Gene: ALLC

55821
ALC
allantoicase
protein-coding
2p25.3
Ensembl:ENSG00000151360 MIM:612396 Vega:OTTHUMG00000151485 UniprotKB:Q8N6M5
NC_000002.12
PubMed
0   ANCO-SNPs
ND
1   
4.305e-1 (AD)  6.136e-1 (ND)   (Frontal_Cortex)
9.064e-1 (AD)  1.411e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg19099433chr2:3748379ALLCGene body9.451e-9Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COLEC110.521
OCM0.415
ANKRD20A30.378
TLX30.373
C3orf350.361
CCDC1550.358
PILRA0.356
FOXD4L60.348
SLC3A10.344
SLC22A310.342

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MRO-0.308
ACBD7-0.293
TTPA-0.283
RANBP3L-0.245
LCTL-0.239
MYO10-0.237
SLC40A1-0.231
SOX21-0.229
HEATR5A-0.227
CCDC121-0.226

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ALLC mRNA"19114083
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ALLC gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ALLC mRNA16483693
D001151ArsenicArsenic affects the methylation of ALLC gene25304211
D053119BenzophenanthridinesBenzophenanthridines analog results in decreased expression of ALLC mRNA22120849
C006780bisphenol Abisphenol A results in decreased expression of ALLC mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of ALLC mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ALLC mRNA23741332
C029892cupric chloridecupric chloride results in increased expression of ALLC protein19616320
D016572CyclosporineCyclosporine results in increased expression of ALLC mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ALLC mRNA24893172
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ALLC mRNA26011545
C014153pirimiphos methylpirimiphos methyl results in increased expression of ALLC mRNA27845199
C009277sodium arsenatesodium arsenate results in decreased expression of ALLC mRNA23922661
C017947sodium arsenitesodium arsenite affects the methylation of ALLC gene28589171
C016104sodium bichromatesodium bichromate results in decreased expression of ALLC mRNA24612858
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ALLC mRNA21296121
D014520UrethaneUrethane results in decreased expression of ALLC mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004037allantoicase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000256allantoin catabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29459480Occupational exposure to pesticides is associated with differential DNA methylation. (2018 Jun)van der Plaat DAOccup Environ Med