Gene info: ID 5583

Gene: PRKCH

GENE ID: 5583

Synonyms: PKC-L|PKCL|PRKCL|nPKC-eta

Description: protein kinase C eta

Gene type: protein-coding

Location: 14q23.1

dbXrefs: Ensembl:ENSG00000027075 MIM:605437 Vega:OTTHUMG00000152341 UniprotKB:P24723

RefSeq: NG_011514.1

Retrived from: PubMed|SNP Mapped

SNPs: 3 ANCO-SNPs

Phenotype: ND|AD

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.509e-1 (AD) 7.649e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs10483734	chr14:61471083 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs767755	chr14:61407730 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs12101174	chr14:61332107 (GRCh38.p7)	A>G	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg19859698	chr14:61822607	PRKCH		7.600e-9	Smoking	27651444
cg10855746	chr14:61938004	PRKCH		2.200e-8	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ERG	0.851
MECOM	0.848
MYCT1	0.846
FLI1	0.837
VWF	0.833
CFH	0.832
CYYR1	0.832
TGFBR2	0.832
ELOVL7	0.824
ABCB1	0.818

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CPLX3	-0.491
NEUROD6	-0.489
GALNT9	-0.484
KCNC2	-0.468
RTN4R	-0.467
TMEM221	-0.458
EXTL1	-0.457
MAGIX	-0.451
CRH	-0.449
CHRNA4	-0.448

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of PRKCH mRNA"	19162173
C032668	1-nitropyrene	1-nitropyrene results in increased expression of PRKCH mRNA	19041380
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PRKCH mRNA"	27291303
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCH mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCH mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCH mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCH mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCH mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCH mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCH mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCH mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCH mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCH mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCH mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCH mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCH mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCH mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCH mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCH mRNA"	27188386
D000082	Acetaminophen	[Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of PRKCH mRNA	17093179
D000082	Acetaminophen	Acetaminophen affects the expression of PRKCH mRNA	17562736
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PRKCH mRNA	16483693
D000661	Amphetamine	Amphetamine results in increased expression of PRKCH mRNA	16101753
C006632	arsenic trioxide	arsenic trioxide results in increased expression of PRKCH mRNA	20458559
D001280	Atrazine	Atrazine results in decreased expression of PRKCH mRNA	22378314
C547126	AZM551248	AZM551248 results in decreased expression of PRKCH mRNA	22323515
D001554	Benzene	Benzene results in increased expression of PRKCH mRNA	20036648
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PRKCH mRNA	21839799
C483161	beta-hydroxy simvastatin acid	beta-hydroxy simvastatin acid results in decreased expression of PRKCH mRNA	18192240
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of PRKCH mRNA	25912373
C006780	bisphenol A	bisphenol A results in decreased expression of PRKCH mRNA	22576693\|2768578
C006780	bisphenol A	bisphenol A results in increased methylation of PRKCH gene	22576693
C006780	bisphenol A	bisphenol A results in decreased expression of PRKCH mRNA	26063408
C006780	bisphenol A	bisphenol A results in increased expression of PRKCH mRNA	25181051
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of PRKCH mRNA	15336504
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of PRKCH mRNA	12734012
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of PRKCH mRNA	17032414
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCH mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of PRKCH mRNA	26272509
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of PRKCH mRNA	17452286\|1936882
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of PRKCH mRNA	28472532
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of PRKCH mRNA	19320972
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of PRKCH mRNA	24386269
D003375	Coumestrol	Coumestrol results in decreased expression of PRKCH mRNA	19167446
D003474	Curcumin	Curcumin inhibits the reaction [PRKCH protein results in increased expression of IVL mRNA]	17148446
D003976	Diazinon	Diazinon results in decreased expression of PRKCH mRNA	17452286
D004040	Dietary Carbohydrates	[Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of PRKCH mRNA	17093179
D004052	Diethylnitrosamine	[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PRKCH mRNA	16158176
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PRKCH mRNA	14656948
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of PRKCH mRNA"	22485181
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of PRKCH mRNA	17032414
C118739	entinostat	entinostat results in increased expression of PRKCH mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCH mRNA"	27188386
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PRKCH mRNA	22079256
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRKCH mRNA	17942748
D015073	2-Acetylaminofluorene	[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PRKCH mRNA	16158176
D015073	2-Acetylaminofluorene	[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PRKCH mRNA	14656948
D005839	Gentamicins	Gentamicins results in increased expression of PRKCH mRNA	22061828
D005947	Glucose	Glucose results in decreased expression of PRKCH mRNA	17178593
D017313	Fenretinide	Fenretinide results in increased expression of PRKCH mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of PRKCH mRNA	20044591
D007213	Indomethacin	Indomethacin results in increased expression of PRKCH protein	10702201
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PRKCH mRNA	25613284
D007657	Ketone Bodies	Ketone Bodies results in decreased expression of PRKCH mRNA	16807920
C008261	lead acetate	lead acetate results in increased expression of PRKCH mRNA	20542052
D001556	Lindane	Lindane affects the expression of PRKCH mRNA	22001173
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of PRKCH mRNA	26582142
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of PRKCH mRNA	25613284
C042720	mercuric bromide	mercuric bromide results in increased expression of PRKCH mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCH mRNA"	27188386
C013598	methoxyacetic acid	methoxyacetic acid affects the expression of PRKCH mRNA	20864626
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of PRKCH mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of PRKCH mRNA"	25554681
D009966	Orphenadrine	Orphenadrine affects the expression of PRKCH mRNA	23665939
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCH mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of PRKCH mRNA	26272509
D010575	Pesticides	Pesticides results in decreased methylation of PRKCH gene	28396702
D010634	Phenobarbital	Phenobarbital results in decreased expression of PRKCH mRNA	19162173
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCH mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of PRKCH mRNA	26272509
D010695	Phlorhizin	Phlorhizin results in increased expression of PRKCH mRNA	22538082
D010862	Pilocarpine	Pilocarpine results in increased expression of PRKCH protein	15058486
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PRKCH mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of PRKCH mRNA	22079256
C005556	propionaldehyde	propionaldehyde results in increased expression of PRKCH mRNA	26079696
D011794	Quercetin	Quercetin results in decreased expression of PRKCH mRNA	26076811
D020123	Sirolimus	PRKCH results in decreased susceptibility to Sirolimus	16832347
D020123	Sirolimus	[Tetradecanoylphorbol Acetate results in increased activity of PRKCH protein] inhibits the reaction [Sirolimus results in decreased phosphorylation of RPS6 protein]	16832347
D053260	Soot	Soot affects the expression of PRKCH mRNA	26551751
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PRKCH mRNA	23152189
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRKCH mRNA	17942748
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of PRKCH mRNA	25975270
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased activity of PRKCH protein	16832347
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate results in increased activity of PRKCH protein] inhibits the reaction [Sirolimus results in decreased phosphorylation of RPS6 protein]	16832347
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PRKCH mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in decreased expression of PRKCH mRNA	22378314
D014212	Tretinoin	Tretinoin results in increased expression of PRKCH mRNA	17431108
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of PRKCH gene	27618143
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCH mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of PRKCH mRNA	24935251\|2627250
D014415	Tunicamycin	Tunicamycin results in decreased expression of PRKCH mRNA	22378314
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCH mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of PRKCH mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of PRKCH mRNA	23179753\|2438349
D014638	Vanadates	Vanadates results in decreased expression of PRKCH mRNA	22714537
C025643	vinclozolin	vinclozolin affects the expression of PRKCH mRNA	19015723
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCH mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of PRKCH mRNA	26272509

