Gene: FOXJ2

55810
FHX
forkhead box J2
protein-coding
12p13.31
Ensembl:ENSG00000065970 Vega:OTTHUMG00000168526 UniprotKB:Q9P0K8
NC_000012.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.542e-1 (AD)  1.543e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3782683chr12:8039315 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMURF10.846
WDR260.835
OSBP0.833
UBR70.827
DCAF50.825
HMGXB30.821
PSMD110.821
OXSR10.82
ASXL10.82
SIK20.817

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.572
OR4F29-0.553
DIAPH3-0.283
NXNL1-0.256
C16orf74-0.245
KLRC2-0.225
S100A1-0.215
LHFPL1-0.215
FOLR1-0.21
ACOT6-0.206

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FOXJ2 mRNA"19114083
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of FOXJ2 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FOXJ2 mRNA22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of FOXJ2 mRNA21179406
C006780bisphenol Abisphenol A affects the methylation of FOXJ2 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of FOXJ2 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of FOXJ2 mRNA26079696
D003078ColchicineColchicine results in decreased expression of FOXJ2 mRNA24211769
D016572CyclosporineCyclosporine results in increased expression of FOXJ2 mRNA25562108
D002945CisplatinCisplatin results in decreased expression of FOXJ2 mRNA24211769
D002945CisplatinCisplatin results in increased expression of FOXJ2 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of FOXJ2 mRNA28302478
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of FOXJ2 mRNA24211769
D005047EtoposideEtoposide results in decreased expression of FOXJ2 mRNA24211769
D006918HydroxyureaHydroxyurea results in decreased expression of FOXJ2 mRNA24211769
D016685MitomycinMitomycin results in decreased expression of FOXJ2 mRNA24211769
C046012pentanalpentanal results in decreased expression of FOXJ2 mRNA26079696
D010936Plant ExtractsPlant Extracts results in decreased expression of FOXJ2 mRNA23557933
D012402RotenoneRotenone results in increased expression of FOXJ2 mRNA19013527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FOXJ2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FOXJ2 mRNA24058054
D014212TretinoinTretinoin results in increased expression of FOXJ2 mRNA23724009
D014415TunicamycinTunicamycin results in increased expression of FOXJ2 mRNA22378314
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FOXJ2 gene25560391
D000225AdenineAdenine results in decreased expression of FOXJ2 mRNA24211769

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA10777590  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA10777590  
GO:0005515protein binding-IPI25416956  
GO:0042802identical protein binding-IPI25609649  
GO ID GO Term Qualifier Evidence PubMed
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0016525negative regulation of angiogenesis-IMP24792364  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA10777590  
GO:0110059negative regulation of blood vessel endothelial cell differentiation-IDA24792364  
GO:1904707positive regulation of vascular smooth muscle cell proliferation-IDA24792364  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005634nucleus-IDA24792364  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal