Gene: CENPN

55839
BM039|C16orf60|CENP-N|ICEN32
centromere protein N
protein-coding
16q23.2
Ensembl:ENSG00000166451 MIM:611509 Vega:OTTHUMG00000137628 UniprotKB:Q96H22
NC_000016.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.184e-1 (AD)  3.178e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AGTPBP10.822
HBS1L0.814
SRP720.809
CEP630.805
MTMR20.797
GNAI10.792
LPGAT10.791
CEP1700.791
SNX300.79
PIGK0.785

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EYA2-0.471
ACOX2-0.433
RFX2-0.404
SIX5-0.401
GPR143-0.398
NHSL1-0.395
MTRNR2L6-0.391
GLI3-0.391
MTRNR2L10-0.385
STON2-0.385

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CENPN mRNA"22698814
C07258116-hydroxycleroda-3,13(14)-dien-15,16-olide"16-hydroxycleroda-3,13(14)-dien-15,16-olide results in decreased expression of CENPN mRNA"21530604
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CENPN mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CENPN mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CENPN mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CENPN mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CENPN mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CENPN mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CENPN mRNA"25510870
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CENPN mRNA"23196670
D000082AcetaminophenAcetaminophen results in increased expression of CENPN mRNA22230336
D020106AcrylamideAcrylamide results in increased expression of CENPN mRNA28959563
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of CENPN mRNA"22863853
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CENPN mRNA"20382639
D004958EstradiolEstradiol results in increased expression of CENPN mRNA16474171|1916744
C006780bisphenol Abisphenol A affects the expression of CENPN mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CENPN mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of CENPN mRNA16474171
C006780bisphenol Abisphenol A results in decreased methylation of CENPN promoter27312807
C006780bisphenol Abisphenol A results in increased expression of CENPN mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of CENPN mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CENPN gene28505145
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of CENPN mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CENPN gene20938992
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CENPN mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of CENPN mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of CENPN mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of CENPN mRNA22147139
D016572CyclosporineCyclosporine results in increased expression of CENPN mRNA25562108
D000069439DasatinibDasatinib results in decreased expression of CENPN mRNA20579391
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CENPN mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of CENPN mRNA28962523
D005485FlutamideFlutamide results in increased expression of CENPN mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CENPN gene20938992
D019833GenisteinGenistein results in increased expression of CENPN mRNA16474171
D017313FenretinideFenretinide results in increased expression of CENPN mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of CENPN mRNA17183730
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CENPN mRNA25613284
C544151jinfukangjinfukang results in increased expression of CENPN mRNA27392435
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CENPN gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CENPN mRNA23649840
D015741MetriboloneMetribolone results in increased expression of CENPN mRNA17010675
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CENPN mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CENPN mRNA"25554681
D009532NickelNickel results in increased expression of CENPN mRNA25583101
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CENPN mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of CENPN mRNA25729387
D010126OzoneOzone results in decreased expression of CENPN mRNA24336422
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CENPN mRNA"25510870
D010634PhenobarbitalPhenobarbital affects the expression of CENPN mRNA23091169
D010936Plant ExtractsPlant Extracts results in increased expression of CENPN mRNA23557933
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of CENPN mRNA16474171
D011374ProgesteroneProgesterone results in decreased expression of CENPN mRNA23012394
D011374ProgesteroneProgesterone results in increased expression of CENPN mRNA18070364
C005556propionaldehydepropionaldehyde results in decreased expression of CENPN mRNA26079696
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of CENPN mRNA19167446
C059514resveratrolresveratrol results in increased expression of CENPN mRNA23419489
D012999SomanSoman results in increased expression of CENPN mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CENPN mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CENPN mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CENPN mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CENPN mRNA25613284
D013849ThimerosalThimerosal results in increased expression of CENPN mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of CENPN mRNA22659510|2341159
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CENPN mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CENPN mRNA25729387
D019772TopotecanTopotecan results in decreased expression of CENPN mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CENPN mRNA19042947
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of CENPN mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of CENPN mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CENPN mRNA27188386|2800136
C025643vinclozolinvinclozolin results in decreased expression of CENPN mRNA23555832
C111237vorinostatvorinostat results in increased expression of CENPN mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007059chromosome segregation-IEA-  
GO:0034080CENP-A containing nucleosome assembly-TAS-  
GO:0051382kinetochore assembly-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000777condensed chromosome kinetochore-IEA-  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-141424Amplification of signal from the kinetochoresTAS
R-HSA-141444Amplification of signal from unattached kinetochores via a MAD2 inhibitory signalTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2500257Resolution of Sister Chromatid CohesionTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-5663220RHO GTPases Activate ForminsTAS
R-HSA-606279Deposition of new CENPA-containing nucleosomes at the centromereTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69618Mitotic Spindle CheckpointTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73886Chromosome MaintenanceTAS
R-HSA-774815Nucleosome assemblyTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26202054Interaction between smoking history and gene expression levels impacts survival of breast cancer patients. (2015 Aug)Andres SABreast Cancer Res Treat
28346444Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility. (2017 May)Wright DJNat Genet