Gene: PECR

55825
DCRRP|HPDHASE|HSA250303|PVIARL|SDR29C1|TERP
peroxisomal trans-2-enoyl-CoA reductase
protein-coding
2q35
Ensembl:ENSG00000115425 MIM:605843 Vega:OTTHUMG00000154825 UniprotKB:Q9BY49
NC_000002.12
PubMed|SNP Mapped
1   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.623e-1 (AD)  1.696e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs705648chr2:216069069 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRAM1L10.764
CLNS1A0.746
PCCB0.745
POLR2G0.741
PYCR20.739
FECH0.738
SDHC0.735
FAM120AOS0.728
PDE6D0.726
AGA0.725

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.512
OR4F29-0.474
FCER2-0.309
MTRNR2L6-0.305
MMP23B-0.302
TMEM236-0.295
RAX2-0.29
PPBP-0.282
EPPIN-0.274
CLEC6A-0.263

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00173AdenineSmall Molecule73-24-5Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PECR mRNA"19114083
D000082AcetaminophenAcetaminophen results in decreased expression of PECR mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of PECR mRNA17562736
D000214Acyl Coenzyme A[Acyl Coenzyme A co-treated with NADP] binds to PECR protein25526675
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PECR protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PECR mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PECR gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PECR mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of PECR mRNA21757418
D000638AmiodaroneAmiodarone affects the expression of PECR mRNA18355885
D000639AmitriptylineAmitriptyline affects the expression of PECR mRNA18355885
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PECR mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PECR mRNA20106945|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PECR mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PECR mRNA"20018196
C053541bicalutamidebicalutamide results in increased expression of PECR mRNA15638997
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of PECR mRNA27685785
C006780bisphenol Abisphenol A affects the expression of PECR mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of PECR mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PECR gene28505145
D002104CadmiumCadmium results in increased expression of PECR mRNA17327699
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PECR mRNA17327699
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PECR mRNA27339419
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of PECR mRNA18804290
D002997ClomipramineClomipramine affects the expression of PECR mRNA18355885
D009249NADP[Acyl Coenzyme A co-treated with NADP] binds to PECR protein25526675
D009249NADP[decanoyl-coenzyme A co-treated with NADP] binds to PECR protein25526675
D009249NADP[hexanoyl-coenzyme A co-treated with NADP] binds to PECR protein25526675
D009249NADP[lauroyl-coenzyme A co-treated with NADP] binds to PECR protein25526675
D009249NADPNADP binds to and results in increased activity of PECR protein25526675
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of PECR mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of PECR mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PECR mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of PECR mRNA27989131
C045561decanoyl-coenzyme A[decanoyl-coenzyme A co-treated with NADP] binds to PECR protein25526675
D064730DexrazoxaneDexrazoxane results in decreased expression of PECR mRNA26873546
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PECR mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PECR mRNA21266533
D002945CisplatinCisplatin results in decreased expression of PECR mRNA24280081
D002945CisplatinCisplatin results in decreased expression of PECR mRNA24280081
C000944dicrotophosdicrotophos results in decreased expression of PECR mRNA28302478
D004026DieldrinDieldrin results in decreased expression of PECR mRNA23041725
D004042Dietary Fats, Unsaturated"Dietary Fats, Unsaturated inhibits the reaction [perfluorooctanoic acid results in increased expression of PECR mRNA]"23626681
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of PECR mRNA24535843
D004178DiquatDiquat affects the expression of PECR mRNA22814884
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of PECR mRNA25198161
D000431EthanolEthanol results in increased expression of PECR protein19609968
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PECR mRNA17555576
D005485FlutamideFlutamide results in decreased expression of PECR mRNA24793618
C044181hexanoyl-coenzyme A[hexanoyl-coenzyme A co-treated with NADP] binds to PECR protein25526675
D007099ImipramineImipramine affects the expression of PECR mRNA18355885
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PECR mRNA23086925
C410337K 7174K 7174 results in decreased expression of PECR mRNA24086573
D007654KetoconazoleKetoconazole affects the expression of PECR mRNA18355885
C050466lauroyl-coenzyme A[lauroyl-coenzyme A co-treated with NADP] binds to PECR protein25526675
D008727MethotrexateMethotrexate results in increased expression of PECR mRNA17400583
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PECR mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of PECR mRNA"25620056
C051752nefazodonenefazodone results in increased expression of PECR mRNA24136188
D009532NickelNickel results in decreased expression of PECR mRNA24768652|2558310
C012655nimesulidenimesulide results in increased expression of PECR mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of PECR mRNA17616710
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of PECR mRNA20971185
C025589ochratoxin Aochratoxin A results in decreased expression of PECR mRNA19287073
C023036perfluorooctanoic acid"Dietary Fats, Unsaturated inhibits the reaction [perfluorooctanoic acid results in increased expression of PECR mRNA]"23626681
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PECR mRNA23626681
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of PECR mRNA17097637
D010695PhlorhizinPhlorhizin results in decreased expression of PECR mRNA22538082
D010695PhlorhizinPhlorhizin results in increased expression of PECR mRNA22538082
D010795Phthalic AcidsPhthalic Acids results in decreased expression of PECR mRNA21061450
C006253pirinixic acidpirinixic acid results in decreased expression of PECR mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of PECR mRNA17426115
D011374ProgesteroneProgesterone results in increased expression of PECR mRNA19690047
C015586propiverinepropiverine binds to PECR protein29273565
D011794QuercetinQuercetin results in decreased expression of PECR mRNA21632981
D015474IsotretinoinIsotretinoin results in decreased expression of PECR mRNA20436886
D012999SomanSoman results in decreased expression of PECR mRNA19281266
D013629TamoxifenTamoxifen affects the expression of PECR mRNA17555576
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of PECR mRNA15885361
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PECR mRNA21998131
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PECR gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PECR mRNA26290441|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PECR mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PECR mRNA21724226
D013752TetracyclineTetracycline results in increased expression of PECR mRNA16917069
C011559tributyltintributyltin results in increased expression of PECR mRNA29191790
D014635Valproic AcidValproic Acid results in increased expression of PECR mRNA28001369|2915479
D014640VancomycinVancomycin results in increased expression of PECR mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PECR gene25487561
C029297vinylidene chloridevinylidene chloride results in decreased expression of PECR mRNA26682919
C111237vorinostatvorinostat results in increased expression of PECR mRNA27188386
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of PECR mRNA"25198161

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IPI11669066  20178365  
GO:00086702,4-dienoyl-CoA reductase (NADPH) activityNOTIDA11669066  
GO:0019166trans-2-enoyl-CoA reductase (NADPH) activity-EXP10811639  16546181  
GO:0019166trans-2-enoyl-CoA reductase (NADPH) activity-IBA21873635  
GO:0019166trans-2-enoyl-CoA reductase (NADPH) activity-IDA16546181  
GO ID GO Term Qualifier Evidence PubMed
GO:0001561fatty acid alpha-oxidation-TAS-  
GO:0006625protein targeting to peroxisome-TAS-  
GO:0006633fatty acid biosynthetic process-IEA-  
GO:0033306phytol metabolic process-IBA21873635  
GO:0033306phytol metabolic process-IDA16546181  
GO:0055114oxidation-reduction process-IBA21873635  
GO:0055114oxidation-reduction process-IDA16546181  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IEA-  
GO:0005777peroxisome-IBA21873635  
GO:0005777peroxisome-IDA11669066  
GO:0005778peroxisomal membrane-ISS10811639  
GO:0005778peroxisomal membrane-TAS-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa01040Biosynthesis of unsaturated fatty acids
hsa04146Peroxisome
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-389599Alpha-oxidation of phytanateTAS
R-HSA-390918Peroxisomal lipid metabolismTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8978868Fatty acid metabolismTAS
R-HSA-9033241Peroxisomal protein importTAS
R-HSA-9033241Peroxisomal protein importIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25278008Genome-wide association discoveries of alcohol dependence. (2014 Nov-Dec)Zuo LAm J Addict