006909phagocytosis-IDA21501828  
GO:0006954inflammatory response-IEA-  
GO:0007165signal transduction-TAS1656220  
GO:0007275multicellular organism development-IBA21873635  
GO:0007283spermatogenesis-IEA-  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0016055Wnt signaling pathway-IBA21873635  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0021885forebrain cell migration-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0030168platelet activation-IEA-  
GO:0031100animal organ regeneration-IEA-  
GO:0031668cellular response to extracellular stimulus-IEA-  
GO:0032689negative regulation of interferon-gamma production-IDA18840707  
GO:0032720negative regulation of tumor necrosis factor production-IEA-  
GO:0032825positive regulation of natural killer cell differentiation-IDA18840707  
GO:0032940secretion by cell-IEA-  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0034101erythrocyte homeostasis-IEA-  
GO:0034446substrate adhesion-dependent cell spreading-IEA-  
GO:0035457cellular response to interferon-alpha-IDA19657094  
GO:0042698ovulation cycle-IEA-  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043277apoptotic cell clearance-IEA-  
GO:0043410positive regulation of MAPK cascade-IBA21873635  
GO:0043491protein kinase B signaling-IEA-  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0045087innate immune response-IEA-  
GO:0046718viral entry into host cell-IMP21047970  
GO:0048010vascular endothelial growth factor receptor signaling pathway-TAS-  
GO:0048469cell maturation-IEP19657094  
GO:0048549positive regulation of pinocytosis-IMP21047970  
GO:0051250negative regulation of lymphocyte activation-IEA-  
GO:0051897positive regulation of protein kinase B signaling-IEA-  
GO:0060068vagina development-IEA-  
GO:0070301cellular response to hydrogen peroxide-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0071222cellular response to lipopolysaccharide-IDA19657094  
GO:0097028dendritic cell differentiation-IEP19657094  
GO:0097350neutrophil clearance-IEA-  
GO:2000669negative regulation of dendritic cell apoptotic process-IDA19657094  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA20088931  
GO:0005622intracellular-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS1656220  
GO:0009986cell surface-HDA19581412  
GO:0009986cell surface-IDA19657094  
GO:0043235receptor complex-IBA21873635  
GO:0044228host cell surface-IDA21529875  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-194138Signaling by VEGFTAS
R-HSA-4420097VEGFA-VEGFR2 PathwayTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25363066Effect of smoking on retina nerve fiber layer and ganglion cell-inner plexiform layer complex. (2015)Dervisogullari MSCutan Ocul Toxicol
27100677Clinical, Pathological, and Molecular Features of Lung Adenocarcinomas with AXL Expression. (2016)Sato KPLoS One
19498054Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation. (2009 Sep 1)Breton CVAm J Respir Crit Care Med
25480659DNA methylation alterations in response to prenatal exposure of maternal cigarette smoking: A persistent epigenetic impact on health from maternal lifestyle? (2016 Feb)Nielsen CHArch Toxicol
21555911Heritability and role for the environment in DNA methylation in AXL receptor tyrosine kinase. (2011 Jul)Breton CVEpigenetics
22975805The transcriptional landscape and mutational profile of lung adenocarcinoma. (2012 Nov)Seo JSGenome Res
23341490Circulating growth arrest-specific 6 protein is associated with adiposity, systemic inflammation, and insulin resistance among overweight and obese adolescents. (2013 Feb)Hsiao FCJ Clin Endocrinol Metab