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004674	protein serine/threonine kinase activity	-	IBA	21873635
GO:0004697	protein kinase C activity	-	TAS	1986216
GO:0004699	calcium-independent protein kinase C activity	-	IEA	-
GO:0005515	protein binding	-	IPI	19114660
GO:0005524	ATP binding	-	IEA	-
GO:0017160	Ral GTPase binding	-	IEA	-
GO:0019899	enzyme binding	-	IPI	15632189
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006468	protein phosphorylation	-	IMP	22304920
GO:0007165	signal transduction	-	TAS	1986216
GO:0010744	positive regulation of macrophage derived foam cell differentiation	-	ISS	-
GO:0018105	peptidyl-serine phosphorylation	-	IBA	21873635
GO:0030168	platelet activation	-	TAS	-
GO:0034351	negative regulation of glial cell apoptotic process	-	IMP	11772428
GO:0035556	intracellular signal transduction	-	IBA	21873635
GO:0045618	positive regulation of keratinocyte differentiation	-	ISS	-
GO:0050861	positive regulation of B cell receptor signaling pathway	-	IMP	18780722
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IMP	21820409
GO:0060252	positive regulation of glial cell proliferation	-	IMP	10806212
GO:0070528	protein kinase C signaling	-	IEA	-
GO:1903078	positive regulation of protein localization to plasma membrane	-	TAS	22732145
GO:2000810	regulation of bicellular tight junction assembly	-	IMP	19114660

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IDA	15632189
GO:0005829	cytosol	-	ISS	-
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	IDA	15632189
GO:0005911	cell-cell junction	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19056867

KEGG ID	KEGG Term
hsa04270	Vascular smooth muscle contraction
hsa04530	Tight junction

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-114508	Effects of PIP2 hydrolysis	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	IEA
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-388396	GPCR downstream signalling	IEA
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-418597	G alpha (z) signalling events	IEA
R-HSA-76002	Platelet activation, signaling and aggregation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25900926	Protein kinase Ceta polymorphism and the susceptibility to ischemic stroke in the Taiwan population. (2015 Sep-Oct)	Chen YC	Biomed J
22808203	The SNP (rs2230500) in PRKCH decreases the risk of carotid intima-media thickness in a Chinese young adult population. (2012)	Wu L	PLoS One