Gene: VPS11

55823
END1|HLD12|PEP5|RNF108|hVPS11
VPS11, CORVET/HOPS core subunit
protein-coding
11q23.3
Ensembl:ENSG00000160695 MIM:608549 Vega:OTTHUMG00000166355 UniprotKB:Q9H270
NG_029670.1
SNP Mapped
1   ANCO-SNPs
AD
0   
9.051e-1 (AD)  7.402e-1 (ND)   (Frontal_Cortex)
8.343e-1 (AD)  4.775e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4531480chr11:119072889 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TM9SF40.958
PSMD30.956
COPG10.953
CCAR20.953
TMUB20.949
MICU10.949
ABCF30.948
PPP5C0.947
USP50.947
ACTR1A0.946

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.7
OR4F29-0.648
MTRNR2L6-0.419
MTRNR2L9-0.405
TFPI2-0.396
MTRNR2L10-0.376
RAI14-0.351
KLF17-0.349
KLRB1-0.347
KCNJ15-0.34

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of VPS11 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of VPS11 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of VPS11 gene27153756
D000638AmiodaroneAmiodarone results in increased expression of VPS11 mRNA19774075
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of VPS11 mRNA"19446018
C006780bisphenol Abisphenol A affects the expression of VPS11 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of VPS11 mRNA25181051
D002994ClofibrateClofibrate results in decreased expression of VPS11 mRNA23811191
D016572CyclosporineCyclosporine results in increased expression of VPS11 mRNA20106945
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of VPS11 mRNA21266533
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of VPS11 protein23301498
D005557FormaldehydeFormaldehyde results in increased expression of VPS11 mRNA23649840
C069837fullerene C60fullerene C60 results in increased expression of VPS11 mRNA19167457
D007213IndomethacinIndomethacin results in decreased expression of VPS11 mRNA28201806
D007213IndomethacinIndomethacin results in increased expression of VPS11 mRNA28201806
D007854LeadLead results in decreased expression of VPS11 mRNA19921347
D008694MethamphetamineMethamphetamine results in increased expression of VPS11 mRNA26307267
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of VPS11 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of VPS11 mRNA"20188158
C028007nickel monoxidenickel monoxide results in increased expression of VPS11 mRNA19167457
D010936Plant ExtractsPlant Extracts results in increased expression of VPS11 mRNA23557933
C017947sodium arsenitesodium arsenite affects the expression of VPS11 mRNA20816728
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of VPS11 mRNA21570461
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of VPS11 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of VPS11 mRNA28818685
C025643vinclozolinvinclozolin results in decreased expression of VPS11 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000166nucleotide binding-IEA-  
GO:0005515protein binding-IPI11382755  21148287  22493164  23901104  25266290  25416956  
26496610  
GO:0019904protein domain specific binding-IPI21148287  
GO:0019905syntaxin binding-IDA11382755  
GO:0030674protein binding, bridging-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IEA-  
GO:0006904vesicle docking involved in exocytosis-IBA21873635  
GO:0006914autophagy-IEA-  
GO:0007032endosome organization-IBA21873635  
GO:0007040lysosome organization-IBA21873635  
GO:0008333endosome to lysosome transport-IMP25783203  
GO:0031647regulation of protein stability-HMP24270810  
GO:0034058endosomal vesicle fusion-IMP21148287  
GO:0035542regulation of SNARE complex assembly-IBA21873635  
GO:1902115regulation of organelle assembly-IMP21148287  
GO:1903364positive regulation of cellular protein catabolic process-IMP21148287  
GO:1903955positive regulation of protein targeting to mitochondrion-HMP24270810  
GO:2000643positive regulation of early endosome to late endosome transport-IMP21148287  
GO ID GO Term Qualifier Evidence PubMed
GO:0005764lysosome-IDA11382755  
GO:0005764lysosomecolocalizes_withIDA21148287  
GO:0005765lysosomal membrane-HDA17897319  
GO:0005768endosome-IBA21873635  
GO:0005768endosome-IDA20682791  
GO:0005769early endosomecolocalizes_withIDA21148287  
GO:0005770late endosome-IDA11382755  
GO:0005770late endosomecolocalizes_withIDA21148287  
GO:0005776autophagosome-IEA-  
GO:0030136clathrin-coated vesicle-IEA-  
GO:0030139endocytic vesicle-IDA20682791  
GO:0030897HOPS complex-IBA21873635  
GO:0030897HOPS complex-IDA19109425  23901104  
GO:0031902late endosome membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal