Gene: PRKCI

5584
DXS1179E|PKCI|nPKC-iota
protein kinase C iota
protein-coding
3q26.2
Ensembl:ENSG00000163558 MIM:600539 Vega:OTTHUMG00000150214 UniprotKB:P41743
NC_000003.12
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.640e-1 (AD)  3.666e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMX30.969
KPNA10.952
BLOC1S60.952
SS18L10.951
TRAPPC110.951
OPA10.948
AVL90.948
UBE2K0.948
CDC270.947
MSH20.945

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.539
OR4F29-0.485
CSAG1-0.438
MTRNR2L6-0.385
MTRNR2L10-0.372
MTRNR2L9-0.371
MYL3-0.37
HEY2-0.367
WDR38-0.346
CNN2-0.344

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB03777Rbt205 InhibitorSmall MoleculeExperimentalTarget
DB00675TamoxifenSmall Molecule10540-29-1ApprovedTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PRKCI mRNA"19114083
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of PRKCI mRNA20829426
D000082AcetaminophenPRKCI gene polymorphism affects the susceptibility to Acetaminophen26104854
D016604Aflatoxin B1[sulforafan co-treated with Aflatoxin B1] affects the expression of PRKCI mRNA25450479
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PRKCI mRNA16483693
D000661AmphetamineAmphetamine results in increased expression of PRKCI mRNA16101753
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PRKCI mRNA24449571
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PRKCI mRNA"20018196
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PRKCI mRNA"26238291
C006780bisphenol Abisphenol A affects the expression of PRKCI mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of PRKCI protein23545179
C006780bisphenol Abisphenol A results in increased expression of PRKCI mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of PRKCI mRNA24752500
D004390ChlorpyrifosChlorpyrifos results in decreased expression of PRKCI mRNA19368821
C031180chrysenechrysene results in increased expression of PRKCI mRNA26377693
D060729Coal AshCoal Ash results in increased expression of PRKCI mRNA19000753
C018021cobaltous chloridecobaltous chloride results in increased expression of PRKCI mRNA19376846
D003300CopperCopper results in increased expression of PRKCI mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of PRKCI mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of PRKCI mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of PRKCI mRNA19549813
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PRKCI mRNA]27941970
D003976DiazinonDiazinon affects the expression of PRKCI mRNA17452286
D002945CisplatinPRKCI protein affects the susceptibility to Cisplatin16217747
D004008DiclofenacDiclofenac affects the expression of PRKCI mRNA24752500
C121718dicyclanildicyclanil results in increased expression of PRKCI mRNA15664270
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of PRKCI mRNA26924002
D004317DoxorubicinPRKCI protein affects the susceptibility to Doxorubicin16217747
D000431EthanolEthanol results in decreased expression of PRKCI mRNA20655511
D000431Ethanol"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of PRKCI mRNA]"20655511
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PRKCI mRNA15212814
D018120FinasterideFinasteride results in increased expression of PRKCI mRNA24136188
D005419FlavonoidsFlavonoids results in decreased expression of PRKCI mRNA18035473
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of PRKCI mRNA]15016801
D005485FlutamideFlutamide results in increased expression of PRKCI mRNA24136188
C069837fullerene C60fullerene C60 results in decreased expression of PRKCI mRNA19167457
D005897GlafenineGlafenine results in decreased expression of PRKCI mRNA24136188
D007213IndomethacinIndomethacin results in decreased expression of PRKCI mRNA16984733
C051890irinotecanirinotecan metabolite results in increased phosphorylation of PRKCI protein15723263
C051890irinotecanirinotecan results in increased phosphorylation of PRKCI protein15723263
C544151jinfukangjinfukang results in decreased expression of PRKCI mRNA27392435
D007854LeadLead results in decreased expression of PRKCI protein16547843
C008261lead acetatelead acetate results in decreased expression of PRKCI protein16547843
C517284monomethyl phthalatemonomethyl phthalate affects the expression of PRKCI mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PRKCI mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PRKCI mRNA"25554681
C051752nefazodonenefazodone results in increased expression of PRKCI mRNA24136188
C028007nickel monoxidenickel monoxide results in decreased expression of PRKCI mRNA19167457
C520612N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of PRKCI mRNA]"20655511
C507134ON 01910ON 01910 results in increased expression of PRKCI mRNA22351695
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PRKCI mRNA27153767
D010695PhlorhizinPhlorhizin results in decreased expression of PRKCI mRNA22538082
C006253pirinixic acidpirinixic acid results in increased expression of PRKCI mRNA18301758|2381119
D010936Plant ExtractsPlant Extracts results in increased expression of PRKCI mRNA23557933
D011794QuercetinQuercetin results in decreased expression of PRKCI mRNA21632981
D011794QuercetinQuercetin results in increased expression of PRKCI mRNA26076811
C059514resveratrolresveratrol results in decreased expression of PRKCI protein18089832
C064758Ro 31-8220Ro 31-8220 results in decreased activity of PRKCI protein14511371
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of PRKCI mRNA19244175
D012643SeleniumSelenium results in decreased expression of PRKCI mRNA19244175
D012715Sesame OilSesame Oil results in decreased expression of PRKCI mRNA29191790
C016766sulforafan[sulforafan co-treated with Aflatoxin B1] affects the expression of PRKCI mRNA25450479
D013467SulindacSulindac results in increased expression of PRKCI mRNA24136188
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of PRKCI mRNA"26680231
C061133tamibarotenetamibarotene results in decreased expression of PRKCI mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PRKCI mRNA21724226
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased localization of PRKCI protein21295103
D013755Tetradecanoylphorbol Acetatewogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of PRKCI protein]21295103
D014212TretinoinTretinoin affects the expression of PRKCI mRNA15498508
C012589trichostatin Atrichostatin A results in increased expression of PRKCI mRNA15901671
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of PRKCI mRNA23537331
D014635Valproic AcidValproic Acid results in increased expression of PRKCI mRNA15901671
D014639VanadiumVanadium results in increased expression of PRKCI mRNA19000753
D014639VanadiumPRKCI protein mutant form inhibits the reaction [Vanadium results in increased phosphorylation of and results in increased activity of AKT1 protein]14971662
D014639VanadiumVanadium affects the localization of PRKCI protein14971662
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PRKCI gene25560391
C025643vinclozolinvinclozolin results in increased expression of PRKCI mRNA23034163
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of PRKCI mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of PRKCI mRNA19244175
C085514wogoninwogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of PRKCI protein]21295103

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IDA11724794  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA8226978  21983565  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0004697protein kinase C activity-ISS-  
GO:0005515protein binding-IPI11257119  11260256  11724794  12725730  12893243  14676191  
15590654  16189514  16792529  17057644  17313651  17979178  
19617897  20562859  20808283  21516116  23446420  24375676  
24525231  24682284  25852190  26496610  26977885  
GO:0005524ATP binding-TAS8226978  
GO:0005543phospholipid binding-IDA8226978  
GO:0019904protein domain specific binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IDA8226978  
GO:0006612protein targeting to membrane-NAS11257119  
GO:0007010cytoskeleton organization-NAS11257119  
GO:0007015actin filament organization-IEA-  
GO:0010976positive regulation of neuron projection development-IMP10467349  
GO:0016192vesicle-mediated transport-TAS11257119  
GO:0016477cell migration-IEA-  
GO:0018105peptidyl-serine phosphorylation-IBA21873635  
GO:0018105peptidyl-serine phosphorylation-IDA21983565  
GO:0032869cellular response to insulin stimulus-ISS-  
GO:0034351negative regulation of glial cell apoptotic process-IMP21419810  
GO:0035089establishment of apical/basal cell polarity-IEA-  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0042462eye photoreceptor cell development-IEA-  
GO:0043066negative regulation of apoptotic process-TAS-  
GO:0043524negative regulation of neuron apoptotic process-IDA10467349  
GO:0045197establishment or maintenance of epithelial cell apical/basal polarity-TAS14676191  
GO:0045216cell-cell junction organization-IMP11257119  
GO:0045747positive regulation of Notch signaling pathway-TAS-  
GO:0046326positive regulation of glucose import-ISS-  
GO:0046903secretion-NAS8226978  
GO:0048194Golgi vesicle budding-IEA-  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IDA10467349  
GO:0060252positive regulation of glial cell proliferation-IMP21419810  
GO:0061024membrane organization-NAS11257119  
GO:0070555response to interleukin-1-IEA-  
GO:0070830bicellular tight junction assembly-TAS-  
GO:1903078positive regulation of protein localization to plasma membrane-ISS-  
GO:2000353positive regulation of endothelial cell apoptotic process-IMP19327373  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005634nucleus-IDA11260256  21419810  
GO:0005654nucleoplasm-TAS-  
GO:0005768endosome-IEA-  
GO:0005829cytosol-IDA11257119  21419810  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0005923bicellular tight junction-IEA-  
GO:0015630microtubule cytoskeleton-IDA-  
GO:0016324apical plasma membrane-IEA-  
GO:0031252cell leading edge-IEA-  
GO:0032991protein-containing complex-IEA-  
GO:0043220Schmidt-Lanterman incisure-IEA-  
GO:0045171intercellular bridge-IDA-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04144Endocytosis
hsa04530Tight junction
hsa04910Insulin signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-157118Signaling by NOTCHTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1912408Pre-NOTCH Transcription and TranslationTAS
R-HSA-1912422Pre-NOTCH Expression and ProcessingTAS
R-HSA-193639p75NTR signals via NF-kBTAS
R-HSA-193704p75 NTR receptor-mediated signallingTAS
R-HSA-209543p75NTR recruits signalling complexesTAS
R-HSA-420029Tight junction interactionsTAS
R-HSA-421270Cell-cell junction organizationTAS
R-HSA-446728Cell junction organizationTAS
R-HSA-73887Death Receptor SignallingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26563126Glutamatergic and HPA-axis pathway genes in bipolar disorder comorbid with alcohol- and substance use disorders. (2016 Feb)Dalvie SMetab Brain Dis
21170350Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancer. (2010 Dec 7)Ostroff RMPLoS One