Gene: CAND1

55832
TIP120|TIP120A
cullin associated and neddylation dissociated 1
protein-coding
12q14.3-q15
Ensembl:ENSG00000111530 MIM:607727 Vega:OTTHUMG00000169060 UniprotKB:Q86VP6
NG_051239.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.106e-1 (AD)  2.684e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14292572chr12:67665055CAND12.500e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VPS350.979
CLTC0.976
NAPG0.976
WDR470.973
ORC40.973
COL4A3BP0.972
RANBP60.972
MTMR90.971
GMPS0.971
PPP2R5E0.97

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.57
OR4F29-0.516
CSAG1-0.463
FZD10-0.382
TFPI2-0.378
MYL3-0.376
HEY2-0.375
MTRNR2L10-0.374
MTRNR2L6-0.37
KLRB1-0.37

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of CAND1 mRNA"19162173
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CAND1 mRNA"21346803
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CAND1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of CAND1 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of CAND1 gene25435355
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CAND1 mRNA"19150397
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of CAND1 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of CAND1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased methylation of CAND1 promoter27312807
C006780bisphenol Abisphenol A results in increased methylation of CAND1 promoter27312807
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of CAND1 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of CAND1 mRNA25181051|2909715
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of CAND1 mRNA15336504
D002273CarcinogensCarcinogens results in increased expression of CAND1 mRNA22269147
C018021cobaltous chloridecobaltous chloride results in increased expression of CAND1 mRNA19376846
D003976DiazinonDiazinon affects the expression of CAND1 mRNA22546817
D002945CisplatinCisplatin results in increased expression of CAND1 protein22023808
C000944dicrotophosdicrotophos results in decreased expression of CAND1 mRNA28302478
D004026DieldrinDieldrin affects the expression of CAND1 mRNA22546817
C118739entinostatentinostat results in decreased expression of CAND1 mRNA26272509
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CAND1 protein23301498
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of CAND1 mRNA17347304
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CAND1 mRNA17108234|2909715
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of CAND1 mRNA17347304
D005485FlutamideFlutamide results in increased expression of CAND1 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of CAND1 mRNA23649840
D005839GentamicinsGentamicins results in increased expression of CAND1 mRNA22061828
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of CAND1 protein18951874
C492448ICG 001ICG 001 results in decreased expression of CAND1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CAND1 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of CAND1 mRNA27392435
D007854LeadLead results in increased expression of CAND1 mRNA19921347
C008261lead acetate[lead acetate co-treated with zinc protoporphyrin] results in increased expression of CAND1 mRNA22839698
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CAND1 mRNA"24972896
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CAND1 mRNA21641980
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CAND1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CAND1 mRNA26011545
D009153MutagensMutagens results in increased expression of CAND1 mRNA22269147
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CAND1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CAND1 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of CAND1 mRNA19167457
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CAND1 mRNA26794494
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of CAND1 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of CAND1 mRNA21318169
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in decreased expression of CAND1 mRNA]21318169
D010894PiroxicamPiroxicam results in increased expression of CAND1 mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of CAND1 mRNA23557933
D011794QuercetinQuercetin results in decreased expression of CAND1 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of CAND1 protein25895662
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CAND1 mRNA21641980
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of CAND1 mRNA"26680231
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CAND1 mRNA25613284
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of CAND1 protein18951874
C009495titanium dioxidetitanium dioxide results in decreased expression of CAND1 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CAND1 mRNA28065790
C057693troglitazonetroglitazone results in decreased expression of CAND1 mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of CAND1 mRNA23179753|2438349
C017803zinc protoporphyrin[lead acetate co-treated with zinc protoporphyrin] results in increased expression of CAND1 mRNA22839698

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12504025  12504026  12609982  15537541  16861300  17290223  
18826954  25435324  26496610  
GO:0017025TBP-class protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006879cellular iron ion homeostasis-TAS-  
GO:0010265SCF complex assembly-IBA21873635  
GO:0010265SCF complex assembly-IDA15537541  21249194  
GO:0016567protein ubiquitination-IBA21873635  
GO:0016567protein ubiquitination-IDA12609982  15537541  21249194  
GO:0030154cell differentiation-IDA10581176  
GO:0043086negative regulation of catalytic activity-IDA12609982  
GO:0043312neutrophil degranulation-TAS-  
GO:0043687post-translational protein modification-TAS-  
GO:0045899positive regulation of RNA polymerase II transcriptional preinitiation complex assembly-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000151ubiquitin ligase complex-IDA12609982  
GO:0005576extracellular region-TAS-  
GO:0005634nucleus-HDA21630459  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA10581176  21249194  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA21249194  
GO:0005794Golgi apparatus-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA19946888  
GO:0031461cullin-RING ubiquitin ligase complex-IDA15537541  21249194  22405651  
GO:0034774secretory granule lumen-TAS-  
GO:0070062extracellular exosome-HDA19056867  20458337  23533145  
GO:1904813ficolin-1-rich granule lumen-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-8951664NeddylationTAS
R-HSA-917937Iron uptake and transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27144936Contribution of Heritability and Epigenetic Factors to Skeletal Muscle Mass Variation in United Kingdom Twins. (2016 Jun)Livshits GJ Clin Endocrinol Metab